Changes in Scleral Architecture in Chronic Vogt-Koyanagi-Harada Disease.

Abstract:

PURPOSE:To describe scleral changes in chronic VKH. METHODS:Medical records of patients with chronic VKH were retrospectively reviewed. Change of scleral architecture was defined as progressive posterior bowing on OCT, axial length elongation, and/or increased myopia more than -1.0 D, not explicable by other etiologies. RESULTS:In total, 28 eyes (16 patients) with mean age of disease onset 32.5 ± 14.0 years were included in the study. Disease duration was 15.1 ± 10.2 years. Eight eyes (28.6%) showed progressive scleral architectural changes. Five eyes (18%) developed scleral changes on OCT, not seen on prior imaging (2-12 years earlier). One eye had posterior bowing on OCT with increased axial length, both eyes of a bilateral pseudophake developed increased myopia with increased axial length. Well-circumscribed chorioretinal atrophy within the arcade was associated with progressive scleral change. CONCLUSIONS:Progressive scleral change may develop as a late complication of VKH. The association with well-circumscribed chorioretinal atrophy suggests that chronic choroidal inflammation may be responsible.

journal_name

Ocul Immunol Inflamm

authors

Harada Y,Bhat P,Munk MR,Goldstein DA

doi

10.3109/09273948.2015.1057600

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

85-92

issue

1

eissn

0927-3948

issn

1744-5078

journal_volume

25

pub_type

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