Tocilizumab for the Treatment of Behçet Uveitis that Failed Interferon Alpha and Anti-Tumor Necrosis Factor-Alpha Therapy.

Abstract:

PURPOSE:To report the results of tocilizumab (TCZ) treatment in patients with Behçet uveitis (BU) who had failed conventional, interferon alpha, and anti-Tumor necrosis factor-alpha therapy. METHODS:We reviewed the records of five patients with BU treated with monthly infusions of TCZ 8 mg/kg. Outcome measures were visual acuity, anterior chamber cells, laser flare meter (LFM) readings, vitreous haze, central macular thickness (CMT), and fluorescein angiography (FA) score. RESULTS:The clinical inactivity of BU and 20/50 or better vision were achieved in three female and two male patients treated with TCZ for 5-19 months. The mean LFM reading was reduced from 15.4 ± 2.7 to 5.0 ± 0.9 ph/ms; the mean CMT from 324.7 ± 36.6 µm to 280.2 ± 34.1 µm; and the mean FA score from 20.6 ± 5.4 to 9.3 ± 4.5 µm at the last visit. The only side effect was a slight elevation of the total cholesterol level in one patient. CONCLUSIONS:Tocilizumab may be a safe and effective therapeutic option for refractory BU.

journal_name

Ocul Immunol Inflamm

authors

Eser Ozturk H,Oray M,Tugal-Tutkun I

doi

10.1080/09273948.2017.1355471

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

1005-1014

issue

7

eissn

0927-3948

issn

1744-5078

journal_volume

26

pub_type

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