Abstract:
PURPOSE:To describe a case of severe central retinal vein occlusion (CRVO) in a young patient, in whom intensive immunosuppressive therapy improved the clinical outcome. CASE REPORT:A 35-year-old men presented with a first episode of CRVO in his right eye in 1990. Despite corticosteroids and laser treatment, rubeotic glaucoma developed and the eye had to be enucleated. Seven years later, CRVO developed in the fellow eye, with venous tortuosity and haemorrhages. An extensive systemic workup was unremarkable. Corticosteroids failed to control the clinical situation. Cells were seen in the anterior vitreous. Visual acuity decreased to 2/60. Cyclosporine and azathioprine were added, but did not prevent recurrences. Campath-1H treatment was then started and visual acuity improved to 6/36. In November 2000, visual acuity was 6/24 and haemorrhages had cleared. DISCUSSION:Many authors have proposed a role for inflammation in the pathophysiology of CRVO in young patients. However, there is no general agreement on corticosteroid use in these patients. Our case illustrates that, in some settings, high-dose corticosteroids and intensive immunosuppression might be used successfully to preserve vision.
journal_name
Ocul Immunol Inflammjournal_title
Ocular immunology and inflammationauthors
Willermain F,Greiner K,Forrester JVdoi
10.1076/ocii.10.2.141.13981subject
Has Abstractpub_date
2002-06-01 00:00:00pages
141-5issue
2eissn
0927-3948issn
1744-5078journal_volume
10pub_type
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journal_title:Ocular immunology and inflammation
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