Abstract:
:Nedocromil sodium (NS) and sodium cromoglycate (CS) (both applied locally into the conjunctival sac) reduced in a dose dependent manner plasma extravasation induced by topical bradykinin and by topical substance P (SP), NS being approximately ten times more potent than CS. Plasma extravasation induced by SP was unaffected by the histamine H(1) receptor antagonist, pyrilamine, which completely blocked the plasma extravasation induced by histamine. NS and CS reduced the plasma extravasation caused by the mechanical stimulation of the conjunctiva, a response that was not affected by the tachykinin NK(1) antagonist CP-(99.994). NS or CS did not affect the contraction of strips of the guinea-pig trachea in vitro caused by SP in the presence of the tachykinin NK(2) receptor antagonist SR-(48968). NS, more potently than CS, reduces the plasma extravasation caused by various inflammatory stimuli in the guinea-pig conjunctiva, without inhibiting tachykinin NK(1) receptors, but probably by acting at the level of the venular endothelium. However, an inhibitory action of NS and CS on neural transmission of sensory nerves cannot be excluded.
journal_name
Ocul Immunol Inflammjournal_title
Ocular immunology and inflammationauthors
Javdan P,Figini M,Ricciardolo FL,Geppetti Pdoi
10.3109/09273949509057809subject
Has Abstractpub_date
1995-01-01 00:00:00pages
37-44issue
1eissn
0927-3948issn
1744-5078journal_volume
3pub_type
杂志文章abstract:PURPOSE:Describe a case series of ocular Cat-scratch-disease (CSD) with vision-threatening findings and poor outcomes, indicating severity of disease. METHODS:Retrospective case series from the Uveitis Department of São Paulo Federal University from 2011 to 2015. RESULTS:In this period, six eyes of four patients had ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1327077
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:The study was to evaluate the diagnostic efficacy of nested polymerase chain reaction (nPCR) using primers targeting B1 gene of Toxoplasma gondii (T. gondii) with Witmer Desmonts coefficient (WDC) technique in intraocular fluids of clinically suspected toxoplasma retino choroiditis (TRC) patients. MATERIALS ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940500545692
更新日期:2006-04-01 00:00:00
abstract:PURPOSE:To describe the evaluation of optical coherence tomography (OCT) scans in the Muliticenter Uveitis Steroid Treatment (MUST) trial and report baseline OCT features of enrolled participants. METHODS:Time-domain OCTs acquired by certified photographers using a standardized scan protocol were evaluated at a readin...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/09273948.2012.719258
更新日期:2012-12-01 00:00:00
abstract::Purpose: To analyze the clinical features and long-term prognosis of uveitis in tubulointerstitial nephritis and uveitis (TINU) syndrome in a cohort of Chinese patients. Methods: A total of 32 patients with TINU syndrome between 2000 - 2016 were analyzed retrospectively. Results: Mild anterior inflammation was observe...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1394469
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To report a case of subretinal fibrosis and uveitis syndrome in association with ectodermal dysplasia. METHODS:Chart review of a patient with subretinal fibrosis and uveitis syndrome and ectodermal dysplasia. RESULTS:The authors identified one case of a patient with the diagnoses of subretinal fibrosis and uv...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273940903168670
更新日期:2009-09-01 00:00:00
abstract:AIM:To compare outcomes of live related limbal allograft (Lr-CLAL) versus cadaveric keratolimbal allograft (KLAL) in limbal stem cell deficiency (LSCD) secondary to ocular burns. METHODS:Twenty patients with stage IIb LSCD were randomized so that cases underwent either Lr-CLAL or KLAL. Fibrovascular pannus was removed...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,随机对照试验
doi:10.3109/09273948.2014.902076
更新日期:2015-06-01 00:00:00
abstract::Recrudescence is a common and troubling feature of Acanthamoeba keratitis and suggests that corneal infection with this organism fails to stimulate the systemic immune apparatus. The present study examined the cell-mediated and humoral immune responses to Acanthamoeba keratitis in the Chinese hamster. Corneal infectio...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949709085064
更新日期:1997-12-01 00:00:00
abstract::The postoperative course of cataract extraction and IOL implantation combined with trabeculectomy in glaucoma patients and of cataract extraction with intraocular lens (IOL) in diabetic patients is more complicated than that of cataract extraction with IOL implantation in otherwise healthy eyes. The main complications...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949309057057
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:Tear lysozyme and tear lactoferrin are enzymes synthesized by the lacrimal gland. Their concentration in human tears reflects tear gland function. Tear gland dysfunction can lead to ocular surface disease. We developed a colorimetric lysozyme assay. The objective of this study was to determine the diagnostic po...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1076/ocii.7.1.7.8108
更新日期:1999-03-01 00:00:00
abstract::The surgical technique and immediate results following posterior chamber IOL implantation after cataract extraction in eight children suffering from chronic uveitis are described. In all cases, improvement of the visual acuity and a better control of the intraocular inflammatory processes could be achieved after surge...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949309086555
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:To report a challenging case of unilateral choroidal effusion. METHODS:A case report about patient who presented with unilateral choroidal effusion and who was taking sulfonamides. Patient has been under care of a multidisciplinary team of uveitis consultant, ocular oncology consultant, and systemic oncology c...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1770300
更新日期:2020-07-09 00:00:00
abstract:PURPOSE:To investigate the incidence and risk factors of secondary glaucoma among uveitis patients. METHODS:Retrospective review of medical records of 642 patients (1220 eyes). RESULTS:Glaucoma was diagnosed in 169 (13.9%) eyes and was most common in eyes with anterior uveitis (19.1%) (p < 0.001). HLA-B27-positive an...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2015.1047036
更新日期:2016-10-01 00:00:00
abstract:INTRODUCTION:The most distinctive patterns of posterior pole affectation in syphilitic patients are acute posterior placoid chorioretinitis (ASPPC), pseudoretinitis pigmentosa and panuveitis with white focal preretinal opacities. However, outer retinitis is not a common presenting feature in this disease. CASE REPORT:...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2020.1787464
更新日期:2020-07-23 00:00:00
abstract::The treatment of articular and extra-articular manifestations associated with HLA-B27 has undergone dramatic changes over the past two decades, mainly as a consequence of the introduction of biologic agents and in particular anti-tumor necrosis factor α (anti-TNFα) agents. Uveitis is known to be the most frequent extr...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1080/09273948.2016.1234625
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To report the visual field changes in patients with serpiginous choroiditis as seen in a referral clinic in India. METHODS:A retrospective noncomparative case series was conducted. Twenty-nine eyes of 17 patients who were diagnosed with serpiginous choroiditis were included in the study. Clinical findings were...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2014.902473
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To describe four cases of familial Juvenile Idiopathic Arthritis (JIA) associated uveitis. DESIGN:Retrospective observational case series. METHODS:Clinical data from patients who present familial JIA-associated uveitis are described and possible genetic influence in disease etiology is reviewed. RESULTS:Two ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273941003678837
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:To investigate prognostic factors for retinal sensitivity assessed by microperimetry in patients with Vogt-Koyanagi-Harada (VKH) disease. METHODS:In total, 34 patients with initial-onset acute disease and 19 patients with chronic recurrent disease were retrospectively evaluated. RESULTS:The mean follow-up per...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2016.1139730
更新日期:2017-08-01 00:00:00
abstract::Purpose: To report a case of chronic anterior uveitis associated with relapsing polychondritis (RP).Case Report: A 43-year-old female patient presenting with bilateral progressive vision loss was diagnosed with bilateral anterior uveitis. According to her clinical signs and symptoms and biopsy results, RP was ultimate...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2018.1547834
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To report a case of toxic anterior uveitis probably secondary to the use of topical podophyllum. DESIGN:Case report, interventional. METHODS:The authors present a 78-year-old male with acute anterior uveitis that developed within a couple of hours of application of topical podophyllum. In vivo confocal micr...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2010.551446
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:To present a case of tubercular serpiginous-like choroiditis (SLC) with previously unreported choroidal findings on enhanced depth imaging OCT (EDI-OCT). DESIGN:Case report. METHODS:A 60-year-old female presented with decreased vision. Serpiginous choroidopathy was diagnosed. Laboratory workup revealed an inf...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2014.964421
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:To report an immunocompetent patient with Nocardia exalbida endogenous endophthalmitis. DESIGN:Case report. METHODS:Clinical-pathologic correlation and microbiologic evaluation were performed on an enucleated eye. RESULTS:A 56-year-old man presented with rapidly progressive vision loss associated with a post...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.3109/09273948.2011.563898
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To evaluate corneal parameters of scleroderma (SC) patients by Pentacam-HR. METHODS:Twenty-two eyes of 22 SC patients and 33 eyes of 33 control subjects were enrolled. All participants underwent Pentacam (Pentacam-HR, Oculus, Germany) evaluation. Both SC and control groups were divided into two subgroups as dr...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2015.1115079
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:The authors observed that eyes with acute fibrinous central serous chorioretinopathy (CSC) masquerading active choroiditis had a "dark spot" within the yellow fibrinous deposit. The present study aims to describe this sign as a clinical indicator of acute serofibrinous exudative detachment, thus helping to diff...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2013.765015
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:Ipilimumab, a monoclonal antibody directed against the immune protein cytotoxic T-lymphocyte antigen-4 (CTLA-4), characteristically induces side effects called "immune-related adverse events" (IRAE). Although ophthalmic involvement is rare, we report 7 cases of eye and orbit complications related to ipilimumab ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.3109/09273948.2014.1001858
更新日期:2016-01-01 00:00:00
abstract:AIM:To report 2 cases of idiopathic anterior uveitis with coexistent myasthenia gravis. MATERIALS AND METHODS:Retrospective case reports. RESULTS:A 60-year-old male and a 40-year-old male presented with chronic nongranulomatous anterior uveitis of unknown etiology. The latter had a history of hypothyroidism. During f...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.3109/09273948.2012.726687
更新日期:2013-01-01 00:00:00
abstract::Onchocercal keratitis (river blindness) is one of the leading worldwide causes of blindness. Light microscopic analysis of human specimens and corneal tissue from experimental models has implicated the eosinophil as an important cell in the inflammatory response. Our previous studies in experimental murine onchocercal...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949709116890
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:To investigate serum inflammatory factors in patients with idiopathic choroidal vascularization (CNV), including vascular endothelial growth factor (VEGF), tumor necrosis factor alpha (TNFα), Interleukin1-beta (IL1-β), IgG, IgA, IgM, IgE, 50% hemolytic unit of complement (CH50), complement C3, complement C4 a...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2010.483315
更新日期:2010-10-01 00:00:00
abstract::Recent reports have shown that dry eye in Sjögren's syndrome (SS) is associated with reactivation of Epstein-Barr virus (EBV) in lacrimal glands. However, the number of patients examined were few and it has not been determined whether dry eye in the absence of SS is also related to EBV reactivation. The authors exam...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949409057066
更新日期:1994-01-01 00:00:00
abstract::Scleritis is a severe and destructive inflammatory eye disease characterized by extensive extracellular matrix degradation. As in rheumatoid arthritis (RA), tissue destruction in scleritis may be mediated in part by matrix metalloproteinases such as collagenase (MMP-1) and stromelysin (MMP-3) which are normally kept i...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949509069111
更新日期:1995-01-01 00:00:00
abstract::Purpose: To evaluate neurosyphilis cerebrospinal fluid (CSF) findings and initial ophthalmic manifestations in patients with syphilitic uveitis. Methods: We retrospectively reviewed the records of CSF analysis of 14 patients with syphilitic uveitis with treponemal analysis - chemiluminescent immunoassay and TPHA- and ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1672193
更新日期:2019-10-24 00:00:00