Neurosyphilis cerebrospinal fluid findings in patients with ocular syphilis.

Abstract:

:Purpose: To evaluate neurosyphilis cerebrospinal fluid (CSF) findings and initial ophthalmic manifestations in patients with syphilitic uveitis. Methods: We retrospectively reviewed the records of CSF analysis of 14 patients with syphilitic uveitis with treponemal analysis - chemiluminescent immunoassay and TPHA- and non-treponemal analysis - Rapid Plasma Reagin test - RPR. Results: 86% were males and 43% HIV+. Ocular signs of syphilis lead to the diagnosis of syphilis in 78% of patients. Typical syphilitic uveitis presentations included: acute syphilitic posterior placoid chorioretinitis (50% of patients), retinitis (21% of patients) and punctate inner retinitis (7% of patients). 57% of patients had definite neurosyphilis by the CDC criteria, while 71% had CSF abnormalities suggestive of central nervous system involvement. Conclusion: Based on international guidelines, the frequent CSF abnormalities found in syphilitic uveitis patient supports the diagnosis of neurosyphilis in a majority of patients.

journal_name

Ocul Immunol Inflamm

authors

Bazewicz M,Lhoir S,Makhoul D,Libois A,Van den Wijngaert S,Caspers L,Willermain F

doi

10.1080/09273948.2019.1672193

subject

Has Abstract

pub_date

2019-10-24 00:00:00

pages

1-7

eissn

0927-3948

issn

1744-5078

pub_type

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