Effect of prolonged oral acyclovir treatment in acute retinal necrosis.

Abstract:

BACKGROUND:To examine the effectiveness of prolonged oral acyclovir treatment in patients with acute retinal necrosis (ARN). METHODS:Fifty-five ARN patients (62 eyes) who had been treated with short-term or long-term oral acyclovir were identified in this retrospective study: one group treated with prolonged oral acyclovir (≥14 weeks) and the other group treated with a shorter duration of oral acyclovir (<14 weeks). The authors examined whether the prolonged treatment reduced the involvement of the contralateral eye. They also evaluated prognostic factors for visual outcome. RESULTS:Prolonged oral acyclovir treatment reduced the involvement of the contralateral eye (p = .036). The visual outcome was influenced by the timing of treatment initiation after symptom onset (p = .030), the age of the patient (p = .027), the area of retinal disease (p = .026), and the retinal detachment (p = .002). CONCLUSIONS:Prolonged oral acyclovir treatment had a significant role in preventing the involvement of the contralateral eye.

journal_name

Ocul Immunol Inflamm

authors

Jeon S,Kakizaki H,Lee WK,Jee D

doi

10.3109/09273948.2012.689073

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

288-92

issue

4

eissn

0927-3948

issn

1744-5078

journal_volume

20

pub_type

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