Abstract:
PURPOSE:To assess the long-term efficacy of mycophenolate mofetil (MMF) in uveitic cystoid macular edema (CMO). METHODS:Thirty-eight uveitis patients with CMO treated with MMF with a follow-up of at least 5 years were analyzed. The patients were divided into two groups: group A, 24 patients with CMO that had occurred before initiation of MMF; group B, 14 patients who developed CMO for the first time during MMF. RESULTS:In group A, a complete remission of CMO without recurrences was observed in 12 of 24 patients (50%, rate: 0.12/patient-year). In group B, CMO occurred in 7 patients (50%) despite standard dosage of MMF, and in 7 patients (50%) during MMF dose reduction. CONCLUSIONS:The results show that MMF is not always sufficiently effective as a long-term treatment for uveitic macular edema. Moreover, in some uveitis patients MMF cannot prevent new development of CMO.
journal_name
Ocul Immunol Inflammjournal_title
Ocular immunology and inflammationauthors
Doycheva D,Zierhut M,Blumenstock G,Stuebiger N,Deuter Cdoi
10.3109/09273948.2012.665562subject
Has Abstractpub_date
2012-06-01 00:00:00pages
203-11issue
3eissn
0927-3948issn
1744-5078journal_volume
20pub_type
杂志文章abstract:PURPOSE:To determine the performance of T-SPOT.TB, an interferon gamma release assay test, in patients with ocular tuberculosis (TB) in a BCG-vaccinated, non-endemic population. METHODS:We employed a nested case-control design. In total, 45 subjects were enrolled (23 patients with ocular tuberculosis and 22 patients w...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2015.1135965
更新日期:2017-08-01 00:00:00
abstract::Background: Post-streptococcal uveitis is a rare ocular disease which is part of other auto-immune conditions associated with post-streptococcal syndrome. It was first mentioned in medical literature in 1991, with only a few cases published at that time. We are presenting the case of a patient with bilateral panuveiti...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2018.1501493
更新日期:2019-01-01 00:00:00
abstract::Purpose: To analyze the clinical features and long-term prognosis of uveitis in tubulointerstitial nephritis and uveitis (TINU) syndrome in a cohort of Chinese patients. Methods: A total of 32 patients with TINU syndrome between 2000 - 2016 were analyzed retrospectively. Results: Mild anterior inflammation was observe...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1394469
更新日期:2019-01-01 00:00:00
abstract::The effects of tachykinins on prostaglandin E2 (PGE2)-induced intraocular inflammation were investigated. PGE2 (0.01% or 0.1%) instillation induced iridal hyperemia and protein leakage into the aqueous humor in rabbits, but caused minimal miosis. Intravitreally injected substance P (SP) or neurokinin A (NKA), on the o...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1076/ocii.6.1.19.8080
更新日期:1998-03-01 00:00:00
abstract:PURPOSE:To describe the clinical and histopathological features of post viper bite anterior segment ischemia. METHODS:Seven patients with ocular complications following viper bite referred to uveitis clinic had slit-lamp examination, intraocular pressure (IOP) measurement, and fundus evaluation. Iris and fundus fluore...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2014.907435
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To identify the means by which in-vitro-generated regulatory T cells, similar to those in anterior chamber-associated immune deviation (ACAID), suppress antigen-specific T-cell responses. METHODS:T regulators (T regs), generated by stimulating ovalbumin (OVA)-specific Tcr transgenic DO11.10 T cells with OVA-pu...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940490895317
更新日期:2004-06-01 00:00:00
abstract::Aim: Ocular sarcoidosis presents a diagnostic challenge because of its varied clinical presentations. It is important to distinguish sarcoidosis from other uveitis diseases. Multimodal imaging provides useful data to be introduced into clinical practice. Methods: This is a review article. Conclusions: This review arti...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1751210
更新日期:2020-11-16 00:00:00
abstract:PURPOSE:The purpose of our study was to evaluate the potential efficacy and safety of intravitreal ranibizumab in patients with pseudophakic cystoid macular edema (CME). METHODS:This retrospective study comprised 7 eyes with CME treated with intravitreal ranibizumab. Patients were examined at 1 week and 1 month after ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2014.898775
更新日期:2015-06-01 00:00:00
abstract::Purpose: To report a case of chronic anterior uveitis associated with relapsing polychondritis (RP).Case Report: A 43-year-old female patient presenting with bilateral progressive vision loss was diagnosed with bilateral anterior uveitis. According to her clinical signs and symptoms and biopsy results, RP was ultimate...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2018.1547834
更新日期:2020-01-01 00:00:00
abstract::Purpose : To clarify whether a true neuroretinitis is part of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome.Methods : Critical literature review.Results : Neuroretinitis has been considered as a prominent feature of IRVAN syndrome. It has been described as late diffuse optic disc stai...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1836234
更新日期:2020-12-17 00:00:00
abstract:PURPOSE:To describe the clinical characteristics, diagnosis, and treatment of VIAU in immunocompromised patients. METHODS:A critical review of literature was performed. RESULTS:Diagnosis and treatment of VIAU in immunocompromised patients may be a challenge due to atypical clinical-courses, severe presentations, and ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1080/09273948.2018.1483519
更新日期:2018-01-01 00:00:00
abstract::Purpose: The purpose of this study is to explore the effects of dihydrotestosterone (DHT) on lipopolysaccharide (LPS)-induced proinflammatory cytokine release in human ocular surface epithelial cells exposed to LPS and LPS-binding protein (LBP).Methods: Immortalized human corneal, conjunctival, and meibomian gland epi...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1686155
更新日期:2019-11-18 00:00:00
abstract:PURPOSE:To report a patient with submacular hemorrhage due to retinal angiomatous proliferation (RAP) in tubercular retinal vasculitis (TRV). METHODS:Case report. RESULTS:We report a 33-year-old Asian Indian patient of TRV presenting with capillary non-perfusion areas, submacular hemorrhage and venous loops. The pati...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2020.1803363
更新日期:2020-09-25 00:00:00
abstract::Purpose: To evaluate the efficacy and safety of intravitreal ganciclovir (GCV) injection in refractory endotheliitis.Methods: Retrospectively recruited 25 eyes with endotheliitis, proved by clinical manifestations, positive PCR for viral DNA and responded poor to topical and systemic antiviral medications. All patient...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1573261
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To describe an unusual manifestation of sarcoidosis as a large tumor of the iris and ciliary body without any other involvement of the body. METHODS:We describe a 20-year-old female presenting with a granulomatous tumor of the right iris and ciliary body and concomitant uveitis. RESULTS:Extensive ocular and s...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/092739490500156
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:To analyze and compare the clinical profile of herpes zoster ophthalmicus (HZO) patients in a South Indian patient population aged <60 years and ≥60 years and determine the risk factors for recurrence of ocular inflammation. METHODS:Retrospective study of 249 cases between 2006 and 2016 from two tertiary refer...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1381272
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To demonstrate that fundus autofluorescence (FAF) imaging aides the diagnosis of rubella retinopathy (RR). METHODS:Four patients with sensorineural hearing loss underwent ophthalmic exams, electro-retinogram testing (ERG), and FAF in both eyes. Fluorescein angiogram (FA) was performed in one case. RESULTS:Sal...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273940903118634
更新日期:2009-11-01 00:00:00
abstract:PURPOSE:The authors observed that eyes with acute fibrinous central serous chorioretinopathy (CSC) masquerading active choroiditis had a "dark spot" within the yellow fibrinous deposit. The present study aims to describe this sign as a clinical indicator of acute serofibrinous exudative detachment, thus helping to diff...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2013.765015
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:To investigate prognostic factors for retinal sensitivity assessed by microperimetry in patients with Vogt-Koyanagi-Harada (VKH) disease. METHODS:In total, 34 patients with initial-onset acute disease and 19 patients with chronic recurrent disease were retrospectively evaluated. RESULTS:The mean follow-up per...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2016.1139730
更新日期:2017-08-01 00:00:00
abstract::Since experimental, herpes simplex virus-induced acute retinal necrosis (ARN) develops in mice only if the mice fail to acquire virus-specific delayed hypersensitivity (DH) and despite their production of anti-viral antibodies (i.e. ACAID), I investigated whether a similar situation exists for patients with either var...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1076/ocii.12.1.17.28066
更新日期:2004-03-01 00:00:00
abstract::Recent reports have shown that dry eye in Sjögren's syndrome (SS) is associated with reactivation of Epstein-Barr virus (EBV) in lacrimal glands. However, the number of patients examined were few and it has not been determined whether dry eye in the absence of SS is also related to EBV reactivation. The authors exam...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949409057066
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:To report a challenging case of unilateral choroidal effusion. METHODS:A case report about patient who presented with unilateral choroidal effusion and who was taking sulfonamides. Patient has been under care of a multidisciplinary team of uveitis consultant, ocular oncology consultant, and systemic oncology c...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1770300
更新日期:2020-07-09 00:00:00
abstract:PURPOSE:To investigate demographic, clinical features and complications of Italian patients with ocular Behçet's disease (BD) over time. METHODS:Retrospective study of 385 patients examined from 1968 to 2011, 265 of whom had follow-up ≥ 12 months. RESULTS:A significant increase in the proportion of females (p = 0.03)...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2015.1094095
更新日期:2017-02-01 00:00:00
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journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1795206
更新日期:2020-09-01 00:00:00
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journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.3109/09273948.2011.563898
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To describe scleral changes in chronic VKH. METHODS:Medical records of patients with chronic VKH were retrospectively reviewed. Change of scleral architecture was defined as progressive posterior bowing on OCT, axial length elongation, and/or increased myopia more than -1.0 D, not explicable by other etiologie...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2015.1057600
更新日期:2017-02-01 00:00:00
abstract::Intraocular tuberculosis presents a diagnostic challenge because of its protean clinical manifestations. Thus, it becomes imperative to distinguish chorioretinal inflammation due to tuberculosis from other infectious as well as non-infectious posterior uveitis since the clinical manifestations of these entities may be...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1080/09273948.2016.1231332
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To describe retinal vascular changes in Birdshot Retinochoroiditis (BSRC) with multimodal imaging techniques and functional values. METHODS:In this single-center study, 64 eyes of 32 subjects with BSRC were classified according to disease activity and duration and underwent imaging with spectral domain optical...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1375532
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:To describe treatment practices for ocular toxoplasmosis among members of the Brazilian Uveitis Society. METHODS:An online questionnaire sent to specialists, between October 2014 and March 2015. RESULTS:Most respondents (67.9%) treat all active cases. Most specialists consider visual acuity <20/200 (88.2%), s...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1215471
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To report a case of acute retinal necrosis (ARN) occurring in the opposite eye to the ophthalmic shingles eruption. DESIGN:Case report. METHODS:Clinical examination and multimodal imaging review, including ultra-widefield photography and fluorescein angiography (FA). RESULTS:A 49-years-old man attended the U...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1770298
更新日期:2020-07-09 00:00:00