Biologic Therapy for HLA-B27-associated Ocular Disorders.

Abstract:

:The treatment of articular and extra-articular manifestations associated with HLA-B27 has undergone dramatic changes over the past two decades, mainly as a consequence of the introduction of biologic agents and in particular anti-tumor necrosis factor α (anti-TNFα) agents. Uveitis is known to be the most frequent extra-articular feature in HLA-B27-associated spondyloarthritides. Topical corticosteroids and cycloplegic agents remain the cornerstones of treatment. However, biologic therapy may be effective in the management of refractory or recurrent forms of uveitis. This review gives an update on the management of HLA-B27-associated ocular disorders with biologics, including anti-TNFα agents and non-anti-TNFα biologic modifier drugs. There is an emerging role for newer biologics targeting interleukin-12/23 and interleukin-17 for the treatment of spondyloarthritides but data on their efficacy on anterior uveitis are sparse.

journal_name

Ocul Immunol Inflamm

authors

Gueudry J,Thorne JE,Bansie R,Braun J,van Hagen PM,Bodaghi B

doi

10.1080/09273948.2016.1234625

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

169-178

issue

2

eissn

0927-3948

issn

1744-5078

journal_volume

25

pub_type

杂志文章,评审
  • Uveal Effusion Associated with Presumed Viral Encephalitis.

    abstract::Background Uveal effusion is a rare disease that is characterized by exudative detachment of the ciliary body and choroid. Herein, we report a rare case of uveal effusion associated with viral encephalitis, which resolved following the treatment of the viral encephalitis and administration of corticosteroids. Case pre...

    journal_title:Ocular immunology and inflammation

    pub_type: 信件

    doi:10.1080/09273948.2020.1797110

    authors: Lee DH,Kim TY,Lee SC,Kim M

    更新日期:2020-08-20 00:00:00

  • Toxoplasmosis, an overview with emphasis on ocular involvement.

    abstract::Toxoplasmosis is a common parasitic zoonosis and an important cause of abortions, mental retardation, encephalitis, blindness, and death worldwide. Although a large body of literature has emerged on the subject in the past decades, many questions about the pathogenesis and treatment of the disease remain unanswered. T...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:10.1076/ocii.10.1.1.10330

    authors: Klaren VN,Kijlstra A

    更新日期:2002-03-01 00:00:00

  • Tuberculin Skin Testing Induces Bilateral Tuberculous Uveitis in a Junior High School Student.

    abstract::We report a rare case of bilateral tuberculous uveitis associated with tuberculin skin testing (TST) in an otherwise healthy junior high school student. A 12-year-old boy presented with severely decreased vision in both eyes and a history of an intradermal PPD (purified protein derivative) skin test 12 days earlier. T...

    journal_title:Ocular immunology and inflammation

    pub_type: 信件

    doi:10.1080/09273948.2020.1778731

    authors: Zhao H,Peng X

    更新日期:2020-08-12 00:00:00

  • Sympathetic ophthalmia following vitrectomy for endophthalmitis after intravitreal bevacizumab.

    abstract:PURPOSE:To describe a case of sympathetic ophthalmia following vitrectomy for endophthalmitis after an intravitreal injection of bevacizumab. DESIGN:Retrospective case report. METHODS:An 84-year-old male developed sympathetic ophthalmia 4 months after vitrectomy for endophthalmitis following an intravitreal injection...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940802409951

    authors: Sisk RA,Davis JL,Dubovy SR,Smiddy WE

    更新日期:2008-09-01 00:00:00

  • Corneal Graft Rejection after Yellow Fever Vaccine: A Case Report.

    abstract::Purpose: To report an unusual case of corneal graft rejection after yellow fever vaccine. Methods: Case report. Results: We have described the case of a 48-year-old man who developed a corneal graft rejection in the left eye 3 weeks after a yellow fever vaccination. The ophthalmic examination of the left eye revealed ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1870146

    authors: Vignapiano R,Vicchio L,Favuzza E,Cennamo M,Mencucci R

    更新日期:2021-01-28 00:00:00

  • Clinical Characteristics of Inflammatory Choroidal Neovascularization in a Chinese Population.

    abstract:PURPOSE:To describe demographic features and clinical and imaging characteristics of inflammatory choroidal neovascularization (CNV) in a Chinese population. METHODS:A retrospective case review of patients with CNV secondary to uveitis from 2002 to 2013. RESULTS:A total of 125 patients (150 eyes, 166 CNVs; bifocal CN...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2015.1015741

    authors: Wu K,Zhang X,Su Y,Ji Y,Zuo C,Li M,Wen F

    更新日期:2016-06-01 00:00:00

  • Diagnostic Challenges in Inflammatory Choroidal Neovascular Membranes.

    abstract:PURPOSE:To describe the clinical presentations of inflammatory choroidal neovascular membranes (CNVMs) and factors leading to their delayed diagnosis. METHODS:Retrospective analysis of chart records and digital images of 60 patients (73 eyes) with inflammatory CNVM (January 1998 to December 2013) to obtain demographic...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2016.1160128

    authors: Bansal R,Bansal P,Gupta A,Gupta V,Dogra MR,Singh R,Katoch D

    更新日期:2017-08-01 00:00:00

  • Subcutaneous Tocilizumab for Cystoid Macular Edema Secondary to Juvenile Idiopathic Arthritis (JIA)-associated Uveitis: A Case Report.

    abstract::Purpose: To report a case of cystoid macular edema (CME) secondary to juvenile idiopathic arthritis (JIA)-associated uveitis. Case report: 26-year-old female patient presented with CME in both eyes. CME became refractory and TCZ-IV was initiated. After 12 infusions was stopped because grade 1 neuropenia developed. On ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1644350

    authors: Adán A,Moll-Udina A,Ramirez J,Llorenç V

    更新日期:2019-10-07 00:00:00

  • Multimodal Imaging in Birdshot Retinochoroiditis.

    abstract:PURPOSE:To describe retinal vascular changes in Birdshot Retinochoroiditis (BSRC) with multimodal imaging techniques and functional values. METHODS:In this single-center study, 64 eyes of 32 subjects with BSRC were classified according to disease activity and duration and underwent imaging with spectral domain optical...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2017.1375532

    authors: Pohlmann D,Macedo S,Stübiger N,Pleyer U,Joussen AM,Winterhalter S

    更新日期:2017-10-01 00:00:00

  • Demographic and Clinical Characteristics of Uveitis in Turkey: The First National Registry Report.

    abstract:PURPOSE:To describe the demographic and clinical profiles of uveitis patients seen at secondary and tertiary care centers in Turkey. METHODS:A nationwide web-based registry of patients with uveitis was initiated in November 2008. We analyzed data from a single baseline registry-enrollment visit. RESULTS:In 33 centers...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,多中心研究

    doi:10.1080/09273948.2016.1196714

    authors: Yalçındağ FN,Özdal PC,Özyazgan Y,Batıoğlu F,Tugal-Tutkun I,BUST Study Group.

    更新日期:2018-01-01 00:00:00

  • Association of Propionibacterium acnes endophthalmitis with HLA-DQw5.

    abstract:BACKGROUND:An HLA-DQ1 association has been suspected in patients who develop Propionibacterium acnes endophthalmitis following cataract surgery. New techniques exist which may help to define this association. MATERIALS AND METHODS:Patients with culture-proven P. acnes endophthalmitis following cataract surgery were HL...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273949609069124

    authors: Davis JL,Winward KR,Lonardo EC,Nussenblatt RB,Meisler DM,Lee TD

    更新日期:1996-01-01 00:00:00

  • Outcomes of cataract surgery in ocular cicatricial pemphigoid.

    abstract:PURPOSE:To report the outcomes of cataract surgery in ocular cicatricial pemphigoid (OCP). SETTING:L. V. Prasad Eye Institute, Hyderabad, India. DESIGN:Retrospective, interventional case series. METHODS:Patients diagnosed with OCP who had undergone cataract surgery were included. Staging of disease, type of surgery,...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2013.819106

    authors: Puranik CJ,Murthy SI,Taneja M,Sangwan VS

    更新日期:2013-12-01 00:00:00

  • Nedocromil sodium and sodium cromoglycate inhibit plasma extravasation in the guinea-pig conjunctiva.

    abstract::Nedocromil sodium (NS) and sodium cromoglycate (CS) (both applied locally into the conjunctival sac) reduced in a dose dependent manner plasma extravasation induced by topical bradykinin and by topical substance P (SP), NS being approximately ten times more potent than CS. Plasma extravasation induced by SP was unaffe...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273949509057809

    authors: Javdan P,Figini M,Ricciardolo FL,Geppetti P

    更新日期:1995-01-01 00:00:00

  • Spectral-domain optical coherence tomography findings after severe exogenous endophthalmitis.

    abstract:PURPOSE:To report outcomes and assess structural changes in the retina in patients with severe endophthalmitis. METHODS:Retrospective, nonrandomized, interventional case series at a tertiary referral centre. Spectral domain optical coherence tomography (OCT) images of both eyes were acquired at least 5 months after pa...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2014.949780

    authors: Zinkernagel MS,Dysli C,Wolf S,Ebneter A

    更新日期:2014-12-01 00:00:00

  • The Use of Optical Coherence Tomography Angiography in the Diagnosis of Inflammatory Type 1 Choroidal Neovascularization Secondary to Tuberculosis: A Case Report.

    abstract::Purpose: To report a case of choroidal neovascularization (CNV), which was not obvious with dye angiography but was detected with optical coherence tomography angiography (OCTA).Methods: A 50-year-old female presented with decreased vision in her right eye. Funduscopic examination revealed a swollen hyperemic disc, pe...

    journal_title:Ocular immunology and inflammation

    pub_type: 信件

    doi:10.1080/09273948.2020.1754862

    authors: Demirel S,Yalçındağ N,Yanık Ö,Batıoğlu F,Özmert E

    更新日期:2020-05-27 00:00:00

  • Medical Therapy of Uveitic Macular Edema: Biologic Agents.

    abstract::Introduction: Uveitic macular edema (UME) is a significant cause of visual impairment in all uveitis types. Methods: Reports that were cited in the MEDLINE database, that analyzed the effectiveness of biologics for UME in at least five patients, with a minimum follow-up of 3 months, published prior to April 1, 2019 we...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1709648

    authors: Radosavljevic A,Agarwal M,Bodaghi B,Smith JR,Zierhut M

    更新日期:2020-11-16 00:00:00

  • Can we be more objective in determining the response to treatment in uveitis patients aside from recording anterior chamber reaction?

    abstract::Several subjective and arbitrary grading methods are used in assessing cell and flare in uveitis. Clinicians are in need of an objective method of determining and monitoring active inflammation. We studied the correlation of changes in macular thickness between the visits and compared the change to visual acuity (VA),...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940802702587

    authors: Akduman L

    更新日期:2009-07-01 00:00:00

  • Pleomorphism of stromal eosinophils in murine experimental onchocercal keratitis.

    abstract::Onchocercal keratitis (river blindness) is one of the leading worldwide causes of blindness. Light microscopic analysis of human specimens and corneal tissue from experimental models has implicated the eosinophil as an important cell in the inflammatory response. Our previous studies in experimental murine onchocercal...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273949709116890

    authors: Bardenstein DS,Lass JH,Kazura JW,Pearlman E

    更新日期:1997-09-01 00:00:00

  • Serpiginous choroiditis in a referral clinic in India: visual field changes and clinical correlates.

    abstract:PURPOSE:To report the visual field changes in patients with serpiginous choroiditis as seen in a referral clinic in India. METHODS:A retrospective noncomparative case series was conducted. Twenty-nine eyes of 17 patients who were diagnosed with serpiginous choroiditis were included in the study. Clinical findings were...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2014.902473

    authors: Balarabe AH,Biswas J

    更新日期:2014-10-01 00:00:00

  • Bacterial contamination of needles used for intravitreal injections: a prospective, multicenter study.

    abstract:PURPOSE:To determine the incidence of bacterial contamination of needles used for intravitreal injections. METHODS:Patients undergoing intravitreal injections were enrolled prospectively. No pre-injection antibiotics were administered. Following povidone-iodine irrigation, conjunctival cultures were taken and the inje...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,多中心研究

    doi:10.3109/09273948.2010.520405

    authors: Stewart JM,Srivastava SK,Fung AE,Mahmoud TH,Telander DG,Hariprasad SM,Ober MD,Mruthyunjaya P

    更新日期:2011-02-01 00:00:00

  • Macular Abnormalities in Vogt-Koyanagi-Harada Disease.

    abstract::Purpose: To investigate the prevalence of macular abnormalities in Chinese Vogt-Koyanagi-Harada (VKH) patients.Methods: Clinical characteristics, therapeutic effectiveness and visual outcome were reviewed and analyzed.Results: The most common macular abnormality was macular edema (ME), followed by macular choroidal ne...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1624781

    authors: Yang P,Ye Z,Xu J,Du L,Zhou Q,Qi J,Liang L,Wang C,Zhou C,Cao Q,Wu L,Kijlstra A

    更新日期:2019-01-01 00:00:00

  • Optic Nerve Infiltration in Systemic Metastatic Retinal Lymphoma (SMRL): Multimodal Imaging and Challenges in Diagnosis.

    abstract::A 45-year-old man was diagnosed with diffuse large B-cell lymphoma stage IV which was confirmed by celiac lymph node biopsy. He subsequently completed six cycles of R-CHOP chemotherapy. Six months later, he presented with panuveitis OU with positive relative afferent pupillary defect OD. OCT revealed hyper-reflective ...

    journal_title:Ocular immunology and inflammation

    pub_type: 信件

    doi:10.1080/09273948.2020.1800050

    authors: Mohd Fauzi Yap MFB,Mohd Zain A,Tumain NR,Palaniappan S,Nasaruddin RA,Md Din N

    更新日期:2020-09-24 00:00:00

  • Multimodal Evaluation of Presumed Tuberculous Serpiginous-Like Choroiditis.

    abstract::Purpose: To evaluate multimodal imaging findings in longitudinal follow-up of a patient with presumed tuberculous serpiginous-like choroiditis (TB-SLC). Method: We evaluated multimodal imaging in a 62-year-old male with TB-SLC. Correlation between optical coherence tomography angiography (OCTA), swept-source OCT (SS-O...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2018.1501497

    authors: Wang H,Tan SZ,Aslam T,Jones NP,Steeples LR

    更新日期:2019-01-01 00:00:00

  • Intravitreal Adalimumab for the Control of Breakthrough Intraocular Inflammation.

    abstract:PURPOSE:Investigate the efficacy of intravitreal adalimumab in breakthrough panuveitis in patients on systemic adalimumab for more than 3 months. METHODS:Retrospective study of patients on systemic adalimumab with breakthrough panuveitis requiring intravitreal adalimumab therapy. RESULTS:Seven eyes of four patients w...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2017.1335756

    authors: Kheir WJ,Mehanna CJ,Abdul Fattah M,Al Ghadban S,El Sabban M,Mansour AM,Hamam RN

    更新日期:2018-01-01 00:00:00

  • Clinical application of a homogeneous colorimetric assay for tear lysozyme.

    abstract:PURPOSE:Tear lysozyme and tear lactoferrin are enzymes synthesized by the lacrimal gland. Their concentration in human tears reflects tear gland function. Tear gland dysfunction can lead to ocular surface disease. We developed a colorimetric lysozyme assay. The objective of this study was to determine the diagnostic po...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1076/ocii.7.1.7.8108

    authors: Klaeger AJ,Cevallos V,Sherman MD,Whitcher JP,Stephens RS

    更新日期:1999-03-01 00:00:00

  • Tolerated cilium in the anterior chamber.

    abstract:PURPOSE:To describe a patient with a tolerated cilium in the anterior chamber. METHODS:A 15-year-old girl, referred with a 5-year trauma history, was examined. A cilium was noted in the anterior chamber without any inflammation during routine ophthalmological examination. RESULTS:The cilium was removed surgically and...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:10.1076/ocii.11.1.73.15576

    authors: Kargi SH,Oz O,Erdinc E,Teke MY,Firat E

    更新日期:2003-03-01 00:00:00

  • Multimodal Imaging in Sympathetic Ophthalmia.

    abstract:PURPOSE:To show the current status of multimodal imaging and its role in supporting an early diagnosis of sympathetic ophthalmia. METHODS:The diagnosis is mainly clinical supported with ancillary investigations; mainly fluorescein angiography and others, including indocyanine angiography optical coherence tomography (...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:10.1080/09273948.2016.1255339

    authors: Mahajan S,Invernizzi A,Agrawal R,Biswas J,Rao NA,Gupta V

    更新日期:2017-04-01 00:00:00

  • Features of Retinitis-like Lesions in Vitreoretinal Lymphoma.

    abstract::Purpose: To describe the distinguishing features of retinitis-like lesions seen in vitreoretinal lymphoma (VRL) from viral and toxoplasma retinitis. Methods: In this multicenter, retrospective study, we reviewed charts and imaging of consecutive patients with VRL. The associated features and the characteristics of ret...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1648835

    authors: Marchese A,Agarwal A,Miserocchi E,Giuffrè C,Bandello F,Modorati G,Prakash G,Gupta N,Bosello F,Sharma SP,Gupta V

    更新日期:2019-09-30 00:00:00

  • Leptospiral Uveitis: Usefulness of Clinical Signs as Diagnostic Predictors.

    abstract:PURPOSE:To analyze the diagnostic predictive ability of clinical variables. METHODS:Demographic and clinical variables of 172 serologically proven leptospiral uveitis patients were compared with 200 controls of non-leptospiral uveitis. Multiple logistic regression analysis identified diagnostic predictors. A receiver ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2016.1217341

    authors: Sivakumar R,Balakrishnan V,Gowri P,Visalakshi J

    更新日期:2018-01-01 00:00:00

  • Application of Laser Flare Photometry in the Quantification of Blood-Aqueous Barrier Breakdown after Micro-incision Vitrectomy.

    abstract::Purpose: The purpose of the study is to quantify aqueous flare using laser flare photometry (LFM) in patients undergoing 25-G pars plana vitrectomy (PPV) and assess the need for postoperative topical corticosteroid administration . Methods: Prospective evaluation of 50 eyes (50 patients) was performed using LFM until ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2018.1449867

    authors: Agarwal A,Joshi D,Katoch D,Aggarwal K,Singh R,Gupta V

    更新日期:2019-01-01 00:00:00