Abstract:
:In the pre-cyclosporin therapy era, BenEzra and Cohen(1) reported an appalling visual prognosis of patients with Behçet's disease, with 74% of eyes losing useful vision six to ten years after diagnosis. This experience was in a population largely of Mediterranean origin and it has been suggested that different ethnic groups may have different rates of ocular disease progression. In addition, newer immunosuppressive agents, e.g. cyclosporin, have been widely used in the last few years in the acute management of patients with Behçet's disease though their long term effect on the visual prognosis has not been established. The authors report the visual findings in a cohort of 28 patients of mixed ethnic extraction with Behçet's disease and ocular involvement who have been followed-up for an average of six years. Posterior segment disease relapse was treated aggressively with high dose corticosteroids, cyclosporin, azathioprine, cyclophosphamide, or chlorambucil in varying combinations. At present, approximately 60% of patients have visual acuity of ± 6/9 in the better eye, 21% are 6/12 to 6/60, and 18% worse than 6/60. These findings, albeit relatively short term at present, are encouraging enough to continue this aggressive therapeutic management in the belief that the depressing figures in the literature reflect the past and not the present.
journal_name
Ocul Immunol Inflammjournal_title
Ocular immunology and inflammationauthors
Towler HM,Lightman Sdoi
10.3109/09273949309085025subject
Has Abstractpub_date
1993-01-01 00:00:00pages
249-54issue
3eissn
0927-3948issn
1744-5078journal_volume
1pub_type
杂志文章abstract:PURPOSE:To present fundus autofluorescence (FAF), indocyanine green angiography (ICGA), and microperimetry (MP) findings of a patient with multiple evanescent white dot syndrome (MEWDS). METHODS:Observational case report. RESULTS:A 30-year-old woman with blurry vision was referred for evaluation. Fundus examination r...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940802026060
更新日期:2008-05-01 00:00:00
abstract::Purpose: To review the broad spectrum of clinical neuro-ophthalmic presentations associated with human immunodeficiency virus (HIV) infection. Methods: Critical review of the literature regarding neuro-ophthalmic consequences of HIV infection and its sequelae. Results: Neuro-ophthalmological diseases are common in bot...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1704024
更新日期:2020-10-02 00:00:00
abstract:PURPOSE:To describe the results of Boston keratoprosthesis implantation in a patient with Stevens-Johnson syndrome following autologous submandibular gland transplantation. DESIGN:Observational case report. METHODS:We report the case of a man diagnosed with Stevens-Johnson syndrome. Autologous submandibular gland tra...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1234624
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To investigate demographic, clinical features and complications of Italian patients with ocular Behçet's disease (BD) over time. METHODS:Retrospective study of 385 patients examined from 1968 to 2011, 265 of whom had follow-up ≥ 12 months. RESULTS:A significant increase in the proportion of females (p = 0.03)...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2015.1094095
更新日期:2017-02-01 00:00:00
abstract::Toxoplasmosis is a common parasitic zoonosis and an important cause of abortions, mental retardation, encephalitis, blindness, and death worldwide. Although a large body of literature has emerged on the subject in the past decades, many questions about the pathogenesis and treatment of the disease remain unanswered. T...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1076/ocii.10.1.1.10330
更新日期:2002-03-01 00:00:00
abstract::Purpose: To assess changes in aqueous humor (AH) levels of cytokines following dexamethasone intravitreal implant (DEX) injection for diabetic macular edema (DME).Methods: Sixteen DME and cataract cases series study. Anterior chamber AH sampling was performed at baseline at DEX injection time (T1), cataract surgery 8 ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1636095
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To report a rare case of intermediate uveitis following rubella infection in pregnancy. DESIGN:Case report. METHODS:A 35-year-old pregnant woman, at 24 weeks of gestation, presented with sudden floaters and blurring of vision of the left eye. Ocular examination revealed vitritis 1-2+ with no retinal involveme...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2011.555593
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To assess long-term efficacy and safety of infliximab for refractory Behçet disease (BD) uveitis and to evaluate the effect of withdrawal of infliximab after achieving long-term remission. METHODS:Retrospective study of 19 patients. RESULTS:Mean follow-up was 44.1 ± 36.5 months and mean number of infliximab i...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2013.779727
更新日期:2013-12-01 00:00:00
abstract:AIM:To report the ocular and systemic features in patients with definite and presumed sarcoidosis presenting to a tertiary referral eye center in south India. MATERIALS AND METHODS:Retrospective observational case series. Records of 51 patients with diagnosis of sarcoidosis were retrieved. A complete ophthalmic evalua...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2010.495813
更新日期:2010-10-01 00:00:00
abstract::Purpose : To clarify whether a true neuroretinitis is part of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome.Methods : Critical literature review.Results : Neuroretinitis has been considered as a prominent feature of IRVAN syndrome. It has been described as late diffuse optic disc stai...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1836234
更新日期:2020-12-17 00:00:00
abstract:PURPOSE:To determine the efficacy of interferon alpha 2b in the treatment of refractory, uveitic cystoid macular edema (CME). METHODS:Retrospective chart review of 4 patients attending the uveitis clinic at the Casey Eye Institute, Oregon Health & Science University. RESULTS:All 4 patients had uveitis and refractory ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2011.645989
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:To report a case of acute retinal necrosis (ARN) occurring in the opposite eye to the ophthalmic shingles eruption. DESIGN:Case report. METHODS:Clinical examination and multimodal imaging review, including ultra-widefield photography and fluorescein angiography (FA). RESULTS:A 49-years-old man attended the U...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1770298
更新日期:2020-07-09 00:00:00
abstract::The effects of tachykinins on prostaglandin E2 (PGE2)-induced intraocular inflammation were investigated. PGE2 (0.01% or 0.1%) instillation induced iridal hyperemia and protein leakage into the aqueous humor in rabbits, but caused minimal miosis. Intravitreally injected substance P (SP) or neurokinin A (NKA), on the o...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1076/ocii.6.1.19.8080
更新日期:1998-03-01 00:00:00
abstract:AIM:To look at markers to differentiate ocular sarcoidosis from ocular tuberculosis in a high TB endemic population. MATERIALS & METHODS:Retrospective multicenter study involving seven tertiary eyecare centers in India between July 2016 to December 2016. Demographic, clinical and laboratory data were retrieved from re...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1778733
更新日期:2020-09-01 00:00:00
abstract::Purpose: To study outcome of secondary glaucoma in pediatric uveitis patients. Methods: Retrospective analysis of records of uveitis patients ≤16 years. Results: Of 182 pediatric uveitis patients, secondary glaucoma was seen in 48 patients (75 eyes, 26.23%) with female preponderance (F:M-29:19) . JIA was the most comm...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1411517
更新日期:2019-01-01 00:00:00
abstract::Background: Rapid and timely diagnosis of tubercular uveitis (TBU) is of paramount importance to save these eyes from blindness. The present study was, therefore, undertaken to carry out a comparative evaluation of Gene Xpert MTB/RIF (Xpert), MTBDRplus and Multiplex PCR (MPCR) for the diagnosis of TBU. These tests wer...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1655581
更新日期:2019-10-03 00:00:00
abstract:PURPOSE:To examine the role of interleukin 27(IL-27) and interleukin 35 (IL-35) in diabetic retinopathy (DR). METHODS:Patients with diabetes mellitus were divided into three groups: diabetes without retinopathy (DWR), non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR). Patients...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1203959
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To describe the medical treatment of severe ocular hypotony in HIV-seropositive patients with cytomegalovirus retinitis and cidofovir-associated uveitis. PATIENTS AND METHODS:Two HIV-seropositive patients with cytomegalovirus retinitis and cidofovir-associated uveitis complicated by severe ocular hypotony we...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1076/ocii.9.3.211.3968
更新日期:2001-09-01 00:00:00
abstract:PURPOSE:To investigate the association between keratoconus (KC) and allergic diseases. METHODS:In a prospective age- and sex-matched case--control study clinical data of 885 KC patients and 1526 controls were evaluated regarding the presence of various allergic diseases. Severity of KC and ophthalmic parameters of KC ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2016.1145697
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:To evaluate the safety and efficacy of intravitreal triamcinolone acetonide (TA) for treating macular edema secondary to non-infectious uveitis. METHODS:Retrospective review of sixteen patients (20 eyes) with chronic cystoid macular edema (CME) as a consequence of controlled intermediate uveitis, posterior ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940590933511
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:Copper (Cu) is an essential trace element; however excess is toxic due to the pro-oxidant activity. Increased intracellular Cu levels in vitreous and monocyte were reported in Eales disease (ED) previously. Copper transporter1 (CTR1) maintains copper homeostasis and hence, we studied the presence of CTR1 in ocu...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2015.1071404
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To describe a case of sympathetic ophthalmia following vitrectomy for endophthalmitis after an intravitreal injection of bevacizumab. DESIGN:Retrospective case report. METHODS:An 84-year-old male developed sympathetic ophthalmia 4 months after vitrectomy for endophthalmitis following an intravitreal injection...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940802409951
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:To describe a patient with a tolerated cilium in the anterior chamber. METHODS:A 15-year-old girl, referred with a 5-year trauma history, was examined. A cilium was noted in the anterior chamber without any inflammation during routine ophthalmological examination. RESULTS:The cilium was removed surgically and...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1076/ocii.11.1.73.15576
更新日期:2003-03-01 00:00:00
abstract::Purpose: To analyze the pattern of laboratory investigations of uveitis at a tertiary referral eye care center in Singapore.Methods: Retrospective analysis of 2040 uveitis cases from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database over a 12-year period (2004 - 2015).Results: Patients with...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2018.1535080
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To investigate the safety and efficacy of daclizumab (Zenapax, humanized anti-Tac, HAT) in controlling the ocular manifestations of Behçet's disease. DESIGN:Randomized, placebo-controlled, double-masked clinical trial. PARTICIPANTS:Seventeen participants with Behçet's disease experiencing at least two prior o...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1080/09273940701299370
更新日期:2007-03-01 00:00:00
abstract::Purpose: To compare vessel density (VD) as measured by optical coherence tomography angiography (OCTA), in uveitic eyes with secondary glaucoma (UG) with VD in uveitic eyes without glaucoma (UV), eyes with primary open-angle glaucoma (POAG), and healthy eyes (HY). Methods: VD was measured at the following segmentation...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1745246
更新日期:2020-11-13 00:00:00
abstract:PURPOSE:Primary vitreoretinal lymphomas (PVRL) pose a major diagnostic challenge, especially in the countries with a high prevalence of infectious variety of uveitis. The present study aims to report the clinical characteristics and diagnostic difficulties in patients with PVRL in an Indian Population. METHODS:Retrosp...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2016.1139731
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:The etiopathogenesis of pterygia is controversial. We wished to explore the effects of inflammatory cells and mediators such as T-lymphocyte subpopulations (CD4 and CD8), mast cells, intercellular adhesion molecule-1 (ICAM-1), and HLA-DR receptors on pterygium development. METHODS:Immunohistochemical stainings...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1076/ocii.11.2.115.15913
更新日期:2003-06-01 00:00:00
abstract::Purpose: To evaluate the efficacy and safety of intravitreal ganciclovir (GCV) injection in refractory endotheliitis.Methods: Retrospectively recruited 25 eyes with endotheliitis, proved by clinical manifestations, positive PCR for viral DNA and responded poor to topical and systemic antiviral medications. All patient...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1573261
更新日期:2020-01-01 00:00:00
abstract::Tacrolimus (FK506) is effective in Japanese endogenous posterior uveitis (EPU), but there is limited data on its role in refractory EPU where cyclosporin A (CsA) toxicity/resistance develops. This open prospective clinical study aimed to assess the efficacy and adverse effects of low-dose FK506 therapy in western pati...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1076/ocii.6.2.101.4051
更新日期:1998-06-01 00:00:00