Objective analysis of retinal function in HIV-positive children without retinitis using optical coherence tomography.

Abstract:

PURPOSE:To assess the retinal nerve fiber layer thickness in children with human immunodeficiency virus disease without cytomegalovirus retinitis or visual symptoms. METHODS:Thirty-eight eyes of 19 human immunodeficiency virus-positive children (group A) with visual acuity of 20/20 or better, normal color vision testing and no ophthalmoscopically detectable disorders were prospectively examined. All subjects of group A had no history of cytomegalovirus retinitis and CD4 counts consistently above 100. Patients in group B (40 eyes of 21 patients) were human immunodeficiency virus-negative age-matched control subjects. Thickness of retinal nerve fiber layer along a 3.4-mm-diameter circle centered on the optic nerve head was evaluated using third-generation optical coherence tomography. CD8 T-lymphocyte count, presence of systemic infection, hemoglobin, hematocrit and serum beta-microglobulin levels were also recorded. RESULTS:The mean overall retinal nerve fiber layer thickness in groups A and B were 89.2 +/- 24.01 microm and 102.82 +/- 29.168 microm (SD) respectively. The difference was considered extremely significant (P < 0.0001). Group A had significantly thinner average nerve fiber layer in temporal, nasal, superior and inferior retinal areas. CONCLUSIONS:Significant retinal nerve fiber layer thinning occurs in human immunodeficiency virus-positive children with no visual impairment or ophthalmologic evidence or retinitis.

journal_name

Ocul Immunol Inflamm

authors

Moschos MM,Mostrou G,Psimenidou E,Spoulou V,Theodoridou M

doi

10.1080/09273940701375154

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

319-23

issue

4

eissn

0927-3948

issn

1744-5078

pii

781509124

journal_volume

15

pub_type

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