Causes of Hypertensive Anterior Uveitis in Thailand.

Abstract:

PURPOSE:To determine the prevalence of viral infections in patients with hypertensive anterior uveitis in Thailand from polymerase chain reaction (PCR) of aqueous humor. METHODS:Thirty-one patients with anterior uveitis with intraocular pressure (IOP) above 25 mmHg were included for PCR analysis for cytomegalovirus (CMV), herpes simplex (HSV), varicella-zoster (VZV), rubella, chikungunya and Zika virus. RESULTS:The prevalence of PCR-positive results was 32%, including 19% for CMV, 10% for HSV, and 3% for VZV; PCR for other tested viruses demonstrated negative results. PCR-positive patients exhibited satisfactory IOP control with antiviral and anti-glaucomatous treatment compared to PCR-negative patients, and more than half of PCR-negative patients required glaucoma surgery within 12 months (P = .01). CONCLUSION:PCR evidence of infection with herpes group viruses was found in one-third of patients with hypertensive anterior uveitis; CMV being the most common pathogen. The PCR-positive group generally responded well to a combination of antiviral and anti-glaucoma treatment.

journal_name

Ocul Immunol Inflamm

authors

Khieu C,Kongyai N,Pathanapitoon K,Van Der Eijk AA,Rothova A

doi

10.1080/09273948.2019.1678651

subject

Has Abstract

pub_date

2020-05-18 00:00:00

pages

559-565

issue

4

eissn

0927-3948

issn

1744-5078

journal_volume

28

pub_type

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