Abstract:
PURPOSE:To examine the role of interleukin 27(IL-27) and interleukin 35 (IL-35) in diabetic retinopathy (DR). METHODS:Patients with diabetes mellitus were divided into three groups: diabetes without retinopathy (DWR), non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR). Patients with idiopathic macular epiretinal membrane (IMEM) were included as a control group. The serum and vitreous levels of IL-27 and IL-35 were measured using ELISA. RESULTS:The serum levels of IL-27 (median 240.900 pg/mL, range 42.224 - 617.810 pg/mL; p < 0.001) and IL-35 (median 11.875 ng/mL, range 8.640 - 19.340 ng/mL; p < 0.001) were significantly decreased in PDR patients compared to controls (median 2712.310 pg/mL, range 1005.375-5786.877 pg/mL and median 25.185 ng/mL, range 22.845 - 29.590 ng/mL, respectively). The vitreous levels of IL-35 were significantly decreased in PDR patients (16.32 ± 3.24 ng/mL) compared to controls (24.54 ± 5.86 ng/mL, p < 0.001). CONCLUSIONS:Serum and vitreous levels of IL-35 and serum level of IL-27 may be associated with the pathogenesis of PDR.
journal_name
Ocul Immunol Inflammjournal_title
Ocular immunology and inflammationauthors
Yan A,You H,Zhang Xdoi
10.1080/09273948.2016.1203959subject
Has Abstractpub_date
2018-01-01 00:00:00pages
273-279issue
2eissn
0927-3948issn
1744-5078journal_volume
26pub_type
杂志文章abstract:AIM:To report the ocular and systemic features in patients with definite and presumed sarcoidosis presenting to a tertiary referral eye center in south India. MATERIALS AND METHODS:Retrospective observational case series. Records of 51 patients with diagnosis of sarcoidosis were retrieved. A complete ophthalmic evalua...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2010.495813
更新日期:2010-10-01 00:00:00
abstract::The standardization of Uveitis Nomenclature (SUN) Working Group recently affirmed the importance of an anatomic classification of uveitis, endorsing the anatomic clasiffication scheme proposed by the International Uveitis Study Group (IUSG). The group however pointed out and addressed ambiguities in the IUSG system, a...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273940903348835
更新日期:2010-01-01 00:00:00
abstract::The effects of tachykinins on prostaglandin E2 (PGE2)-induced intraocular inflammation were investigated. PGE2 (0.01% or 0.1%) instillation induced iridal hyperemia and protein leakage into the aqueous humor in rabbits, but caused minimal miosis. Intravitreally injected substance P (SP) or neurokinin A (NKA), on the o...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1076/ocii.6.1.19.8080
更新日期:1998-03-01 00:00:00
abstract:PURPOSE:To describe ocular manifestations and particularly optical coherence tomography (OCT) findings in choroidopathy revealing a systemic lupus erythematosus, without systemic hypertension. METHODS:Observational case report. RESULTS:The diagnosis of systemic lupus erythematosus choroidopathy was suggested by the o...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273940903353785
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:To report the outcomes of cataract surgery in ocular cicatricial pemphigoid (OCP). SETTING:L. V. Prasad Eye Institute, Hyderabad, India. DESIGN:Retrospective, interventional case series. METHODS:Patients diagnosed with OCP who had undergone cataract surgery were included. Staging of disease, type of surgery,...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2013.819106
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:To describe a patient with a tolerated cilium in the anterior chamber. METHODS:A 15-year-old girl, referred with a 5-year trauma history, was examined. A cilium was noted in the anterior chamber without any inflammation during routine ophthalmological examination. RESULTS:The cilium was removed surgically and...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1076/ocii.11.1.73.15576
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:To evaluate the safety and efficacy of intravitreal triamcinolone acetonide (TA) for treating macular edema secondary to non-infectious uveitis. METHODS:Retrospective review of sixteen patients (20 eyes) with chronic cystoid macular edema (CME) as a consequence of controlled intermediate uveitis, posterior ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940590933511
更新日期:2005-04-01 00:00:00
abstract::Background: Rapid and timely diagnosis of tubercular uveitis (TBU) is of paramount importance to save these eyes from blindness. The present study was, therefore, undertaken to carry out a comparative evaluation of Gene Xpert MTB/RIF (Xpert), MTBDRplus and Multiplex PCR (MPCR) for the diagnosis of TBU. These tests wer...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1655581
更新日期:2019-10-03 00:00:00
abstract:PURPOSE:To report a case of post-streptococcal retinal vasculitis. DESIGN:Review of a case. METHODS:Review of patient chart and fluorescein angiography. RESULTS:A 17 year old African American female presented with moderate vitritis and macular edema in the right eye and retinal vessel sheathing in both eyes. CONCLU...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940701799163
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To describe the clinical characteristics, diagnosis, and treatment of VIAU in immunocompromised patients. METHODS:A critical review of literature was performed. RESULTS:Diagnosis and treatment of VIAU in immunocompromised patients may be a challenge due to atypical clinical-courses, severe presentations, and ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1080/09273948.2018.1483519
更新日期:2018-01-01 00:00:00
abstract:AIM:The objective of this study is to describe the surgical outcomes of patients of HIV on HAART who underwent surgery for CMV retinitis related retinal detachment. METHOD AND MATERIALS:A retrospective analysis of the medical records of 40 eyes of 35 consecutive HIV positive patients who underwent surgical repair for ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,多中心研究
doi:10.3109/09273948.2014.999376
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To evaluate the clinical outcome and safety of adalimumab in patients with Vogt-Koyanagi-Harada (VKH) disease. METHODS:VKH patients treated with adalimumab seen at the University of Buenos Aires were reviewed. Main outcome measures were visual acuity, anterior segment inflammation, optic nerve inflammation (ON...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1236969
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To study the safety and efficacy of intravitreal injection of dexamethasone implant in the management of posterior segment involvement in tubercular uveitis (TBU). METHODS:In this study, retrospective analysis of safety and efficacy of intravitreal injection of dexamethasone implant for various indications suc...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1400074
更新日期:2018-01-01 00:00:00
abstract::Experimental autoimmune uveoretinitis (EAU) induced by immunization of male Lewis rats with bovine S-antigen (S-Ag) is prevented by injection of S-Ag into the testis prior to immunization. This protection of animals is due to the induction of systemic immunotolerance or immunosuppression, which the authors designate o...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949509085041
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:To assess long-term efficacy and safety of infliximab for refractory Behçet disease (BD) uveitis and to evaluate the effect of withdrawal of infliximab after achieving long-term remission. METHODS:Retrospective study of 19 patients. RESULTS:Mean follow-up was 44.1 ± 36.5 months and mean number of infliximab i...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2013.779727
更新日期:2013-12-01 00:00:00
abstract::We report a case of unilateral glaucoma with falsely low intraocular pressure reading as a result of scleral thinning from anterior scleritis. ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940490912344
更新日期:2005-12-01 00:00:00
abstract:PURPOSE:To demonstrate that fundus autofluorescence (FAF) imaging aides the diagnosis of rubella retinopathy (RR). METHODS:Four patients with sensorineural hearing loss underwent ophthalmic exams, electro-retinogram testing (ERG), and FAF in both eyes. Fluorescein angiogram (FA) was performed in one case. RESULTS:Sal...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273940903118634
更新日期:2009-11-01 00:00:00
abstract::Scleritis is a severe and destructive inflammatory eye disease characterized by extensive extracellular matrix degradation. As in rheumatoid arthritis (RA), tissue destruction in scleritis may be mediated in part by matrix metalloproteinases such as collagenase (MMP-1) and stromelysin (MMP-3) which are normally kept i...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949509069111
更新日期:1995-01-01 00:00:00
abstract::Purpose: To describe with multimodal imaging a case of post-infectious unilateral outer retinopathy with choroiditis. Methods: Retrospective chart review of a case of a 67-year old male who presented following the onset of viral symptoms with an acute onset outer retinopathy, small vessel leakage on fluorescein angiog...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2018.1485954
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To describe the clinical and histopathological features of post viper bite anterior segment ischemia. METHODS:Seven patients with ocular complications following viper bite referred to uveitis clinic had slit-lamp examination, intraocular pressure (IOP) measurement, and fundus evaluation. Iris and fundus fluore...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2014.907435
更新日期:2016-01-01 00:00:00
abstract::Purpose: The purpose of this study is to explore the effects of dihydrotestosterone (DHT) on lipopolysaccharide (LPS)-induced proinflammatory cytokine release in human ocular surface epithelial cells exposed to LPS and LPS-binding protein (LBP).Methods: Immortalized human corneal, conjunctival, and meibomian gland epi...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1686155
更新日期:2019-11-18 00:00:00
abstract::Purpose: To assess changes in aqueous humor (AH) levels of cytokines following dexamethasone intravitreal implant (DEX) injection for diabetic macular edema (DME).Methods: Sixteen DME and cataract cases series study. Anterior chamber AH sampling was performed at baseline at DEX injection time (T1), cataract surgery 8 ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1636095
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To compare histopathological and biochemical effects of the anti-TNF-alpha drugs adalimumab and infliximab in a uveitis experimental model. METHODS:Histopathological evaluation was performed 24 h after endotoxin (200 microg into the footpad) and drug administration, as well as biochemical analysis of oxidative...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273940903521964
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:To report the clinical course, treatment response, and prognosis of Stenotrophomonas maltophilia endophthalmitis following cataract extraction. METHODS:The clinical records of six cases of S. maltophilia endophthalmitis after cataract extraction were retrospectively reviewed. Data were collected for surgical c...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940590950981
更新日期:2006-02-01 00:00:00
abstract::Behçet's disease is the most frequently encountered form of endogenous uveitis in Japan. The authors examined the clinical manifestations in cases with Behçet's disease over six years (1987-1992), and compared the results with those of a previous study (1978-1983). In the more recent study the number of new patients w...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949509069117
更新日期:1995-01-01 00:00:00
abstract::Human cytomegalovirus (HCMV) is a complex DNA virus encoding more than 200 viral proteins. This highly adapted opportunist agent has developed several ways to evade the immune system. Among all clinical features due to HCMV, retinitis occurs especially in severely immunosuppressed patients, particularly during the end...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1076/ocii.7.3.133.3998
更新日期:1999-12-01 00:00:00
abstract:PURPOSE:To retrospectively assess the frequency of ocular relapse and the possibility of long-term remission in patients treated with interferon (IFN) for severe uveitis associated with Behçet disease. METHODS:All patients were treated with an initial dosage of 3 million IU IFN three times a week. The main outcome mea...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1206204
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To determine the prevalence of viral infections in patients with hypertensive anterior uveitis in Thailand from polymerase chain reaction (PCR) of aqueous humor. METHODS:Thirty-one patients with anterior uveitis with intraocular pressure (IOP) above 25 mmHg were included for PCR analysis for cytomegalovirus (C...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1678651
更新日期:2020-05-18 00:00:00
abstract:PURPOSE:To determine factors conferring an increased risk of developing ocular hypertension secondary to the fluocinolone acetonide (FA) sustained-release surgical implant (Retisert). DESIGN:Retrospective, observational case series. METHODS:Patients with a history of chronic noninfectious posterior uveitis undergoing...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1624778
更新日期:2020-07-03 00:00:00
abstract::Purpose: To report a case of choroidal neovascularization (CNV), which was not obvious with dye angiography but was detected with optical coherence tomography angiography (OCTA).Methods: A 50-year-old female presented with decreased vision in her right eye. Funduscopic examination revealed a swollen hyperemic disc, pe...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2020.1754862
更新日期:2020-05-27 00:00:00