Aqueous Humour Cytokine Changes with Intravitreal Dexamethasone Implant Injection for Diabetic Macular Edema.

Abstract:

:Purpose: To assess changes in aqueous humor (AH) levels of cytokines following dexamethasone intravitreal implant (DEX) injection for diabetic macular edema (DME).Methods: Sixteen DME and cataract cases series study. Anterior chamber AH sampling was performed at baseline at DEX injection time (T1), cataract surgery 8 weeks afterward (T2), and whenever DME relapsed (T3) in order to assess changes in IL-1β, IL-3, IL-6, IL-8, IL-10, MCP-1, IP-10, TNF-α, and VEGF levels.Results: IP-10 and MCP-1 levels significantly decreased at T2 (p = .034 and p = .044, respectively) compared to baseline (T1). Relapsed DME cases (T3) showed significantly higher levels of IL-6 (p = .028), IL-8 (p = .005), IP-10 (p = .013) and MCP-1 (p = .005) compared to T2.Conclusion: IP-10 and MCP-1 AH levels seem to be related to DEX intraocular action, decreasing after injection and increasing when DME relapses. In addition, IL-6 and IL-8 may play a role in DME late evolution and clinical relapse beyond DEX effect.

journal_name

Ocul Immunol Inflamm

authors

Figueras-Roca M,Sala-Puigdollers A,Alforja S,Torras J,Peraza-Nieves J,Zarranz-Ventura J,Adan Civera A,Molins B

doi

10.1080/09273948.2019.1636095

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

1203-1210

issue

8

eissn

0927-3948

issn

1744-5078

journal_volume

27

pub_type

杂志文章
  • Atypical presentation of multiple evanescent white dot syndrome (MEWDS).

    abstract:PURPOSE:To present fundus autofluorescence (FAF), indocyanine green angiography (ICGA), and microperimetry (MP) findings of a patient with multiple evanescent white dot syndrome (MEWDS). METHODS:Observational case report. RESULTS:A 30-year-old woman with blurry vision was referred for evaluation. Fundus examination r...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940802026060

    authors: Yenerel NM,Kucumen B,Gorgun E,Dinc UA

    更新日期:2008-05-01 00:00:00

  • Clinical application of a homogeneous colorimetric assay for tear lysozyme.

    abstract:PURPOSE:Tear lysozyme and tear lactoferrin are enzymes synthesized by the lacrimal gland. Their concentration in human tears reflects tear gland function. Tear gland dysfunction can lead to ocular surface disease. We developed a colorimetric lysozyme assay. The objective of this study was to determine the diagnostic po...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1076/ocii.7.1.7.8108

    authors: Klaeger AJ,Cevallos V,Sherman MD,Whitcher JP,Stephens RS

    更新日期:1999-03-01 00:00:00

  • A privileged view of NKT cells and peripheral tolerance through the eye.

    abstract::The eye is an immune-privileged site that uses specialized mechanisms to protect itself from damage and to preserve its visual acuity. Among the mechanisms that contribute to the eye's privileged existence is its ability to induce both local and peripheral tolerance to antigens that may transgress its chambers. Experi...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:10.1080/09273940490912371

    authors: Stein-Streilein J

    更新日期:2005-04-01 00:00:00

  • Effect of prolonged oral acyclovir treatment in acute retinal necrosis.

    abstract:BACKGROUND:To examine the effectiveness of prolonged oral acyclovir treatment in patients with acute retinal necrosis (ARN). METHODS:Fifty-five ARN patients (62 eyes) who had been treated with short-term or long-term oral acyclovir were identified in this retrospective study: one group treated with prolonged oral acyc...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2012.689073

    authors: Jeon S,Kakizaki H,Lee WK,Jee D

    更新日期:2012-08-01 00:00:00

  • Ten-Year Retention Rate of Infliximab in Patients with Behçet's Disease-Related Uveitis.

    abstract:PURPOSE:To evaluate the 10-year drug retention rate of infliximab (IFX) in Behçet's disease (BD)-related uveitis, the effect of a concomitant use of disease modifying anti-rheumatic drugs (DMARDs) on drug survival and differences according to the lines of biologic treatment. METHODS:Cumulative survival rates were stud...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2017.1391297

    authors: Fabiani C,Sota J,Vitale A,Emmi G,Vannozzi L,Bacherini D,Lopalco G,Guerriero S,Venerito V,Orlando I,Franceschini R,Fusco F,Frediani B,Galeazzi M,Iannone F,Tosi GM,Cantarini L

    更新日期:2019-01-01 00:00:00

  • Tuberculous Uveitis Presenting with a Bullous Exudative Retinal Detachment: A Case Report and Systematic Literature Review.

    abstract::Purpose: To describe tuberculous uveitis (TU) presenting as a bullous retinal detachment (RD) and to perform a comprehensive literature review on TU with similar features. Methods: Observational case report and systematic literature review. Results: An 84-year-old woman presented with bilateral granulomatous uveitis a...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2018.1485958

    authors: Song JH,Koreishi AF,Goldstein DA

    更新日期:2019-01-01 00:00:00

  • Fluorodeoxyglucose positron emission tomography for the diagnosis of sarcoidosis in patients with unexplained chronic uveitis.

    abstract:PURPOSE:To assess the value of fluorine-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in patients with unexplained chronic uveitis. METHODS:Retrospective review of 19 (18)F-FDG PET scans. All patients had normal chest CT. In the final analysis, the authors used criteria similar to the criteria of ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940902788221

    authors: Seve P,Billotey C,Janier M,Grange JD,Broussolle C,Kodjikian L

    更新日期:2009-05-01 00:00:00

  • Medical Therapy of Uveitic Macular Edema: Biologic Agents.

    abstract::Introduction: Uveitic macular edema (UME) is a significant cause of visual impairment in all uveitis types. Methods: Reports that were cited in the MEDLINE database, that analyzed the effectiveness of biologics for UME in at least five patients, with a minimum follow-up of 3 months, published prior to April 1, 2019 we...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1709648

    authors: Radosavljevic A,Agarwal M,Bodaghi B,Smith JR,Zierhut M

    更新日期:2020-11-16 00:00:00

  • Clinical Characteristics of Primary Vitreoretinal Lymphoma in an Indian Population.

    abstract:PURPOSE:Primary vitreoretinal lymphomas (PVRL) pose a major diagnostic challenge, especially in the countries with a high prevalence of infectious variety of uveitis. The present study aims to report the clinical characteristics and diagnostic difficulties in patients with PVRL in an Indian Population. METHODS:Retrosp...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2016.1139731

    authors: Mahajan S,Nijhawan R,Rajwanshi A,Karkhur S,Mulkutar S,Dogra M,Lal V,Gupta V,Gupta A

    更新日期:2017-10-01 00:00:00

  • Live Related versus Cadaveric Limbal Allograft in Limbal Stem Cell Deficiency.

    abstract:AIM:To compare outcomes of live related limbal allograft (Lr-CLAL) versus cadaveric keratolimbal allograft (KLAL) in limbal stem cell deficiency (LSCD) secondary to ocular burns. METHODS:Twenty patients with stage IIb LSCD were randomized so that cases underwent either Lr-CLAL or KLAL. Fibrovascular pannus was removed...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/09273948.2014.902076

    authors: Titiyal JS,Sharma N,Agarwal AK,Prakash G,Tandon R,Vajpayee R

    更新日期:2015-06-01 00:00:00

  • Isolated Nocardia exalbida endogenous endophthalmitis.

    abstract:PURPOSE:To report an immunocompetent patient with Nocardia exalbida endogenous endophthalmitis. DESIGN:Case report. METHODS:Clinical-pathologic correlation and microbiologic evaluation were performed on an enucleated eye. RESULTS:A 56-year-old man presented with rapidly progressive vision loss associated with a post...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,评审

    doi:10.3109/09273948.2011.563898

    authors: Milman T,Trubnik V,Shah M,McCormick SA,Finger PT

    更新日期:2011-08-01 00:00:00

  • OCT follow-up of systemic lupus erythematosus choroidopathy.

    abstract:PURPOSE:To describe ocular manifestations and particularly optical coherence tomography (OCT) findings in choroidopathy revealing a systemic lupus erythematosus, without systemic hypertension. METHODS:Observational case report. RESULTS:The diagnosis of systemic lupus erythematosus choroidopathy was suggested by the o...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273940903353785

    authors: Kouprianoff S,Chiquet C,Bouillet L,Romanet JP

    更新日期:2010-04-01 00:00:00

  • Long-term clinical outcomes in patients with refractory uveitis associated with Behçet disease treated with infliximab.

    abstract:PURPOSE:To assess long-term efficacy and safety of infliximab for refractory Behçet disease (BD) uveitis and to evaluate the effect of withdrawal of infliximab after achieving long-term remission. METHODS:Retrospective study of 19 patients. RESULTS:Mean follow-up was 44.1 ± 36.5 months and mean number of infliximab i...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2013.779727

    authors: Al Rashidi S,Al Fawaz A,Kangave D,Abu El-Asrar AM

    更新日期:2013-12-01 00:00:00

  • Levels of Selected Aqueous Humor Mediators (IL-10, IL-17, CCL2, VEGF, FasL) in Diabetic Cataract.

    abstract:PURPOSE:To compare levels of selected mediators in serums and aqueous humor (AH) of type 2 diabetes mellitus cataract patients with senile cataract patients, and to determine their association with postoperative corneal edema (CE). METHODS:Patients (32 senile and 29 diabetic cataract) undergoing standardized phacoemul...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2014.949779

    authors: Mitrović S,Kelava T,Šućur A,Grčević D

    更新日期:2016-01-01 00:00:00

  • Mucormycosis Endophthalmitis in a Silicone Oil-Filled Eye of an Immunocompetent Patient.

    abstract::Purpose:: Fungal endophthalmitis following pars plana vitrectomy with silicone oil tamponade is an infrequent entity. Filamentous fungi like aspergillus are generally associated with endophthalmitis. Mucor is a rarely implicated pathogen in cases of endophthalmitis with only two reported cases in medical literature. B...

    journal_title:Ocular immunology and inflammation

    pub_type: 信件

    doi:10.1080/09273948.2018.1518462

    authors: Dogra M,Bhutani G,Gupta V

    更新日期:2019-01-01 00:00:00

  • Impact of Inflammation and Treatment on Self-reported Quality of Life in Patients with Non-acute Vogt-Koyanagi-Harada Disease (VKHD).

    abstract::Aims: To evaluate associations between vision-related (VR-) and health-related (HR-) QoL metrics and inflammation and treatment in non-acute VKHD patients.Methods: Cross-sectional study in a tertiary center in Sao Paulo, Brazil with 22 patients with non-acute VKHD followed prospectively for ≥12 months since acute dise...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1668431

    authors: Souto FMS,Missaka RFBG,Magalhães BM,Caetano VMC,Takiuti JT,Lavezzo MM,Sakata VM,Oyamada MK,Hirata CE,Yamamoto JH

    更新日期:2019-10-31 00:00:00

  • Clinical profile of ocular sarcoidosis in a South Indian patient population.

    abstract:AIM:To report the ocular and systemic features in patients with definite and presumed sarcoidosis presenting to a tertiary referral eye center in south India. MATERIALS AND METHODS:Retrospective observational case series. Records of 51 patients with diagnosis of sarcoidosis were retrieved. A complete ophthalmic evalua...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2010.495813

    authors: Babu K,Kini R,Mehta R,Abraham MP,Subbakrishna DK,Murthy KR

    更新日期:2010-10-01 00:00:00

  • Analysis of retinal findings of acute retinal necrosis using optical coherence tomography.

    abstract:PURPOSE:To analyze the retinal findings in patients with ARN, optical coherence tomography (OCT) was performed. METHODS:Seven patients (7 eyes) with ARN were studied using OCT. RESULTS:OCT images depicted highly reflective areas in the inner layers of the retina in all seven cases, corresponding with the yellowish-wh...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940600672198

    authors: Suzuki J,Goto H,Minoda H,Iwasaki T,Sakai J,Usui M

    更新日期:2006-06-01 00:00:00

  • Visual prognosis in Behçet's disease.

    abstract::In the pre-cyclosporin therapy era, BenEzra and Cohen(1) reported an appalling visual prognosis of patients with Behçet's disease, with 74% of eyes losing useful vision six to ten years after diagnosis. This experience was in a population largely of Mediterranean origin and it has been suggested that different ethnic ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273949309085025

    authors: Towler HM,Lightman S

    更新日期:1993-01-01 00:00:00

  • Serpiginous choroiditis in a referral clinic in India: visual field changes and clinical correlates.

    abstract:PURPOSE:To report the visual field changes in patients with serpiginous choroiditis as seen in a referral clinic in India. METHODS:A retrospective noncomparative case series was conducted. Twenty-nine eyes of 17 patients who were diagnosed with serpiginous choroiditis were included in the study. Clinical findings were...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2014.902473

    authors: Balarabe AH,Biswas J

    更新日期:2014-10-01 00:00:00

  • Subcutaneous Tocilizumab for Cystoid Macular Edema Secondary to Juvenile Idiopathic Arthritis (JIA)-associated Uveitis: A Case Report.

    abstract::Purpose: To report a case of cystoid macular edema (CME) secondary to juvenile idiopathic arthritis (JIA)-associated uveitis. Case report: 26-year-old female patient presented with CME in both eyes. CME became refractory and TCZ-IV was initiated. After 12 infusions was stopped because grade 1 neuropenia developed. On ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2019.1644350

    authors: Adán A,Moll-Udina A,Ramirez J,Llorenç V

    更新日期:2019-10-07 00:00:00

  • Tacrolimus (FK506) in failed cyclosporin A therapy in endogenous posterior uveitis.

    abstract::Tacrolimus (FK506) is effective in Japanese endogenous posterior uveitis (EPU), but there is limited data on its role in refractory EPU where cyclosporin A (CsA) toxicity/resistance develops. This open prospective clinical study aimed to assess the efficacy and adverse effects of low-dose FK506 therapy in western pati...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1076/ocii.6.2.101.4051

    authors: Kilmartin DJ,Forrester JV,Dick AD

    更新日期:1998-06-01 00:00:00

  • The spectrum of ocular involvement in systemic lupus erythematosus in a tertiary eye care center in Nepal.

    abstract:PURPOSE:Manifestations of Systemic lupus erythematosus are protean and the eye can get affected in more than a third of the cases. This study was conducted to evaluate the spectrum of ocular manifestation among Nepalese patients diagnosed with Systemic lupus erythematosus. METHODS:In this hospital based cross-sectiona...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2011.610023

    authors: Sitaula R,Shah DN,Singh D

    更新日期:2011-12-01 00:00:00

  • Occurrence of and Risk Factors for Ocular Hypertension and Secondary Glaucoma in Juvenile Idiopathic Arthritis-associated Uveitis.

    abstract:PURPOSE:To describe the incidence of ocular hypertension (OHT) and secondary glaucoma (SG) in JIA-associated uveitis, identify risk factors for development of these complications, and describe their effect on visual outcomes. METHODS:A retrospective cohort of 108 patients (196 eyes) with JIA-associated uveitis seen ov...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2016.1142573

    authors: Stroh IG,Moradi A,Burkholder BM,Hornbeak DM,Leung TG,Thorne JE

    更新日期:2017-08-01 00:00:00

  • Use of a high infusion rate to prevent posterior dislocation of fluocinolone acetonide implant during surgical removal.

    abstract:PURPOSE:To describe a strategy for reducing the risk of posterior dislocation of a fluocinolone implant during exchange or removal. DESIGN:Case report and in vitro model. METHODS:Description of a surgical case and an in vitro experiment evaluating the role of infusion pressure in maintaining implant stability in surg...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.3109/09273948.2011.553980

    authors: Wan W,Stewart JM

    更新日期:2011-06-01 00:00:00

  • Expanding the Clinical Spectrum of Multiple Evanescent White Dot Syndrome with Overlapping Multifocal Choroiditis.

    abstract:PURPOSE:To evaluate multifocal evanescent white dot syndrome (MEWDS) patients with and without overlapping multifocal choroiditis (MFC). METHODS:Thirty-four patients diagnosed between November 2008 and August 2018 at 2 hospitals were retrospectively reviewed. Multimodal imaging including optical coherence tomography a...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2020.1795206

    authors: Kang HG,Kim TY,Kim M,Byeon SH,Kim SS,Koh HJ,Lee SC,Lee CS

    更新日期:2020-09-01 00:00:00

  • Tear secretory IgA: evaluation of usefulness as a diagnostic marker in herpetic keratitis.

    abstract::In a South Indian study, an 'in-house' enzyme-linked immunosorbent assay (ELISA) was developed to evaluate the potential of herpes simplex virus (HSV)-specific tear secretory IgA (sIgA) in the diagnosis of herpes simplex keratitis (HSK). The presence of HSV-specific tear sIgA was found to be diagnostic in 20.28% of ca...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1076/ocii.7.2.61.4023

    authors: Pramod NP,Dhevahi E,Sudhamathi K,Kannan K,Thyagarajan SP

    更新日期:1999-06-01 00:00:00

  • Combined low dose cyclosporine and prednisone down-regulate natural killer cell-like effector functions of CD8brightCD56+ T cells in patients with active Behçet uveitis.

    abstract:PURPOSE:To investigate the changes of effector-related phenotypic markers and the natural killer (NK)-like effector functions of CD8(bright)CD56+ T cells in patients with Behçet uveitis after combined cyclosporine and prednisone (Cs/Pd) treatment. METHODS:Ten patients with active Behçet panuveitis and 10 healthy contr...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273940600966616

    authors: Ahn JK,Park YG,Park SW,Yoon KC,Yu HG,Chung H

    更新日期:2006-10-01 00:00:00

  • Clinical Outcomes of Retinal Detachment Surgery following Cytomegalovirus Retinitis in Patients on Highly Active Anti-retroviral Therapy for Acquired Immune Deficiency Syndrome.

    abstract:AIM:The objective of this study is to describe the surgical outcomes of patients of HIV on HAART who underwent surgery for CMV retinitis related retinal detachment. METHOD AND MATERIALS:A retrospective analysis of the medical records of 40 eyes of 35 consecutive HIV positive patients who underwent surgical repair for ...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章,多中心研究

    doi:10.3109/09273948.2014.999376

    authors: Mathur G,Ratra D,Bhuibhar SS,Roy R

    更新日期:2015-01-01 00:00:00

  • Biologic Treatment Options for Retinal Neovascularization in Behçet's Disease.

    abstract:PURPOSE:Relapsing ocular inflammation occurs in about 70% of patients with Behçet's disease (BD) and can lead to permanent loss of vision. Neovascularization of the optic disc (NVD) or elsewhere in the retina (NVE) is a relatively uncommon but severe complication that lacks standardized treatment. METHODS:We report on...

    journal_title:Ocular immunology and inflammation

    pub_type: 杂志文章

    doi:10.1080/09273948.2017.1332228

    authors: Markomichelakis NN,Aissopou EK,Maselos S,Tugal-Tutkun I,Sfikakis PP

    更新日期:2019-01-01 00:00:00