Characteristics of immunotolerance induced by intratesticular injection of S-antigen.

Abstract:

:Experimental autoimmune uveoretinitis (EAU) induced by immunization of male Lewis rats with bovine S-antigen (S-Ag) is prevented by injection of S-Ag into the testis prior to immunization. This protection of animals is due to the induction of systemic immunotolerance or immunosuppression, which the authors designate orchidic tolerance. In this paper they first present a brief review of several features of orchidic tolerance reported previously and features uncovered more recently, and then propose a possible sequence of events that is initiated by antigen challenge in the testis and results in the proliferation of specific subclasses of lymphocytes with immunosuppressive activity and prevention of the onset of EAU.

journal_name

Ocul Immunol Inflamm

authors

Ren J,Singh AK,Shichi H

doi

10.3109/09273949509085041

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

129-38

issue

2

eissn

0927-3948

issn

1744-5078

journal_volume

3

pub_type

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