Abstract:
:Uveitis is an intraocular inflammation that can be caused by infection, autoimmune disease, trauma or malignancy. It is a serious cause of visual handicap and therapy is targeted at: removal of possible infectious agents, the immunological processes that lead to or sustain the inflammation and finally to prevent or treat the destructive effects of the inflammation on the delicate ocular structures. In this review the latest developments concerning the treatment of posterior uveitis are illuminated, e. g., new approaches concerning the treatment of infectious uveitis including the therapy of herpes virus (VZV, HSV and CMV), bacterial and toxoplasma infections of the eye. Several new ways to influence the immune response and inflammation are described including the use of interferons, modulation of cytokines, soft steroids, other new immunosuppressive drugs and treatment of autoimmune uveitis by oral tolerization. An overview is given to illustrate new ways to administer drugs into eyes, such as intravitreal devices. Finally new developments in the field of the treatment of the various complications of uveitis (cystoid macular edema) are described.
journal_name
Ocul Immunol Inflammjournal_title
Ocular immunology and inflammationauthors
Suttorp-Schulten MS,Jager MJ,Kijlstra Adoi
10.3109/09273949609079654subject
Has Abstractpub_date
1996-01-01 00:00:00pages
207-17issue
4eissn
0927-3948issn
1744-5078journal_volume
4pub_type
杂志文章abstract::Purpose: The purpose of the article is to describe a novel case of idiopathic central nervous system inflammatory disease with bilateral human leukocyte antigen (HLA)-B27-positive anterior uveitis. Methods/Results: A 15-year-old African American boy with bilateral HLA-B27-positive anterior uveitis controlled with topi...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2018.1449865
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To report the pattern of uveitis in patients attending a tertiary uveitis service in Sydney, Australia. METHODS:The charts of patients seen between January 2009 and December 2015 were retrospectively reviewed. Data pertaining to patient demographics, eye examination on presentation, work-up and final diagnoses...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1247871
更新日期:2017-01-01 00:00:00
abstract:AIM:To report 2 cases of idiopathic anterior uveitis with coexistent myasthenia gravis. MATERIALS AND METHODS:Retrospective case reports. RESULTS:A 60-year-old male and a 40-year-old male presented with chronic nongranulomatous anterior uveitis of unknown etiology. The latter had a history of hypothyroidism. During f...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.3109/09273948.2012.726687
更新日期:2013-01-01 00:00:00
abstract::Purpose: Anterior uveitis is the most common anatomic subset of uveitis. We developed a novel multi-parametric flow cytometry panel to identify immune dysregulation signatures in HLA B27-associated acute anterior uveitis (AAU) and axial spondyloarthritis (AxSpA).Methods: We used fluorescence activated cell sorting to ...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2019.1686156
更新日期:2019-11-25 00:00:00
abstract::The surgical technique and immediate results following posterior chamber IOL implantation after cataract extraction in eight children suffering from chronic uveitis are described. In all cases, improvement of the visual acuity and a better control of the intraocular inflammatory processes could be achieved after surge...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949309086555
更新日期:1993-01-01 00:00:00
abstract::Purpose: To describe tuberculous uveitis (TU) presenting as a bullous retinal detachment (RD) and to perform a comprehensive literature review on TU with similar features. Methods: Observational case report and systematic literature review. Results: An 84-year-old woman presented with bilateral granulomatous uveitis a...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2018.1485958
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To evaluate the clinical outcome and safety of adalimumab in patients with Vogt-Koyanagi-Harada (VKH) disease. METHODS:VKH patients treated with adalimumab seen at the University of Buenos Aires were reviewed. Main outcome measures were visual acuity, anterior segment inflammation, optic nerve inflammation (ON...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1236969
更新日期:2018-01-01 00:00:00
abstract::Several subjective and arbitrary grading methods are used in assessing cell and flare in uveitis. Clinicians are in need of an objective method of determining and monitoring active inflammation. We studied the correlation of changes in macular thickness between the visits and compared the change to visual acuity (VA),...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940802702587
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:Uveitis is a common, sight-threatening inflammatory ocular disease and includes multiple heterogeneous clinical entities. The prevalence of various types of uveitis depends upon multiple factors, such as age, sex, race, geographic distribution, environmental influence, genetics, and social habits. Epidemiologic...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1080/09273948.2016.1196713
更新日期:2018-01-01 00:00:00
abstract::Behçet's disease is the most frequently encountered form of endogenous uveitis in Japan. The authors examined the clinical manifestations in cases with Behçet's disease over six years (1987-1992), and compared the results with those of a previous study (1978-1983). In the more recent study the number of new patients w...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949509069117
更新日期:1995-01-01 00:00:00
abstract::Purpose: To investigate the prevalence of macular abnormalities in Chinese Vogt-Koyanagi-Harada (VKH) patients.Methods: Clinical characteristics, therapeutic effectiveness and visual outcome were reviewed and analyzed.Results: The most common macular abnormality was macular edema (ME), followed by macular choroidal ne...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1624781
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To describe the demographic and clinical profiles of uveitis patients seen at secondary and tertiary care centers in Turkey. METHODS:A nationwide web-based registry of patients with uveitis was initiated in November 2008. We analyzed data from a single baseline registry-enrollment visit. RESULTS:In 33 centers...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,多中心研究
doi:10.1080/09273948.2016.1196714
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:The study was to evaluate the diagnostic efficacy of nested polymerase chain reaction (nPCR) using primers targeting B1 gene of Toxoplasma gondii (T. gondii) with Witmer Desmonts coefficient (WDC) technique in intraocular fluids of clinically suspected toxoplasma retino choroiditis (TRC) patients. MATERIALS ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273940500545692
更新日期:2006-04-01 00:00:00
abstract::Background: Post-streptococcal uveitis is a rare ocular disease which is part of other auto-immune conditions associated with post-streptococcal syndrome. It was first mentioned in medical literature in 1991, with only a few cases published at that time. We are presenting the case of a patient with bilateral panuveiti...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2018.1501493
更新日期:2019-01-01 00:00:00
abstract:AIMS/BACKGROUND:To assess the outcome and complications of cataract extraction in patients with Behçet's disease. METHODS:Thirty-six Behçet's disease patients underwent cataract surgery without intraocular lens implantation. Twenty-six patients had phacoemulsification or extracapsular cataract extraction, and ten pati...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273949709085047
更新日期:1997-03-01 00:00:00
abstract:PURPOSE:Uveitis is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA) and is associated with considerable morbidity. The aim of this study was to examine the risk factors associated with uveitis in oligoarticular JIA. METHODS:We conducted a chart review of 86 patients with oligoarticu...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2013.841495
更新日期:2014-06-01 00:00:00
abstract::A 45-year-old man was diagnosed with diffuse large B-cell lymphoma stage IV which was confirmed by celiac lymph node biopsy. He subsequently completed six cycles of R-CHOP chemotherapy. Six months later, he presented with panuveitis OU with positive relative afferent pupillary defect OD. OCT revealed hyper-reflective ...
journal_title:Ocular immunology and inflammation
pub_type: 信件
doi:10.1080/09273948.2020.1800050
更新日期:2020-09-24 00:00:00
abstract::We report on a 22-years-old Thai male patient with congenital HIV infection. Due to his non-adherence to antiretroviral treatment he developed disseminated Talaromyces marneffei infection and was treated with intravenous amphotericin B. Despite this treatment, he presented with bilateral granulomatous anterior uveitis...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1657468
更新日期:2020-10-02 00:00:00
abstract:BACKGROUND:To describe ocular findings in Turkish patients with Fuchs' uveitis (FU). METHODS:The medical records of FU were retrospectively reviewed. RESULTS:The study included 281 eyes of 258 patients with FU. There were diffusely spread keratic precipitates (KPs)[(medium sized in 253 (90.0%) eyes, stellate-medium i...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2020.1795207
更新日期:2020-08-24 00:00:00
abstract::The eye is an immune-privileged site that uses specialized mechanisms to protect itself from damage and to preserve its visual acuity. Among the mechanisms that contribute to the eye's privileged existence is its ability to induce both local and peripheral tolerance to antigens that may transgress its chambers. Experi...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.1080/09273940490912371
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:To report an immunocompetent patient with Nocardia exalbida endogenous endophthalmitis. DESIGN:Case report. METHODS:Clinical-pathologic correlation and microbiologic evaluation were performed on an enucleated eye. RESULTS:A 56-year-old man presented with rapidly progressive vision loss associated with a post...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,评审
doi:10.3109/09273948.2011.563898
更新日期:2011-08-01 00:00:00
abstract::Purpose: The purpose of this study is to explore the effects of dihydrotestosterone (DHT) on lipopolysaccharide (LPS)-induced proinflammatory cytokine release in human ocular surface epithelial cells exposed to LPS and LPS-binding protein (LBP).Methods: Immortalized human corneal, conjunctival, and meibomian gland epi...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2019.1686155
更新日期:2019-11-18 00:00:00
abstract:PURPOSE:To describe an unusual manifestation of sarcoidosis as a large tumor of the iris and ciliary body without any other involvement of the body. METHODS:We describe a 20-year-old female presenting with a granulomatous tumor of the right iris and ciliary body and concomitant uveitis. RESULTS:Extensive ocular and s...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/092739490500156
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:To analyze and compare the clinical profile of herpes zoster ophthalmicus (HZO) patients in a South Indian patient population aged <60 years and ≥60 years and determine the risk factors for recurrence of ocular inflammation. METHODS:Retrospective study of 249 cases between 2006 and 2016 from two tertiary refer...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2017.1381272
更新日期:2018-01-01 00:00:00
abstract:AIM:To compare outcomes of live related limbal allograft (Lr-CLAL) versus cadaveric keratolimbal allograft (KLAL) in limbal stem cell deficiency (LSCD) secondary to ocular burns. METHODS:Twenty patients with stage IIb LSCD were randomized so that cases underwent either Lr-CLAL or KLAL. Fibrovascular pannus was removed...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章,随机对照试验
doi:10.3109/09273948.2014.902076
更新日期:2015-06-01 00:00:00
abstract::Purpose: To compare toll-like receptors 2 (TLR2) and 4 (TLR4) expression in cells of corneal and conjunctival epithelium between unilateral KC patients and control subjects. Methods: Prospective cross-sectional case-control study, including 50 unilateral KC patients and 20 control subjects. TLR2 and TLR4 expression wa...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2018.1511813
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To analyze the diagnostic predictive ability of clinical variables. METHODS:Demographic and clinical variables of 172 serologically proven leptospiral uveitis patients were compared with 200 controls of non-leptospiral uveitis. Multiple logistic regression analysis identified diagnostic predictors. A receiver ...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1217341
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Manifestations of Systemic lupus erythematosus are protean and the eye can get affected in more than a third of the cases. This study was conducted to evaluate the spectrum of ocular manifestation among Nepalese patients diagnosed with Systemic lupus erythematosus. METHODS:In this hospital based cross-sectiona...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2011.610023
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To present a population of patients sharing atypical manifestations of vitreoretinal lymphoma (VRL). METHODS:Institutional case series in a single tertiary center. Patients with cytologically proven VRL, referred between November 2009 and May 2010, were retrospectively reviewed. Diagnosis of VRL was based on c...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.3109/09273948.2013.835427
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:To examine the role of interleukin 27(IL-27) and interleukin 35 (IL-35) in diabetic retinopathy (DR). METHODS:Patients with diabetes mellitus were divided into three groups: diabetes without retinopathy (DWR), non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR). Patients...
journal_title:Ocular immunology and inflammation
pub_type: 杂志文章
doi:10.1080/09273948.2016.1203959
更新日期:2018-01-01 00:00:00