Abstract:
:The study aimed at assessing the potential use of lower total and HMW adiponectin levels for predicting cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Concentrations of total adiponectin or high molecular weight (HMW) adiponectin decrease in association with the development of metabolic dysfunction such as obesity, insulin resistance, or T2DM. Increased adiponectin levels are associated with a lower risk for coronary heart disease. A total of 551 individuals were assessed. The first group comprised metabolically healthy participants (143 females, and 126 males) and the second group were T2DM patients (164 females, and 118 males). Both total adiponectin and HMW adiponectin in diabetic patients were significantly lower when compared with the group of metabolically healthy individuals. There was a weak monotonic correlation between HMW adiponectin levels and triglycerides levels. Binary logistic regression analysis, gender adjusted, showed a higher cardiovascular risk in diabetic persons when both total adiponectin (OR = 1.700) and HMW adiponectin (OR = 2.785) levels were decreased. A decrease in total adiponectin levels as well as a decrease in its HMW adiponectin is associated with a higher cardiovascular risk in individuals with T2DM. This association suggests that adiponectin levels may be potentially used as an epidemiological marker for cardiovascular risk in diabetic patients.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Horáková D,Azeem K,Benešová R,Pastucha D,Horák V,Dumbrovská L,Martínek A,Novotný D,Švagera Z,Hobzová M,Galuszková D,Janout V,Doněvská S,Vrbková J,Kollárová Hdoi
10.1155/2015/545068subject
Has Abstractpub_date
2015-01-01 00:00:00pages
545068eissn
1687-8337issn
1687-8345journal_volume
2015pub_type
杂志文章abstract:BACKGROUND:Recent guidelines from the American Thyroid Association (ATA) indicate that, in many patients affected by differentiated thyroid cancer (DTC), the serum TSH should be maintained between 0.1 and 0.5 mU/L. The purpose of this study was to evaluate the TSH variability of patients affected by DTC treated with li...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2017/7053959
更新日期:2017-01-01 00:00:00
abstract::Spermatozoa are highly specialized cells that can be easily obtained and purified. Mature spermatozoa are transcriptionally and translationally inactive and incapable of protein synthesis. In addition, spermatozoa contain relatively higher amounts of membrane proteins compared to other cells; therefore, they are very ...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2013/360986
更新日期:2013-01-01 00:00:00
abstract::Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2017/2452853
更新日期:2017-01-01 00:00:00
abstract::In the present study we evaluated in vivo and in vitro effects of 4-tert-octylphenol (OP) on the expression and distribution of adherens and gap junction proteins, N-cadherin, β -catenin, and connexin 43 (Cx43), in testes of seasonally breeding rodents, bank voles. We found that in bank vole testes expression and dist...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/134589
更新日期:2013-01-01 00:00:00
abstract::We investigated the role of urokinase plasminogen activator (uPA) and its soluble receptors (suPAR) and plasminogen activator inhibitor-1 (PAI-1) in metabolic syndrome (MetS) components, insulin secretion, and resistance in schoolchildren. We enrolled 387 children, aged 10.3 ± 1.5 years, in Taipei. Anthropometry, fibr...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/170987
更新日期:2015-01-01 00:00:00
abstract:Background:Little information is available on the association between parents' metabolic syndrome (MetS) and adolescent offspring's obesity in Korea. The aim of our study is to determine the association between parent's metabolic syndrome and offspring's obesity. Methods:The study data were obtained from the Korean Na...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/8737912
更新日期:2020-10-30 00:00:00
abstract::Whether serum magnesium deficiency is independently associated with the prevalence of microalbuminuria is still unclear. The objective of the present study was to elucidate the association between serum magnesium and microalbuminuria in diabetic patients. A cross-sectional study was conducted in 1829 diabetic subjects...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/580685
更新日期:2013-01-01 00:00:00
abstract::Obesity is a growing problem in modern society and medicine. It closely associates with metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and cardiovascular diseases such as nonalcoholic fatty liver disease, atherosclerosis, myocarditis, and hypertension. Obesity is often associated with latent i...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2017/5076732
更新日期:2017-01-01 00:00:00
abstract::Background. Separate lines of research have shown that menstrual cycling and contextual factors such as the gender of research personnel influence experimental pain reporting. Objectives. This study examines how brief, procedural interactions with female and male experimenters can affect experimentally reported pain (...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/520719
更新日期:2015-01-01 00:00:00
abstract::Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the c...
journal_title:International journal of endocrinology
pub_type:
doi:10.1155/2010/910636
更新日期:2010-01-01 00:00:00
abstract::Enucleation-induced adrenal regeneration is a highly controlled process; however, only some elements involved in this process have been recognized. Therefore, we performed studies on regenerating rat adrenals. Microarray RNA analysis and QPCR revealed that enucleation resulted in a rapid elevation of expression of gen...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/130359
更新日期:2014-01-01 00:00:00
abstract::This study investigated potential markers for predicting nonfunctioning pituitary adenoma (NFPA) invasion and recurrence by high-throughput tissue microarray analyses. We retrospectively studied two groups of patients: 60 nonrecurrent NFPA cases that included noninvasion and invasion subtypes and 43 recurrent cases th...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/5731639
更新日期:2019-05-16 00:00:00
abstract::Partial androgen insensitivity syndrome (PAIS) is associated with impaired male genital development and can be transmitted through mutations in the androgen receptor (AR). The aim of this study is to develop a cell model suitable for studying the impact AR mutations might have on AR interacting proteins. For this purp...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/381824
更新日期:2012-01-01 00:00:00
abstract::Type 2 diabetes and depression are regarded as comorbid conditions, and three possible directions of the association between the diseases can underlie this observation of comorbidity. First, common etiology can increase a person's risk of both diseases; second, persons with type 2 diabetes have increased prevalence or...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/164760
更新日期:2015-01-01 00:00:00
abstract::Objective. In pediatric central diabetes insipidus (CDI), etiology diagnosis and pituitary function monitoring are usually delayed. This study aimed to illustrate the importance of regular follow-up and pituitary function monitoring in pediatric CDI. Methods. The clinical, hormonal, and neuroradiological characteristi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/6365830
更新日期:2016-01-01 00:00:00
abstract::The chemosensitivity of anaplastic thyroid cancer (ATC) to some cytotoxic agents was investigated by the histoculture drug response assay (HDRA). Thirty specimens from 22 patients with ATC were obtained from surgically resected subjects. The drugs tested were paclitaxel (PTX), docetaxel (DOC), adriamycin (ADM), nedapl...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/967286
更新日期:2015-01-01 00:00:00
abstract::Thyroid cancer is the most common endocrine malignancy, and its incidence has increased rapidly in recent decades worldwide. Papillary thyroid cancer (PTC) is the most common type of all thyroid cancers. The molecular mechanisms underlying the disease still need to be further investigated. Long noncoding RNAs (lncRNAs...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/7043509
更新日期:2019-04-07 00:00:00
abstract:Objective:We sought to evaluate the association between femoral neck (FN) and lumbar spine (LS) bone mineral densities (BMDs) with severity of chronic kidney disease (CKD) and prevalence of osteopenia or osteoporosis (OP) among the CKD group. Methods:Cross-sectional data from 11050 participants aged ≥20 years from the...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/8852690
更新日期:2020-10-26 00:00:00
abstract::Purpose. To evaluate alteration in serum TSH in hypertensives with OSA and its relation with cardiometabolic risk factors. Methods. 517 hypertensives were cross-sectionally studied. OSA was determined by polysomnography and thyroid function by standard methods. Results. OSA was diagnosed in 373 hypertensives (72.15%)....
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/4802720
更新日期:2016-01-01 00:00:00
abstract::Objective. To examine the association of three most common obesity measures including body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) with chronic kidney disease (CKD) risk in patients with type 2 diabetes mellitus (T2D). Design. Cross-sectional evaluation of the effect of anthropometric ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/715871
更新日期:2015-01-01 00:00:00
abstract::Aim. To examine the relationship between plasma 25-hydroxyvitamin D (25(OH)D) levels and blood hemoglobin A1c (HbA1c) levels in diabetic patients at various stages of chronic kidney disease (CKD). Methods. We screened for data collected between 2003 and 2012. The correlation between 25(OH)D and HbA1c levels was studie...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/142468
更新日期:2014-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/7838290.]. ...
journal_title:International journal of endocrinology
pub_type: 已发布勘误
doi:10.1155/2018/1239718
更新日期:2018-10-23 00:00:00
abstract:Objective:Selenium, as an antioxidant, has been implicated in the development of autoimmune thyroiditis (AIT). Many studies showed selenium supplementation could decrease thyroid autoantibodies in patients with AIT. However, the underlying mechanisms have not been well determined. Therefore, we performed a clinical stu...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/9210572
更新日期:2020-06-30 00:00:00
abstract:Objective:To evaluate the effectiveness and safety of coenzyme Q10 for patients with type 2 diabetes mellitus (T2DM). Methods:Data from randomized controlled trials were obtained to assess the effects of coenzyme Q10 versus placebo or western medicine on patients with T2DM. The study's registration number is CRD420180...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/6484839
更新日期:2018-09-16 00:00:00
abstract:Purpose:Hyperoside, a flavonoid isolated from conventional medicinal herbs, has been demonstrated to exert a significant protective effect in diabetic nephropathy. This study aimed to determine the underlying mechanisms, by which hyperoside inhibits high glucose-(HG-) induced proliferation in mouse renal mesangial cell...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/1361924
更新日期:2020-07-21 00:00:00
abstract::Gestational diabetes mellitus (GDM) is defined as any degree of carbohydrate intolerance, with onset or first recognition during second or third trimester of gestation. It is estimated that approximately 7% of all pregnancies are complicated by GDM and that its prevalence is rising all over the world. Thus, the screen...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/6380463
更新日期:2018-04-12 00:00:00
abstract::There is inconsistency among published guidelines for the optimal diagnostic and management pathways for patients with typical (TC) or atypical (AC) pulmonary carcinoid tumours. We conducted a UK-wide clinician survey to assess current practice for the diagnosis, management, and follow-up of patients with TC/AC and de...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/9287536
更新日期:2020-02-28 00:00:00
abstract::To examine the gene expression of ghrelin, a growth hormone releasing and appetite stimulating hormone from stomach, we constructed human ghrelin promoter-reporter vectors and analyzed the promoter activity. The ghrelin promoter activity was high when cultured cells that express ghrelin mRNA endogenously like TT or EC...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/580908
更新日期:2015-01-01 00:00:00
abstract:Background:Currently, energy obtained from hypercaloric diets has been part of the obesity and type 2 diabetes mellitus (T2DM) epidemics from childhood to old age. Treatment alternatives have been sought from plants, minerals, and trace elements with metabolic effects. Vanadyl sulfate (VS) has been investigated as a hy...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/5257216
更新日期:2018-12-25 00:00:00
abstract:Background:Type 2 diabetes mellitus is a serious public health problem worldwide. Accumulating evidence has shown that β-cell dysfunction is an important mechanism underlying diabetes mellitus. The changes in the physiological state of islet stellate cells (ISCs) and the effects of these cells on β-cell dysfunction is ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/4708132
更新日期:2020-02-24 00:00:00