Abstract:
Background:Currently, energy obtained from hypercaloric diets has been part of the obesity and type 2 diabetes mellitus (T2DM) epidemics from childhood to old age. Treatment alternatives have been sought from plants, minerals, and trace elements with metabolic effects. Vanadyl sulfate (VS) has been investigated as a hypoglycemic compound in animal and human studies showing effective insulin-mimetic properties. This characteristic encompasses several molecules that have beneficial pleiotropic effects. The aim was to determine the antiobesity, hypoglycemic, and hypolipidemic effects of VS on fructose-induced metabolic syndrome in aged rats. Material and Methods:Five groups of male Wistar rats were made, each with six rats: two groups with normal diet (ND) and three with high-fructose diet (HFD). The first ND group was treated with saline solution (SS), the second with VS; treatment for HFD groups was in the first group with SS, second with VS, and third with metformin. Weight, body mass index (BMI), blood glucose, and lipidic profile were measured; water, food, fructose and energy consumption were also determined. All parameters were compared among groups. Results and Discussion:Although obese rats treated with VS presented anorexia, oligodipsia, and a marked weight loss in the first two weeks. They recovered food and water intake in the third week with a slow recovery of some weight weeks later. VS normalized blood glucose level and decreased triglyceride and insulin levels in obese rats. These results suggest that vanadyl sulfate shows antiobesity, hypoglycemic, and hypolipidemic properties in old obese rats and could be useful as an alternative, additional, and potent preventive treatment for obesity and T2DM control in elderly obese and poorly controlled diabetic patients. Conclusion:VS could play an important role in the treatment of metabolic syndrome, contributing to a decrease in obesity and T2DM, through different ways, such as euglycemia, satiety, weight loss, and lipid profile optimization, among others. However, more research is needed to confirm this suggestion.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Ortega-Pacheco D,Jiménez-Pérez MM,Serafín-López J,Juárez-Rojas JG,Ruiz-García A,Pacheco-García Udoi
10.1155/2018/5257216subject
Has Abstractpub_date
2018-12-25 00:00:00pages
5257216eissn
1687-8337issn
1687-8345journal_volume
2018pub_type
杂志文章abstract::With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through infl...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2019/9691345
更新日期:2019-10-13 00:00:00
abstract::To investigate the correlation between gender and the clinical presentation of papillary thyroid cancer and the long-term followup results, 435 patients who underwent total or near-total thyroidectomy were enrolled in this study. Among these papillary thyroid cancer patients, 12.2% showed lymph node metastases and a h...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/379097
更新日期:2012-01-01 00:00:00
abstract:Objective:Atypical parathyroid adenoma is a rare neoplasm, showing atypical histological features intermediate between classic benign adenoma and the rarest parathyroid carcinoma, whose the clinical behaviour and outcome is not yet understood or predictable. Up to date only two cases of atypical adenoma were found asso...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/2080797
更新日期:2020-04-27 00:00:00
abstract::The goal of this study was to determine the prevalence and associated risk factors of impaired glucose regulation (IGR) in the population of Tongzhou, China, and to provide scientific basis for preventive interventions. In the study, the overall age-standardized prevalence of IGR (16.0%) in Tongzhou residents was high...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/731583
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abstract::Parathyroid carcinoma (PC) is a rare disease responsible for about 1% of primary hyperparathyroidism (PHPT) cases. PC usually has an indolent course, tough to differentiate from the benign causes of PHPT, and the only certain diagnosis is histologic. The gold standard surgical treatment is the en bloc resection associ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/7048185
更新日期:2020-03-06 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2010/957174
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Recent guidelines from the American Thyroid Association (ATA) indicate that, in many patients affected by differentiated thyroid cancer (DTC), the serum TSH should be maintained between 0.1 and 0.5 mU/L. The purpose of this study was to evaluate the TSH variability of patients affected by DTC treated with li...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2017/7053959
更新日期:2017-01-01 00:00:00
abstract:Background:Gynecomastia (GM) is a benign enlargement of male breast due to glandular tissue proliferation. GM is a symptom of systemic or local hormonal disturbances, which could be associated with functional changes or pathological conditions. However, the long-lasting steroid imbalance in men with GM might exert nega...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/6718761
更新日期:2019-10-03 00:00:00
abstract::Bariatric surgery is currently the most effective therapy to induce weight loss in morbidly obese patients. Objective. This controlled, clinical trial with a two-year intervention was aimed at comparing the efficacy of two nonsurgical approaches versus bariatric surgery, on body weight changes and metabolic parameters...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/194696
更新日期:2015-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/594710
更新日期:2014-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/957105
更新日期:2015-01-01 00:00:00
abstract:Introduction:Gut microbiota is involved in the progression of metabolic diseases such as obesity and type 2 diabetes. The ob/ob and db/db mice are extensively used as models in studies on the pathogenesis of these diseases. The goal of this study is to characterize the composition and structure of gut microbiota in the...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/1394097
更新日期:2019-03-11 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/8693516
更新日期:2019-07-16 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/7863867
更新日期:2016-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/6380463
更新日期:2018-04-12 00:00:00
abstract::Primary hyperparathyroidism (PHPT) is not an uncommon disease in the western countries. In Thailand, on the contrary, PHPT was a rare condition with various clinical presentations. All 45 PHPT patients who underwent parathyroidectomy at the Department of Surgery, Siriraj Hospital during January 1997 and December 2007 ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/952426
更新日期:2012-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/685375
更新日期:2013-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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更新日期:2019-12-18 00:00:00
abstract::[This corrects the article DOI: 10.1155/2015/164087.]. ...
journal_title:International journal of endocrinology
pub_type: 已发布勘误
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journal_title:International journal of endocrinology
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更新日期:2017-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/534320
更新日期:2015-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/6890501
更新日期:2018-03-07 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2010/205357
更新日期:2010-01-01 00:00:00
abstract:Background:Little information is available on the association between parents' metabolic syndrome (MetS) and adolescent offspring's obesity in Korea. The aim of our study is to determine the association between parent's metabolic syndrome and offspring's obesity. Methods:The study data were obtained from the Korean Na...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/8737912
更新日期:2020-10-30 00:00:00
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journal_title:International journal of endocrinology
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doi:10.1155/2019/5731639
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/505849
更新日期:2015-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/4708132
更新日期:2020-02-24 00:00:00