当前位置： SCI文献检索 > International Journal of Endocrinology期刊下所有文献 > Gut Microbiota Composition and Structure of the Ob/Ob and Db/Db Mice.

Gut Microbiota Composition and Structure of the Ob/Ob and Db/Db Mice.

Abstract：

Introduction:Gut microbiota is involved in the progression of metabolic diseases such as obesity and type 2 diabetes. The ob/ob and db/db mice are extensively used as models in studies on the pathogenesis of these diseases. The goal of this study is to characterize the composition and structure of gut microbiota in these model mice at different ages. Materials and methods:High-throughput sequencing was used to obtain the sequences of the highly variable 16S rRNA V3-V4 region from fecal samples. The taxa with high abundance in both model mice were identified by bioinformatics analysis. Moreover, the taxa with divergent abundance in one model mice at different ages or in both model mice at the same age were also recognized. Discussion and conclusion:The high abundance of Bacteroidetes and Firmicutes in microbiota composition and their imbalanced ratio in both model mice reflect the state of metabolic disorders of these mice. Differences in microbiota composition between the two model mice of the same age or in one model mice with different ages were assumed to be closely linked to the fluctuation of their blood glucose levels with age. The data on gut microbiota in ob/ob and db/db mice investigated herein has broad implications for the pathogenesis study and drug discovery on obesity and related complications.

journal_name

Int J Endocrinol

journal_title

International journal of endocrinology

authors

Yang M,Liu Y,Xie H,Wen Z,Zhang Y,Wu C,Huang L,Wu J,Xie C,Wang T,Peng W,Liu S,Chen L,Liu X

doi

10.1155/2019/1394097

subject

Has Abstract

pub_date

2019-03-11 00:00:00

pages

1394097

eissn

1687-8337

issn

1687-8345

journal_volume

2019

pub_type

杂志文章

相关文献

International Journal of Endocrinology文献大全
  • Age- and Gender-Related Differences in LDL-Cholesterol Management in Outpatients with Type 2 Diabetes Mellitus.

    abstract：:Background. Dyslipidemia contribute to the excess of coronary heart disease (CHD) risk observed in women with type 2 diabetes (T2DM). Low density lipoprotein-cholesterol (LDL-C) is the major target for CHD prevention, and T2DM women seem to reach LDL-C targets less frequently than men. Aim. To explore age- and gender-...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2015/957105

    authors： Russo G,Pintaudi B,Giorda C,Lucisano G,Nicolucci A,Cristofaro MR,Suraci C,Mulas MF,Napoli A,Rossi MC,Manicardi V

    更新日期：2015-01-01 00:00:00

  • Peripheral arterial tonometry to measure the effects of vardenafil on sympathetic tone in men with lifelong premature ejaculation.

    abstract：:To elucidate whether adrenergic overtone is involved in the pathophysiology of men with lifelong (LL) premature ejaculation (PE), we investigated differences in reactive hyperemia index (RHI) responses by using peripheral arterial tonometry (PAT). 20 men with LL-PE (18-40 years) were enrolled in an 8-week, double-blin...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2013/394934

    authors： Francomano D,Donini LM,Lenzi A,Aversa A

    更新日期：2013-01-01 00:00:00

  • GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis.

    abstract：:Objective. To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis. Methods. This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy subjects (group HP...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2016/5141089

    authors： Song W,Wang X,Tian Y,Zhang X,Lu R,Meng H

    更新日期：2016-01-01 00:00:00

  • GnRH Antagonist Improves Pubertal Cyclophosphamide-Induced Long-Term Testicular Injury in Adult Rats.

    abstract：Background:Gonadal injury following chemotherapy is of increasing importance with the continuous improvement of survival rates. The protection of gonadotropin hormone antagonist (GnRHant) in long-term adult survivors of adolescent cancers and some autoimmune diseases has not yet been evaluated. Methods:The present stu...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2018/4272575

    authors： Xie R,Chen L,Wu H,Chen T,Wang F,Chen X,Sun H,Li X

    更新日期：2018-06-10 00:00:00

  • Sex- and Age-Specific Optimal Anthropometric Indices as Screening Tools for Metabolic Syndrome in Chinese Adults.

    abstract：Objectives:To compare the predictive ability of six anthropometric indices for identification of metabolic syndrome (MetS) and to determine their optimal cut-off points among Chinese adults. Methods:A total of 59,029 participants were enrolled. Body mass index (BMI), waist circumference (WC), waist-to-height ratio (WH...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2018/1067603

    authors： Zhang J,Zhu W,Qiu L,Huang L,Fang L

    更新日期：2018-09-17 00:00:00

  • Enucleation-induced rat adrenal gland regeneration: expression profile of selected genes involved in control of adrenocortical cell proliferation.

    abstract：:Enucleation-induced adrenal regeneration is a highly controlled process; however, only some elements involved in this process have been recognized. Therefore, we performed studies on regenerating rat adrenals. Microarray RNA analysis and QPCR revealed that enucleation resulted in a rapid elevation of expression of gen...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2014/130359

    authors： Tyczewska M,Rucinski M,Ziolkowska A,Szyszka M,Trejter M,Hochol-Molenda A,Nowak KW,Malendowicz LK

    更新日期：2014-01-01 00:00:00

  • Risk Factors for Cervical Lymph Node Metastasis of Papillary Thyroid Microcarcinoma: A Single-Center Retrospective Study.

    abstract：Objective:To identify the clinicopathological features correlated to lymph node metastasis (LNM) in patients with papillary thyroid microcarcinoma (PTMC). Methods:Clinical data of 785 PTMC patients who underwent surgical treatment at the Lishui Municipal Central Hospital from September 2008 to December 2017 were retro...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2019/8579828

    authors： Cheng F,Chen Y,Zhu L,Zhou B,Xu Y,Chen Y,Wen L,Chen S

    更新日期：2019-01-15 00:00:00

  • ATP Synthase β-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level.

    abstract：:HDL cholesterol is known to be inversely correlated with cardiovascular disease due to its diverse antiatherogenic functions. SR-BI mediates the selective uptake of HDL-C. SR-BI knockout diminishes but does not completely block the transport of HDL; other receptors may be involved. Ectopic ATP synthase β-chain in hepa...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2014/356432

    authors： Song K,Han Y,Zhang L,Liu G,Yang P,Cheng X,Bu L,Sheng H,Qu S

    更新日期：2014-01-01 00:00:00

  • Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI 3 K/mTOR Signaling Pathway.

    abstract：:Sestrin (SESN) is known as a cysteine sulfinic acid reductase. Recently, nonredox functions of SESN in metabolic regulation and antitumor property have been recognized. While mechanisms underlying the expression of SESN are not fully understood. Here we report that insulin markedly increased SESN2 level in HepG2 cells...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2015/505849

    authors： Chai D,Wang G,Zhou Z,Yang H,Yu Z

    更新日期：2015-01-01 00:00:00

  • Autoimmune Diseases in Patients with Cushing's Syndrome after Resolution of Hypercortisolism: Case Reports and Literature Review.

    abstract：Introduction:Cushing's syndrome (CS) is a clinical condition characterized by excessive cortisol production, associated with metabolic complications, such as diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, and cardiovascular diseases. Nowadays, the occurrence of autoimmune diseases in CS have not bee...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2018/1464967

    authors： Petramala L,Olmati F,Conforti MG,Concistré A,Bisogni V,Alfieri N,Iannucci G,de Toma G,Letizia C

    更新日期：2018-12-18 00:00:00

  • Sexual dysfunction in women with diabetic kidney.

    abstract：:Few studies address alteration of sexual function in women with diabetes and chronic kidney disease (CKD). Quality of life surveys suggest that discussion of sexual function and other reproductive issues are of psychosocial assessment and that education on sexual function in the setting of chronic diseases such as dia...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章,收录出版,评审

    doi：10.1155/2014/346834

    authors： Satta E,Magno C,Galì A,Inferrera A,Granese R,Aloisi C,Buemi M,Bellinghieri G,Santoro D

    更新日期：2014-01-01 00:00:00

  • The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas.

    abstract：:Objectives. The roles of PI3K/AKT/mTOR and MAPK/ERK pathways involved in the pathogenesis of pheochromocytoma and paraganglioma (PPGL) were demonstrated mostly by in vitro studies with rat or mouse cells and were mainly studied at transcriptional level. This study aimed to investigate the effect of these pathways on t...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2016/5286972

    authors： Du J,Tong A,Wang F,Cui Y,Li C,Zhang Y,Yan Z

    更新日期：2016-01-01 00:00:00

  • Long-term results after treatment of very low-, low-, and high-risk thyroid cancers in a combined setting of thyroidectomy and radio ablation therapy in euthyroidism.

    abstract：:Introduction. Differentiated thyroid cancer treatment usually consists of thyroidectomy and radio ablation in hypothyroidism 4-6 weeks after surgery. Replacing hypothyroidism by recombinant human thyroid stimulating hormone can facilitate radio ablation in euthyroidism within one week after surgery. The outcome of thi...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2013/769473

    authors： Emmanouilidis N,Schrem H,Winkler M,Klempnauer J,Scheumann GF

    更新日期：2013-01-01 00:00:00

  • Regulation of the Human Ghrelin Promoter Activity by Transcription Factors, NF-κB and Nkx2.2.

    abstract：:To examine the gene expression of ghrelin, a growth hormone releasing and appetite stimulating hormone from stomach, we constructed human ghrelin promoter-reporter vectors and analyzed the promoter activity. The ghrelin promoter activity was high when cultured cells that express ghrelin mRNA endogenously like TT or EC...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2015/580908

    authors： Shiimura Y,Ohgusu H,Sato T,Kojima M

    更新日期：2015-01-01 00:00:00

  • Trends in prevalence, awareness, treatment, and control of diabetes mellitus in mainland china from 1979 to 2012.

    abstract：:Diabetes mellitus (DM) is one of the primary causes of premature death and disability worldwide. We performed a systematic review and meta-analysis of the published literature regarding the trends in prevalence, awareness, treatment, and control of diabetes mellitus in mainland China. PUBMED, EMBASE, Chinese Biomedica...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1155/2013/753150

    authors： Li MZ,Su L,Liang BY,Tan JJ,Chen Q,Long JX,Xie JJ,Wu GL,Yan Y,Guo XJ,Gu L

    更新日期：2013-01-01 00:00:00

  • Puerarin Suppress Apoptosis of Human Osteoblasts via ERK Signaling Pathway.

    abstract：:Puerarin, the main isoflavone glycoside extracted from Radix Puerariae, is an isoflavone traditional Chinese herb. Previous studies have demonstrated that puerarin could regulate osteoblast proliferation and differentiation to promote bone formation. However, the effect of puerarin on the process of human osteoblasts ...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2013/786574

    authors： Liu LJ,Liu LQ,Bo T,Li SJ,Zhu Z,Cui RR,Mao DA

    更新日期：2013-01-01 00:00:00

  • Stability of miR-126 in Urine and Its Potential as a Biomarker for Renal Endothelial Injury with Diabetic Nephropathy.

    abstract：:Background. The purpose of the present study was to assess the feasibility of using miR-126 in the urine as a biomarker for diabetic nephropathy. Methods. miRNAs were extracted from the urine samples of T2DM patients with diabetic nephropathy (DN; n = 92), T2DM without DN (n = 86), and 85 healthy volunteers using quan...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2014/393109

    authors： Liu Y,Gao G,Yang C,Zhou K,Shen B,Liang H,Jiang X

    更新日期：2014-01-01 00:00:00

  • Association among Fibrinolytic Proteins, Metabolic Syndrome Components, Insulin Secretion, and Resistance in Schoolchildren.

    abstract：:We investigated the role of urokinase plasminogen activator (uPA) and its soluble receptors (suPAR) and plasminogen activator inhibitor-1 (PAI-1) in metabolic syndrome (MetS) components, insulin secretion, and resistance in schoolchildren. We enrolled 387 children, aged 10.3 ± 1.5 years, in Taipei. Anthropometry, fibr...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2015/170987

    authors： Chen JS,Wu CZ,Chu NF,Chang LC,Pei D,Lin YF

    更新日期：2015-01-01 00:00:00

  • X-Linked Adrenal Hypoplasia Congenita in a Boy due to a Novel Deletion of the Entire NR0B1 (DAX1) and MAGEB1-4 Genes.

    abstract：:X-linked Adrenal Hypoplasia Congenita (AHC) is caused by deletions or point mutations in the NR0B1 (DAX1) gene. We present a boy with AHC who came at the age of 25 days in a severe state due to prolonged vomiting and progressive dehydration. Laboratory studies showed prominent hyponatremia and hyperkaliemia but not hy...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2016/5178953

    authors： Rojek A,Krawczynski MR,Jamsheer A,Sowinska-Seidler A,Iwaniszewska B,Malunowicz E,Niedziela M

    更新日期：2016-01-01 00:00:00

  • Long Noncoding RNA LOC100129940-N Is Upregulated in Papillary Thyroid Cancer and Promotes the Invasion and Progression.

    abstract：:Thyroid cancer is the most common endocrine malignancy, and its incidence has increased rapidly in recent decades worldwide. Papillary thyroid cancer (PTC) is the most common type of all thyroid cancers. The molecular mechanisms underlying the disease still need to be further investigated. Long noncoding RNAs (lncRNAs...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2019/7043509

    authors： Choy M,Guo Y,Li H,Wei G,Ye R,Liang W,Xiao H,Li Y,Guan H

    更新日期：2019-04-07 00:00:00

  • Primary hyperparathyroidism: 11-year experience in a single institute in Thailand.

    abstract：:Primary hyperparathyroidism (PHPT) is not an uncommon disease in the western countries. In Thailand, on the contrary, PHPT was a rare condition with various clinical presentations. All 45 PHPT patients who underwent parathyroidectomy at the Department of Surgery, Siriraj Hospital during January 1997 and December 2007 ...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2012/952426

    authors： Prasarttong-Osoth P,Wathanaoran P,Imruetaicharoenchoke W,Rojananin S

    更新日期：2012-01-01 00:00:00

  • Corrigendum to "The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes".

    abstract：:[This corrects the article DOI: 10.1155/2014/690783.]. ...

    journal_title：International journal of endocrinology

    pub_type： 已发布勘误

    doi：10.1155/2017/5924671

    authors： Napoli N,Strollo R,Paladini A,Briganti SI,Pozzilli P,Epstein S

    更新日期：2017-01-01 00:00:00

  • Inflammatory response in islet transplantation.

    abstract：:Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes. Here we revie...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1155/2014/451035

    authors： Kanak MA,Takita M,Kunnathodi F,Lawrence MC,Levy MF,Naziruddin B

    更新日期：2014-01-01 00:00:00

  • Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers.

    abstract：:Melatonin (N-acetyl-5-methoxytryptamine) is a hormone synthesized and secreted by the pineal gland mainly during the night, since light exposure suppresses its production. Initially, an implication of this indoleamine in malignant disease was described in endocrine-responsive breast cancer. Data from several clinical ...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1155/2018/3271948

    authors： Menéndez-Menéndez J,Martínez-Campa C

    更新日期：2018-10-02 00:00:00

  • High fasting insulin levels and insulin resistance may be linked to idiopathic recurrent pregnancy loss: a case-control study.

    abstract：:Objective. Patients with more than two spontaneous pregnancy losses are diagnosed with recurrent pregnancy loss. The aim of this study was to evaluate the IR (insulin resistance) in patients with idiopathic recurrent pregnancy loss. Material and Method. A single center, case control study was performed on one hundred ...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2013/576926

    authors： Ispasoiu CA,Chicea R,Stamatian FV,Ispasoiu F

    更新日期：2013-01-01 00:00:00

  • Vitamin d status in central europe.

    abstract：:Little published information is available regarding epidemiological data on vitamin D status in the large geographical region of Central Europe (CE). We searched the journal literature with regard to 25(OH)D concentrations among community-dwelling or healthy people living in CE. 25(OH)D concentrations varied by age, s...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1155/2014/589587

    authors： Pludowski P,Grant WB,Bhattoa HP,Bayer M,Povoroznyuk V,Rudenka E,Ramanau H,Varbiro S,Rudenka A,Karczmarewicz E,Lorenc R,Czech-Kowalska J,Konstantynowicz J

    更新日期：2014-01-01 00:00:00

  • Low serum magnesium level is associated with microalbuminuria in chinese diabetic patients.

    abstract：:Whether serum magnesium deficiency is independently associated with the prevalence of microalbuminuria is still unclear. The objective of the present study was to elucidate the association between serum magnesium and microalbuminuria in diabetic patients. A cross-sectional study was conducted in 1829 diabetic subjects...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2013/580685

    authors： Xu B,Sun J,Deng X,Huang X,Sun W,Xu Y,Xu M,Lu J,Bi Y

    更新日期：2013-01-01 00:00:00

  • Angiogenesis in pituitary adenomas: human studies and new mutant mouse models.

    abstract：:The role of angiogenesis in pituitary tumor development has been questioned, as pituitary tumors have been usually found to be less vascularized than the normal pituitary tissue. Nevertheless, a significantly higher degree of vasculature has been shown in invasive or macropituitary prolactinomas when compared to nonin...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1155/2014/608497

    authors： Cristina C,Luque GM,Demarchi G,Lopez Vicchi F,Zubeldia-Brenner L,Perez Millan MI,Perrone S,Ornstein AM,Lacau-Mengido IM,Berner SI,Becu-Villalobos D

    更新日期：2014-01-01 00:00:00

  • Effects of Maternal Hypoxia during Pregnancy on Bone Development in Offspring: A Guinea Pig Model.

    abstract：:Low birth weight is associated with reduced bone mass and density in adult life. However, effects of maternal hypoxia (MH) on offspring bone development are not known. Objective. The current study investigated the effects of fetal growth restriction induced by MH during the last half of gestation on bone structure and...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2014/916918

    authors： Lee AM,Morrison JL,Botting KJ,Shandala T,Xian CJ

    更新日期：2014-01-01 00:00:00

  • The estimation of first-phase insulin secretion by using components of the metabolic syndrome in a chinese population.

    abstract：:Aims. There are two phases of insulin secretion, the first (FPIS) and second phase (SPIS). In this study, we built equations to predict FPIS with metabolic syndrome (MetS) components and fasting plasma insulin (FPI). Methods. Totally, 186 participants were enrolled. 75% of participants were randomly selected as the st...

    journal_title：International journal of endocrinology

    pub_type： 杂志文章

    doi：10.1155/2015/675245

    authors： Lin JD,Hsu CH,Liang YJ,Lian WC,Hsieh CH,Wu CZ,Pei D,Chen YL

    更新日期：2015-01-01 00:00:00