Abstract:
:The role of angiogenesis in pituitary tumor development has been questioned, as pituitary tumors have been usually found to be less vascularized than the normal pituitary tissue. Nevertheless, a significantly higher degree of vasculature has been shown in invasive or macropituitary prolactinomas when compared to noninvasive and microprolactinomas. Many growth factors and their receptors are involved in pituitary tumor development. For example, VEGF, FGF-2, FGFR1, and PTTG, which give a particular vascular phenotype, are modified in human and experimental pituitary adenomas of different histotypes. In particular, vascular endothelial growth factor, VEGF, the central mediator of angiogenesis in endocrine glands, was encountered in experimental and human pituitary tumors at different levels of expression and, in particular, was higher in dopamine agonist resistant prolactinomas. Furthermore, several anti-VEGF techniques lowered tumor burden in human and experimental pituitary adenomas. Therefore, even though the role of angiogenesis in pituitary adenomas is contentious, VEGF, making permeable pituitary endothelia, might contribute to adequate temporal vascular supply and mechanisms other than endothelial cell proliferation. The study of angiogenic factor expression in aggressive prolactinomas with resistance to dopamine agonists will yield important data in the search of therapeutical alternatives.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Cristina C,Luque GM,Demarchi G,Lopez Vicchi F,Zubeldia-Brenner L,Perez Millan MI,Perrone S,Ornstein AM,Lacau-Mengido IM,Berner SI,Becu-Villalobos Ddoi
10.1155/2014/608497subject
Has Abstractpub_date
2014-01-01 00:00:00pages
608497eissn
1687-8337issn
1687-8345journal_volume
2014pub_type
杂志文章,评审abstract::Whether serum magnesium deficiency is independently associated with the prevalence of microalbuminuria is still unclear. The objective of the present study was to elucidate the association between serum magnesium and microalbuminuria in diabetic patients. A cross-sectional study was conducted in 1829 diabetic subjects...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/580685
更新日期:2013-01-01 00:00:00
abstract::Hypogonadotropic hypogonadism (HH) can be sustained by organic or functional alterations of the hypothalamic-pituitary-testicular axis. Functional HH is related to systemic alterations, such as obesity or chronic inflammatory diseases, but could contribute to a negative course of the illness. For such situation, accor...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2020/9649838
更新日期:2020-01-21 00:00:00
abstract::Puerarin, the main isoflavone glycoside extracted from Radix Puerariae, is an isoflavone traditional Chinese herb. Previous studies have demonstrated that puerarin could regulate osteoblast proliferation and differentiation to promote bone formation. However, the effect of puerarin on the process of human osteoblasts ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2018-09-16 00:00:00
abstract::Background. Separate lines of research have shown that menstrual cycling and contextual factors such as the gender of research personnel influence experimental pain reporting. Objectives. This study examines how brief, procedural interactions with female and male experimenters can affect experimentally reported pain (...
journal_title:International journal of endocrinology
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abstract::Objective. Patients with more than two spontaneous pregnancy losses are diagnosed with recurrent pregnancy loss. The aim of this study was to evaluate the IR (insulin resistance) in patients with idiopathic recurrent pregnancy loss. Material and Method. A single center, case control study was performed on one hundred ...
journal_title:International journal of endocrinology
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更新日期:2013-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
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更新日期:2018-12-25 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
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更新日期:2019-11-06 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/380902
更新日期:2012-01-01 00:00:00
abstract:Background:Gynecomastia (GM) is a benign enlargement of male breast due to glandular tissue proliferation. GM is a symptom of systemic or local hormonal disturbances, which could be associated with functional changes or pathological conditions. However, the long-lasting steroid imbalance in men with GM might exert nega...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/6718761
更新日期:2019-10-03 00:00:00
abstract::Little published information is available regarding epidemiological data on vitamin D status in the large geographical region of Central Europe (CE). We searched the journal literature with regard to 25(OH)D concentrations among community-dwelling or healthy people living in CE. 25(OH)D concentrations varied by age, s...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/589587
更新日期:2014-01-01 00:00:00
abstract::Type 2 diabetes mellitus (T2D) is a disorder of glucose metabolism. It is a complex process involving the regulation of insulin secretion, insulin sensitivity, gluconeogenesis, and glucose uptake at the cellular level. Diabetic peripheral neuropathy (DPN) is one of the debilitating complications that is present in app...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/8641942
更新日期:2018-03-15 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/142468
更新日期:2014-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/786362
更新日期:2015-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/436725
更新日期:2014-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/451035
更新日期:2014-01-01 00:00:00
abstract:Objective:Cystic parathyroid adenoma is a rare cause of primary hyperparathyroidism, but its preoperative diagnosis and management remain inconclusive. Method:We retrospectively identified patients with cystic parathyroid adenomas who underwent surgery at Peking Union Medical College Hospital. Results:Patients with c...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/3745239
更新日期:2018-07-15 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:International journal of endocrinology
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更新日期:2015-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/6536178
更新日期:2018-03-05 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/2521096
更新日期:2019-03-27 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/6170154
更新日期:2018-10-31 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/367312
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/6380463
更新日期:2018-04-12 00:00:00