Abstract:
:Aim. To examine the relationship between plasma 25-hydroxyvitamin D (25(OH)D) levels and blood hemoglobin A1c (HbA1c) levels in diabetic patients at various stages of chronic kidney disease (CKD). Methods. We screened for data collected between 2003 and 2012. The correlation between 25(OH)D and HbA1c levels was studied in patients categorized according to the severity of CKD and their vitamin D status. A multivariate linear regression model was used to determine whether 25(OH)D and HbA1c levels were independently associated after adjustment for a number of covariates (including erythrocyte metformin levels). Results. We identified 542 reports from 245 patients. The mean HbA1c value was 6.7 ± 1.0% in vitamin D sufficiency, 7.3 ± 1.5% in insufficiency, and 8.4 ± 2.0% in deficiency (P < 0.0001). There was a negative correlation between 25(OH)D and HbA1c levels for the population as a whole (r = -0.387, P < 0.0001) and in the CKD severity subgroups (r = -0.384, P < 0.0001 and r = -0.333, P < 0.0001 for CKD stages 1-3 and 4-5, resp.). In the multivariate analysis, the 25(OH)D level was the only factor associated with HbA1c (P < 0.0001). Conclusion. 25(OH)D levels were negatively correlated with HbA1c levels independently of study covariates.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Kajbaf F,Mentaverri R,Diouf M,Fournier A,Kamel S,Lalau JDdoi
10.1155/2014/142468subject
Has Abstractpub_date
2014-01-01 00:00:00pages
142468eissn
1687-8337issn
1687-8345journal_volume
2014pub_type
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journal_title:International journal of endocrinology
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更新日期:2013-01-01 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:International journal of endocrinology
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更新日期:2018-04-12 00:00:00
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更新日期:2011-01-01 00:00:00