Abstract:
:A quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism. Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis. We conducted a randomized, placebo-controlled trial to evaluate the effect of one dose of intranasal insulin (40 IU of regular insulin) or saline on LH concentrations in 14 men (8 with type 2 diabetes and 6 healthy lean men). Insulin or saline was administered intranasally on two different occasions, at least one week apart. Blood samples were collected to measure LH concentrations every 15 minutes for 5 hours. Study drug was administered intranasally after a 2-hour baseline sampling period. Patients remained fasting throughout the procedure. The primary endpoint of the study was to compare the change in LH concentrations after intranasal insulin as compared to placebo (intranasal saline). Change was defined as the difference between baseline LH concentrations (average of the 9 samples collected in two hours prior to drug administration) and average LH concentrations following drug administration (average of the 12 samples collected in 3 hours). There was no change in LH concentrations following insulin administration as compared to placebo in men with diabetes or in lean men. We conclude that one dose of 40 IU of regular insulin administered intranasally does not change LH concentrations acutely in men.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Dhindsa S,Chemitiganti R,Ghanim H,Santiago E,Haider A,Chaar N,Mok M,McKee A,Dandona Pdoi
10.1155/2018/6170154subject
Has Abstractpub_date
2018-10-31 00:00:00pages
6170154eissn
1687-8337issn
1687-8345journal_volume
2018pub_type
杂志文章abstract:Background:Gonadal injury following chemotherapy is of increasing importance with the continuous improvement of survival rates. The protection of gonadotropin hormone antagonist (GnRHant) in long-term adult survivors of adolescent cancers and some autoimmune diseases has not yet been evaluated. Methods:The present stu...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/4272575
更新日期:2018-06-10 00:00:00
abstract::X-linked Adrenal Hypoplasia Congenita (AHC) is caused by deletions or point mutations in the NR0B1 (DAX1) gene. We present a boy with AHC who came at the age of 25 days in a severe state due to prolonged vomiting and progressive dehydration. Laboratory studies showed prominent hyponatremia and hyperkaliemia but not hy...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/5178953
更新日期:2016-01-01 00:00:00
abstract::Objectives. Growth hormone deficiency patients exhibited reduced bone mineral density compared with healthy controls, but previous researches demonstrated uncertainty about the effect of growth hormone replacement therapy on bone in growth hormone deficient adults. The aim of this study was to determine whether the gr...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/216107
更新日期:2013-01-01 00:00:00
abstract::Type 2 diabetes is characterized by frequent ectopic fat accumulation in several tissues and organs. In particular, a number of studies showed that these subjects frequently have hepatic fat accumulation, which may play a role in the metabolic abnormalities typical of diabetes and has been also linked to increased ris...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2013/309191
更新日期:2013-01-01 00:00:00
abstract::Thyroid nodules, with their high prevalence in the general population, represent a diagnostic challenge for clinicians. Ultrasound (US), although absolutely reliable in detecting thyroid nodules, is still not accurate enough to differentiate them into benign and malignant. A promising novel modality, US elastography, ...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/908575
更新日期:2015-01-01 00:00:00
abstract::Aims. To evaluate the predictive power of pretransplant HbA1c for new-onset diabetes after transplantation (NODAT) in kidney transplant candidates, who had several predispositions for fluctuated HbA1c levels. Methods. We performed a retrospective study of 119 patients without diabetes who received kidney transplantati...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/436725
更新日期:2014-01-01 00:00:00
abstract:Objective:Type 2 diabetes (T2DM) is a global epidemic and increases mortality due to its vascular complications. Chemerin has been found to exert a major role in glucose and lipid metabolism. The aim of this study was to explore the correlation between plasma chemerin levels and microangiopathy in patients with T2DM. ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/8693516
更新日期:2019-07-16 00:00:00
abstract::To examine the gene expression of ghrelin, a growth hormone releasing and appetite stimulating hormone from stomach, we constructed human ghrelin promoter-reporter vectors and analyzed the promoter activity. The ghrelin promoter activity was high when cultured cells that express ghrelin mRNA endogenously like TT or EC...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/580908
更新日期:2015-01-01 00:00:00
abstract::Sunlight-induced vitamin D, synthesis in the skin is the major source of vitamin D, but data on the relationship of sun-related behaviour with vitamin D and parathyroid hormone (PTH) levels are relatively sparse. We evaluated whether habitual sun exposure is associated with 25-hydroxyvitamin D (25[OH]D) and PTH levels...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/732636
更新日期:2012-01-01 00:00:00
abstract::Purpose. To evaluate the associations between metformin, insulin, statins, and levothyroxine and breast cancer characteristics and outcome. Methods. Retrospective chart review of patients treated in our institute for early estrogen receptor (ER) positive, human epidermal growth factor receptor 2 negative breast cancer...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/4658469
更新日期:2016-01-01 00:00:00
abstract:Background:The purpose of the current study is to determine PTH reference values in vitamin-D-replete Lebanese adults using 2nd and 3rd generation PTH assays and to look at the factors that affect PTH variations. Methods:Fasting PTH was measured using 2nd and 3rd generation Diasorin PTH assays in 339 vitamin-D-replete...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/6302861
更新日期:2020-02-21 00:00:00
abstract:Objectives:To compare the predictive ability of six anthropometric indices for identification of metabolic syndrome (MetS) and to determine their optimal cut-off points among Chinese adults. Methods:A total of 59,029 participants were enrolled. Body mass index (BMI), waist circumference (WC), waist-to-height ratio (WH...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/1067603
更新日期:2018-09-17 00:00:00
abstract::Enucleation-induced adrenal regeneration is a highly controlled process; however, only some elements involved in this process have been recognized. Therefore, we performed studies on regenerating rat adrenals. Microarray RNA analysis and QPCR revealed that enucleation resulted in a rapid elevation of expression of gen...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/130359
更新日期:2014-01-01 00:00:00
abstract::Glucose is the major source of energy for the human brain which in turn uses ketone bodies as a supplement for energy deficit in glucose cell deficiency conditions. Pregnancy complicated by gestational diabetes is a condition associated with significantly increased risk of ketonemia development. The data available pro...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/1242901
更新日期:2018-06-04 00:00:00
abstract:Aims:Emerging evidence has suggested a mechanistic link from vitamin D metabolism to glucose and insulin homeostasis. This study is aimed at specifically quantifying the direct effects of vitamin D supplementation on indexes of glucose and insulin homeostasis as well as incidence of type 2 diabetes (T2D) among nondiabe...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/7908764
更新日期:2018-12-03 00:00:00
abstract::Estroprogestins (EPs) are combinations of estrogen and progestin with several actions on women's health. The different pharmacological composition of EPs is responsible for different clinical effects. One of the most used low-dose EP associations is ethinylestradiol 20 mcg plus levonorgestrel 100 mcg in monophasic reg...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/102184
更新日期:2014-01-01 00:00:00
abstract::Spermatozoa are highly specialized cells that can be easily obtained and purified. Mature spermatozoa are transcriptionally and translationally inactive and incapable of protein synthesis. In addition, spermatozoa contain relatively higher amounts of membrane proteins compared to other cells; therefore, they are very ...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2013/360986
更新日期:2013-01-01 00:00:00
abstract::Obesity is a growing problem in modern society and medicine. It closely associates with metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and cardiovascular diseases such as nonalcoholic fatty liver disease, atherosclerosis, myocarditis, and hypertension. Obesity is often associated with latent i...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2017/5076732
更新日期:2017-01-01 00:00:00
abstract::Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is an autosomal dominant disorder characterized by parathyroid tumors in association with fibro-osseous jaw tumors and uterine and renal lesions. HPT-JT syndrome is caused by germline mutations of the cell division cycle 73 (CDC73) gene that encodes the parafibromin, a 5...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2019/1761030
更新日期:2019-12-18 00:00:00
abstract:Objective:Many patients with diabetes opt to fast for lab tests, especially for lipid profiles, thus missing breakfast. In parallel, recent studies and international guidelines have indicated that routine fasting for lipid panels may not be necessary. Missing breakfast while fasting for lab tests may invoke hypoglycemi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/1528437
更新日期:2018-10-24 00:00:00
abstract::Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2017/2452853
更新日期:2017-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2014/690783.]. ...
journal_title:International journal of endocrinology
pub_type: 已发布勘误
doi:10.1155/2017/5924671
更新日期:2017-01-01 00:00:00
abstract::Introduction. Differentiated thyroid cancer treatment usually consists of thyroidectomy and radio ablation in hypothyroidism 4-6 weeks after surgery. Replacing hypothyroidism by recombinant human thyroid stimulating hormone can facilitate radio ablation in euthyroidism within one week after surgery. The outcome of thi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/769473
更新日期:2013-01-01 00:00:00
abstract::Background. The Japan Thyroid Association recently published guidelines for clinical practice for the management of thyroid nodules, which include a diagnostic system for reporting thyroid fine needle aspiration cytology. It is characterized by the subclassification of follicular neoplasms, which is different from oth...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/938305
更新日期:2015-01-01 00:00:00
abstract::Whether serum magnesium deficiency is independently associated with the prevalence of microalbuminuria is still unclear. The objective of the present study was to elucidate the association between serum magnesium and microalbuminuria in diabetic patients. A cross-sectional study was conducted in 1829 diabetic subjects...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/580685
更新日期:2013-01-01 00:00:00
abstract::Bariatric surgery is currently the most effective therapy to induce weight loss in morbidly obese patients. Objective. This controlled, clinical trial with a two-year intervention was aimed at comparing the efficacy of two nonsurgical approaches versus bariatric surgery, on body weight changes and metabolic parameters...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/194696
更新日期:2015-01-01 00:00:00
abstract::Present therapies to minify hyperglycaemia and insulin resistance mainly target ATP-sensitive K(+) channels (K(ATP)) of pancreatic cells and PPAR-γ to enhance the insulin secretion and potential for GLUT expression, respectively. These current approaches are frequently associated with the various side effects such as ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2011/530274
更新日期:2011-01-01 00:00:00
abstract::Aim. To compare two creatinine-based estimated glomerular filtration rate (eGFR) equations, the chronic kidney disease epidemiology collaboration (CKD-EPI) and the modification of diet in renal disease (MDRD), for predicting the risk of CKD progression in type 2 diabetic patients with nephropathy. Methods. A total of ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/848963
更新日期:2013-01-01 00:00:00
abstract:Objective:Neuroendocrine neoplasias (NENs) represent a rare and biologically heterogeneous group of malignancies. Treatment of NEN patients remains challenging due to lack of prospective evidence on the choice of ideal therapeutic sequence and therapeutic efficacy in specific individual scenarios. Methods:Clinical dat...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/1491475
更新日期:2020-01-31 00:00:00
abstract::In the present study we evaluated in vivo and in vitro effects of 4-tert-octylphenol (OP) on the expression and distribution of adherens and gap junction proteins, N-cadherin, β -catenin, and connexin 43 (Cx43), in testes of seasonally breeding rodents, bank voles. We found that in bank vole testes expression and dist...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/134589
更新日期:2013-01-01 00:00:00