Abstract:
Background:The aim was to investigate the amounts of saliva and serum asprosin in order to determine whether it is related to obesity and whether salivary glands synthesize asprosin or not. Methods:A total of 116 underweight, normal weight, overweight, and obese (class I, class II, and class III) volunteers participated in the study. Saliva and blood samples were collected simultaneously from the participants. The amounts of asprosin in saliva, salivary gland tissue supernatants, and bloods were determined by ELISA, whereas asprosin synthesis sites of salivary gland tissues were determined immunohistochemically. Results:The amount of asprosin from the lowest to the highest was in the order as follows: underweight, normal weight (control), overweight, and obese classes I and III. The lowest level of asprosin was detected in underweight individuals. It was also found that the interlobular striated ducts and the interlobular ducts of the submandibular and parotid salivary glands produce asprosin. According to these data, the asprosin level is related with obesity as the amount increases in accordance with increasing body mass index (BMI). On the other hand, there is also a relationship between the underweight and asprosin because the amount decreases with BMI decrease. Conclusions:Asprosin, a new adipokine, may be a novel indicator of adipose tissue mass. Therefore, we anticipate that antiasprosin preparations may be an alternative in the treatment of obesity in the future.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Ugur K,Aydin Sdoi
10.1155/2019/2521096subject
Has Abstractpub_date
2019-03-27 00:00:00pages
2521096eissn
1687-8337issn
1687-8345journal_volume
2019pub_type
杂志文章abstract::Objective. The follow-up of GH levels in short-stature children with pituitary hyperplasia secondary to primary hypothyroidism (PPH) is reported in a few cases. We aimed to observe changes in GH secretion in short-stature children with PPH. Methods. A total of 11 short-stature children with PPH accompanied by low GH l...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/283492
更新日期:2015-01-01 00:00:00
abstract::Background. The purpose of the present study was to assess the feasibility of using miR-126 in the urine as a biomarker for diabetic nephropathy. Methods. miRNAs were extracted from the urine samples of T2DM patients with diabetic nephropathy (DN; n = 92), T2DM without DN (n = 86), and 85 healthy volunteers using quan...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/393109
更新日期:2014-01-01 00:00:00
abstract::Varicocele in infertile males is associated with Leydig cell dysfunction and hypogonadism. The effect of varicocelectomy on serum testosterone level is not yet established. We analysed 200 heterosexual infertile men diagnosed to have clinical varicocele they were divided into two groups: group 1 (100 men) had microsur...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2011/916380
更新日期:2011-01-01 00:00:00
abstract::Diabetes is a lifelong course disease, so insulin treatment has to be effective and safe, and patients should be satisfied with it. We aimed to compare efficacy, safety, and quality of treatment satisfaction of human and premixed analogue insulin among 3264 patients (53.58% women) with type 2 diabetes mellitus (T2DM) ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/6536178
更新日期:2018-03-05 00:00:00
abstract::Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. Cancer cells are well known to display an enhanced sugar uptake and consumption. In fact, sugar transporters ar...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2010/205357
更新日期:2010-01-01 00:00:00
abstract::Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2017/2452853
更新日期:2017-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2014/690783.]. ...
journal_title:International journal of endocrinology
pub_type: 已发布勘误
doi:10.1155/2017/5924671
更新日期:2017-01-01 00:00:00
abstract::To elucidate whether adrenergic overtone is involved in the pathophysiology of men with lifelong (LL) premature ejaculation (PE), we investigated differences in reactive hyperemia index (RHI) responses by using peripheral arterial tonometry (PAT). 20 men with LL-PE (18-40 years) were enrolled in an 8-week, double-blin...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/394934
更新日期:2013-01-01 00:00:00
abstract::In the last 20 years, a pituitary-hypothalamus tissue culture system with intact neural and portal connections has been developed in our lab and used to understand the feedback mechanisms that regulate the secretions of adenohypophyseal hormones and fertility of male rats. In the last decade, several in vivo rat model...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2009/687259
更新日期:2009-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/7838290.]. ...
journal_title:International journal of endocrinology
pub_type: 已发布勘误
doi:10.1155/2018/1239718
更新日期:2018-10-23 00:00:00
abstract:Objective:To evaluate the impact of preconceptional serum TSH levels on the clinical outcomes of infertile patients undergoing their first IUI treatment cycle. Method:This was a retrospective study. Euthyroid patients undergoing the first cycle of IUI treatment from Jan 2017 to Aug 2018 were included. The patients wer...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/8492904
更新日期:2019-12-18 00:00:00
abstract::A quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism. Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis. We conducted a randomiz...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/6170154
更新日期:2018-10-31 00:00:00
abstract:OBJECTIVE:Current study was designed to investigate the association of metabolic syndrome (MetS) with depression, anxiety, psychological distress, and quality of life (QoL). DESIGN:Two hundred and fifteen contributors with MetS and 253 participants without MetS were randomly selected from 2151 participants of Isfahan ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/380902
更新日期:2012-01-01 00:00:00
abstract:Objective:The aim of the present study was to investigate the association between dietary patterns and precocious puberty among Shanghai children. Methods:A cross-sectional study was conducted among Shanghai children by multistage stratified cluster random sampling in June 2014. Diet was assessed using a simplified fo...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/4528704
更新日期:2018-01-16 00:00:00
abstract::Point-of-care (POC) glucose technology is currently considered to be insufficiently accurate for the diagnosis of diabetes. The objective of this study was to investigate the diagnostic accuracy of an innovative, interference-resistant POC glucose meter (StatStrip glucose hospital meter, Nova Biomedical, USA) in subje...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/206309
更新日期:2013-01-01 00:00:00
abstract::Background. Management of thyroid nodules with benign aspirates following atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is not well established. We reviewed the risk of malignancy and the role of ultrasound (US) features among thyroid nodules with benign results followin...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/354612
更新日期:2014-01-01 00:00:00
abstract::Objective. To identify factors predicting the need for insulin therapy in pregnancies complicated by gestational diabetes mellitus (GDM). Methods. A total of 1352 patients with GDM diagnosed by the 75-g/2-h oral glucose tolerance test (OGTT) were enrolled in this study. Univariate and multivariate analysis were perfor...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/4858976
更新日期:2016-01-01 00:00:00
abstract::The aim of this work was to study the androgen receptors (AR) expression in pituitary pars distalis (PD) of male viscachas in relation to growth and reproductive cycle. AR were detected by immunocytochemistry and quantified by image analysis. Pituitary glands from fetus, immature, prepubertal, and adult viscachas duri...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/168047
更新日期:2015-01-01 00:00:00
abstract::Hypogonadotropic hypogonadism (HH) can be sustained by organic or functional alterations of the hypothalamic-pituitary-testicular axis. Functional HH is related to systemic alterations, such as obesity or chronic inflammatory diseases, but could contribute to a negative course of the illness. For such situation, accor...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2020/9649838
更新日期:2020-01-21 00:00:00
abstract::Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes. Here we revie...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/451035
更新日期:2014-01-01 00:00:00
abstract::Purpose. To evaluate the associations between metformin, insulin, statins, and levothyroxine and breast cancer characteristics and outcome. Methods. Retrospective chart review of patients treated in our institute for early estrogen receptor (ER) positive, human epidermal growth factor receptor 2 negative breast cancer...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/4658469
更新日期:2016-01-01 00:00:00
abstract:Background:Total thyroidectomy (TT) is recommended in the treatment of malignant and benignant thyroid diseases, and, to date, transient hypocalcemia is the most frequent complication after the procedure. We prospectively evaluated the role of vitamin D deficiency as a predictor of postoperative hypocalcemia. Methods:...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/8875257
更新日期:2020-10-10 00:00:00
abstract::The role of angiogenesis in pituitary tumor development has been questioned, as pituitary tumors have been usually found to be less vascularized than the normal pituitary tissue. Nevertheless, a significantly higher degree of vasculature has been shown in invasive or macropituitary prolactinomas when compared to nonin...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/608497
更新日期:2014-01-01 00:00:00
abstract::Type 2 diabetes mellitus (T2D) is a disorder of glucose metabolism. It is a complex process involving the regulation of insulin secretion, insulin sensitivity, gluconeogenesis, and glucose uptake at the cellular level. Diabetic peripheral neuropathy (DPN) is one of the debilitating complications that is present in app...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/8641942
更新日期:2018-03-15 00:00:00
abstract::The aim of this study is to investigate the circulating OPG levels in postmenopausal women with diabetes and prediabetes and explore the relationships between serum OPG and insulin resistance. A total of 271 unrelated Chinese postmenopausal women were recruited in this study. The subjects were divided into type 2 diab...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2017/8724869
更新日期:2017-01-01 00:00:00
abstract::Anovulatory cycles and endometriosis are the main causes of female infertility. The most frequently anovulatory cycles are related to polycystic ovary syndrome (PCOS) commonly associated with obesity and hormonal disturbances in the course of obesity. Recently published studies revealed that infertility affects about ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/236217
更新日期:2012-01-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women of reproductive age. Although PCOS is diagnosed exclusively based on reproductive criteria, it is also a metabolic disorder. Insulin resistance, impaired glucose tolerance, type 2 diabetes mellitus, obesity, and dyslipidemia are more ...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/786362
更新日期:2015-01-01 00:00:00
abstract:Objective:Type 2 diabetes (T2DM) is a global epidemic and increases mortality due to its vascular complications. Chemerin has been found to exert a major role in glucose and lipid metabolism. The aim of this study was to explore the correlation between plasma chemerin levels and microangiopathy in patients with T2DM. ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/8693516
更新日期:2019-07-16 00:00:00
abstract:Aims:Emerging evidence has suggested a mechanistic link from vitamin D metabolism to glucose and insulin homeostasis. This study is aimed at specifically quantifying the direct effects of vitamin D supplementation on indexes of glucose and insulin homeostasis as well as incidence of type 2 diabetes (T2D) among nondiabe...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/7908764
更新日期:2018-12-03 00:00:00
abstract::Iodine supplementation through salt iodization is a worldwide, effective strategy for preventing iodine deficiency-related problems. Its safety and efficacy profile has been extensively investigated, and benefits far outweigh the potential iodine-induced risks. Moreover, iodine supplementation during pregnancy in orde...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/312305
更新日期:2015-01-01 00:00:00