Abstract:
:In the last 20 years, a pituitary-hypothalamus tissue culture system with intact neural and portal connections has been developed in our lab and used to understand the feedback mechanisms that regulate the secretions of adenohypophyseal hormones and fertility of male rats. In the last decade, several in vivo rat models have also been developed in our lab with a view to substantiate the in vitro findings, in order to delineate the role of pituitary hormones in the regulation of fertility of male rats. These studies have relied on both surgical and pharmacological interventions to modulate the secretions of gonadotropins and testosterone. The interrelationship between the circadian release of reproductive hormones has also been ascertained in normal men. Our studies suggest that testosterone regulates the secretion of prolactin through a long feedback mechanism, which appears to have been conserved from rats to humans. These studies have filled in a major lacuna pertaining to the role of prolactin in male reproductive physiology by demonstrating the interdependence between testosterone and prolactin. Systemic levels of prolactin play a deterministic role in the mechanism of chromatin condensation during spermiogenesis.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Gill-Sharma MKdoi
10.1155/2009/687259subject
Has Abstractpub_date
2009-01-01 00:00:00pages
687259eissn
1687-8337issn
1687-8345journal_volume
2009pub_type
杂志文章abstract:Objective:To evaluate the impact of preconceptional serum TSH levels on the clinical outcomes of infertile patients undergoing their first IUI treatment cycle. Method:This was a retrospective study. Euthyroid patients undergoing the first cycle of IUI treatment from Jan 2017 to Aug 2018 were included. The patients wer...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/8492904
更新日期:2019-12-18 00:00:00
abstract::Iodine supplementation through salt iodization is a worldwide, effective strategy for preventing iodine deficiency-related problems. Its safety and efficacy profile has been extensively investigated, and benefits far outweigh the potential iodine-induced risks. Moreover, iodine supplementation during pregnancy in orde...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/312305
更新日期:2015-01-01 00:00:00
abstract::Objective. Black thyroid is a rare pigmented change seen almost exclusively in patients upon minocycline ingestion, and the process has previously been thought to be generally benign. There have been 61 reported cases of black thyroid. We are aware of 13 cases previously reported in association with thyroid carcinoma....
journal_title:International journal of endocrinology
pub_type:
doi:10.1155/2010/681647
更新日期:2010-01-01 00:00:00
abstract::Partial androgen insensitivity syndrome (PAIS) is associated with impaired male genital development and can be transmitted through mutations in the androgen receptor (AR). The aim of this study is to develop a cell model suitable for studying the impact AR mutations might have on AR interacting proteins. For this purp...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/381824
更新日期:2012-01-01 00:00:00
abstract::Gestational diabetes mellitus (GDM) is defined as any degree of carbohydrate intolerance, with onset or first recognition during second or third trimester of gestation. It is estimated that approximately 7% of all pregnancies are complicated by GDM and that its prevalence is rising all over the world. Thus, the screen...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/6380463
更新日期:2018-04-12 00:00:00
abstract::Aims. To evaluate the predictive power of pretransplant HbA1c for new-onset diabetes after transplantation (NODAT) in kidney transplant candidates, who had several predispositions for fluctuated HbA1c levels. Methods. We performed a retrospective study of 119 patients without diabetes who received kidney transplantati...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/436725
更新日期:2014-01-01 00:00:00
abstract::Aim. Our aim was (1) to determine the frequency of insulin resistance (IR) in patients with Duchenne/Becker muscular dystrophy (DMD/BMD), (2) to identify deleted exons of DMD gene associated with obesity and IR, and (3) to explore some likely molecular mechanisms leading to IR. Materials and Methods. In 66 patients wi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/867273
更新日期:2015-01-01 00:00:00
abstract::Background. The Japan Thyroid Association recently published guidelines for clinical practice for the management of thyroid nodules, which include a diagnostic system for reporting thyroid fine needle aspiration cytology. It is characterized by the subclassification of follicular neoplasms, which is different from oth...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/938305
更新日期:2015-01-01 00:00:00
abstract:Background:Currently, energy obtained from hypercaloric diets has been part of the obesity and type 2 diabetes mellitus (T2DM) epidemics from childhood to old age. Treatment alternatives have been sought from plants, minerals, and trace elements with metabolic effects. Vanadyl sulfate (VS) has been investigated as a hy...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/5257216
更新日期:2018-12-25 00:00:00
abstract:Objectives:To compare the predictive ability of six anthropometric indices for identification of metabolic syndrome (MetS) and to determine their optimal cut-off points among Chinese adults. Methods:A total of 59,029 participants were enrolled. Body mass index (BMI), waist circumference (WC), waist-to-height ratio (WH...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/1067603
更新日期:2018-09-17 00:00:00
abstract::Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is an autosomal dominant disorder characterized by parathyroid tumors in association with fibro-osseous jaw tumors and uterine and renal lesions. HPT-JT syndrome is caused by germline mutations of the cell division cycle 73 (CDC73) gene that encodes the parafibromin, a 5...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2019/1761030
更新日期:2019-12-18 00:00:00
abstract::In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have pivotal roles in key pathogenic processes of microvascular compl...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/6890501
更新日期:2018-03-07 00:00:00
abstract::The determination of B-type natriuretic peptides (BNP) may have a role in the diagnosis of heart failure (HF) or guiding HF therapy. This study investigated the role of BNP determination in a cohort of elderly patients admitted to hospital with acute decompensated HF and its correlation with main demographic, clinical...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/239136
更新日期:2015-01-01 00:00:00
abstract::Diabetes mellitus (DM) is one of the primary causes of premature death and disability worldwide. We performed a systematic review and meta-analysis of the published literature regarding the trends in prevalence, awareness, treatment, and control of diabetes mellitus in mainland China. PUBMED, EMBASE, Chinese Biomedica...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2013/753150
更新日期:2013-01-01 00:00:00
abstract::The hypothalamus is an essential relay in the neural circuitry underlying energy metabolism that needs to continually adapt to changes in the energetic environment. The neuroendocrine control of food intake and energy expenditure is associated with, and likely dependent upon, hypothalamic plasticity. Severe disturbanc...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/732975
更新日期:2012-01-01 00:00:00
abstract::Background. Pediatric CAH patients have an increased risk of cardiovascular disease, and it remains unknown if genetic predisposition is a contributing factor. Glucocorticoid receptor gene (NR3C1) polymorphisms are associated with an adverse metabolic profile. Our aim was to analyze the association between the NR3C1 p...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/594710
更新日期:2014-01-01 00:00:00
abstract::Objective. Patients with more than two spontaneous pregnancy losses are diagnosed with recurrent pregnancy loss. The aim of this study was to evaluate the IR (insulin resistance) in patients with idiopathic recurrent pregnancy loss. Material and Method. A single center, case control study was performed on one hundred ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/576926
更新日期:2013-01-01 00:00:00
abstract:Background:Little information is available on the association between parents' metabolic syndrome (MetS) and adolescent offspring's obesity in Korea. The aim of our study is to determine the association between parent's metabolic syndrome and offspring's obesity. Methods:The study data were obtained from the Korean Na...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/8737912
更新日期:2020-10-30 00:00:00
abstract:Objective:Aim of this study is to evaluate determinants of secondary normocalcemic hyperparathyroidism (SNHPT) persistence in patients who have undergone Roux-en-Y gastric bypass on vertical-banded gastroplasty. Methods:226 consecutive patients submitted to bariatric surgery were prospectively enrolled and divided in ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/5010287
更新日期:2018-03-06 00:00:00
abstract::Whether serum magnesium deficiency is independently associated with the prevalence of microalbuminuria is still unclear. The objective of the present study was to elucidate the association between serum magnesium and microalbuminuria in diabetic patients. A cross-sectional study was conducted in 1829 diabetic subjects...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/580685
更新日期:2013-01-01 00:00:00
abstract::X-linked Adrenal Hypoplasia Congenita (AHC) is caused by deletions or point mutations in the NR0B1 (DAX1) gene. We present a boy with AHC who came at the age of 25 days in a severe state due to prolonged vomiting and progressive dehydration. Laboratory studies showed prominent hyponatremia and hyperkaliemia but not hy...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/5178953
更新日期:2016-01-01 00:00:00
abstract::Bariatric surgery is currently the most effective therapy to induce weight loss in morbidly obese patients. Objective. This controlled, clinical trial with a two-year intervention was aimed at comparing the efficacy of two nonsurgical approaches versus bariatric surgery, on body weight changes and metabolic parameters...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/194696
更新日期:2015-01-01 00:00:00
abstract:Introduction:Gut microbiota is involved in the progression of metabolic diseases such as obesity and type 2 diabetes. The ob/ob and db/db mice are extensively used as models in studies on the pathogenesis of these diseases. The goal of this study is to characterize the composition and structure of gut microbiota in the...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/1394097
更新日期:2019-03-11 00:00:00
abstract::Endocannabinoids and their G-protein coupled receptors (GPCR) are a current research focus in the area of obesity due to the system's role in food intake and glucose and lipid metabolism. Importantly, overweight and obese individuals often have higher circulating levels of the arachidonic acid-derived endocannabinoids...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/361895
更新日期:2013-01-01 00:00:00
abstract:Objective:Cystic parathyroid adenoma is a rare cause of primary hyperparathyroidism, but its preoperative diagnosis and management remain inconclusive. Method:We retrospectively identified patients with cystic parathyroid adenomas who underwent surgery at Peking Union Medical College Hospital. Results:Patients with c...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/3745239
更新日期:2018-07-15 00:00:00
abstract::Purpose. To evaluate the associations between metformin, insulin, statins, and levothyroxine and breast cancer characteristics and outcome. Methods. Retrospective chart review of patients treated in our institute for early estrogen receptor (ER) positive, human epidermal growth factor receptor 2 negative breast cancer...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/4658469
更新日期:2016-01-01 00:00:00
abstract::Purpose. To evaluate alteration in serum TSH in hypertensives with OSA and its relation with cardiometabolic risk factors. Methods. 517 hypertensives were cross-sectionally studied. OSA was determined by polysomnography and thyroid function by standard methods. Results. OSA was diagnosed in 373 hypertensives (72.15%)....
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/4802720
更新日期:2016-01-01 00:00:00
abstract::With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through infl...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2019/9691345
更新日期:2019-10-13 00:00:00
abstract:Introduction:Cushing's syndrome (CS) is a clinical condition characterized by excessive cortisol production, associated with metabolic complications, such as diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, and cardiovascular diseases. Nowadays, the occurrence of autoimmune diseases in CS have not bee...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/1464967
更新日期:2018-12-18 00:00:00
abstract:Purpose:Primary hypertrophic osteoarthropathy (PHO) is a rare, autosomal, recessive genetic disease characterized by digital clubbing, periostosis, and pachydermia. The underlying cause for the pathogenesis of this disease is a defect in prostaglandin E2 (PGE2) degradation, caused by mutations in HPGD or SLCO2A1. In th...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/6698878
更新日期:2020-12-03 00:00:00