Abstract:
:Purpose. To evaluate alteration in serum TSH in hypertensives with OSA and its relation with cardiometabolic risk factors. Methods. 517 hypertensives were cross-sectionally studied. OSA was determined by polysomnography and thyroid function by standard methods. Results. OSA was diagnosed in 373 hypertensives (72.15%). Prevalence of subclinical hypothyroidism was significantly higher in OSA hypertensives than in non-OSA ones (15.0% versus 6.9%, P = 0.014). Serum LnTSH in hypertensives with severe OSA was significantly higher (0.99 ± 0.81 versus 0.74 ± 0.77 μIU/mL, P < 0.05) than in those without OSA. AHI, LSaO2, ODI3, and ODI4 were independently associated with serum TSH for those aged 30-65 years. Dividing subjects into four groups as TSH < 1.0 μIU/mL, 1.0 ≤ THS ≤ 1.9 μIU/mL, 1.91 ≤ TSH < 4.5 μIU/mL, and TSH ≥ 4.5 μIU/mL, only 26.3% of OSA subjects exhibited TSH between 1.0 and 1.9 μIU/mL, significantly less than non-OSA subjects (26.3% versus 38.2%, P = 0.01). DBP and serum LDL-c elevated with TSH increasing and were only significantly higher in TSH ≥ 4.5 μIU/mL group than in 1.0 ≤ TSH ≤ 1.9 μIU/mL group (96.32 ± 14.19 versus 92.31 ± 12.86 mmHg; P = 0.040; 0.99 ± 0.60 versus 0.87 ± 0.34 mmol/L, P = 0.023). Conclusion. OSA might be a risk factor for increased TSH even within reference range in hypertensive population.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Li N,Heizhati M,Sun C,Abulikemu S,Shao L,Yao X,Wang Y,Hong J,Zhou L,Wang L,Zhang Y,Zhang Wdoi
10.1155/2016/4802720subject
Has Abstractpub_date
2016-01-01 00:00:00pages
4802720eissn
1687-8337issn
1687-8345journal_volume
2016pub_type
杂志文章abstract::Objectives. Growth hormone deficiency patients exhibited reduced bone mineral density compared with healthy controls, but previous researches demonstrated uncertainty about the effect of growth hormone replacement therapy on bone in growth hormone deficient adults. The aim of this study was to determine whether the gr...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/216107
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/7838290.]. ...
journal_title:International journal of endocrinology
pub_type: 已发布勘误
doi:10.1155/2018/1239718
更新日期:2018-10-23 00:00:00
abstract::Growth failure is almost inextricably linked with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Growth failure in CKD has been associated with both increased morbidity and mortality. Growth failure in the setting of kidney disease is multifactorial and is related to poor nutritional status as well a...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2013/970946
更新日期:2013-01-01 00:00:00
abstract::The study explored the utility of four-point preprandial glucose self-monitoring to calculate several indices of glycemic control and variability in a study adding the DPP-4 inhibitor vildagliptin to ongoing insulin therapy. This analysis utilized data from a double-blind, randomized, placebo-controlled crossover stud...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/484231
更新日期:2015-01-01 00:00:00
abstract::The role of angiogenesis in pituitary tumor development has been questioned, as pituitary tumors have been usually found to be less vascularized than the normal pituitary tissue. Nevertheless, a significantly higher degree of vasculature has been shown in invasive or macropituitary prolactinomas when compared to nonin...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/608497
更新日期:2014-01-01 00:00:00
abstract::Background. Management of thyroid nodules with benign aspirates following atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is not well established. We reviewed the risk of malignancy and the role of ultrasound (US) features among thyroid nodules with benign results followin...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/354612
更新日期:2014-01-01 00:00:00
abstract::Epidemiological studies have shown an association between short or disrupted sleep and an increased risk for metabolic disorders. To assess a possible causal relationship, we examined the effects of experimental sleep disturbance on glucose regulation in Wistar rats under controlled laboratory conditions. Three groups...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2010/819414
更新日期:2010-01-01 00:00:00
abstract::Estroprogestins (EPs) are combinations of estrogen and progestin with several actions on women's health. The different pharmacological composition of EPs is responsible for different clinical effects. One of the most used low-dose EP associations is ethinylestradiol 20 mcg plus levonorgestrel 100 mcg in monophasic reg...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/102184
更新日期:2014-01-01 00:00:00
abstract::There is inconsistency among published guidelines for the optimal diagnostic and management pathways for patients with typical (TC) or atypical (AC) pulmonary carcinoid tumours. We conducted a UK-wide clinician survey to assess current practice for the diagnosis, management, and follow-up of patients with TC/AC and de...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/9287536
更新日期:2020-02-28 00:00:00
abstract:Objective:The aim of the present study was to investigate the association between dietary patterns and precocious puberty among Shanghai children. Methods:A cross-sectional study was conducted among Shanghai children by multistage stratified cluster random sampling in June 2014. Diet was assessed using a simplified fo...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/4528704
更新日期:2018-01-16 00:00:00
abstract::Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer. It shows a wide spectrum of morphological presentations and the diagnosis could be challenging due to its high degree of dedifferentiation. Molecular and genetic features of ATC are widely heterogeneous as well and many efforts have been...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/790834
更新日期:2014-01-01 00:00:00
abstract::The circadian system is a supraphysiological system that modulates different biological functions such as metabolism, sleep-wake, cellular proliferation, and body temperature. Different chronodisruptors have been identified, such as shift work, feeding time, long days, and stress. The environmental changes and our mod...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2016/2746909
更新日期:2016-01-01 00:00:00
abstract::Sestrin (SESN) is known as a cysteine sulfinic acid reductase. Recently, nonredox functions of SESN in metabolic regulation and antitumor property have been recognized. While mechanisms underlying the expression of SESN are not fully understood. Here we report that insulin markedly increased SESN2 level in HepG2 cells...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/505849
更新日期:2015-01-01 00:00:00
abstract::Aim of the study was to examine cardiorespiratory parameters at individual ventilatory threshold (IVT) and peak exercise capacity ([Formula: see text]) in outpatient diabetic and sarcopenic obese subjects. Seventeen obese subjects (BMI: 36.6 ± 4.1 kg·m(-1)) and sixteen SO subjects (BMI: 37.0 ± 7.3 kg·m(-1)) were compa...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/6739150
更新日期:2016-01-01 00:00:00
abstract::Glucose is the major source of energy for the human brain which in turn uses ketone bodies as a supplement for energy deficit in glucose cell deficiency conditions. Pregnancy complicated by gestational diabetes is a condition associated with significantly increased risk of ketonemia development. The data available pro...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/1242901
更新日期:2018-06-04 00:00:00
abstract:Objective:Many patients with diabetes opt to fast for lab tests, especially for lipid profiles, thus missing breakfast. In parallel, recent studies and international guidelines have indicated that routine fasting for lipid panels may not be necessary. Missing breakfast while fasting for lab tests may invoke hypoglycemi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/1528437
更新日期:2018-10-24 00:00:00
abstract::Objective. The follow-up of GH levels in short-stature children with pituitary hyperplasia secondary to primary hypothyroidism (PPH) is reported in a few cases. We aimed to observe changes in GH secretion in short-stature children with PPH. Methods. A total of 11 short-stature children with PPH accompanied by low GH l...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/283492
更新日期:2015-01-01 00:00:00
abstract::Endocannabinoids and their G-protein coupled receptors (GPCR) are a current research focus in the area of obesity due to the system's role in food intake and glucose and lipid metabolism. Importantly, overweight and obese individuals often have higher circulating levels of the arachidonic acid-derived endocannabinoids...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/361895
更新日期:2013-01-01 00:00:00
abstract::Purpose. To evaluate whether inferior rectus muscle (IRM) thickness, the degree of adipose change in the IRM, smoking status, and the previous history of orbital radiotherapy can predict the dose-effect relationship regarding unilateral IRM recession in thyroid eye disease (TED). Methods. Twenty-five patients were ret...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/703671
更新日期:2015-01-01 00:00:00
abstract::A retrospective review of 626 patients with multifocal papillary thyroid carcinoma (PTC) including 147 patients (23.5%) with multifocal papillary thyroid microcarcinoma (PTMC) from a total of 2,536 patients with PTC who visited the Chang Gung Medical Center in Linkou, Taiwan, was performed. A comparison of the clinica...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2017/4208178
更新日期:2017-01-01 00:00:00
abstract::The determination of B-type natriuretic peptides (BNP) may have a role in the diagnosis of heart failure (HF) or guiding HF therapy. This study investigated the role of BNP determination in a cohort of elderly patients admitted to hospital with acute decompensated HF and its correlation with main demographic, clinical...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/239136
更新日期:2015-01-01 00:00:00
abstract::Objective. In pediatric central diabetes insipidus (CDI), etiology diagnosis and pituitary function monitoring are usually delayed. This study aimed to illustrate the importance of regular follow-up and pituitary function monitoring in pediatric CDI. Methods. The clinical, hormonal, and neuroradiological characteristi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/6365830
更新日期:2016-01-01 00:00:00
abstract::In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have pivotal roles in key pathogenic processes of microvascular compl...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/6890501
更新日期:2018-03-07 00:00:00
abstract::Acromegaly is caused by hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor-I (IGF-1) due to pituitary tumor. Other causes, such as increased growth-hormone releasing hormone (GHRH) production, ectopic GHRH production, and ectopic GH secretion, are rare. Growth hormone and IGF-1 play a...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/839282
更新日期:2012-01-01 00:00:00
abstract::The liver is one of the most essential organs involved in the regulation of energy homeostasis. Hepatic steatosis, a major manifestation of metabolic syndrome, is associated with imbalance between lipid formation and breakdown, glucose production and catabolism, and cholesterol synthesis and secretion. Epidemiological...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/294278
更新日期:2015-01-01 00:00:00
abstract::HDL cholesterol is known to be inversely correlated with cardiovascular disease due to its diverse antiatherogenic functions. SR-BI mediates the selective uptake of HDL-C. SR-BI knockout diminishes but does not completely block the transport of HDL; other receptors may be involved. Ectopic ATP synthase β-chain in hepa...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/356432
更新日期:2014-01-01 00:00:00
abstract::This study investigated potential markers for predicting nonfunctioning pituitary adenoma (NFPA) invasion and recurrence by high-throughput tissue microarray analyses. We retrospectively studied two groups of patients: 60 nonrecurrent NFPA cases that included noninvasion and invasion subtypes and 43 recurrent cases th...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/5731639
更新日期:2019-05-16 00:00:00
abstract:Background:Genome-wide association studies have found an obesity-related single-nucleotide polymorphism rs10938397 near the glucosamine-6-phosphate deaminase 2 gene (GNPDA2) encoding, an enzyme that catalyzes the deamination of the glucosamine-6-phosphate involved in the hexosamine signaling pathway, but the molecular ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/9145452
更新日期:2019-08-01 00:00:00
abstract::Insulin resistance increases the risk for cardiovascular disease (CVD) even in the absence of classic risk factors, such as hyperglycemia, hypertension, dyslipidemia, and obesity. Low-grade chronic inflammatory state is associated both with insulin resistance and atherosclerosis. An increased circulating level of proi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/3470412
更新日期:2018-09-13 00:00:00
abstract:Background:Diagnosing polycystic ovary syndrome (PCOS) is based on ovulatory dysfunction, ovarian ultrasound data, and androgen excess. Total testosterone is frequently used to identify androgen excess, but testosterone is mainly bound to sex hormone-binding globulin (SHBG) and albumin. Only 1-2% of nonprotein-bound te...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/7956951
更新日期:2018-09-10 00:00:00