Abstract:
:There is inconsistency among published guidelines for the optimal diagnostic and management pathways for patients with typical (TC) or atypical (AC) pulmonary carcinoid tumours. We conducted a UK-wide clinician survey to assess current practice for the diagnosis, management, and follow-up of patients with TC/AC and descriptively compared management between European Neuroendocrine Tumor Society (ENETS) accredited centres of excellence (CoE) and nonaccredited centres (non-CoE). Twenty-seven clinicians (10 CoE; 17 non-CoE) participated. Computed tomography of thorax, abdomen, and pelvis was the most commonly reported diagnostic tool (96% of respondents), and bone scans and gallium somatostatin receptor scintigraphy positron emission tomography (SRS PET) were the least commonly reported (30% and 37% of respondents, respectively). Adjuvant therapy is considered for resected TC/AC by <5% of respondents for patients with stage N0 M0 AC or TC, up to 48% of respondents for patients with AC with R1 disease. Somatostatin analogues were the most commonly reported first-line treatment (63% of respondents), and chemotherapy was the most commonly reported second-line therapy and third-line therapy (33% and 41%, respectively) for unresectable and metastatic disease. Reported frequency of initial follow-up after primary surgery ranged from every 2 months to annual, and total follow-up duration ranged from 2 years to indefinite depending on disease type (TC/AC) and stage. For most diagnostic investigations, the highest reported frequency of use was in CoE, most notably gallium SRS PET (70% CoE vs. 18% non-CoE respondents). 93% of respondents (100% CoE; 88% non-CoE) reported having neuroendocrine tumour- (NET-) specialist multidisciplinary team meetings at their centre; 59% (90% CoE; 41% non-CoE) had a NET Clinical Nurse Specialist (CNS) and 48% (80% CoE; 29% non-CoE) had a lung NET patient database. The survey results suggest variability between UK centres in diagnostic pathways and management of patients with TC/AC and suggest that CoE may be able to offer an improved service to patients.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Mansoor W,Ferguson S,Ross V,Talbot Ddoi
10.1155/2020/9287536subject
Has Abstractpub_date
2020-02-28 00:00:00pages
9287536eissn
1687-8337issn
1687-8345journal_volume
2020pub_type
杂志文章abstract::Background. The Japan Thyroid Association recently published guidelines for clinical practice for the management of thyroid nodules, which include a diagnostic system for reporting thyroid fine needle aspiration cytology. It is characterized by the subclassification of follicular neoplasms, which is different from oth...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/938305
更新日期:2015-01-01 00:00:00
abstract:Background:Gynecomastia (GM) is a benign enlargement of male breast due to glandular tissue proliferation. GM is a symptom of systemic or local hormonal disturbances, which could be associated with functional changes or pathological conditions. However, the long-lasting steroid imbalance in men with GM might exert nega...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/6718761
更新日期:2019-10-03 00:00:00
abstract::Estroprogestins (EPs) are combinations of estrogen and progestin with several actions on women's health. The different pharmacological composition of EPs is responsible for different clinical effects. One of the most used low-dose EP associations is ethinylestradiol 20 mcg plus levonorgestrel 100 mcg in monophasic reg...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/102184
更新日期:2014-01-01 00:00:00
abstract::Insulin resistance increases the risk for cardiovascular disease (CVD) even in the absence of classic risk factors, such as hyperglycemia, hypertension, dyslipidemia, and obesity. Low-grade chronic inflammatory state is associated both with insulin resistance and atherosclerosis. An increased circulating level of proi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/3470412
更新日期:2018-09-13 00:00:00
abstract::Aim of the study was to examine cardiorespiratory parameters at individual ventilatory threshold (IVT) and peak exercise capacity ([Formula: see text]) in outpatient diabetic and sarcopenic obese subjects. Seventeen obese subjects (BMI: 36.6 ± 4.1 kg·m(-1)) and sixteen SO subjects (BMI: 37.0 ± 7.3 kg·m(-1)) were compa...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/6739150
更新日期:2016-01-01 00:00:00
abstract::Background. Hyperinsulinaemic Hypoglycaemia (HH) is the most common cause of severe and persistent hypoglycemia in the neonatal period. It has been shown that the neonates with HH fail to generate adequate serum cortisol counterregulatory response to symptomatic hypoglycemia. However the role played by growth hormone ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/638257
更新日期:2013-01-01 00:00:00
abstract::While vitamin D3 is recognized as a neuroactive steroid affecting both brain development and function, efficient analytical method in determining vitamin D3 metabolites in the brain tissue is still lacking, and the relationship of vitamin D3 status between serum and brain remains elusive. Therefore, we developed a nov...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/296531
更新日期:2015-01-01 00:00:00
abstract::The determination of B-type natriuretic peptides (BNP) may have a role in the diagnosis of heart failure (HF) or guiding HF therapy. This study investigated the role of BNP determination in a cohort of elderly patients admitted to hospital with acute decompensated HF and its correlation with main demographic, clinical...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/239136
更新日期:2015-01-01 00:00:00
abstract:Objective:We sought to evaluate the association between femoral neck (FN) and lumbar spine (LS) bone mineral densities (BMDs) with severity of chronic kidney disease (CKD) and prevalence of osteopenia or osteoporosis (OP) among the CKD group. Methods:Cross-sectional data from 11050 participants aged ≥20 years from the...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/8852690
更新日期:2020-10-26 00:00:00
abstract::[This corrects the article DOI: 10.1155/2015/164087.]. ...
journal_title:International journal of endocrinology
pub_type: 已发布勘误
doi:10.1155/2018/6069189
更新日期:2018-09-06 00:00:00
abstract::HDL cholesterol is known to be inversely correlated with cardiovascular disease due to its diverse antiatherogenic functions. SR-BI mediates the selective uptake of HDL-C. SR-BI knockout diminishes but does not completely block the transport of HDL; other receptors may be involved. Ectopic ATP synthase β-chain in hepa...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/356432
更新日期:2014-01-01 00:00:00
abstract::Sex steroid hormones have neuroprotective properties which may be mediated by brain-derived neurotrophic factor (BDNF). This study sought to determine the interactive effects of preadolescent hormone manipulation and BDNF heterozygosity (+/-) on hippocampal NMDA-R expression. Wild-type and BDNF+/- mice were gonadectom...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/7231915
更新日期:2018-01-31 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women of reproductive age. Although PCOS is diagnosed exclusively based on reproductive criteria, it is also a metabolic disorder. Insulin resistance, impaired glucose tolerance, type 2 diabetes mellitus, obesity, and dyslipidemia are more ...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/786362
更新日期:2015-01-01 00:00:00
abstract::The liver is one of the most essential organs involved in the regulation of energy homeostasis. Hepatic steatosis, a major manifestation of metabolic syndrome, is associated with imbalance between lipid formation and breakdown, glucose production and catabolism, and cholesterol synthesis and secretion. Epidemiological...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/294278
更新日期:2015-01-01 00:00:00
abstract::Aim. To compare two creatinine-based estimated glomerular filtration rate (eGFR) equations, the chronic kidney disease epidemiology collaboration (CKD-EPI) and the modification of diet in renal disease (MDRD), for predicting the risk of CKD progression in type 2 diabetic patients with nephropathy. Methods. A total of ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/848963
更新日期:2013-01-01 00:00:00
abstract::Type 2 diabetes and depression are regarded as comorbid conditions, and three possible directions of the association between the diseases can underlie this observation of comorbidity. First, common etiology can increase a person's risk of both diseases; second, persons with type 2 diabetes have increased prevalence or...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/164760
更新日期:2015-01-01 00:00:00
abstract::Gestational diabetes mellitus (GDM) is defined as any degree of carbohydrate intolerance, with onset or first recognition during second or third trimester of gestation. It is estimated that approximately 7% of all pregnancies are complicated by GDM and that its prevalence is rising all over the world. Thus, the screen...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/6380463
更新日期:2018-04-12 00:00:00
abstract:Background:Gonadal injury following chemotherapy is of increasing importance with the continuous improvement of survival rates. The protection of gonadotropin hormone antagonist (GnRHant) in long-term adult survivors of adolescent cancers and some autoimmune diseases has not yet been evaluated. Methods:The present stu...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/4272575
更新日期:2018-06-10 00:00:00
abstract:Introduction:Obesity has an unclear pathogenesis. MicroRNAs (miRNAs) may function as biologically active molecules for obesity through regulating adipocyte differentiation. This study aimed to identify how miR-129-5p (a specific miRNA) regulates adipogenesis in vitro and explore its possible role in the pathogenesis of...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/5069578
更新日期:2019-11-06 00:00:00
abstract::Objective. To analyze changes in vital signs (heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP)) during and after intravenous methylprednisolone (IVMP) and any other adverse effects. Methods. Retrospective review of charts of patients who received IVMP as treatment regime for thyroid eye disease. All...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/457123
更新日期:2015-01-01 00:00:00
abstract::We aimed to estimate the impact of ingestion of a pure protein load on the glucose levels in T1DM patients treated with insulin pumps. We examined 10 T1DM patients (6 females, mean age-32.3 years, mean HbA1c-6.8%) treated with insulin pumps equipped with a continuous glucose monitoring system (CGMS). In Phase I, basel...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/216918
更新日期:2015-01-01 00:00:00
abstract::Varicocele in infertile males is associated with Leydig cell dysfunction and hypogonadism. The effect of varicocelectomy on serum testosterone level is not yet established. We analysed 200 heterosexual infertile men diagnosed to have clinical varicocele they were divided into two groups: group 1 (100 men) had microsur...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2011/916380
更新日期:2011-01-01 00:00:00
abstract:Purpose:Hyperoside, a flavonoid isolated from conventional medicinal herbs, has been demonstrated to exert a significant protective effect in diabetic nephropathy. This study aimed to determine the underlying mechanisms, by which hyperoside inhibits high glucose-(HG-) induced proliferation in mouse renal mesangial cell...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/1361924
更新日期:2020-07-21 00:00:00
abstract::Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2017/2452853
更新日期:2017-01-01 00:00:00
abstract::Thyroid cancer is the most common endocrine malignancy, and its incidence has increased rapidly in recent decades worldwide. Papillary thyroid cancer (PTC) is the most common type of all thyroid cancers. The molecular mechanisms underlying the disease still need to be further investigated. Long noncoding RNAs (lncRNAs...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/7043509
更新日期:2019-04-07 00:00:00
abstract::A quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism. Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis. We conducted a randomiz...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/6170154
更新日期:2018-10-31 00:00:00
abstract::Type 2 diabetes is characterized by frequent ectopic fat accumulation in several tissues and organs. In particular, a number of studies showed that these subjects frequently have hepatic fat accumulation, which may play a role in the metabolic abnormalities typical of diabetes and has been also linked to increased ris...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2013/309191
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/7838290.]. ...
journal_title:International journal of endocrinology
pub_type: 已发布勘误
doi:10.1155/2018/1239718
更新日期:2018-10-23 00:00:00
abstract::Sestrin (SESN) is known as a cysteine sulfinic acid reductase. Recently, nonredox functions of SESN in metabolic regulation and antitumor property have been recognized. While mechanisms underlying the expression of SESN are not fully understood. Here we report that insulin markedly increased SESN2 level in HepG2 cells...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/505849
更新日期:2015-01-01 00:00:00
abstract::Preeclampsia is a serious medical problem affecting the mother and her child and influences their health not only during the pregnancy, but also many years after. Although preeclampsia is a subject of many research projects, the etiology of the condition remains unclear. One of the hypotheses related to the etiology o...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2016/5279462
更新日期:2016-01-01 00:00:00