Abstract:
:Sex steroid hormones have neuroprotective properties which may be mediated by brain-derived neurotrophic factor (BDNF). This study sought to determine the interactive effects of preadolescent hormone manipulation and BDNF heterozygosity (+/-) on hippocampal NMDA-R expression. Wild-type and BDNF+/- mice were gonadectomised, and females received either 17β-estradiol or progesterone treatment, while males received either testosterone or dihydrotestosterone (DHT) treatment. Dorsal (DHP) and ventral hippocampus (VHP) were dissected, and protein expression of GluN1, GluN2A, GluN2B, and PSD-95 was assessed by Western blot analysis. Significant genotype × OVX interactions were found for GluN1 and GluN2 expression within the DHP of female mice, suggesting modulation of select NMDA-R levels by female sex hormones is mediated by BDNF. Furthermore, within the DHP BDNF+/- mice show a hypersensitive response to hormone treatment on GluN2 expression which may result from upstream alterations in TrkB phosphorylation. In contrast to the DHP, the VHP showed no effects of hormone manipulation but significant effects of genotype on NMDA-R expression. Castration had no effect on NMDA-R expression; however, androgen treatment had selective effects on GluN2B. These data show case distinct, interactive roles for sex steroid hormones and BDNF in the regulation of NMDA-R expression that are dependent on dorsal versus ventral hippocampal region.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
McCarthny CR,Du X,Wu YC,Hill RAdoi
10.1155/2018/7231915subject
Has Abstractpub_date
2018-01-31 00:00:00pages
7231915eissn
1687-8337issn
1687-8345journal_volume
2018pub_type
杂志文章abstract::Type 2 diabetes mellitus (T2D) is a disorder of glucose metabolism. It is a complex process involving the regulation of insulin secretion, insulin sensitivity, gluconeogenesis, and glucose uptake at the cellular level. Diabetic peripheral neuropathy (DPN) is one of the debilitating complications that is present in app...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2018-03-15 00:00:00
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:International journal of endocrinology
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doi:10.1155/2009/687259
更新日期:2009-01-01 00:00:00
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doi:10.1155/2014/354612
更新日期:2014-01-01 00:00:00
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doi:10.1155/2013/361895
更新日期:2013-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/580685
更新日期:2013-01-01 00:00:00
abstract::Aims. There are two phases of insulin secretion, the first (FPIS) and second phase (SPIS). In this study, we built equations to predict FPIS with metabolic syndrome (MetS) components and fasting plasma insulin (FPI). Methods. Totally, 186 participants were enrolled. 75% of participants were randomly selected as the st...
journal_title:International journal of endocrinology
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doi:10.1155/2015/675245
更新日期:2015-01-01 00:00:00
abstract::Enucleation-induced adrenal regeneration is a highly controlled process; however, only some elements involved in this process have been recognized. Therefore, we performed studies on regenerating rat adrenals. Microarray RNA analysis and QPCR revealed that enucleation resulted in a rapid elevation of expression of gen...
journal_title:International journal of endocrinology
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doi:10.1155/2014/130359
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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更新日期:2019-04-07 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/8134548
更新日期:2020-03-17 00:00:00
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pub_type: 杂志文章
doi:10.1155/2020/2901393
更新日期:2020-03-19 00:00:00
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journal_title:International journal of endocrinology
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更新日期:2017-01-01 00:00:00
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更新日期:2020-06-30 00:00:00
abstract::Puerarin, the main isoflavone glycoside extracted from Radix Puerariae, is an isoflavone traditional Chinese herb. Previous studies have demonstrated that puerarin could regulate osteoblast proliferation and differentiation to promote bone formation. However, the effect of puerarin on the process of human osteoblasts ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/786574
更新日期:2013-01-01 00:00:00