Abstract:
:Bariatric surgery is currently the most effective therapy to induce weight loss in morbidly obese patients. Objective. This controlled, clinical trial with a two-year intervention was aimed at comparing the efficacy of two nonsurgical approaches versus bariatric surgery, on body weight changes and metabolic parameters in morbidly obese patients. Methods. Patients were randomized to an Intensive Lifestyle Intervention (ILI) (n = 60) or Conventional Obesity Therapy (COT) (n = 46). The ILI group received behavioral therapy and nutritional counseling. The COT group received standard medical treatment. They were compared with a third group, Surgical Obesity Group (SOG) (n = 37). Results. Patients who received ILI had a greater percentage of weight loss than patients receiving COT (-11.3% versus -1.6%; p < 0.0044). Interestingly 31.4% of patients included in the ILI group were no longer morbidly obese after just six months of intervention, increasing to 44.4% after 24 months of intervention. The percentage weight loss in SOG was -29.6% after that same period of time. Conclusions. ILI was associated with significant weight loss when compared to COT, in a group of patients with obesity. An ILI approach could be an alternative therapy to patients with obesity, who are not candidates to undergo bariatric surgery. This trial is registered with EudraCT 2009-013737-24.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Burguera B,Jesús Tur J,Escudero AJ,Alos M,Pagán A,Cortés B,González XF,Soriano JBdoi
10.1155/2015/194696subject
Has Abstractpub_date
2015-01-01 00:00:00pages
194696eissn
1687-8337issn
1687-8345journal_volume
2015pub_type
杂志文章abstract::Neurofibromatosis type 1 (NF1) patients are more likely to have vitamin D deficiency when compared to the general population. This study aimed to determine the levels of 25-OH-vitamin D [25(OH)D] in individuals with NF1 and disease-unaffected controls and analyze FokI and BsmI VDR gene polymorphisms in a case and in a...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/402838
更新日期:2015-01-01 00:00:00
abstract:Objective:Many patients with diabetes opt to fast for lab tests, especially for lipid profiles, thus missing breakfast. In parallel, recent studies and international guidelines have indicated that routine fasting for lipid panels may not be necessary. Missing breakfast while fasting for lab tests may invoke hypoglycemi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/1528437
更新日期:2018-10-24 00:00:00
abstract::Objective. Black thyroid is a rare pigmented change seen almost exclusively in patients upon minocycline ingestion, and the process has previously been thought to be generally benign. There have been 61 reported cases of black thyroid. We are aware of 13 cases previously reported in association with thyroid carcinoma....
journal_title:International journal of endocrinology
pub_type:
doi:10.1155/2010/681647
更新日期:2010-01-01 00:00:00
abstract::Aim. To compare two creatinine-based estimated glomerular filtration rate (eGFR) equations, the chronic kidney disease epidemiology collaboration (CKD-EPI) and the modification of diet in renal disease (MDRD), for predicting the risk of CKD progression in type 2 diabetic patients with nephropathy. Methods. A total of ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/848963
更新日期:2013-01-01 00:00:00
abstract::The objective of this cross-sectional study was to assess differences in the control and treatment of modifiable cardiovascular risk factors (CVRF: HbA1c, blood pressure [BP], LDL-cholesterol, body mass index, and smoking habit) according to gender and the presence of cardiovascular disease (CVD) in patients with type...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/131709
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abstract:Background:Gonadal injury following chemotherapy is of increasing importance with the continuous improvement of survival rates. The protection of gonadotropin hormone antagonist (GnRHant) in long-term adult survivors of adolescent cancers and some autoimmune diseases has not yet been evaluated. Methods:The present stu...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/4272575
更新日期:2018-06-10 00:00:00
abstract:Objective:Atypical parathyroid adenoma is a rare neoplasm, showing atypical histological features intermediate between classic benign adenoma and the rarest parathyroid carcinoma, whose the clinical behaviour and outcome is not yet understood or predictable. Up to date only two cases of atypical adenoma were found asso...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/2080797
更新日期:2020-04-27 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/685375
更新日期:2013-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2020/9649838
更新日期:2020-01-21 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/6698878
更新日期:2020-12-03 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/3161730
更新日期:2020-05-06 00:00:00
abstract:BACKGROUND:Recent guidelines from the American Thyroid Association (ATA) indicate that, in many patients affected by differentiated thyroid cancer (DTC), the serum TSH should be maintained between 0.1 and 0.5 mU/L. The purpose of this study was to evaluate the TSH variability of patients affected by DTC treated with li...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2017/7053959
更新日期:2017-01-01 00:00:00
abstract::Parathyroid glands contain the vitamin D receptor (VDR) and 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24A1), which catalyze the production and degradation of 1,25-dihydroxyvitamin D [1,25(OH)2D], respectively. Previous studies have shown that the serum level of intact parathyroid hormone (iPT...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/7257913
更新日期:2020-04-09 00:00:00
abstract::There is inconsistency among published guidelines for the optimal diagnostic and management pathways for patients with typical (TC) or atypical (AC) pulmonary carcinoid tumours. We conducted a UK-wide clinician survey to assess current practice for the diagnosis, management, and follow-up of patients with TC/AC and de...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/9287536
更新日期:2020-02-28 00:00:00
abstract::In the present study we evaluated in vivo and in vitro effects of 4-tert-octylphenol (OP) on the expression and distribution of adherens and gap junction proteins, N-cadherin, β -catenin, and connexin 43 (Cx43), in testes of seasonally breeding rodents, bank voles. We found that in bank vole testes expression and dist...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/134589
更新日期:2013-01-01 00:00:00
abstract::Introduction. The mechanisms underlying the association between insulin resistance and intrahepatic lipid (IHL) accumulation are not completely understood. We sought to determine whether this association was explained by differences in fasting non-esterified fatty acid (NEFA) levels and/or NEFA suppression after oral ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/870487
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Evidence on the association between subclinical thyroid dysfunction and the risk of cardiovascular outcomes are conflicting. METHODS AND RESULTS:PubMed, EMbase, Web of Science, Cochrane Library, and China Biology Medicine (CBM) databases were searched from inception to July 10, 2016. A total of 16 studies w...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2017/8130796
更新日期:2017-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2014/690783.]. ...
journal_title:International journal of endocrinology
pub_type: 已发布勘误
doi:10.1155/2017/5924671
更新日期:2017-01-01 00:00:00
abstract::Objective. In pediatric central diabetes insipidus (CDI), etiology diagnosis and pituitary function monitoring are usually delayed. This study aimed to illustrate the importance of regular follow-up and pituitary function monitoring in pediatric CDI. Methods. The clinical, hormonal, and neuroradiological characteristi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/6365830
更新日期:2016-01-01 00:00:00
abstract:Introduction:Cushing's syndrome (CS) is a clinical condition characterized by excessive cortisol production, associated with metabolic complications, such as diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, and cardiovascular diseases. Nowadays, the occurrence of autoimmune diseases in CS have not bee...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/1464967
更新日期:2018-12-18 00:00:00
abstract::Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes. Here we revie...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/451035
更新日期:2014-01-01 00:00:00
abstract:Background:Genome-wide association studies have found an obesity-related single-nucleotide polymorphism rs10938397 near the glucosamine-6-phosphate deaminase 2 gene (GNPDA2) encoding, an enzyme that catalyzes the deamination of the glucosamine-6-phosphate involved in the hexosamine signaling pathway, but the molecular ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/9145452
更新日期:2019-08-01 00:00:00
abstract::Acromegaly is caused by hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor-I (IGF-1) due to pituitary tumor. Other causes, such as increased growth-hormone releasing hormone (GHRH) production, ectopic GHRH production, and ectopic GH secretion, are rare. Growth hormone and IGF-1 play a...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/839282
更新日期:2012-01-01 00:00:00
abstract:Objective:To evaluate the impact of preconceptional serum TSH levels on the clinical outcomes of infertile patients undergoing their first IUI treatment cycle. Method:This was a retrospective study. Euthyroid patients undergoing the first cycle of IUI treatment from Jan 2017 to Aug 2018 were included. The patients wer...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/8492904
更新日期:2019-12-18 00:00:00
abstract::Thyroid cancer is the most common endocrine malignancy, and its incidence has increased rapidly in recent decades worldwide. Papillary thyroid cancer (PTC) is the most common type of all thyroid cancers. The molecular mechanisms underlying the disease still need to be further investigated. Long noncoding RNAs (lncRNAs...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/7043509
更新日期:2019-04-07 00:00:00
abstract:Objectives:To compare the predictive ability of six anthropometric indices for identification of metabolic syndrome (MetS) and to determine their optimal cut-off points among Chinese adults. Methods:A total of 59,029 participants were enrolled. Body mass index (BMI), waist circumference (WC), waist-to-height ratio (WH...
journal_title:International journal of endocrinology
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doi:10.1155/2018/1067603
更新日期:2018-09-17 00:00:00
abstract::The hypothalamus is an essential relay in the neural circuitry underlying energy metabolism that needs to continually adapt to changes in the energetic environment. The neuroendocrine control of food intake and energy expenditure is associated with, and likely dependent upon, hypothalamic plasticity. Severe disturbanc...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/732975
更新日期:2012-01-01 00:00:00
abstract::Diabetes is a lifelong course disease, so insulin treatment has to be effective and safe, and patients should be satisfied with it. We aimed to compare efficacy, safety, and quality of treatment satisfaction of human and premixed analogue insulin among 3264 patients (53.58% women) with type 2 diabetes mellitus (T2DM) ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
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更新日期:2018-03-05 00:00:00
abstract::Sex steroid hormones have neuroprotective properties which may be mediated by brain-derived neurotrophic factor (BDNF). This study sought to determine the interactive effects of preadolescent hormone manipulation and BDNF heterozygosity (+/-) on hippocampal NMDA-R expression. Wild-type and BDNF+/- mice were gonadectom...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/7231915
更新日期:2018-01-31 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/957105
更新日期:2015-01-01 00:00:00