Abstract:
:Puerarin, the main isoflavone glycoside extracted from Radix Puerariae, is an isoflavone traditional Chinese herb. Previous studies have demonstrated that puerarin could regulate osteoblast proliferation and differentiation to promote bone formation. However, the effect of puerarin on the process of human osteoblasts (hOBs) apoptosis is still unclear. In this study, we detected the function of puerarin on serum-free-induced cell apoptosis using ELISA and TUNEL arrays and then found that the mortality of hOBs was significantly decreased after exposure to 10(-10)-10(-6) M puerarin and reached the maximal antiapoptotic effect at the concentration of 10(-8) M. In addition, compared with the control group, puerarin notably increased the Bcl-2 protein levels while it decreased the Bax protein levels in the hOBs in a dose-dependent way. 10(-7) M puerarin decreased the Bax/Bcl-2 ratio with a maximal decrease to 0.08. Moreover, puerarin activated ERK signaling pathways in hOBs, and the antiapoptotic effect induced by puerarin was abolished by incubation of ERK inhibitor PD98059. Similarly, the estrogen receptor antagonist ICI182780 also suppressed the inhibitory effect of puerarin on hOBs apoptosis. In conclusion, puerarin could prevent hOBs apoptosis via ERK signaling pathway, which might be effective in providing protection against bone loss and bone remolding associated with osteoporosis.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Liu LJ,Liu LQ,Bo T,Li SJ,Zhu Z,Cui RR,Mao DAdoi
10.1155/2013/786574subject
Has Abstractpub_date
2013-01-01 00:00:00pages
786574eissn
1687-8337issn
1687-8345journal_volume
2013pub_type
杂志文章abstract::Sex steroid hormones have neuroprotective properties which may be mediated by brain-derived neurotrophic factor (BDNF). This study sought to determine the interactive effects of preadolescent hormone manipulation and BDNF heterozygosity (+/-) on hippocampal NMDA-R expression. Wild-type and BDNF+/- mice were gonadectom...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/7231915
更新日期:2018-01-31 00:00:00
abstract::Parathyroid carcinoma (PC) is a rare disease responsible for about 1% of primary hyperparathyroidism (PHPT) cases. PC usually has an indolent course, tough to differentiate from the benign causes of PHPT, and the only certain diagnosis is histologic. The gold standard surgical treatment is the en bloc resection associ...
journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:We aimed to explore whether squamous cell carcinoma antigen (SCC), cytokeratin 19 fragment (Cyfra21-1), neuron-specific enolase (NSE), and carcinoembryonic antigen (CEA) are elevated in diabetic nephropathy (DN) and the association between urinary albumin-to-creatinine ratio (UACR) and tumor markers in diabet...
journal_title:International journal of endocrinology
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-01-06 00:00:00
abstract::To isolate pancreatic progenitor cells with the surface markers of hematopoietic stem cells, the expression of stem cell antigen (Sca-1) and c-Kit and the coexpression of them with pancreatic duodenal homeobox-1 (PDX-1), neurogenin 3 (Ngn3), and insulin were examined in murine embryonic pancreas. Then different pancre...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/948683
更新日期:2012-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/8134548
更新日期:2020-03-17 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/8875257
更新日期:2020-10-10 00:00:00
abstract::Type 2 diabetes is characterized by frequent ectopic fat accumulation in several tissues and organs. In particular, a number of studies showed that these subjects frequently have hepatic fat accumulation, which may play a role in the metabolic abnormalities typical of diabetes and has been also linked to increased ris...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2013/309191
更新日期:2013-01-01 00:00:00
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journal_title:International journal of endocrinology
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更新日期:2010-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/3189879
更新日期:2018-04-29 00:00:00
abstract::The determination of B-type natriuretic peptides (BNP) may have a role in the diagnosis of heart failure (HF) or guiding HF therapy. This study investigated the role of BNP determination in a cohort of elderly patients admitted to hospital with acute decompensated HF and its correlation with main demographic, clinical...
journal_title:International journal of endocrinology
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doi:10.1155/2015/239136
更新日期:2015-01-01 00:00:00
abstract::Background. Separate lines of research have shown that menstrual cycling and contextual factors such as the gender of research personnel influence experimental pain reporting. Objectives. This study examines how brief, procedural interactions with female and male experimenters can affect experimentally reported pain (...
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pub_type: 杂志文章
doi:10.1155/2015/520719
更新日期:2015-01-01 00:00:00
abstract:Objectives:To compare the predictive ability of six anthropometric indices for identification of metabolic syndrome (MetS) and to determine their optimal cut-off points among Chinese adults. Methods:A total of 59,029 participants were enrolled. Body mass index (BMI), waist circumference (WC), waist-to-height ratio (WH...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/1067603
更新日期:2018-09-17 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2011/530274
更新日期:2011-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/638257
更新日期:2013-01-01 00:00:00
abstract::Spermatozoa are highly specialized cells that can be easily obtained and purified. Mature spermatozoa are transcriptionally and translationally inactive and incapable of protein synthesis. In addition, spermatozoa contain relatively higher amounts of membrane proteins compared to other cells; therefore, they are very ...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2013/360986
更新日期:2013-01-01 00:00:00
abstract::Objectives. Vitamin D deficiency plays a role in insulin resistance and the pathogenesis of type 2 diabetes mellitus. Little information is available about the association between vitamin D status and insulin resistance in the Chinese population. Currently, vitamin D status is evaluated by the concentrations of serum ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/1794894
更新日期:2016-01-01 00:00:00
abstract::The aim of this study is to evaluate carotid atherosclerosis in patients of type 2 diabetes mellitus with microalbuminuria (MA) by high-frequency ultrasonography. Two hundred and fifty patients of type 2 diabetes mellitus were divided into two groups according to urinary albumin excretion rate (UAER): normoalbuminuria...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/819584
更新日期:2013-01-01 00:00:00
abstract::Partial androgen insensitivity syndrome (PAIS) is associated with impaired male genital development and can be transmitted through mutations in the androgen receptor (AR). The aim of this study is to develop a cell model suitable for studying the impact AR mutations might have on AR interacting proteins. For this purp...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/381824
更新日期:2012-01-01 00:00:00
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更新日期:2018-01-16 00:00:00
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journal_title:International journal of endocrinology
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doi:10.1155/2020/9287536
更新日期:2020-02-28 00:00:00
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journal_title:International journal of endocrinology
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doi:10.1155/2018/6170154
更新日期:2018-10-31 00:00:00
abstract::Purpose. To evaluate alteration in serum TSH in hypertensives with OSA and its relation with cardiometabolic risk factors. Methods. 517 hypertensives were cross-sectionally studied. OSA was determined by polysomnography and thyroid function by standard methods. Results. OSA was diagnosed in 373 hypertensives (72.15%)....
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pub_type: 杂志文章
doi:10.1155/2016/4802720
更新日期:2016-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/848963
更新日期:2013-01-01 00:00:00
abstract::Varicocele in infertile males is associated with Leydig cell dysfunction and hypogonadism. The effect of varicocelectomy on serum testosterone level is not yet established. We analysed 200 heterosexual infertile men diagnosed to have clinical varicocele they were divided into two groups: group 1 (100 men) had microsur...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2011/916380
更新日期:2011-01-01 00:00:00
abstract::The study aimed at assessing the potential use of lower total and HMW adiponectin levels for predicting cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Concentrations of total adiponectin or high molecular weight (HMW) adiponectin decrease in association with the development of metabolic dysfunct...
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doi:10.1155/2015/545068
更新日期:2015-01-01 00:00:00
abstract::Parathyroid glands contain the vitamin D receptor (VDR) and 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24A1), which catalyze the production and degradation of 1,25-dihydroxyvitamin D [1,25(OH)2D], respectively. Previous studies have shown that the serum level of intact parathyroid hormone (iPT...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/7257913
更新日期:2020-04-09 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/854392
更新日期:2014-01-01 00:00:00