Abstract：
:Gestational diabetes mellitus (GDM) is defined as any degree of carbohydrate intolerance, with onset or first recognition during second or third trimester of gestation. It is estimated that approximately 7% of all pregnancies are complicated by GDM and that its prevalence is rising all over the world. Thus, the screening for abnormal glucose levels is generally recommended as a routine component of care for pregnant women. However, additional biomarkers are needed in order to predict the onset or accurately monitor the status of gestational diabetes. Recently, microRNAs, a class of small noncoding RNAs demonstrated to modulate gene expression, have been proven to be secreted by cells of origin and can be found in many biological fluids such as serum or plasma. Such feature renders microRNAs as optimal biomarkers and sensors of in situ tissue alterations. Furthermore, secretion of microRNAs via exosomes has been reported to contribute to tissue cross talk, thus potentially represents, if disrupted, a mechanistic cause of tissue/cell dysfunction in a specific disease. In this review, we summarized the recent findings on circulating microRNAs and gestational diabetes mellitus with particular focus on the potential use of microRNAs as putative biomarkers of disease as well as a potential cause of GDM complications and β cell dysfunction.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Guarino E,Delli Poggi C,Grieco GE,Cenci V,Ceccarelli E,Crisci I,Sebastiani G,Dotta Fdoi
10.1155/2018/6380463subject
Has Abstractpub_date
2018-04-12 00:00:00pages
6380463eissn
1687-8337issn
1687-8345journal_volume
2018pub_type
杂志文章,评审abstract：:Ghrelin is a relatively novel multifaceted hormone that has been found to exert a plethora of physiological effects. In this review, we found/confirmed that ghrelin has effect on all body systems. It induces appetite; promotes the use of carbohydrates as a source of fuel while sparing fat; inhibits lipid oxidation and...
journal_title：International journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1155/2020/1385138
更新日期：2020-05-25 00:00:00
abstract：:Background. The Japan Thyroid Association recently published guidelines for clinical practice for the management of thyroid nodules, which include a diagnostic system for reporting thyroid fine needle aspiration cytology. It is characterized by the subclassification of follicular neoplasms, which is different from oth...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2015/938305
更新日期：2015-01-01 00:00:00
abstract：:The complementary role of hyperglycemia and p27(kip1) suppression on islet beta cell regeneration was investigated in a syngeneic mouse model. p27(kip1) gene silencing was performed by infecting islets of C57BL/6 with shRNA lentiviral particles. At 54 hours after viral infection, p27(kip1) protein content in cultured ...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2012/417390
更新日期：2012-01-01 00:00:00
abstract：:The 5-alpha-reductase type 2 deficiency (5ARD2) is an autosomal recessive condition associated with impairment in the conversion of testosterone to dihydrotestosterone. This condition leads to undervirilisation in 46,XY individuals. To date, there have been more than 100 variations identified in the gene responsible f...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2019/7676341
更新日期：2019-12-01 00:00:00
abstract：:Introduction. Differentiated thyroid cancer treatment usually consists of thyroidectomy and radio ablation in hypothyroidism 4-6 weeks after surgery. Replacing hypothyroidism by recombinant human thyroid stimulating hormone can facilitate radio ablation in euthyroidism within one week after surgery. The outcome of thi...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2013/769473
更新日期：2013-01-01 00:00:00
abstract：:Objectives. Vitamin D deficiency plays a role in insulin resistance and the pathogenesis of type 2 diabetes mellitus. Little information is available about the association between vitamin D status and insulin resistance in the Chinese population. Currently, vitamin D status is evaluated by the concentrations of serum ...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2016/1794894
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abstract：:Bariatric surgery is currently the most effective therapy to induce weight loss in morbidly obese patients. Objective. This controlled, clinical trial with a two-year intervention was aimed at comparing the efficacy of two nonsurgical approaches versus bariatric surgery, on body weight changes and metabolic parameters...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2015/194696
更新日期：2015-01-01 00:00:00
abstract：:Insulin resistance increases the risk for cardiovascular disease (CVD) even in the absence of classic risk factors, such as hyperglycemia, hypertension, dyslipidemia, and obesity. Low-grade chronic inflammatory state is associated both with insulin resistance and atherosclerosis. An increased circulating level of proi...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2018/3470412
更新日期：2018-09-13 00:00:00
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journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2016/6365830
更新日期：2016-01-01 00:00:00
abstract：:This study investigated potential markers for predicting nonfunctioning pituitary adenoma (NFPA) invasion and recurrence by high-throughput tissue microarray analyses. We retrospectively studied two groups of patients: 60 nonrecurrent NFPA cases that included noninvasion and invasion subtypes and 43 recurrent cases th...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2019/5731639
更新日期：2019-05-16 00:00:00
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journal_title：International journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1155/2018/8641942
更新日期：2018-03-15 00:00:00
abstract：:Objective. To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis. Methods. This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy subjects (group HP...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2016/5141089
更新日期：2016-01-01 00:00:00
abstract：:Iodine supplementation through salt iodization is a worldwide, effective strategy for preventing iodine deficiency-related problems. Its safety and efficacy profile has been extensively investigated, and benefits far outweigh the potential iodine-induced risks. Moreover, iodine supplementation during pregnancy in orde...
journal_title：International journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1155/2015/312305
更新日期：2015-01-01 00:00:00
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journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2011/530274
更新日期：2011-01-01 00:00:00
abstract：:Aim. To compare two creatinine-based estimated glomerular filtration rate (eGFR) equations, the chronic kidney disease epidemiology collaboration (CKD-EPI) and the modification of diet in renal disease (MDRD), for predicting the risk of CKD progression in type 2 diabetic patients with nephropathy. Methods. A total of ...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2013/848963
更新日期：2013-01-01 00:00:00
abstract：Background:Gonadal injury following chemotherapy is of increasing importance with the continuous improvement of survival rates. The protection of gonadotropin hormone antagonist (GnRHant) in long-term adult survivors of adolescent cancers and some autoimmune diseases has not yet been evaluated. Methods:The present stu...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2018/4272575
更新日期：2018-06-10 00:00:00
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journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2017/5304391
更新日期：2017-01-01 00:00:00
abstract：:Background. Liraglutide (a glucagon-like peptide 1 analog) was used for the treatment of type 2 diabetes (T2DM) which could produce glucose-dependent insulin secretion. Aim. The aim was to investigate whether liraglutide could improve myofibril and mitochondria injury in skeletal muscle and the mechanisms in diabetic ...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2014/312452
更新日期：2014-01-01 00:00:00
abstract：:The circadian system is a supraphysiological system that modulates different biological functions such as metabolism, sleep-wake, cellular proliferation, and body temperature. Different chronodisruptors have been identified, such as shift work, feeding time, long days, and stress. The environmental changes and our mod...
journal_title：International journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1155/2016/2746909
更新日期：2016-01-01 00:00:00
abstract：Objective:Type 2 diabetes (T2DM) is a global epidemic and increases mortality due to its vascular complications. Chemerin has been found to exert a major role in glucose and lipid metabolism. The aim of this study was to explore the correlation between plasma chemerin levels and microangiopathy in patients with T2DM. ...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2019/8693516
更新日期：2019-07-16 00:00:00
abstract：Objective:To evaluate the effectiveness and safety of coenzyme Q10 for patients with type 2 diabetes mellitus (T2DM). Methods:Data from randomized controlled trials were obtained to assess the effects of coenzyme Q10 versus placebo or western medicine on patients with T2DM. The study's registration number is CRD420180...
journal_title：International journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1155/2018/6484839
更新日期：2018-09-16 00:00:00
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journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2010/205357
更新日期：2010-01-01 00:00:00
abstract：:Introduction. The mechanisms underlying the association between insulin resistance and intrahepatic lipid (IHL) accumulation are not completely understood. We sought to determine whether this association was explained by differences in fasting non-esterified fatty acid (NEFA) levels and/or NEFA suppression after oral ...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2013/870487
更新日期：2013-01-01 00:00:00
abstract：:The increased prevalence of obesity represents, currently, one of the major public health issues, due to its consequences on physical and psychological health status as well as on the psychosocial functioning. As defined by the World Health Organization, sexual health is "a state of physical, emotional, mental, and so...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2014/847871
更新日期：2014-01-01 00:00:00
abstract：:The main purpose of our retrospective study was to evaluate the medical care of the patients with subclinical hypothyroidism (sHT) and to investigate the rationale for administering L-thyroxine (LT-4) to young sHT patients. Patients and Methods. Based on a retrospective review of the charts of 261 patients referred to...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2016/1671820
更新日期：2016-01-01 00:00:00
abstract：:Fibroblast growth factor 21 (FGF21) modulates a diverse range of biological functions, including glucose and lipid metabolism, adaptive starvation response, and energy homeostasis, but with limited mechanistic insight. FGF21 treatment has been shown to inhibit hepatic growth hormone (GH) intracellular signaling. To ev...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2015/282375
更新日期：2015-01-01 00:00:00
abstract：:Primary hyperparathyroidism (PHPT) is not an uncommon disease in the western countries. In Thailand, on the contrary, PHPT was a rare condition with various clinical presentations. All 45 PHPT patients who underwent parathyroidectomy at the Department of Surgery, Siriraj Hospital during January 1997 and December 2007 ...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2012/952426
更新日期：2012-01-01 00:00:00
abstract：:Endocannabinoids and their G-protein coupled receptors (GPCR) are a current research focus in the area of obesity due to the system's role in food intake and glucose and lipid metabolism. Importantly, overweight and obese individuals often have higher circulating levels of the arachidonic acid-derived endocannabinoids...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2013/361895
更新日期：2013-01-01 00:00:00
abstract：Objective:The aim of the present study was to investigate the association between dietary patterns and precocious puberty among Shanghai children. Methods:A cross-sectional study was conducted among Shanghai children by multistage stratified cluster random sampling in June 2014. Diet was assessed using a simplified fo...
journal_title：International journal of endocrinology
pub_type： 杂志文章
doi：10.1155/2018/4528704
更新日期：2018-01-16 00:00:00
abstract：:Obesity is a growing problem in modern society and medicine. It closely associates with metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and cardiovascular diseases such as nonalcoholic fatty liver disease, atherosclerosis, myocarditis, and hypertension. Obesity is often associated with latent i...
journal_title：International journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1155/2017/5076732
更新日期：2017-01-01 00:00:00
