Evaluation of Subclinical Hypothyroidism in Children and Adolescents: A Single-Center Study.

abstract：:Thyroid nodules, with their high prevalence in the general population, represent a diagnostic challenge for clinicians. Ultrasound (US), although absolutely reliable in detecting thyroid nodules, is still not accurate enough to differentiate them into benign and malignant. A promising novel modality, US elastography, ...

journal_title：International journal of endocrinology

authors： Cantisani V,Grazhdani H,Drakonaki E,D'Andrea V,Di Segni M,Kaleshi E,Calliada F,Catalano C,Redler A,Brunese L,Drudi FM,Fumarola A,Carbotta G,Frattaroli F,Di Leo N,Ciccariello M,Caratozzolo M,D'Ambrosio F

更新日期：2015-01-01 00:00:00

abstract：:The hypothalamus is an essential relay in the neural circuitry underlying energy metabolism that needs to continually adapt to changes in the energetic environment. The neuroendocrine control of food intake and energy expenditure is associated with, and likely dependent upon, hypothalamic plasticity. Severe disturbanc...

journal_title：International journal of endocrinology

authors： Stranahan AM,Martin B,Chadwick W,Park SS,Wang L,Becker KG,Woodiii WH,Zhang Y,Maudsley S

更新日期：2012-01-01 00:00:00

abstract：:The risk for cardiovascular diseases and type 2 diabetes mellitus significantly increases in the patient population with metabolic syndrome (MeS). The present study aimed to investigate the association between the epicardial adipose tissue thickness (EATT) and the oxidative stress parameters in MeS patients. The study...

journal_title：International journal of endocrinology

authors： Demir B,Demir E,Acıksarı G,Uygun T,Utku IK,Gedikbasi A,Caglar IM,Pirhan O,Tureli HO,Oflar E,Ungan İ,Ciftci S,Karakaya O

更新日期：2014-01-01 00:00:00

abstract：Objectives:To compare the predictive ability of six anthropometric indices for identification of metabolic syndrome (MetS) and to determine their optimal cut-off points among Chinese adults. Methods:A total of 59,029 participants were enrolled. Body mass index (BMI), waist circumference (WC), waist-to-height ratio (WH...

journal_title：International journal of endocrinology

authors： Zhang J,Zhu W,Qiu L,Huang L,Fang L

更新日期：2018-09-17 00:00:00

abstract：:Background. The purpose of the present study was to assess the feasibility of using miR-126 in the urine as a biomarker for diabetic nephropathy. Methods. miRNAs were extracted from the urine samples of T2DM patients with diabetic nephropathy (DN; n = 92), T2DM without DN (n = 86), and 85 healthy volunteers using quan...

journal_title：International journal of endocrinology

authors： Liu Y,Gao G,Yang C,Zhou K,Shen B,Liang H,Jiang X

更新日期：2014-01-01 00:00:00

abstract：:Insulin resistance increases the risk for cardiovascular disease (CVD) even in the absence of classic risk factors, such as hyperglycemia, hypertension, dyslipidemia, and obesity. Low-grade chronic inflammatory state is associated both with insulin resistance and atherosclerosis. An increased circulating level of proi...

journal_title：International journal of endocrinology

authors： Nikołajuk A,Matulewicz N,Stefanowicz M,Karczewska-Kupczewska M

更新日期：2018-09-13 00:00:00

abstract：:Objectives. Growth hormone deficiency patients exhibited reduced bone mineral density compared with healthy controls, but previous researches demonstrated uncertainty about the effect of growth hormone replacement therapy on bone in growth hormone deficient adults. The aim of this study was to determine whether the gr...

journal_title：International journal of endocrinology

authors： Xue P,Wang Y,Yang J,Li Y

更新日期：2013-01-01 00:00:00

abstract：:Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been established. Howeve...

journal_title：International journal of endocrinology

authors： Gacci M,Baldi E,Tamburrino L,Detti B,Livi L,De Nunzio C,Tubaro A,Gravas S,Carini M,Serni S

更新日期：2014-01-01 00:00:00

abstract：:Present therapies to minify hyperglycaemia and insulin resistance mainly target ATP-sensitive K(+) channels (K(ATP)) of pancreatic cells and PPAR-γ to enhance the insulin secretion and potential for GLUT expression, respectively. These current approaches are frequently associated with the various side effects such as ...

journal_title：International journal of endocrinology

authors： Ahmed D,Sharma M

更新日期：2011-01-01 00:00:00

abstract：:Oxidized low density lipoprotein (ox-LDL) is a product of oxidative stress. In this cross-sectional study, we compared the ox-LDL concentrations in diabetic patients with normoalbuminuria (n = 28), microalbuminuria (n = 28), and macroalbuminuria (n = 28) with their first degree relatives (n = 28) and healthy control p...

journal_title：International journal of endocrinology

authors： Behzadi P,Torabi F,Amini M,Aminorroaya A

更新日期：2012-01-01 00:00:00

abstract：:While vitamin D3 is recognized as a neuroactive steroid affecting both brain development and function, efficient analytical method in determining vitamin D3 metabolites in the brain tissue is still lacking, and the relationship of vitamin D3 status between serum and brain remains elusive. Therefore, we developed a nov...

journal_title：International journal of endocrinology

authors： Xue Y,He X,Li HD,Deng Y,Yan M,Cai HL,Tang MM,Dang RL,Jiang P

更新日期：2015-01-01 00:00:00

abstract：Objective:Neuroendocrine neoplasias (NENs) represent a rare and biologically heterogeneous group of malignancies. Treatment of NEN patients remains challenging due to lack of prospective evidence on the choice of ideal therapeutic sequence and therapeutic efficacy in specific individual scenarios. Methods:Clinical dat...

journal_title：International journal of endocrinology

authors： Mayer K,Kiry S,Yordanova A,Ahmadzadehfar H,Gaertner FC,Bundschuh RA,Essler M,Gonzalez-Carmona MA,Strassburg CP,Matthaei H,Lingohr P,Bisht S,Brossart P,Feldmann G

更新日期：2020-01-31 00:00:00

abstract：Introduction:Obesity has an unclear pathogenesis. MicroRNAs (miRNAs) may function as biologically active molecules for obesity through regulating adipocyte differentiation. This study aimed to identify how miR-129-5p (a specific miRNA) regulates adipogenesis in vitro and explore its possible role in the pathogenesis of...

journal_title：International journal of endocrinology

authors： Fu X,Jin L,Han L,Yuan Y,Mu Q,Wang H,Yang J,Ning G,Zhou D,Zhang Z

更新日期：2019-11-06 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) modulates a diverse range of biological functions, including glucose and lipid metabolism, adaptive starvation response, and energy homeostasis, but with limited mechanistic insight. FGF21 treatment has been shown to inhibit hepatic growth hormone (GH) intracellular signaling. To ev...

journal_title：International journal of endocrinology

authors： Boparai RK,Arum O,Miquet JG,Masternak MM,Bartke A,Khardori RK

更新日期：2015-01-01 00:00:00

abstract：:The goal of this study was to determine the prevalence and associated risk factors of impaired glucose regulation (IGR) in the population of Tongzhou, China, and to provide scientific basis for preventive interventions. In the study, the overall age-standardized prevalence of IGR (16.0%) in Tongzhou residents was high...

journal_title：International journal of endocrinology

authors： Zhao D,Wu N,Yang J,Liu S,Zhang N,Wang X,Zhang H

更新日期：2015-01-01 00:00:00

abstract：Aim:To clarify the contributions of fasting glucose (FG) and postprandial glucose (PG) to HbA1c in drug-naïve patients with type 2 diabetes (T2D) and impaired glucose tolerate (IGT)/impaired fasting glucose (IFG). Methods:Continuous glucose monitoring (CGM) was performed in 305 drug-naïve Chinese patients with T2D or ...

journal_title：International journal of endocrinology

authors： Yan R,Hu Y,Li F,Jiang L,Xu X,Wang J,Zhang Y,Ye L,Lee KO,Su X,Ma J

更新日期：2019-12-01 00:00:00

abstract：:Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes. Here we revie...

journal_title：International journal of endocrinology

authors： Kanak MA,Takita M,Kunnathodi F,Lawrence MC,Levy MF,Naziruddin B

更新日期：2014-01-01 00:00:00

abstract：:Aim. Our aim was (1) to determine the frequency of insulin resistance (IR) in patients with Duchenne/Becker muscular dystrophy (DMD/BMD), (2) to identify deleted exons of DMD gene associated with obesity and IR, and (3) to explore some likely molecular mechanisms leading to IR. Materials and Methods. In 66 patients wi...

journal_title：International journal of endocrinology

authors： Rodríguez-Cruz M,Sanchez R,Escobar RE,Cruz-Guzmán Odel R,López-Alarcón M,Bernabe García M,Coral-Vázquez R,Matute G,Velázquez Wong AC

更新日期：2015-01-01 00:00:00

abstract：:The 5-alpha-reductase type 2 deficiency (5ARD2) is an autosomal recessive condition associated with impairment in the conversion of testosterone to dihydrotestosterone. This condition leads to undervirilisation in 46,XY individuals. To date, there have been more than 100 variations identified in the gene responsible f...

journal_title：International journal of endocrinology

authors： Marzuki NS,Idris FP,Kartapradja HD,Harahap AR,Batubara JRL

更新日期：2019-12-01 00:00:00

abstract：:Obesity is a growing problem in modern society and medicine. It closely associates with metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and cardiovascular diseases such as nonalcoholic fatty liver disease, atherosclerosis, myocarditis, and hypertension. Obesity is often associated with latent i...

journal_title：International journal of endocrinology

authors： Stafeev IS,Vorotnikov AV,Ratner EI,Menshikov MY,Parfyonova YV

更新日期：2017-01-01 00:00:00

abstract：Objective:Type 2 diabetes (T2DM) is a global epidemic and increases mortality due to its vascular complications. Chemerin has been found to exert a major role in glucose and lipid metabolism. The aim of this study was to explore the correlation between plasma chemerin levels and microangiopathy in patients with T2DM. ...

journal_title：International journal of endocrinology

authors： Gu P,Wang W,Yao Y,Xu Y,Wang L,Zang P,Ma J,Yang C,Liang J,Lu B,Shao J

更新日期：2019-07-16 00:00:00

abstract：:Background. Papillary thyroid cancer (PTC) exhibits a higher incidence in women. Due to various ages at menarche and menopause, estrogen levels vary, which may account for the differences in the occurrence, development, and prognosis of female patients with PTC. Objective. The aim of this study was to investigate the ...

journal_title：International journal of endocrinology

authors： Zhu X,Yu B,Huang YQ,Zhou JN,Ge MH

更新日期：2017-01-01 00:00:00

abstract：:Objective. To determine the role of imaging-cytology correlation in reducing false negative results of fine-needle aspiration (FNA) at thyroid nodules. Methods. This retrospective study included 667 nodules 1 cm or larger in 649 patients diagnosed as benign at initial cytologic evaluation and that underwent follow-up ...

journal_title：International journal of endocrinology

authors： Hwang SH,Sung JM,Kim EK,Moon HJ,Kwak JY

更新日期：2014-01-01 00:00:00

abstract：Background:Gonadal injury following chemotherapy is of increasing importance with the continuous improvement of survival rates. The protection of gonadotropin hormone antagonist (GnRHant) in long-term adult survivors of adolescent cancers and some autoimmune diseases has not yet been evaluated. Methods:The present stu...

journal_title：International journal of endocrinology

authors： Xie R,Chen L,Wu H,Chen T,Wang F,Chen X,Sun H,Li X

更新日期：2018-06-10 00:00:00

abstract：:With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through infl...

journal_title：International journal of endocrinology

authors： Xiong Q,Liu J,Xu Y

更新日期：2019-10-13 00:00:00

abstract：:Plasma FGF-23 concentrations and its relationship with calcium-phosphate homeostasis were evaluated in 48 perimenopausal obese women and in 29 nonobese controls. Serum parathyroid hormone, 25-hydroxyvitamin D(3), CTX1, osteocalcin, total calcium, phosphorus, creatinine, and plasma intact FGF-23 concentrations were ass...

journal_title：International journal of endocrinology

authors： Holecki M,Chudek J,Więcek A,Titz-Bober M,Duława J

更新日期：2011-01-01 00:00:00

abstract：Background:gp91phox, the catalytic core of NADPH oxidase (NOX) and biomarker of NOX activation, has been recently recognized as a parameter of systemic oxidative stress in several studies. Subclinical hypothyroidism (SH) is characteristic of elevated level of serum thyroid stimulating hormone (TSH) and is frequently ac...

journal_title：International journal of endocrinology

authors： Ma X,Wang F,Zhen X,Zhao L,Fang L,Dong Z,Chen W,Zhou X

更新日期：2020-05-06 00:00:00

abstract：Aims:The present study assessed the therapeutic effect of exenatide and metformin as the initial therapy on overweight/obese patients with newly diagnosed type 2 diabetes (T2D). Methods:The prospective, nonrandomized, interventional study enrolled a total of 230 overweight or obese patients with newly diagnosed T2D wh...

journal_title：International journal of endocrinology

authors： Liu J,Hu Y,Xu Y,Jia Y,Miao L,Wang G

更新日期：2017-01-01 00:00:00

abstract：:Aim. To compare two creatinine-based estimated glomerular filtration rate (eGFR) equations, the chronic kidney disease epidemiology collaboration (CKD-EPI) and the modification of diet in renal disease (MDRD), for predicting the risk of CKD progression in type 2 diabetic patients with nephropathy. Methods. A total of ...

journal_title：International journal of endocrinology

authors： Lee EY,Lee YM,Choi KH,Lee HC,Lee BW,Kim BS

更新日期：2013-01-01 00:00:00

abstract：:Low birth weight is associated with reduced bone mass and density in adult life. However, effects of maternal hypoxia (MH) on offspring bone development are not known. Objective. The current study investigated the effects of fetal growth restriction induced by MH during the last half of gestation on bone structure and...

journal_title：International journal of endocrinology

authors： Lee AM,Morrison JL,Botting KJ,Shandala T,Xian CJ

更新日期：2014-01-01 00:00:00