Abstract:
:Oxidized low density lipoprotein (ox-LDL) is a product of oxidative stress. In this cross-sectional study, we compared the ox-LDL concentrations in diabetic patients with normoalbuminuria (n = 28), microalbuminuria (n = 28), and macroalbuminuria (n = 28) with their first degree relatives (n = 28) and healthy control people (n = 31). They were selected by consecutive patient selection method. The ox-LDL level was assayed using ELISA. We measured blood pressure, lipid profile, fasting plasma glucose (FPG), and HbA1c in all groups. There was no significant difference in ox-LDL concentrations among normoalbuminuric, microalbuminuric, and macroalbuminuric diabetic groups. In diabetic patients with micro- and macroalbuminuria, ox-LDL concentration was higher than their first degree relatives (P = 0.04 and P = 0.03) and control group (P = 0.001 and P = 0.03, resp.). In normoalbuminuric diabetic persons, ox-LDL concentration was just higher than that of healthy people (P = 0.02). There was no statistically significant difference in ox-LDL levels between normoalbuminuric diabetic patients and their first degree relatives. In conclusion, the presence and progression of albuminuria in diabetic patients are not related to ox-LDL concentration and genetic predisposition influences the plasma OX-LDL level. Larger sample size is needed to confirm this conclusion in future studies.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Behzadi P,Torabi F,Amini M,Aminorroaya Adoi
10.1155/2012/167154subject
Has Abstractpub_date
2012-01-01 00:00:00pages
167154eissn
1687-8337issn
1687-8345journal_volume
2012pub_type
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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