Abstract:
:Objective. To determine the role of imaging-cytology correlation in reducing false negative results of fine-needle aspiration (FNA) at thyroid nodules. Methods. This retrospective study included 667 nodules 1 cm or larger in 649 patients diagnosed as benign at initial cytologic evaluation and that underwent follow-up ultrasound (US) or FNA following a radiologist's opinion on concordance between imaging and cytologic results. We compared the risk of malignancy of nodules classified into subgroups according to the initial US features and imaging-cytology correlation. Results. Among included nodules, 11 nodules were proven to be malignant (1.6%) in follow-up FNA or surgery. The malignancy rate was higher in nodules with suspicious US features (11.4%) than in nodules without suspicious US features (0.5%, P < 0.001). When a thyroid nodule had discordant US findings on image review after having benign FNA results, malignancy rate increased to 23.3%, significantly higher than that of nodules with suspicious US features (P < 0.001). However, no significant difference was found in the risk of malignancy between the nodules without suspicious US features (0.5%) and imaging-cytology concordant nodules (0.6%, P = 0.438). Conclusions. Repeat FNA can be effectively limited to patients with cytologically benign thyroid nodules showing discordance in imaging-cytology correlation after initial biopsy, which reduces unnecessary repeat aspirations.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Hwang SH,Sung JM,Kim EK,Moon HJ,Kwak JYdoi
10.1155/2014/491508subject
Has Abstractpub_date
2014-01-01 00:00:00pages
491508eissn
1687-8337issn
1687-8345journal_volume
2014pub_type
杂志文章abstract::Background. The Japan Thyroid Association recently published guidelines for clinical practice for the management of thyroid nodules, which include a diagnostic system for reporting thyroid fine needle aspiration cytology. It is characterized by the subclassification of follicular neoplasms, which is different from oth...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/938305
更新日期:2015-01-01 00:00:00
abstract::The circadian system is a supraphysiological system that modulates different biological functions such as metabolism, sleep-wake, cellular proliferation, and body temperature. Different chronodisruptors have been identified, such as shift work, feeding time, long days, and stress. The environmental changes and our mod...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2016/2746909
更新日期:2016-01-01 00:00:00
abstract::Objective. In pediatric central diabetes insipidus (CDI), etiology diagnosis and pituitary function monitoring are usually delayed. This study aimed to illustrate the importance of regular follow-up and pituitary function monitoring in pediatric CDI. Methods. The clinical, hormonal, and neuroradiological characteristi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/6365830
更新日期:2016-01-01 00:00:00
abstract::Objectives. The roles of PI3K/AKT/mTOR and MAPK/ERK pathways involved in the pathogenesis of pheochromocytoma and paraganglioma (PPGL) were demonstrated mostly by in vitro studies with rat or mouse cells and were mainly studied at transcriptional level. This study aimed to investigate the effect of these pathways on t...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/5286972
更新日期:2016-01-01 00:00:00
abstract::Objective. To analyze changes in vital signs (heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP)) during and after intravenous methylprednisolone (IVMP) and any other adverse effects. Methods. Retrospective review of charts of patients who received IVMP as treatment regime for thyroid eye disease. All...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/457123
更新日期:2015-01-01 00:00:00
abstract::There is inconsistency among published guidelines for the optimal diagnostic and management pathways for patients with typical (TC) or atypical (AC) pulmonary carcinoid tumours. We conducted a UK-wide clinician survey to assess current practice for the diagnosis, management, and follow-up of patients with TC/AC and de...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/9287536
更新日期:2020-02-28 00:00:00
abstract::Type 2 diabetes is characterized by frequent ectopic fat accumulation in several tissues and organs. In particular, a number of studies showed that these subjects frequently have hepatic fat accumulation, which may play a role in the metabolic abnormalities typical of diabetes and has been also linked to increased ris...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2013/309191
更新日期:2013-01-01 00:00:00
abstract::Vascular calcification and bone fragility are common and interrelated health problems that affect chronic kidney disease (CKD) patients. Bone fragility, which leads to higher risk of fracture and mortality, arises from the abnormal bone remodeling and mineralization that are seen in chronic kidney disease. Recently, s...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/5893514
更新日期:2018-04-02 00:00:00
abstract::Objective. To examine the association of three most common obesity measures including body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) with chronic kidney disease (CKD) risk in patients with type 2 diabetes mellitus (T2D). Design. Cross-sectional evaluation of the effect of anthropometric ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/715871
更新日期:2015-01-01 00:00:00
abstract::Present therapies to minify hyperglycaemia and insulin resistance mainly target ATP-sensitive K(+) channels (K(ATP)) of pancreatic cells and PPAR-γ to enhance the insulin secretion and potential for GLUT expression, respectively. These current approaches are frequently associated with the various side effects such as ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2011/530274
更新日期:2011-01-01 00:00:00
abstract::The aim of this study is to evaluate carotid atherosclerosis in patients of type 2 diabetes mellitus with microalbuminuria (MA) by high-frequency ultrasonography. Two hundred and fifty patients of type 2 diabetes mellitus were divided into two groups according to urinary albumin excretion rate (UAER): normoalbuminuria...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/819584
更新日期:2013-01-01 00:00:00
abstract::The chemosensitivity of anaplastic thyroid cancer (ATC) to some cytotoxic agents was investigated by the histoculture drug response assay (HDRA). Thirty specimens from 22 patients with ATC were obtained from surgically resected subjects. The drugs tested were paclitaxel (PTX), docetaxel (DOC), adriamycin (ADM), nedapl...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/967286
更新日期:2015-01-01 00:00:00
abstract::The BRAF(V600E) mutation is commonly found in papillary thyroid cancers (PTCs) at different frequencies in different regions. However, the association between the BRAF(V600E) mutation and clinicopathological features in Chinese PTC patients is unknown. A total of 543 Chinese patients with histologically confirmed PTC ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/642046
更新日期:2015-01-01 00:00:00
abstract::The aim of this study is to investigate the circulating OPG levels in postmenopausal women with diabetes and prediabetes and explore the relationships between serum OPG and insulin resistance. A total of 271 unrelated Chinese postmenopausal women were recruited in this study. The subjects were divided into type 2 diab...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2017/8724869
更新日期:2017-01-01 00:00:00
abstract::Thyroid cancer is the most common endocrine malignancy, and its incidence has increased rapidly in recent decades worldwide. Papillary thyroid cancer (PTC) is the most common type of all thyroid cancers. The molecular mechanisms underlying the disease still need to be further investigated. Long noncoding RNAs (lncRNAs...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/7043509
更新日期:2019-04-07 00:00:00
abstract::Parathyroid glands contain the vitamin D receptor (VDR) and 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24A1), which catalyze the production and degradation of 1,25-dihydroxyvitamin D [1,25(OH)2D], respectively. Previous studies have shown that the serum level of intact parathyroid hormone (iPT...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/7257913
更新日期:2020-04-09 00:00:00
abstract:Objective:To evaluate the impact of preconceptional serum TSH levels on the clinical outcomes of infertile patients undergoing their first IUI treatment cycle. Method:This was a retrospective study. Euthyroid patients undergoing the first cycle of IUI treatment from Jan 2017 to Aug 2018 were included. The patients wer...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/8492904
更新日期:2019-12-18 00:00:00
abstract::Background. Reduced testicular volume (TV) (<12 cm(3)) is associated with lower testicular function. Several studies explored the conventional sperm parameters (concentration, motility, and morphology) and the endocrine function (gonadotropins and testosterone serum concentrations) in the patients with reduction of TV...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/145792
更新日期:2013-01-01 00:00:00
abstract::A considerable increase in endocrine abnormalities has been reported over the last few decades worldwide. A growing exposure to endocrine-disrupting chemicals (EDCs) can be one of the causes of endocrine disorders in populations, and these disorders are not only restricted to the metabolic hormone system but can also ...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2019/7396716
更新日期:2019-04-17 00:00:00
abstract::Background. Separate lines of research have shown that menstrual cycling and contextual factors such as the gender of research personnel influence experimental pain reporting. Objectives. This study examines how brief, procedural interactions with female and male experimenters can affect experimentally reported pain (...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/520719
更新日期:2015-01-01 00:00:00
abstract::Aim. Our aim was (1) to determine the frequency of insulin resistance (IR) in patients with Duchenne/Becker muscular dystrophy (DMD/BMD), (2) to identify deleted exons of DMD gene associated with obesity and IR, and (3) to explore some likely molecular mechanisms leading to IR. Materials and Methods. In 66 patients wi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/867273
更新日期:2015-01-01 00:00:00
abstract::Plasma FGF-23 concentrations and its relationship with calcium-phosphate homeostasis were evaluated in 48 perimenopausal obese women and in 29 nonobese controls. Serum parathyroid hormone, 25-hydroxyvitamin D(3), CTX1, osteocalcin, total calcium, phosphorus, creatinine, and plasma intact FGF-23 concentrations were ass...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2011/707126
更新日期:2011-01-01 00:00:00
abstract::Background. Hyperinsulinaemic Hypoglycaemia (HH) is the most common cause of severe and persistent hypoglycemia in the neonatal period. It has been shown that the neonates with HH fail to generate adequate serum cortisol counterregulatory response to symptomatic hypoglycemia. However the role played by growth hormone ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/638257
更新日期:2013-01-01 00:00:00
abstract::To examine the gene expression of ghrelin, a growth hormone releasing and appetite stimulating hormone from stomach, we constructed human ghrelin promoter-reporter vectors and analyzed the promoter activity. The ghrelin promoter activity was high when cultured cells that express ghrelin mRNA endogenously like TT or EC...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/580908
更新日期:2015-01-01 00:00:00
abstract:Objective:To evaluate the effectiveness and safety of coenzyme Q10 for patients with type 2 diabetes mellitus (T2DM). Methods:Data from randomized controlled trials were obtained to assess the effects of coenzyme Q10 versus placebo or western medicine on patients with T2DM. The study's registration number is CRD420180...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/6484839
更新日期:2018-09-16 00:00:00
abstract::Background. Oxidative stress induced by reactive oxygen and nitrogen species is critically involved in the impairment of β -cell function during the development of diabetes. Methods. HIT-T15 cells were cultured in 5% CO2 and then preincubated with Gelam honey extracts (20, 40, 60, and 80 µg/mL) as well as quercetin (2...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/367312
更新日期:2013-01-01 00:00:00
abstract::The hypothalamus is an essential relay in the neural circuitry underlying energy metabolism that needs to continually adapt to changes in the energetic environment. The neuroendocrine control of food intake and energy expenditure is associated with, and likely dependent upon, hypothalamic plasticity. Severe disturbanc...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/732975
更新日期:2012-01-01 00:00:00
abstract:Objective:Once-weekly PEGylated recombinant human growth hormone (rhGH) is the sole long-acting GH formulation available currently for pediatric patients with GH deficiency (GHD). The aim of this study was to evaluate the efficacy and safety of PEGylated rhGH therapy compared to daily rhGH therapy in GHD children treat...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/1438723
更新日期:2019-09-19 00:00:00
abstract::Type 2 diabetes mellitus (T2D) is a disorder of glucose metabolism. It is a complex process involving the regulation of insulin secretion, insulin sensitivity, gluconeogenesis, and glucose uptake at the cellular level. Diabetic peripheral neuropathy (DPN) is one of the debilitating complications that is present in app...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/8641942
更新日期:2018-03-15 00:00:00
abstract:Objective:The aim of the present study was to investigate the association between dietary patterns and precocious puberty among Shanghai children. Methods:A cross-sectional study was conducted among Shanghai children by multistage stratified cluster random sampling in June 2014. Diet was assessed using a simplified fo...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/4528704
更新日期:2018-01-16 00:00:00