Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus.

abstract：:Stevia rebaudiana (Bert.) Bertoni besides being a source of noncaloric sweeteners is also an important source of bioactive molecules. Many plant extracts, mostly obtained with ethyl acetate solvent, are rich in polyphenol compounds that present insulinotropic effects. To investigate whether the nonsweetener fraction, ...

journal_title：International journal of endocrinology

authors： Piovan S,Pavanello A,Peixoto GML,Matiusso CCI,de Moraes AMP,Martins IP,Malta A,Palma-Rigo K,da Silva Franco CC,Milani PG,Dacome AS,da Costa SC,de Freitas Mathias PC,Mareze-Costa CE

更新日期：2018-04-29 00:00:00

abstract：:Objective. To analyze changes in vital signs (heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP)) during and after intravenous methylprednisolone (IVMP) and any other adverse effects. Methods. Retrospective review of charts of patients who received IVMP as treatment regime for thyroid eye disease. All...

journal_title：International journal of endocrinology

authors： Yong KL,Chng CL,Htoon HM,Lim LH,Seah LL

更新日期：2015-01-01 00:00:00

abstract：:Enucleation-induced adrenal regeneration is a highly controlled process; however, only some elements involved in this process have been recognized. Therefore, we performed studies on regenerating rat adrenals. Microarray RNA analysis and QPCR revealed that enucleation resulted in a rapid elevation of expression of gen...

journal_title：International journal of endocrinology

authors： Tyczewska M,Rucinski M,Ziolkowska A,Szyszka M,Trejter M,Hochol-Molenda A,Nowak KW,Malendowicz LK

更新日期：2014-01-01 00:00:00

abstract：:Type 2 diabetes and depression are regarded as comorbid conditions, and three possible directions of the association between the diseases can underlie this observation of comorbidity. First, common etiology can increase a person's risk of both diseases; second, persons with type 2 diabetes have increased prevalence or...

journal_title：International journal of endocrinology

authors： Berge LI,Riise T

更新日期：2015-01-01 00:00:00

abstract：:Background. Management of thyroid nodules with benign aspirates following atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is not well established. We reviewed the risk of malignancy and the role of ultrasound (US) features among thyroid nodules with benign results followin...

journal_title：International journal of endocrinology

authors： Kim GR,Yoon JH,Kim EK,Moon HJ,Kwak JY

更新日期：2014-01-01 00:00:00

abstract：:Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the c...

journal_title：International journal of endocrinology

authors： Carrion AF,Czul F,Arosemena LR,Selvaggi G,Garcia MT,Tekin A,Tzakis AG,Martin P,Ghanta RK

更新日期：2010-01-01 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) modulates a diverse range of biological functions, including glucose and lipid metabolism, adaptive starvation response, and energy homeostasis, but with limited mechanistic insight. FGF21 treatment has been shown to inhibit hepatic growth hormone (GH) intracellular signaling. To ev...

journal_title：International journal of endocrinology

authors： Boparai RK,Arum O,Miquet JG,Masternak MM,Bartke A,Khardori RK

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Evidence on the association between subclinical thyroid dysfunction and the risk of cardiovascular outcomes are conflicting. METHODS AND RESULTS:PubMed, EMbase, Web of Science, Cochrane Library, and China Biology Medicine (CBM) databases were searched from inception to July 10, 2016. A total of 16 studies w...

journal_title：International journal of endocrinology

authors： Sun J,Yao L,Fang Y,Yang R,Chen Y,Yang K,Tian L

更新日期：2017-01-01 00:00:00

abstract：:Whether serum magnesium deficiency is independently associated with the prevalence of microalbuminuria is still unclear. The objective of the present study was to elucidate the association between serum magnesium and microalbuminuria in diabetic patients. A cross-sectional study was conducted in 1829 diabetic subjects...

journal_title：International journal of endocrinology

authors： Xu B,Sun J,Deng X,Huang X,Sun W,Xu Y,Xu M,Lu J,Bi Y

更新日期：2013-01-01 00:00:00

abstract：:Parathyroid glands contain the vitamin D receptor (VDR) and 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24A1), which catalyze the production and degradation of 1,25-dihydroxyvitamin D [1,25(OH)2D], respectively. Previous studies have shown that the serum level of intact parathyroid hormone (iPT...

journal_title：International journal of endocrinology

authors： Jiang Y,Liao L,Li J,Wang L,Xie Z

更新日期：2020-04-09 00:00:00

abstract：:The study aimed at assessing the potential use of lower total and HMW adiponectin levels for predicting cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Concentrations of total adiponectin or high molecular weight (HMW) adiponectin decrease in association with the development of metabolic dysfunct...

journal_title：International journal of endocrinology

authors： Horáková D,Azeem K,Benešová R,Pastucha D,Horák V,Dumbrovská L,Martínek A,Novotný D,Švagera Z,Hobzová M,Galuszková D,Janout V,Doněvská S,Vrbková J,Kollárová H

更新日期：2015-01-01 00:00:00

abstract：:The increased prevalence of obesity represents, currently, one of the major public health issues, due to its consequences on physical and psychological health status as well as on the psychosocial functioning. As defined by the World Health Organization, sexual health is "a state of physical, emotional, mental, and so...

journal_title：International journal of endocrinology

authors： Poggiogalle E,Di Lazzaro L,Pinto A,Migliaccio S,Lenzi A,Donini LM

更新日期：2014-01-01 00:00:00

abstract：:The liver is one of the most essential organs involved in the regulation of energy homeostasis. Hepatic steatosis, a major manifestation of metabolic syndrome, is associated with imbalance between lipid formation and breakdown, glucose production and catabolism, and cholesterol synthesis and secretion. Epidemiological...

journal_title：International journal of endocrinology

authors： Shen M,Shi H

更新日期：2015-01-01 00:00:00

abstract：:The complementary role of hyperglycemia and p27(kip1) suppression on islet beta cell regeneration was investigated in a syngeneic mouse model. p27(kip1) gene silencing was performed by infecting islets of C57BL/6 with shRNA lentiviral particles. At 54 hours after viral infection, p27(kip1) protein content in cultured ...

journal_title：International journal of endocrinology

authors： Chen ST,Fu SH,Hsu S,Huang YY,Hsu BR

更新日期：2012-01-01 00:00:00

abstract：:Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is an autosomal dominant disorder characterized by parathyroid tumors in association with fibro-osseous jaw tumors and uterine and renal lesions. HPT-JT syndrome is caused by germline mutations of the cell division cycle 73 (CDC73) gene that encodes the parafibromin, a 5...

journal_title：International journal of endocrinology

authors： Torresan F,Iacobone M

更新日期：2019-12-18 00:00:00

abstract：:We investigated the role of urokinase plasminogen activator (uPA) and its soluble receptors (suPAR) and plasminogen activator inhibitor-1 (PAI-1) in metabolic syndrome (MetS) components, insulin secretion, and resistance in schoolchildren. We enrolled 387 children, aged 10.3 ± 1.5 years, in Taipei. Anthropometry, fibr...

journal_title：International journal of endocrinology

authors： Chen JS,Wu CZ,Chu NF,Chang LC,Pei D,Lin YF

更新日期：2015-01-01 00:00:00

abstract：:A quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism. Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis. We conducted a randomiz...

journal_title：International journal of endocrinology

authors： Dhindsa S,Chemitiganti R,Ghanim H,Santiago E,Haider A,Chaar N,Mok M,McKee A,Dandona P

更新日期：2018-10-31 00:00:00

abstract：Objective:To identify the clinicopathological features correlated to lymph node metastasis (LNM) in patients with papillary thyroid microcarcinoma (PTMC). Methods:Clinical data of 785 PTMC patients who underwent surgical treatment at the Lishui Municipal Central Hospital from September 2008 to December 2017 were retro...

journal_title：International journal of endocrinology

authors： Cheng F,Chen Y,Zhu L,Zhou B,Xu Y,Chen Y,Wen L,Chen S

更新日期：2019-01-15 00:00:00

abstract：:Oxidized low density lipoprotein (ox-LDL) is a product of oxidative stress. In this cross-sectional study, we compared the ox-LDL concentrations in diabetic patients with normoalbuminuria (n = 28), microalbuminuria (n = 28), and macroalbuminuria (n = 28) with their first degree relatives (n = 28) and healthy control p...

journal_title：International journal of endocrinology

authors： Behzadi P,Torabi F,Amini M,Aminorroaya A

更新日期：2012-01-01 00:00:00

abstract：:Insulin resistance increases the risk for cardiovascular disease (CVD) even in the absence of classic risk factors, such as hyperglycemia, hypertension, dyslipidemia, and obesity. Low-grade chronic inflammatory state is associated both with insulin resistance and atherosclerosis. An increased circulating level of proi...

journal_title：International journal of endocrinology

authors： Nikołajuk A,Matulewicz N,Stefanowicz M,Karczewska-Kupczewska M

更新日期：2018-09-13 00:00:00

abstract：:Thyroid cancer is the most common endocrine malignancy, and its incidence has increased rapidly in recent decades worldwide. Papillary thyroid cancer (PTC) is the most common type of all thyroid cancers. The molecular mechanisms underlying the disease still need to be further investigated. Long noncoding RNAs (lncRNAs...

journal_title：International journal of endocrinology

authors： Choy M,Guo Y,Li H,Wei G,Ye R,Liang W,Xiao H,Li Y,Guan H

更新日期：2019-04-07 00:00:00

abstract：:Background. Abdominal obesity and its relative distribution are known to differ in association with metabolic characteristics and cardiorespiratory fitness. This study aimed to determine an association between fitness level and abdominal adiposity in overweight and obese adults. Methods. 228 overweight and obese indiv...

journal_title：International journal of endocrinology

authors： Kim S,Kim JY,Lee DC,Lee HS,Lee JW,Jeon JY

更新日期：2014-01-01 00:00:00

abstract：:X-linked Adrenal Hypoplasia Congenita (AHC) is caused by deletions or point mutations in the NR0B1 (DAX1) gene. We present a boy with AHC who came at the age of 25 days in a severe state due to prolonged vomiting and progressive dehydration. Laboratory studies showed prominent hyponatremia and hyperkaliemia but not hy...

journal_title：International journal of endocrinology

authors： Rojek A,Krawczynski MR,Jamsheer A,Sowinska-Seidler A,Iwaniszewska B,Malunowicz E,Niedziela M

更新日期：2016-01-01 00:00:00

abstract：:Aim. To examine the relationship between plasma 25-hydroxyvitamin D (25(OH)D) levels and blood hemoglobin A1c (HbA1c) levels in diabetic patients at various stages of chronic kidney disease (CKD). Methods. We screened for data collected between 2003 and 2012. The correlation between 25(OH)D and HbA1c levels was studie...

journal_title：International journal of endocrinology

authors： Kajbaf F,Mentaverri R,Diouf M,Fournier A,Kamel S,Lalau JD

更新日期：2014-01-01 00:00:00

abstract：:Type 2 diabetes is characterized by frequent ectopic fat accumulation in several tissues and organs. In particular, a number of studies showed that these subjects frequently have hepatic fat accumulation, which may play a role in the metabolic abnormalities typical of diabetes and has been also linked to increased ris...

journal_title：International journal of endocrinology

authors： Bacchi E,Moghetti P

更新日期：2013-01-01 00:00:00

abstract：Objective:Neuroendocrine neoplasias (NENs) represent a rare and biologically heterogeneous group of malignancies. Treatment of NEN patients remains challenging due to lack of prospective evidence on the choice of ideal therapeutic sequence and therapeutic efficacy in specific individual scenarios. Methods:Clinical dat...

journal_title：International journal of endocrinology

authors： Mayer K,Kiry S,Yordanova A,Ahmadzadehfar H,Gaertner FC,Bundschuh RA,Essler M,Gonzalez-Carmona MA,Strassburg CP,Matthaei H,Lingohr P,Bisht S,Brossart P,Feldmann G

更新日期：2020-01-31 00:00:00

abstract：:Thyroid nodules, with their high prevalence in the general population, represent a diagnostic challenge for clinicians. Ultrasound (US), although absolutely reliable in detecting thyroid nodules, is still not accurate enough to differentiate them into benign and malignant. A promising novel modality, US elastography, ...

journal_title：International journal of endocrinology

authors： Cantisani V,Grazhdani H,Drakonaki E,D'Andrea V,Di Segni M,Kaleshi E,Calliada F,Catalano C,Redler A,Brunese L,Drudi FM,Fumarola A,Carbotta G,Frattaroli F,Di Leo N,Ciccariello M,Caratozzolo M,D'Ambrosio F

更新日期：2015-01-01 00:00:00

abstract：:Gestational diabetes mellitus (GDM) is defined as any degree of carbohydrate intolerance, with onset or first recognition during second or third trimester of gestation. It is estimated that approximately 7% of all pregnancies are complicated by GDM and that its prevalence is rising all over the world. Thus, the screen...

journal_title：International journal of endocrinology

authors： Guarino E,Delli Poggi C,Grieco GE,Cenci V,Ceccarelli E,Crisci I,Sebastiani G,Dotta F

更新日期：2018-04-12 00:00:00

abstract：:Background. Pediatric CAH patients have an increased risk of cardiovascular disease, and it remains unknown if genetic predisposition is a contributing factor. Glucocorticoid receptor gene (NR3C1) polymorphisms are associated with an adverse metabolic profile. Our aim was to analyze the association between the NR3C1 p...

journal_title：International journal of endocrinology

authors： Moreira RP,Gomes LG,Madureira G,Mendonca BB,Bachega TA

更新日期：2014-01-01 00:00:00

abstract：Background:Insulin promotes glucose consumption as the main cardiac energy source, while increasing myocardial efficiency. The short-term effects of insulin on cardiac function and its potential curative role in an acute diabetological cardiology setting remain unknown. Our study evaluated the role of acute insulin adm...

journal_title：International journal of endocrinology

authors： Daoud Naccache D,Yalonetsky S,Bar-Yoseph R

更新日期：2020-03-17 00:00:00