Abstract:
:Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the clinical presentation, histological characteristics, and posttransplant management are described as well as alternative therapeutic options. Frequent monitoring for PTU-induced hepatic dysfunction is strongly advised because timely discontinuation of this drug and implementation of noninvasive therapeutic interventions may prevent progression to liver failure or even death.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Carrion AF,Czul F,Arosemena LR,Selvaggi G,Garcia MT,Tekin A,Tzakis AG,Martin P,Ghanta RKdoi
10.1155/2010/910636subject
Has Abstractpub_date
2010-01-01 00:00:00pages
910636eissn
1687-8337issn
1687-8345journal_volume
2010pub_type
abstract::Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer. It shows a wide spectrum of morphological presentations and the diagnosis could be challenging due to its high degree of dedifferentiation. Molecular and genetic features of ATC are widely heterogeneous as well and many efforts have been...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/790834
更新日期:2014-01-01 00:00:00
abstract::Insulin resistance increases the risk for cardiovascular disease (CVD) even in the absence of classic risk factors, such as hyperglycemia, hypertension, dyslipidemia, and obesity. Low-grade chronic inflammatory state is associated both with insulin resistance and atherosclerosis. An increased circulating level of proi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/3470412
更新日期:2018-09-13 00:00:00
abstract::Introduction. Differentiated thyroid cancer treatment usually consists of thyroidectomy and radio ablation in hypothyroidism 4-6 weeks after surgery. Replacing hypothyroidism by recombinant human thyroid stimulating hormone can facilitate radio ablation in euthyroidism within one week after surgery. The outcome of thi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/769473
更新日期:2013-01-01 00:00:00
abstract::Melatonin (N-acetyl-5-methoxytryptamine) is a hormone synthesized and secreted by the pineal gland mainly during the night, since light exposure suppresses its production. Initially, an implication of this indoleamine in malignant disease was described in endocrine-responsive breast cancer. Data from several clinical ...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/3271948
更新日期:2018-10-02 00:00:00
abstract::Point-of-care (POC) glucose technology is currently considered to be insufficiently accurate for the diagnosis of diabetes. The objective of this study was to investigate the diagnostic accuracy of an innovative, interference-resistant POC glucose meter (StatStrip glucose hospital meter, Nova Biomedical, USA) in subje...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/206309
更新日期:2013-01-01 00:00:00
abstract::Aim. Our aim was (1) to determine the frequency of insulin resistance (IR) in patients with Duchenne/Becker muscular dystrophy (DMD/BMD), (2) to identify deleted exons of DMD gene associated with obesity and IR, and (3) to explore some likely molecular mechanisms leading to IR. Materials and Methods. In 66 patients wi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/867273
更新日期:2015-01-01 00:00:00
abstract::The study aimed at assessing the potential use of lower total and HMW adiponectin levels for predicting cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Concentrations of total adiponectin or high molecular weight (HMW) adiponectin decrease in association with the development of metabolic dysfunct...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/545068
更新日期:2015-01-01 00:00:00
abstract::Objective. To determine the role of imaging-cytology correlation in reducing false negative results of fine-needle aspiration (FNA) at thyroid nodules. Methods. This retrospective study included 667 nodules 1 cm or larger in 649 patients diagnosed as benign at initial cytologic evaluation and that underwent follow-up ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/491508
更新日期:2014-01-01 00:00:00
abstract::To elucidate whether adrenergic overtone is involved in the pathophysiology of men with lifelong (LL) premature ejaculation (PE), we investigated differences in reactive hyperemia index (RHI) responses by using peripheral arterial tonometry (PAT). 20 men with LL-PE (18-40 years) were enrolled in an 8-week, double-blin...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/394934
更新日期:2013-01-01 00:00:00
abstract::Parathyroid glands contain the vitamin D receptor (VDR) and 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24A1), which catalyze the production and degradation of 1,25-dihydroxyvitamin D [1,25(OH)2D], respectively. Previous studies have shown that the serum level of intact parathyroid hormone (iPT...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/7257913
更新日期:2020-04-09 00:00:00
abstract::With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through infl...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2019/9691345
更新日期:2019-10-13 00:00:00
abstract::Aim. To examine the relationship between plasma 25-hydroxyvitamin D (25(OH)D) levels and blood hemoglobin A1c (HbA1c) levels in diabetic patients at various stages of chronic kidney disease (CKD). Methods. We screened for data collected between 2003 and 2012. The correlation between 25(OH)D and HbA1c levels was studie...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/142468
更新日期:2014-01-01 00:00:00
abstract:Objective:To evaluate the impact of preconceptional serum TSH levels on the clinical outcomes of infertile patients undergoing their first IUI treatment cycle. Method:This was a retrospective study. Euthyroid patients undergoing the first cycle of IUI treatment from Jan 2017 to Aug 2018 were included. The patients wer...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/8492904
更新日期:2019-12-18 00:00:00
abstract::Neurofibromatosis type 1 (NF1) patients are more likely to have vitamin D deficiency when compared to the general population. This study aimed to determine the levels of 25-OH-vitamin D [25(OH)D] in individuals with NF1 and disease-unaffected controls and analyze FokI and BsmI VDR gene polymorphisms in a case and in a...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/402838
更新日期:2015-01-01 00:00:00
abstract::Aims. To seek high risk population for diabetes and to improve their health care by investigating the characteristics and outcome of hospitalization in hospitals with predominant Arab patients in Northern Israel. Methods. Retrospective analysis of the prevalence of diabetes and the outcome of diabetic in comparison to...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/371608
更新日期:2013-01-01 00:00:00
abstract::Estroprogestins (EPs) are combinations of estrogen and progestin with several actions on women's health. The different pharmacological composition of EPs is responsible for different clinical effects. One of the most used low-dose EP associations is ethinylestradiol 20 mcg plus levonorgestrel 100 mcg in monophasic reg...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/102184
更新日期:2014-01-01 00:00:00
abstract:Objective:Cystic parathyroid adenoma is a rare cause of primary hyperparathyroidism, but its preoperative diagnosis and management remain inconclusive. Method:We retrospectively identified patients with cystic parathyroid adenomas who underwent surgery at Peking Union Medical College Hospital. Results:Patients with c...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/3745239
更新日期:2018-07-15 00:00:00
abstract::Type 2 diabetes is characterized by frequent ectopic fat accumulation in several tissues and organs. In particular, a number of studies showed that these subjects frequently have hepatic fat accumulation, which may play a role in the metabolic abnormalities typical of diabetes and has been also linked to increased ris...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2013/309191
更新日期:2013-01-01 00:00:00
abstract:Purpose:Hyperoside, a flavonoid isolated from conventional medicinal herbs, has been demonstrated to exert a significant protective effect in diabetic nephropathy. This study aimed to determine the underlying mechanisms, by which hyperoside inhibits high glucose-(HG-) induced proliferation in mouse renal mesangial cell...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/1361924
更新日期:2020-07-21 00:00:00
abstract:Background:Currently, energy obtained from hypercaloric diets has been part of the obesity and type 2 diabetes mellitus (T2DM) epidemics from childhood to old age. Treatment alternatives have been sought from plants, minerals, and trace elements with metabolic effects. Vanadyl sulfate (VS) has been investigated as a hy...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/5257216
更新日期:2018-12-25 00:00:00
abstract::Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. Cancer cells are well known to display an enhanced sugar uptake and consumption. In fact, sugar transporters ar...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2010/205357
更新日期:2010-01-01 00:00:00
abstract::Spermatozoa are highly specialized cells that can be easily obtained and purified. Mature spermatozoa are transcriptionally and translationally inactive and incapable of protein synthesis. In addition, spermatozoa contain relatively higher amounts of membrane proteins compared to other cells; therefore, they are very ...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2013/360986
更新日期:2013-01-01 00:00:00
abstract:Purpose:Primary hypertrophic osteoarthropathy (PHO) is a rare, autosomal, recessive genetic disease characterized by digital clubbing, periostosis, and pachydermia. The underlying cause for the pathogenesis of this disease is a defect in prostaglandin E2 (PGE2) degradation, caused by mutations in HPGD or SLCO2A1. In th...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/6698878
更新日期:2020-12-03 00:00:00
abstract::The circadian system is a supraphysiological system that modulates different biological functions such as metabolism, sleep-wake, cellular proliferation, and body temperature. Different chronodisruptors have been identified, such as shift work, feeding time, long days, and stress. The environmental changes and our mod...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2016/2746909
更新日期:2016-01-01 00:00:00
abstract:Background:Little information is available on the association between parents' metabolic syndrome (MetS) and adolescent offspring's obesity in Korea. The aim of our study is to determine the association between parent's metabolic syndrome and offspring's obesity. Methods:The study data were obtained from the Korean Na...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/8737912
更新日期:2020-10-30 00:00:00
abstract::Present therapies to minify hyperglycaemia and insulin resistance mainly target ATP-sensitive K(+) channels (K(ATP)) of pancreatic cells and PPAR-γ to enhance the insulin secretion and potential for GLUT expression, respectively. These current approaches are frequently associated with the various side effects such as ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2011/530274
更新日期:2011-01-01 00:00:00
abstract::Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been established. Howeve...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/470592
更新日期:2014-01-01 00:00:00
abstract::Background. Management of thyroid nodules with benign aspirates following atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is not well established. We reviewed the risk of malignancy and the role of ultrasound (US) features among thyroid nodules with benign results followin...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/354612
更新日期:2014-01-01 00:00:00
abstract::This study investigated potential markers for predicting nonfunctioning pituitary adenoma (NFPA) invasion and recurrence by high-throughput tissue microarray analyses. We retrospectively studied two groups of patients: 60 nonrecurrent NFPA cases that included noninvasion and invasion subtypes and 43 recurrent cases th...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/5731639
更新日期:2019-05-16 00:00:00
abstract::Objective. To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis. Methods. This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy subjects (group HP...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/5141089
更新日期:2016-01-01 00:00:00