Propylthiouracil-induced acute liver failure: role of liver transplantation.

Abstract:

:Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the clinical presentation, histological characteristics, and posttransplant management are described as well as alternative therapeutic options. Frequent monitoring for PTU-induced hepatic dysfunction is strongly advised because timely discontinuation of this drug and implementation of noninvasive therapeutic interventions may prevent progression to liver failure or even death.

journal_name

Int J Endocrinol

authors

Carrion AF,Czul F,Arosemena LR,Selvaggi G,Garcia MT,Tekin A,Tzakis AG,Martin P,Ghanta RK

doi

10.1155/2010/910636

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

910636

eissn

1687-8337

issn

1687-8345

journal_volume

2010

pub_type

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