Abstract:
:Introduction. Differentiated thyroid cancer treatment usually consists of thyroidectomy and radio ablation in hypothyroidism 4-6 weeks after surgery. Replacing hypothyroidism by recombinant human thyroid stimulating hormone can facilitate radio ablation in euthyroidism within one week after surgery. The outcome of this approach was investigated. Methods. This is a prospective randomized trial to compare thyroidectomy and radio ablation within a few days after preconditioning with recombinant human thyroid stimulating hormone versus thyroidectomy and radio ablation separated by four weeks of L-T4 withdrawal. Tumors were graded into very low-, low- , or high-risk tumors. Recurrence-free survival was confirmed at follow-up controls by neck ultrasound and serum thyroglobulin. Suspected tumor recurrence was treated by additional radio ablation or surgery. Quality-of-life questionnaires with additional evaluation of job performance and sick-leave time were used in all patients. Results. Radio ablation in euthyroidism in quick succession after thyroidectomy did not lead to higher tumor recurrence rates of differentiated thyroid cancers in any risk category and was significantly advantageous with respect to quality-of-life (P < 0.001), sick-leave time (P < 0.001), and job performance (P = 0.002). Conclusion. Recombinant human thyroid stimulating hormone can be used safely and with good efficacy to allow radio ablation under sustained euthyroidism within one week after thyroidectomy.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Emmanouilidis N,Schrem H,Winkler M,Klempnauer J,Scheumann GFdoi
10.1155/2013/769473subject
Has Abstractpub_date
2013-01-01 00:00:00pages
769473eissn
1687-8337issn
1687-8345journal_volume
2013pub_type
杂志文章abstract::Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes. Here we revie...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
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journal_title:International journal of endocrinology
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更新日期:2014-01-01 00:00:00
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2018/3189879
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更新日期:2019-09-19 00:00:00
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journal_title:International journal of endocrinology
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更新日期:2018-10-24 00:00:00
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journal_title:International journal of endocrinology
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更新日期:2019-07-16 00:00:00
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更新日期:2020-05-25 00:00:00
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doi:10.1155/2015/694273
更新日期:2015-01-01 00:00:00
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journal_title:International journal of endocrinology
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doi:10.1155/2009/687259
更新日期:2009-01-01 00:00:00
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journal_title:International journal of endocrinology
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更新日期:2014-01-01 00:00:00
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
pub_type: 杂志文章
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更新日期:2020-06-30 00:00:00
abstract::[This corrects the article DOI: 10.1155/2014/690783.]. ...
journal_title:International journal of endocrinology
pub_type: 已发布勘误
doi:10.1155/2017/5924671
更新日期:2017-01-01 00:00:00
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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更新日期:2010-01-01 00:00:00
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journal_title:International journal of endocrinology
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更新日期:2013-01-01 00:00:00