Long-term results after treatment of very low-, low-, and high-risk thyroid cancers in a combined setting of thyroidectomy and radio ablation therapy in euthyroidism.

Abstract:

:Introduction. Differentiated thyroid cancer treatment usually consists of thyroidectomy and radio ablation in hypothyroidism 4-6 weeks after surgery. Replacing hypothyroidism by recombinant human thyroid stimulating hormone can facilitate radio ablation in euthyroidism within one week after surgery. The outcome of this approach was investigated. Methods. This is a prospective randomized trial to compare thyroidectomy and radio ablation within a few days after preconditioning with recombinant human thyroid stimulating hormone versus thyroidectomy and radio ablation separated by four weeks of L-T4 withdrawal. Tumors were graded into very low-, low- , or high-risk tumors. Recurrence-free survival was confirmed at follow-up controls by neck ultrasound and serum thyroglobulin. Suspected tumor recurrence was treated by additional radio ablation or surgery. Quality-of-life questionnaires with additional evaluation of job performance and sick-leave time were used in all patients. Results. Radio ablation in euthyroidism in quick succession after thyroidectomy did not lead to higher tumor recurrence rates of differentiated thyroid cancers in any risk category and was significantly advantageous with respect to quality-of-life (P < 0.001), sick-leave time (P < 0.001), and job performance (P = 0.002). Conclusion. Recombinant human thyroid stimulating hormone can be used safely and with good efficacy to allow radio ablation under sustained euthyroidism within one week after thyroidectomy.

journal_name

Int J Endocrinol

authors

Emmanouilidis N,Schrem H,Winkler M,Klempnauer J,Scheumann GF

doi

10.1155/2013/769473

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

769473

eissn

1687-8337

issn

1687-8345

journal_volume

2013

pub_type

杂志文章
  • Inflammatory response in islet transplantation.

    abstract::Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes. Here we revie...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2014/451035

    authors: Kanak MA,Takita M,Kunnathodi F,Lawrence MC,Levy MF,Naziruddin B

    更新日期:2014-01-01 00:00:00

  • gp91phox, a Novel Biomarker Evaluating Oxidative Stress, Is Elevated in Subclinical Hypothyroidism.

    abstract:Background:gp91phox, the catalytic core of NADPH oxidase (NOX) and biomarker of NOX activation, has been recently recognized as a parameter of systemic oxidative stress in several studies. Subclinical hypothyroidism (SH) is characteristic of elevated level of serum thyroid stimulating hormone (TSH) and is frequently ac...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/3161730

    authors: Ma X,Wang F,Zhen X,Zhao L,Fang L,Dong Z,Chen W,Zhou X

    更新日期:2020-05-06 00:00:00

  • Primary hyperparathyroidism: 11-year experience in a single institute in Thailand.

    abstract::Primary hyperparathyroidism (PHPT) is not an uncommon disease in the western countries. In Thailand, on the contrary, PHPT was a rare condition with various clinical presentations. All 45 PHPT patients who underwent parathyroidectomy at the Department of Surgery, Siriraj Hospital during January 1997 and December 2007 ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2012/952426

    authors: Prasarttong-Osoth P,Wathanaoran P,Imruetaicharoenchoke W,Rojananin S

    更新日期:2012-01-01 00:00:00

  • Simultaneous Quantification of 25-Hydroxyvitamin D3 and 24,25-Dihydroxyvitamin D3 in Rats Shows Strong Correlations between Serum and Brain Tissue Levels.

    abstract::While vitamin D3 is recognized as a neuroactive steroid affecting both brain development and function, efficient analytical method in determining vitamin D3 metabolites in the brain tissue is still lacking, and the relationship of vitamin D3 status between serum and brain remains elusive. Therefore, we developed a nov...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/296531

    authors: Xue Y,He X,Li HD,Deng Y,Yan M,Cai HL,Tang MM,Dang RL,Jiang P

    更新日期:2015-01-01 00:00:00

  • Gut Microbiota Composition and Structure of the Ob/Ob and Db/Db Mice.

    abstract:Introduction:Gut microbiota is involved in the progression of metabolic diseases such as obesity and type 2 diabetes. The ob/ob and db/db mice are extensively used as models in studies on the pathogenesis of these diseases. The goal of this study is to characterize the composition and structure of gut microbiota in the...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2019/1394097

    authors: Yang M,Liu Y,Xie H,Wen Z,Zhang Y,Wu C,Huang L,Wu J,Xie C,Wang T,Peng W,Liu S,Chen L,Liu X

    更新日期:2019-03-11 00:00:00

  • Chronic sleep disturbance impairs glucose homeostasis in rats.

    abstract::Epidemiological studies have shown an association between short or disrupted sleep and an increased risk for metabolic disorders. To assess a possible causal relationship, we examined the effects of experimental sleep disturbance on glucose regulation in Wistar rats under controlled laboratory conditions. Three groups...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2010/819414

    authors: Barf RP,Meerlo P,Scheurink AJ

    更新日期:2010-01-01 00:00:00

  • A cell model for conditional profiling of androgen-receptor-interacting proteins.

    abstract::Partial androgen insensitivity syndrome (PAIS) is associated with impaired male genital development and can be transmitted through mutations in the androgen receptor (AR). The aim of this study is to develop a cell model suitable for studying the impact AR mutations might have on AR interacting proteins. For this purp...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2012/381824

    authors: Mooslehner KA,Davies JD,Hughes IA

    更新日期:2012-01-01 00:00:00

  • Enucleation-induced rat adrenal gland regeneration: expression profile of selected genes involved in control of adrenocortical cell proliferation.

    abstract::Enucleation-induced adrenal regeneration is a highly controlled process; however, only some elements involved in this process have been recognized. Therefore, we performed studies on regenerating rat adrenals. Microarray RNA analysis and QPCR revealed that enucleation resulted in a rapid elevation of expression of gen...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/130359

    authors: Tyczewska M,Rucinski M,Ziolkowska A,Szyszka M,Trejter M,Hochol-Molenda A,Nowak KW,Malendowicz LK

    更新日期:2014-01-01 00:00:00

  • Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice.

    abstract::Fibroblast growth factor 21 (FGF21) modulates a diverse range of biological functions, including glucose and lipid metabolism, adaptive starvation response, and energy homeostasis, but with limited mechanistic insight. FGF21 treatment has been shown to inhibit hepatic growth hormone (GH) intracellular signaling. To ev...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/282375

    authors: Boparai RK,Arum O,Miquet JG,Masternak MM,Bartke A,Khardori RK

    更新日期:2015-01-01 00:00:00

  • Regulation of the Human Ghrelin Promoter Activity by Transcription Factors, NF-κB and Nkx2.2.

    abstract::To examine the gene expression of ghrelin, a growth hormone releasing and appetite stimulating hormone from stomach, we constructed human ghrelin promoter-reporter vectors and analyzed the promoter activity. The ghrelin promoter activity was high when cultured cells that express ghrelin mRNA endogenously like TT or EC...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/580908

    authors: Shiimura Y,Ohgusu H,Sato T,Kojima M

    更新日期:2015-01-01 00:00:00

  • Exercise for hepatic fat accumulation in type 2 diabetic subjects.

    abstract::Type 2 diabetes is characterized by frequent ectopic fat accumulation in several tissues and organs. In particular, a number of studies showed that these subjects frequently have hepatic fat accumulation, which may play a role in the metabolic abnormalities typical of diabetes and has been also linked to increased ris...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2013/309191

    authors: Bacchi E,Moghetti P

    更新日期:2013-01-01 00:00:00

  • Stevia Nonsweetener Fraction Displays an Insulinotropic Effect Involving Neurotransmission in Pancreatic Islets.

    abstract::Stevia rebaudiana (Bert.) Bertoni besides being a source of noncaloric sweeteners is also an important source of bioactive molecules. Many plant extracts, mostly obtained with ethyl acetate solvent, are rich in polyphenol compounds that present insulinotropic effects. To investigate whether the nonsweetener fraction, ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2018/3189879

    authors: Piovan S,Pavanello A,Peixoto GML,Matiusso CCI,de Moraes AMP,Martins IP,Malta A,Palma-Rigo K,da Silva Franco CC,Milani PG,Dacome AS,da Costa SC,de Freitas Mathias PC,Mareze-Costa CE

    更新日期:2018-04-29 00:00:00

  • Use of PEGylated Recombinant Human Growth Hormone in Chinese Children with Growth Hormone Deficiency: A 24-Month Follow-Up Study.

    abstract:Objective:Once-weekly PEGylated recombinant human growth hormone (rhGH) is the sole long-acting GH formulation available currently for pediatric patients with GH deficiency (GHD). The aim of this study was to evaluate the efficacy and safety of PEGylated rhGH therapy compared to daily rhGH therapy in GHD children treat...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2019/1438723

    authors: Qiao Y,Wang Z,Han J,Li G

    更新日期:2019-09-19 00:00:00

  • Fasting-Evoked En Route Hypoglycemia in Diabetes (FEEHD): An Overlooked Form of Hypoglycemia in Clinical Practice.

    abstract:Objective:Many patients with diabetes opt to fast for lab tests, especially for lipid profiles, thus missing breakfast. In parallel, recent studies and international guidelines have indicated that routine fasting for lipid panels may not be necessary. Missing breakfast while fasting for lab tests may invoke hypoglycemi...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2018/1528437

    authors: Aldasouqi S,Mora S,Bhalla G,Kakumanu N,Corser W,Abela G,Dlewati M,Estrada K,Almounajed A,Tabbaa T,Hammoud J,Newkirk C

    更新日期:2018-10-24 00:00:00

  • Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes.

    abstract:Objective:Type 2 diabetes (T2DM) is a global epidemic and increases mortality due to its vascular complications. Chemerin has been found to exert a major role in glucose and lipid metabolism. The aim of this study was to explore the correlation between plasma chemerin levels and microangiopathy in patients with T2DM. ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2019/8693516

    authors: Gu P,Wang W,Yao Y,Xu Y,Wang L,Zang P,Ma J,Yang C,Liang J,Lu B,Shao J

    更新日期:2019-07-16 00:00:00

  • Physiological Effect of Ghrelin on Body Systems.

    abstract::Ghrelin is a relatively novel multifaceted hormone that has been found to exert a plethora of physiological effects. In this review, we found/confirmed that ghrelin has effect on all body systems. It induces appetite; promotes the use of carbohydrates as a source of fuel while sparing fat; inhibits lipid oxidation and...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2020/1385138

    authors: Akalu Y,Molla MD,Dessie G,Ayelign B

    更新日期:2020-05-25 00:00:00

  • Usefulness of an Image Fusion Model Using Three-Dimensional CT and MRI with Indocyanine Green Fluorescence Endoscopy as a Multimodal Assistant System in Endoscopic Transsphenoidal Surgery.

    abstract::Purpose. We investigate the usefulness of multimodal assistant systems using a fusion model of preoperative three-dimensional (3D) computed tomography (CT) and magnetic resonance imaging (MRI) along with endoscopy with indocyanine green (ICG) fluorescence in establishing endoscopic endonasal transsphenoidal surgery (E...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/694273

    authors: Inoue A,Ohnishi T,Kohno S,Nishida N,Nakamura Y,Ohtsuka Y,Matsumoto S,Ohue S

    更新日期:2015-01-01 00:00:00

  • Prolactin and male fertility: the long and short feedback regulation.

    abstract::In the last 20 years, a pituitary-hypothalamus tissue culture system with intact neural and portal connections has been developed in our lab and used to understand the feedback mechanisms that regulate the secretions of adenohypophyseal hormones and fertility of male rats. In the last decade, several in vivo rat model...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2009/687259

    authors: Gill-Sharma MK

    更新日期:2009-01-01 00:00:00

  • Angiogenesis in pituitary adenomas: human studies and new mutant mouse models.

    abstract::The role of angiogenesis in pituitary tumor development has been questioned, as pituitary tumors have been usually found to be less vascularized than the normal pituitary tissue. Nevertheless, a significantly higher degree of vasculature has been shown in invasive or macropituitary prolactinomas when compared to nonin...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2014/608497

    authors: Cristina C,Luque GM,Demarchi G,Lopez Vicchi F,Zubeldia-Brenner L,Perez Millan MI,Perrone S,Ornstein AM,Lacau-Mengido IM,Berner SI,Becu-Villalobos D

    更新日期:2014-01-01 00:00:00

  • Effects of long-term testosterone therapy on patients with "diabesity": results of observational studies of pooled analyses in obese hypogonadal men with type 2 diabetes.

    abstract::To investigate effects of long-term testosterone (T) therapy in obese men with T deficiency (TD) and type 2 diabetes mellitus (T2DM), data were collected from two observational, prospective, and cumulative registry studies of 561 men with TD receiving T therapy for up to 6 years. A subgroup of obese hypogonadal men wi...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/683515

    authors: Haider A,Yassin A,Doros G,Saad F

    更新日期:2014-01-01 00:00:00

  • Effect of Denosumab on Glucose Homeostasis in Postmenopausal Women with Breast Cancer Treated with Aromatase Inhibitors: A Pilot Study.

    abstract:Background:Aromatase inhibitors in women with breast cancer have been associated with cancer treatment-induced bone loss (CTIBL), increased fracture risk, and impairment of glucose metabolism. Denosumab (Dmab), a monoclonal antibody against RANKL, which is a key regulator of the osteoclast activity, is effective as an ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/1809150

    authors: Rossini A,Frigerio S,Dozio E,Trevisan R,Perseghin G,Corbetta S

    更新日期:2020-11-06 00:00:00

  • Relationship between Testicular Volume and Conventional or Nonconventional Sperm Parameters.

    abstract::Background. Reduced testicular volume (TV) (<12 cm(3)) is associated with lower testicular function. Several studies explored the conventional sperm parameters (concentration, motility, and morphology) and the endocrine function (gonadotropins and testosterone serum concentrations) in the patients with reduction of TV...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2013/145792

    authors: Condorelli R,Calogero AE,La Vignera S

    更新日期:2013-01-01 00:00:00

  • Clinicopathological Characteristics and Prognosis of Papillary Thyroid Carcinoma in Naturally Menopausal Women with Various Durations of Premenarche, Reproductive Periods, and Postmenopausal Stages.

    abstract::Background. Papillary thyroid cancer (PTC) exhibits a higher incidence in women. Due to various ages at menarche and menopause, estrogen levels vary, which may account for the differences in the occurrence, development, and prognosis of female patients with PTC. Objective. The aim of this study was to investigate the ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2017/5702716

    authors: Zhu X,Yu B,Huang YQ,Zhou JN,Ge MH

    更新日期:2017-01-01 00:00:00

  • Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis.

    abstract:Objective:Selenium, as an antioxidant, has been implicated in the development of autoimmune thyroiditis (AIT). Many studies showed selenium supplementation could decrease thyroid autoantibodies in patients with AIT. However, the underlying mechanisms have not been well determined. Therefore, we performed a clinical stu...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/9210572

    authors: Tian X,Li N,Su R,Dai C,Zhang R

    更新日期:2020-06-30 00:00:00

  • Corrigendum to "The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes".

    abstract::[This corrects the article DOI: 10.1155/2014/690783.]. ...

    journal_title:International journal of endocrinology

    pub_type: 已发布勘误

    doi:10.1155/2017/5924671

    authors: Napoli N,Strollo R,Paladini A,Briganti SI,Pozzilli P,Epstein S

    更新日期:2017-01-01 00:00:00

  • Effects of Aerobic Exercise Based upon Heart Rate at Aerobic Threshold in Obese Elderly Subjects with Type 2 Diabetes.

    abstract::In obese diabetic subjects, a correct life style, including diet and physical activity, is part of a correct intervention protocol. Thus, the aim of this study was to evaluate the effects of aerobic training intervention, based on heart rate at aerobic gas exchange threshold (AerTge), on clinical and physiological par...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/695297

    authors: Emerenziani GP,Gallotta MC,Meucci M,Di Luigi L,Migliaccio S,Donini LM,Strollo F,Guidetti L

    更新日期:2015-01-01 00:00:00

  • Black thyroid associated with thyroid carcinoma.

    abstract::Objective. Black thyroid is a rare pigmented change seen almost exclusively in patients upon minocycline ingestion, and the process has previously been thought to be generally benign. There have been 61 reported cases of black thyroid. We are aware of 13 cases previously reported in association with thyroid carcinoma....

    journal_title:International journal of endocrinology

    pub_type:

    doi:10.1155/2010/681647

    authors: Kandil E,Abdel Khalek M,Alabbas H,Daroca P,Thethi T,Friedlander P,Leblanc R,Abdullah O,Jaffe B,Crawford B

    更新日期:2010-01-01 00:00:00

  • Clinical and Metabolic Effects of Alpha-Lipoic Acid Associated with Two Different Doses of Myo-Inositol in Women with Polycystic Ovary Syndrome.

    abstract::The aim of this retrospective study was to evaluate the effects of a treatment with α-lipoic acid (ALA) associated with two different doses of myo-inositol (MI) on clinical and metabolic features of women with polycystic ovary syndrome (PCOS). Eighty-eight women received the treatment, and 71 among them had complete c...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/2901393

    authors: Fruzzetti F,Benelli E,Fidecicchi T,Tonacchera M

    更新日期:2020-03-19 00:00:00

  • Stability of miR-126 in Urine and Its Potential as a Biomarker for Renal Endothelial Injury with Diabetic Nephropathy.

    abstract::Background. The purpose of the present study was to assess the feasibility of using miR-126 in the urine as a biomarker for diabetic nephropathy. Methods. miRNAs were extracted from the urine samples of T2DM patients with diabetic nephropathy (DN; n = 92), T2DM without DN (n = 86), and 85 healthy volunteers using quan...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/393109

    authors: Liu Y,Gao G,Yang C,Zhou K,Shen B,Liang H,Jiang X

    更新日期:2014-01-01 00:00:00

  • Fatty Acid modulation of the endocannabinoid system and the effect on food intake and metabolism.

    abstract::Endocannabinoids and their G-protein coupled receptors (GPCR) are a current research focus in the area of obesity due to the system's role in food intake and glucose and lipid metabolism. Importantly, overweight and obese individuals often have higher circulating levels of the arachidonic acid-derived endocannabinoids...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2013/361895

    authors: Naughton SS,Mathai ML,Hryciw DH,McAinch AJ

    更新日期:2013-01-01 00:00:00