Hyperoside Alleviates High Glucose-Induced Proliferation of Mesangial Cells through the Inhibition of the ERK/CREB/miRNA-34a Signaling Pathway.

Abstract:

Purpose:Hyperoside, a flavonoid isolated from conventional medicinal herbs, has been demonstrated to exert a significant protective effect in diabetic nephropathy. This study aimed to determine the underlying mechanisms, by which hyperoside inhibits high glucose-(HG-) induced proliferation in mouse renal mesangial cells. Methods:Mouse glomerular mesangial cells line (SV40-MES13) was used to study the inhibitory effect of hyperoside on cell proliferation induced by 30 mM glucose, which was used to simulate a diabetic condition. Viable cell count was assessed using the Cell Counting Kit-8 and by the 5-ethynyl-20-deoxyuridine incorporation assay. The underlying mechanism involving miRNA-34a was further investigated by quantitative RT-PCR and transfection with miRNA-34a agomir. The phosphorylation levels of extracellular signal-regulated kinases (ERKs) and cAMP-response element-binding protein (CREB) were measured by Western blotting. The binding region and the critical binding sites of CREB in the miRNA-34a promoter were investigated by the chromatin immunoprecipitation assay and luciferase reporter assay, respectively. Results:We found that hyperoside could significantly decrease HG-induced proliferation of SV40-MES13 cells in a dose-dependent manner, without causing obvious cell death. In addition, hyperoside inhibited the activation of ERK pathway and phosphorylation of its downstream transcriptional factor CREB, as well as the miRNA-34a expression. We further confirmed that CREB-mediated regulation of miRNA-34a is dependent on the direct binding to specific sites in the promoter region of miRNA-34a. Conclusion:Our cumulative results suggested that hyperoside inhibits the proliferation of SV40-MES13 cells through the suppression of the ERK/CREB/miRNA-34a signaling pathway, which provides new insight to the current investigation on therapeutic strategies for diabetic nephropathy.

journal_name

Int J Endocrinol

authors

Zhang L,Dai Q,Hu L,Yu H,Qiu J,Zhou J,Long M,Zhou S,Zhang K

doi

10.1155/2020/1361924

subject

Has Abstract

pub_date

2020-07-21 00:00:00

pages

1361924

eissn

1687-8337

issn

1687-8345

journal_volume

2020

pub_type

杂志文章
  • Sexual dysfunction in women with diabetic kidney.

    abstract::Few studies address alteration of sexual function in women with diabetes and chronic kidney disease (CKD). Quality of life surveys suggest that discussion of sexual function and other reproductive issues are of psychosocial assessment and that education on sexual function in the setting of chronic diseases such as dia...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,收录出版,评审

    doi:10.1155/2014/346834

    authors: Satta E,Magno C,Galì A,Inferrera A,Granese R,Aloisi C,Buemi M,Bellinghieri G,Santoro D

    更新日期:2014-01-01 00:00:00

  • Fasting-Evoked En Route Hypoglycemia in Diabetes (FEEHD): An Overlooked Form of Hypoglycemia in Clinical Practice.

    abstract:Objective:Many patients with diabetes opt to fast for lab tests, especially for lipid profiles, thus missing breakfast. In parallel, recent studies and international guidelines have indicated that routine fasting for lipid panels may not be necessary. Missing breakfast while fasting for lab tests may invoke hypoglycemi...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2018/1528437

    authors: Aldasouqi S,Mora S,Bhalla G,Kakumanu N,Corser W,Abela G,Dlewati M,Estrada K,Almounajed A,Tabbaa T,Hammoud J,Newkirk C

    更新日期:2018-10-24 00:00:00

  • Prevalence of nonclassic congenital adrenal hyperplasia in Turkish children presenting with premature pubarche, hirsutism, or oligomenorrhoea.

    abstract::Background. Nonclassic congenital adrenal hyperplasia (NCAH), caused by mutations in the gene encoding 21-hydroxylase, is a common autosomal recessive disorder. In the present work, our aim was to determine the prevalence of NCAH presenting as premature pubarche (PP), hirsutism, or polycystic ovarian syndrome (PCOS) a...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/768506

    authors: Binay C,Simsek E,Cilingir O,Yuksel Z,Kutlay O,Artan S

    更新日期:2014-01-01 00:00:00

  • Health-related quality of life and quality of sexual life in obese subjects.

    abstract::The increased prevalence of obesity represents, currently, one of the major public health issues, due to its consequences on physical and psychological health status as well as on the psychosocial functioning. As defined by the World Health Organization, sexual health is "a state of physical, emotional, mental, and so...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/847871

    authors: Poggiogalle E,Di Lazzaro L,Pinto A,Migliaccio S,Lenzi A,Donini LM

    更新日期:2014-01-01 00:00:00

  • Low serum magnesium level is associated with microalbuminuria in chinese diabetic patients.

    abstract::Whether serum magnesium deficiency is independently associated with the prevalence of microalbuminuria is still unclear. The objective of the present study was to elucidate the association between serum magnesium and microalbuminuria in diabetic patients. A cross-sectional study was conducted in 1829 diabetic subjects...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2013/580685

    authors: Xu B,Sun J,Deng X,Huang X,Sun W,Xu Y,Xu M,Lu J,Bi Y

    更新日期:2013-01-01 00:00:00

  • Imaging-cytology correlation of thyroid nodules with initially benign cytology.

    abstract::Objective. To determine the role of imaging-cytology correlation in reducing false negative results of fine-needle aspiration (FNA) at thyroid nodules. Methods. This retrospective study included 667 nodules 1 cm or larger in 649 patients diagnosed as benign at initial cytologic evaluation and that underwent follow-up ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/491508

    authors: Hwang SH,Sung JM,Kim EK,Moon HJ,Kwak JY

    更新日期:2014-01-01 00:00:00

  • ATP Synthase β-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level.

    abstract::HDL cholesterol is known to be inversely correlated with cardiovascular disease due to its diverse antiatherogenic functions. SR-BI mediates the selective uptake of HDL-C. SR-BI knockout diminishes but does not completely block the transport of HDL; other receptors may be involved. Ectopic ATP synthase β-chain in hepa...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/356432

    authors: Song K,Han Y,Zhang L,Liu G,Yang P,Cheng X,Bu L,Sheng H,Qu S

    更新日期:2014-01-01 00:00:00

  • Differences in Ventilatory Threshold for Exercise Prescription in Outpatient Diabetic and Sarcopenic Obese Subjects.

    abstract::Aim of the study was to examine cardiorespiratory parameters at individual ventilatory threshold (IVT) and peak exercise capacity ([Formula: see text]) in outpatient diabetic and sarcopenic obese subjects. Seventeen obese subjects (BMI: 36.6 ± 4.1 kg·m(-1)) and sixteen SO subjects (BMI: 37.0 ± 7.3 kg·m(-1)) were compa...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2016/6739150

    authors: Emerenziani GP,Gallotta MC,Migliaccio S,Greco EA,Marocco C,di Lazzaro L,Fornari R,Lenzi A,Baldari C,Guidetti L

    更新日期:2016-01-01 00:00:00

  • Strain US Elastography for the Characterization of Thyroid Nodules: Advantages and Limitation.

    abstract::Thyroid nodules, with their high prevalence in the general population, represent a diagnostic challenge for clinicians. Ultrasound (US), although absolutely reliable in detecting thyroid nodules, is still not accurate enough to differentiate them into benign and malignant. A promising novel modality, US elastography, ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2015/908575

    authors: Cantisani V,Grazhdani H,Drakonaki E,D'Andrea V,Di Segni M,Kaleshi E,Calliada F,Catalano C,Redler A,Brunese L,Drudi FM,Fumarola A,Carbotta G,Frattaroli F,Di Leo N,Ciccariello M,Caratozzolo M,D'Ambrosio F

    更新日期:2015-01-01 00:00:00

  • The Impact of Preconceptional Serum TSH Levels between 2.5 and 4.0 mIU/L on Infertile Women Going through Their First IUI Treatment Cycle.

    abstract:Objective:To evaluate the impact of preconceptional serum TSH levels on the clinical outcomes of infertile patients undergoing their first IUI treatment cycle. Method:This was a retrospective study. Euthyroid patients undergoing the first cycle of IUI treatment from Jan 2017 to Aug 2018 were included. The patients wer...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2019/8492904

    authors: Zhang Y,Wu W,Liu Y,Wang X,Jia L

    更新日期:2019-12-18 00:00:00

  • Black thyroid associated with thyroid carcinoma.

    abstract::Objective. Black thyroid is a rare pigmented change seen almost exclusively in patients upon minocycline ingestion, and the process has previously been thought to be generally benign. There have been 61 reported cases of black thyroid. We are aware of 13 cases previously reported in association with thyroid carcinoma....

    journal_title:International journal of endocrinology

    pub_type:

    doi:10.1155/2010/681647

    authors: Kandil E,Abdel Khalek M,Alabbas H,Daroca P,Thethi T,Friedlander P,Leblanc R,Abdullah O,Jaffe B,Crawford B

    更新日期:2010-01-01 00:00:00

  • Four-Point Preprandial Self-Monitoring of Blood Glucose for the Assessment of Glycemic Control and Variability in Patients with Type 2 Diabetes Treated with Insulin and Vildagliptin.

    abstract::The study explored the utility of four-point preprandial glucose self-monitoring to calculate several indices of glycemic control and variability in a study adding the DPP-4 inhibitor vildagliptin to ongoing insulin therapy. This analysis utilized data from a double-blind, randomized, placebo-controlled crossover stud...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/484231

    authors: Tura A,Farngren J,Schweizer A,Foley JE,Pacini G,Ahrén B

    更新日期:2015-01-01 00:00:00

  • Propylthiouracil-induced acute liver failure: role of liver transplantation.

    abstract::Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the c...

    journal_title:International journal of endocrinology

    pub_type:

    doi:10.1155/2010/910636

    authors: Carrion AF,Czul F,Arosemena LR,Selvaggi G,Garcia MT,Tekin A,Tzakis AG,Martin P,Ghanta RK

    更新日期:2010-01-01 00:00:00

  • Rare Somatic MEN1 Gene Pathogenic Variant in a Patient Affected by Atypical Parathyroid Adenoma.

    abstract:Objective:Atypical parathyroid adenoma is a rare neoplasm, showing atypical histological features intermediate between classic benign adenoma and the rarest parathyroid carcinoma, whose the clinical behaviour and outcome is not yet understood or predictable. Up to date only two cases of atypical adenoma were found asso...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/2080797

    authors: Cinque L,Pugliese F,Clemente C,Castellana S,Leone MP,de Martino D,Balsamo T,Battista C,Biagini T,Graziano P,Castori M,Scillitani A,Guarnieri V

    更新日期:2020-04-27 00:00:00

  • Evidence of Insulin Resistance and Other Metabolic Alterations in Boys with Duchenne or Becker Muscular Dystrophy.

    abstract::Aim. Our aim was (1) to determine the frequency of insulin resistance (IR) in patients with Duchenne/Becker muscular dystrophy (DMD/BMD), (2) to identify deleted exons of DMD gene associated with obesity and IR, and (3) to explore some likely molecular mechanisms leading to IR. Materials and Methods. In 66 patients wi...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/867273

    authors: Rodríguez-Cruz M,Sanchez R,Escobar RE,Cruz-Guzmán Odel R,López-Alarcón M,Bernabe García M,Coral-Vázquez R,Matute G,Velázquez Wong AC

    更新日期:2015-01-01 00:00:00

  • Relationship between Subclinical Thyroid Dysfunction and the Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies.

    abstract:BACKGROUND:Evidence on the association between subclinical thyroid dysfunction and the risk of cardiovascular outcomes are conflicting. METHODS AND RESULTS:PubMed, EMbase, Web of Science, Cochrane Library, and China Biology Medicine (CBM) databases were searched from inception to July 10, 2016. A total of 16 studies w...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2017/8130796

    authors: Sun J,Yao L,Fang Y,Yang R,Chen Y,Yang K,Tian L

    更新日期:2017-01-01 00:00:00

  • Risk Factors for Cervical Lymph Node Metastasis of Papillary Thyroid Microcarcinoma: A Single-Center Retrospective Study.

    abstract:Objective:To identify the clinicopathological features correlated to lymph node metastasis (LNM) in patients with papillary thyroid microcarcinoma (PTMC). Methods:Clinical data of 785 PTMC patients who underwent surgical treatment at the Lishui Municipal Central Hospital from September 2008 to December 2017 were retro...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2019/8579828

    authors: Cheng F,Chen Y,Zhu L,Zhou B,Xu Y,Chen Y,Wen L,Chen S

    更新日期:2019-01-15 00:00:00

  • MicroRNA and Microvascular Complications of Diabetes.

    abstract::In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have pivotal roles in key pathogenic processes of microvascular compl...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2018/6890501

    authors: Barutta F,Bellini S,Mastrocola R,Bruno G,Gruden G

    更新日期:2018-03-07 00:00:00

  • Benign Aspirates on Follow-Up FNA May Be Enough in Patients with Initial Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance.

    abstract::Background. Management of thyroid nodules with benign aspirates following atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is not well established. We reviewed the risk of malignancy and the role of ultrasound (US) features among thyroid nodules with benign results followin...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/354612

    authors: Kim GR,Yoon JH,Kim EK,Moon HJ,Kwak JY

    更新日期:2014-01-01 00:00:00

  • Efficacy, Safety, and Quality of Treatment Satisfaction of Premixed Human and Analogue Insulin Regimens in a Large Cohort of Type 2 Diabetic Patients: PROGENS BENEFIT Observational Study.

    abstract::Diabetes is a lifelong course disease, so insulin treatment has to be effective and safe, and patients should be satisfied with it. We aimed to compare efficacy, safety, and quality of treatment satisfaction of human and premixed analogue insulin among 3264 patients (53.58% women) with type 2 diabetes mellitus (T2DM) ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2018/6536178

    authors: Nabrdalik K,Kwiendacz H,Sawczyn T,Tomasik A,Kukla M,Masierek M,Gumprecht J

    更新日期:2018-03-05 00:00:00

  • Potential role of sugar transporters in cancer and their relationship with anticancer therapy.

    abstract::Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. Cancer cells are well known to display an enhanced sugar uptake and consumption. In fact, sugar transporters ar...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2010/205357

    authors: Calvo MB,Figueroa A,Pulido EG,Campelo RG,Aparicio LA

    更新日期:2010-01-01 00:00:00

  • Comorbidity between Type 2 Diabetes and Depression in the Adult Population: Directions of the Association and Its Possible Pathophysiological Mechanisms.

    abstract::Type 2 diabetes and depression are regarded as comorbid conditions, and three possible directions of the association between the diseases can underlie this observation of comorbidity. First, common etiology can increase a person's risk of both diseases; second, persons with type 2 diabetes have increased prevalence or...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2015/164760

    authors: Berge LI,Riise T

    更新日期:2015-01-01 00:00:00

  • Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus.

    abstract::Present therapies to minify hyperglycaemia and insulin resistance mainly target ATP-sensitive K(+) channels (K(ATP)) of pancreatic cells and PPAR-γ to enhance the insulin secretion and potential for GLUT expression, respectively. These current approaches are frequently associated with the various side effects such as ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2011/530274

    authors: Ahmed D,Sharma M

    更新日期:2011-01-01 00:00:00

  • Psychological status and quality of life in relation to the metabolic syndrome: Isfahan Cohort Study.

    abstract:OBJECTIVE:Current study was designed to investigate the association of metabolic syndrome (MetS) with depression, anxiety, psychological distress, and quality of life (QoL). DESIGN:Two hundred and fifteen contributors with MetS and 253 participants without MetS were randomly selected from 2151 participants of Isfahan ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2012/380902

    authors: Roohafza H,Sadeghi M,Talaei M,Pourmoghaddas Z,Sarrafzadegan N

    更新日期:2012-01-01 00:00:00

  • gp91phox, a Novel Biomarker Evaluating Oxidative Stress, Is Elevated in Subclinical Hypothyroidism.

    abstract:Background:gp91phox, the catalytic core of NADPH oxidase (NOX) and biomarker of NOX activation, has been recently recognized as a parameter of systemic oxidative stress in several studies. Subclinical hypothyroidism (SH) is characteristic of elevated level of serum thyroid stimulating hormone (TSH) and is frequently ac...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/3161730

    authors: Ma X,Wang F,Zhen X,Zhao L,Fang L,Dong Z,Chen W,Zhou X

    更新日期:2020-05-06 00:00:00

  • Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and Perspectives.

    abstract::Gestational diabetes mellitus (GDM) is defined as any degree of carbohydrate intolerance, with onset or first recognition during second or third trimester of gestation. It is estimated that approximately 7% of all pregnancies are complicated by GDM and that its prevalence is rising all over the world. Thus, the screen...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2018/6380463

    authors: Guarino E,Delli Poggi C,Grieco GE,Cenci V,Ceccarelli E,Crisci I,Sebastiani G,Dotta F

    更新日期:2018-04-12 00:00:00

  • Clinical and Metabolic Effects of Alpha-Lipoic Acid Associated with Two Different Doses of Myo-Inositol in Women with Polycystic Ovary Syndrome.

    abstract::The aim of this retrospective study was to evaluate the effects of a treatment with α-lipoic acid (ALA) associated with two different doses of myo-inositol (MI) on clinical and metabolic features of women with polycystic ovary syndrome (PCOS). Eighty-eight women received the treatment, and 71 among them had complete c...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/2901393

    authors: Fruzzetti F,Benelli E,Fidecicchi T,Tonacchera M

    更新日期:2020-03-19 00:00:00

  • Long-term results after treatment of very low-, low-, and high-risk thyroid cancers in a combined setting of thyroidectomy and radio ablation therapy in euthyroidism.

    abstract::Introduction. Differentiated thyroid cancer treatment usually consists of thyroidectomy and radio ablation in hypothyroidism 4-6 weeks after surgery. Replacing hypothyroidism by recombinant human thyroid stimulating hormone can facilitate radio ablation in euthyroidism within one week after surgery. The outcome of thi...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2013/769473

    authors: Emmanouilidis N,Schrem H,Winkler M,Klempnauer J,Scheumann GF

    更新日期:2013-01-01 00:00:00

  • Effect of Denosumab on Glucose Homeostasis in Postmenopausal Women with Breast Cancer Treated with Aromatase Inhibitors: A Pilot Study.

    abstract:Background:Aromatase inhibitors in women with breast cancer have been associated with cancer treatment-induced bone loss (CTIBL), increased fracture risk, and impairment of glucose metabolism. Denosumab (Dmab), a monoclonal antibody against RANKL, which is a key regulator of the osteoclast activity, is effective as an ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/1809150

    authors: Rossini A,Frigerio S,Dozio E,Trevisan R,Perseghin G,Corbetta S

    更新日期:2020-11-06 00:00:00

  • Inflammatory response in islet transplantation.

    abstract::Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes. Here we revie...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2014/451035

    authors: Kanak MA,Takita M,Kunnathodi F,Lawrence MC,Levy MF,Naziruddin B

    更新日期:2014-01-01 00:00:00