Abstract:
:Objective. Black thyroid is a rare pigmented change seen almost exclusively in patients upon minocycline ingestion, and the process has previously been thought to be generally benign. There have been 61 reported cases of black thyroid. We are aware of 13 cases previously reported in association with thyroid carcinoma. This paper reports six patients with black thyroid pigmentation in association with thyroid carcinoma. Design. The medical records of six patients who were diagnosed with black thyroid syndrome, all of whom underwent thyroid surgery, were reviewed. Data on age, gender, race, preoperative fine needle aspiration biopsy (FNA), thyroid function levels, and pathology reports were collected. Main Outcome. The mean age was 60 years. There were 5 females, 4 of whom were African American. All patients were clinically and biochemically euthyroid. Black pigmentation was not diagnosed in preoperative FNA, and only one patient had a preoperative diagnosis of papillary thyroid carcinoma. The other patients underwent surgery and were found to have black pigmentation of the thyroid associated with carcinoma. Conclusions. FNA does not diagnose black thyroid, which is associated with thyroid carcinoma. Thyroid glands with black pigmentation deserve thorough pathologic examination, including several sections of each specimen.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Kandil E,Abdel Khalek M,Alabbas H,Daroca P,Thethi T,Friedlander P,Leblanc R,Abdullah O,Jaffe B,Crawford Bdoi
10.1155/2010/681647subject
Has Abstractpub_date
2010-01-01 00:00:00pages
681647eissn
1687-8337issn
1687-8345journal_volume
2010pub_type
abstract::Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes. Here we revie...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/451035
更新日期:2014-01-01 00:00:00
abstract::In obese diabetic subjects, a correct life style, including diet and physical activity, is part of a correct intervention protocol. Thus, the aim of this study was to evaluate the effects of aerobic training intervention, based on heart rate at aerobic gas exchange threshold (AerTge), on clinical and physiological par...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/695297
更新日期:2015-01-01 00:00:00
abstract::Thyroid cancer is the most common endocrine malignancy, and its incidence has increased rapidly in recent decades worldwide. Papillary thyroid cancer (PTC) is the most common type of all thyroid cancers. The molecular mechanisms underlying the disease still need to be further investigated. Long noncoding RNAs (lncRNAs...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/7043509
更新日期:2019-04-07 00:00:00
abstract:Objective:Selenium, as an antioxidant, has been implicated in the development of autoimmune thyroiditis (AIT). Many studies showed selenium supplementation could decrease thyroid autoantibodies in patients with AIT. However, the underlying mechanisms have not been well determined. Therefore, we performed a clinical stu...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/9210572
更新日期:2020-06-30 00:00:00
abstract::The determination of B-type natriuretic peptides (BNP) may have a role in the diagnosis of heart failure (HF) or guiding HF therapy. This study investigated the role of BNP determination in a cohort of elderly patients admitted to hospital with acute decompensated HF and its correlation with main demographic, clinical...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/239136
更新日期:2015-01-01 00:00:00
abstract::Ghrelin is a relatively novel multifaceted hormone that has been found to exert a plethora of physiological effects. In this review, we found/confirmed that ghrelin has effect on all body systems. It induces appetite; promotes the use of carbohydrates as a source of fuel while sparing fat; inhibits lipid oxidation and...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2020/1385138
更新日期:2020-05-25 00:00:00
abstract::Neurofibromatosis type 1 (NF1) patients are more likely to have vitamin D deficiency when compared to the general population. This study aimed to determine the levels of 25-OH-vitamin D [25(OH)D] in individuals with NF1 and disease-unaffected controls and analyze FokI and BsmI VDR gene polymorphisms in a case and in a...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/402838
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Current study was designed to investigate the association of metabolic syndrome (MetS) with depression, anxiety, psychological distress, and quality of life (QoL). DESIGN:Two hundred and fifteen contributors with MetS and 253 participants without MetS were randomly selected from 2151 participants of Isfahan ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/380902
更新日期:2012-01-01 00:00:00
abstract::Aim. To examine the relationship between plasma 25-hydroxyvitamin D (25(OH)D) levels and blood hemoglobin A1c (HbA1c) levels in diabetic patients at various stages of chronic kidney disease (CKD). Methods. We screened for data collected between 2003 and 2012. The correlation between 25(OH)D and HbA1c levels was studie...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/142468
更新日期:2014-01-01 00:00:00
abstract::Aims. To seek high risk population for diabetes and to improve their health care by investigating the characteristics and outcome of hospitalization in hospitals with predominant Arab patients in Northern Israel. Methods. Retrospective analysis of the prevalence of diabetes and the outcome of diabetic in comparison to...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/371608
更新日期:2013-01-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women of reproductive age. Although PCOS is diagnosed exclusively based on reproductive criteria, it is also a metabolic disorder. Insulin resistance, impaired glucose tolerance, type 2 diabetes mellitus, obesity, and dyslipidemia are more ...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/786362
更新日期:2015-01-01 00:00:00
abstract::Parathyroid carcinoma (PC) is a rare disease responsible for about 1% of primary hyperparathyroidism (PHPT) cases. PC usually has an indolent course, tough to differentiate from the benign causes of PHPT, and the only certain diagnosis is histologic. The gold standard surgical treatment is the en bloc resection associ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/7048185
更新日期:2020-03-06 00:00:00
abstract:Background:Diagnosing polycystic ovary syndrome (PCOS) is based on ovulatory dysfunction, ovarian ultrasound data, and androgen excess. Total testosterone is frequently used to identify androgen excess, but testosterone is mainly bound to sex hormone-binding globulin (SHBG) and albumin. Only 1-2% of nonprotein-bound te...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/7956951
更新日期:2018-09-10 00:00:00
abstract::Fibroblast growth factor 21 (FGF21) modulates a diverse range of biological functions, including glucose and lipid metabolism, adaptive starvation response, and energy homeostasis, but with limited mechanistic insight. FGF21 treatment has been shown to inhibit hepatic growth hormone (GH) intracellular signaling. To ev...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/282375
更新日期:2015-01-01 00:00:00
abstract::Varicocele in infertile males is associated with Leydig cell dysfunction and hypogonadism. The effect of varicocelectomy on serum testosterone level is not yet established. We analysed 200 heterosexual infertile men diagnosed to have clinical varicocele they were divided into two groups: group 1 (100 men) had microsur...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2011/916380
更新日期:2011-01-01 00:00:00
abstract::Iodine supplementation through salt iodization is a worldwide, effective strategy for preventing iodine deficiency-related problems. Its safety and efficacy profile has been extensively investigated, and benefits far outweigh the potential iodine-induced risks. Moreover, iodine supplementation during pregnancy in orde...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/312305
更新日期:2015-01-01 00:00:00
abstract::Clinical evidences have highlighted the efficacy of myo-inositol and selenium in the treatment of autoimmune thyroiditis. Aim of this study was to further analyze the role of myo-inositol plus selenium (Myo-Ins-Se) in restoring a normal thyroid function of Hashimoto's patients with subclinical hypothyroidism. Eighty-s...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2017/2549491
更新日期:2017-01-01 00:00:00
abstract::Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. Cancer cells are well known to display an enhanced sugar uptake and consumption. In fact, sugar transporters ar...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2010/205357
更新日期:2010-01-01 00:00:00
abstract::Aim of the study was to examine cardiorespiratory parameters at individual ventilatory threshold (IVT) and peak exercise capacity ([Formula: see text]) in outpatient diabetic and sarcopenic obese subjects. Seventeen obese subjects (BMI: 36.6 ± 4.1 kg·m(-1)) and sixteen SO subjects (BMI: 37.0 ± 7.3 kg·m(-1)) were compa...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/6739150
更新日期:2016-01-01 00:00:00
abstract::Background. Papillary thyroid cancer (PTC) exhibits a higher incidence in women. Due to various ages at menarche and menopause, estrogen levels vary, which may account for the differences in the occurrence, development, and prognosis of female patients with PTC. Objective. The aim of this study was to investigate the ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2017/5702716
更新日期:2017-01-01 00:00:00
abstract::Oxidized low density lipoprotein (ox-LDL) is a product of oxidative stress. In this cross-sectional study, we compared the ox-LDL concentrations in diabetic patients with normoalbuminuria (n = 28), microalbuminuria (n = 28), and macroalbuminuria (n = 28) with their first degree relatives (n = 28) and healthy control p...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/167154
更新日期:2012-01-01 00:00:00
abstract:Background:gp91phox, the catalytic core of NADPH oxidase (NOX) and biomarker of NOX activation, has been recently recognized as a parameter of systemic oxidative stress in several studies. Subclinical hypothyroidism (SH) is characteristic of elevated level of serum thyroid stimulating hormone (TSH) and is frequently ac...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/3161730
更新日期:2020-05-06 00:00:00
abstract::The aim of this work was to study the androgen receptors (AR) expression in pituitary pars distalis (PD) of male viscachas in relation to growth and reproductive cycle. AR were detected by immunocytochemistry and quantified by image analysis. Pituitary glands from fetus, immature, prepubertal, and adult viscachas duri...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/168047
更新日期:2015-01-01 00:00:00
abstract::Objectives. Growth hormone deficiency patients exhibited reduced bone mineral density compared with healthy controls, but previous researches demonstrated uncertainty about the effect of growth hormone replacement therapy on bone in growth hormone deficient adults. The aim of this study was to determine whether the gr...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/216107
更新日期:2013-01-01 00:00:00
abstract:Background:The aim was to investigate the amounts of saliva and serum asprosin in order to determine whether it is related to obesity and whether salivary glands synthesize asprosin or not. Methods:A total of 116 underweight, normal weight, overweight, and obese (class I, class II, and class III) volunteers participat...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/2521096
更新日期:2019-03-27 00:00:00
abstract::This study investigated potential markers for predicting nonfunctioning pituitary adenoma (NFPA) invasion and recurrence by high-throughput tissue microarray analyses. We retrospectively studied two groups of patients: 60 nonrecurrent NFPA cases that included noninvasion and invasion subtypes and 43 recurrent cases th...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/5731639
更新日期:2019-05-16 00:00:00
abstract::Background. Nonclassic congenital adrenal hyperplasia (NCAH), caused by mutations in the gene encoding 21-hydroxylase, is a common autosomal recessive disorder. In the present work, our aim was to determine the prevalence of NCAH presenting as premature pubarche (PP), hirsutism, or polycystic ovarian syndrome (PCOS) a...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/768506
更新日期:2014-01-01 00:00:00
abstract:Aim:To clarify the contributions of fasting glucose (FG) and postprandial glucose (PG) to HbA1c in drug-naïve patients with type 2 diabetes (T2D) and impaired glucose tolerate (IGT)/impaired fasting glucose (IFG). Methods:Continuous glucose monitoring (CGM) was performed in 305 drug-naïve Chinese patients with T2D or ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/1267475
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Evidence on the association between subclinical thyroid dysfunction and the risk of cardiovascular outcomes are conflicting. METHODS AND RESULTS:PubMed, EMbase, Web of Science, Cochrane Library, and China Biology Medicine (CBM) databases were searched from inception to July 10, 2016. A total of 16 studies w...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2017/8130796
更新日期:2017-01-01 00:00:00
abstract::Despite 70 years of experience treating thyrotoxic patients with radioiodine not all patients are successfully treated by a single dose. Multiple factors predicting radioiodine efficacy have been reported. The aim of this study was to assess whether ethnicity was associated with radioiodine response. A retrospective r...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/7863867
更新日期:2016-01-01 00:00:00