Abstract:
:Type 2 diabetes and depression are regarded as comorbid conditions, and three possible directions of the association between the diseases can underlie this observation of comorbidity. First, common etiology can increase a person's risk of both diseases; second, persons with type 2 diabetes have increased prevalence or risk of future development of depression; or third, persons with depression have increased prevalence or risk of development of type 2 diabetes. This review gives an overview over possible pathophysiological mechanisms for each of the directions of the association between type 2 diabetes and depression and further discusses epigenetics as an additional, direction independent approach. We argue that unspecific pathophysiological mechanisms involved in the stress response might, at least to some extent, explain each of the directions of the association between type 2 diabetes and depression, while changes in brain structure and function among persons with diabetes and possible increased risk of development of type 2 diabetes after use of antidepressant agents could represent more disease specific mechanisms underlying the comorbidity.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Berge LI,Riise Tdoi
10.1155/2015/164760subject
Has Abstractpub_date
2015-01-01 00:00:00pages
164760eissn
1687-8337issn
1687-8345journal_volume
2015pub_type
杂志文章,评审abstract:Background:Little information is available on the association between parents' metabolic syndrome (MetS) and adolescent offspring's obesity in Korea. The aim of our study is to determine the association between parent's metabolic syndrome and offspring's obesity. Methods:The study data were obtained from the Korean Na...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/8737912
更新日期:2020-10-30 00:00:00
abstract::Aim. To compare two creatinine-based estimated glomerular filtration rate (eGFR) equations, the chronic kidney disease epidemiology collaboration (CKD-EPI) and the modification of diet in renal disease (MDRD), for predicting the risk of CKD progression in type 2 diabetic patients with nephropathy. Methods. A total of ...
journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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abstract:OBJECTIVE:We aimed to explore whether squamous cell carcinoma antigen (SCC), cytokeratin 19 fragment (Cyfra21-1), neuron-specific enolase (NSE), and carcinoembryonic antigen (CEA) are elevated in diabetic nephropathy (DN) and the association between urinary albumin-to-creatinine ratio (UACR) and tumor markers in diabet...
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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