Abstract:
Background:Little information is available on the association between parents' metabolic syndrome (MetS) and adolescent offspring's obesity in Korea. The aim of our study is to determine the association between parent's metabolic syndrome and offspring's obesity. Methods:The study data were obtained from the Korean National Health and Nutrition Examination Survey conducted during 2009-2016. In the present study, 3140 adolescents aged 12 to 18 years, their paternal pairs (PP, fathers = 2244), and maternal pairs (MP, mothers = 3022) were analyzed. Of these 3140 adolescents, 2637 had normal weight {age- and sex-specific body mass index (BMI) under the 85th percentile}, whereas 467 were overweight (age- and sex-specific BMI over the 85th percentile). Results:Offspring's overweight and central obesity were associated with all components of the PP's metabolic risk factors, including central obesity (p < 0.001), systolic (p < 0.001) and diastolic blood pressure (p < 0.001), glucose intolerance (p < 0.001), and triglyceride (p < 0.002) and high-density lipoprotein levels (p=0.049). In addition, offspring's overweight and central obesity were also associated with the metabolic risk factors of MP, including central obesity (p < 0.001), systolic (p < 0.001) and diastolic blood pressure (p < 0.001), glucose intolerance (p < 0.001), and triglyceride levels (p < 0.001). In multivariate logistic regression analysis, offspring's overweight was significantly and positively associated with parental central obesity (PP, adjusted odds ratio (OR) = 1.593; 95% confidence interval (CI): 1.192-2.128; MP, adjusted OR = 2.221, 95% CI: 1.755-2.812) and parental metabolic syndrome (PP, adjusted OR = 2.032; 95% CI: 1.451-2.846; MP, adjusted OR = 2.972, 95% CI: 2.239-3.964). As the number of parental metabolic risk factors increased, offspring's risk for overweight and central obesity increased (p for trends < 0.001). Conclusion:Parental metabolic syndrome was associated with obesity in 12- to 18-year-old offspring in Korea.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Lee NY,Han K,Lee Y,Kim S,Lee S,Choi Y,Ahn MB,Kim SH,Cho WK,Cho KS,Jung MH,Park YG,Suh BKdoi
10.1155/2020/8737912subject
Has Abstractpub_date
2020-10-30 00:00:00pages
8737912eissn
1687-8337issn
1687-8345journal_volume
2020pub_type
杂志文章abstract::Thyroid cancer is the most common endocrine malignancy, and its incidence has increased rapidly in recent decades worldwide. Papillary thyroid cancer (PTC) is the most common type of all thyroid cancers. The molecular mechanisms underlying the disease still need to be further investigated. Long noncoding RNAs (lncRNAs...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/7043509
更新日期:2019-04-07 00:00:00
abstract::To isolate pancreatic progenitor cells with the surface markers of hematopoietic stem cells, the expression of stem cell antigen (Sca-1) and c-Kit and the coexpression of them with pancreatic duodenal homeobox-1 (PDX-1), neurogenin 3 (Ngn3), and insulin were examined in murine embryonic pancreas. Then different pancre...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/948683
更新日期:2012-01-01 00:00:00
abstract::Anaplastic thyroid cancers (ATC) are among the most aggressive human neoplasms with a dire prognosis and a median survival time of few months from the diagnosis. The complete absence of effective therapies for ATC renders the identification of novel therapeutic approaches sorely needed. Chromosomal instability, a feat...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/816430
更新日期:2014-01-01 00:00:00
abstract::The aim of this retrospective study was to evaluate the effects of a treatment with α-lipoic acid (ALA) associated with two different doses of myo-inositol (MI) on clinical and metabolic features of women with polycystic ovary syndrome (PCOS). Eighty-eight women received the treatment, and 71 among them had complete c...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/2901393
更新日期:2020-03-19 00:00:00
abstract::Glucose is the major source of energy for the human brain which in turn uses ketone bodies as a supplement for energy deficit in glucose cell deficiency conditions. Pregnancy complicated by gestational diabetes is a condition associated with significantly increased risk of ketonemia development. The data available pro...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/1242901
更新日期:2018-06-04 00:00:00
abstract::Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been established. Howeve...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/470592
更新日期:2014-01-01 00:00:00
abstract::Preeclampsia is a serious medical problem affecting the mother and her child and influences their health not only during the pregnancy, but also many years after. Although preeclampsia is a subject of many research projects, the etiology of the condition remains unclear. One of the hypotheses related to the etiology o...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2016/5279462
更新日期:2016-01-01 00:00:00
abstract::Objectives. Vitamin D deficiency plays a role in insulin resistance and the pathogenesis of type 2 diabetes mellitus. Little information is available about the association between vitamin D status and insulin resistance in the Chinese population. Currently, vitamin D status is evaluated by the concentrations of serum ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/1794894
更新日期:2016-01-01 00:00:00
abstract::Ghrelin is a relatively novel multifaceted hormone that has been found to exert a plethora of physiological effects. In this review, we found/confirmed that ghrelin has effect on all body systems. It induces appetite; promotes the use of carbohydrates as a source of fuel while sparing fat; inhibits lipid oxidation and...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2020/1385138
更新日期:2020-05-25 00:00:00
abstract::Introduction. The mechanisms underlying the association between insulin resistance and intrahepatic lipid (IHL) accumulation are not completely understood. We sought to determine whether this association was explained by differences in fasting non-esterified fatty acid (NEFA) levels and/or NEFA suppression after oral ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/870487
更新日期:2013-01-01 00:00:00
abstract::The goal of this study was to determine the prevalence and associated risk factors of impaired glucose regulation (IGR) in the population of Tongzhou, China, and to provide scientific basis for preventive interventions. In the study, the overall age-standardized prevalence of IGR (16.0%) in Tongzhou residents was high...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/731583
更新日期:2015-01-01 00:00:00
abstract::Whether serum magnesium deficiency is independently associated with the prevalence of microalbuminuria is still unclear. The objective of the present study was to elucidate the association between serum magnesium and microalbuminuria in diabetic patients. A cross-sectional study was conducted in 1829 diabetic subjects...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/580685
更新日期:2013-01-01 00:00:00
abstract::Type 2 diabetes mellitus (T2D) is a disorder of glucose metabolism. It is a complex process involving the regulation of insulin secretion, insulin sensitivity, gluconeogenesis, and glucose uptake at the cellular level. Diabetic peripheral neuropathy (DPN) is one of the debilitating complications that is present in app...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/8641942
更新日期:2018-03-15 00:00:00
abstract::The aim of this study is to evaluate carotid atherosclerosis in patients of type 2 diabetes mellitus with microalbuminuria (MA) by high-frequency ultrasonography. Two hundred and fifty patients of type 2 diabetes mellitus were divided into two groups according to urinary albumin excretion rate (UAER): normoalbuminuria...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/819584
更新日期:2013-01-01 00:00:00
abstract::With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through infl...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2019/9691345
更新日期:2019-10-13 00:00:00
abstract::Background. Papillary thyroid cancer (PTC) exhibits a higher incidence in women. Due to various ages at menarche and menopause, estrogen levels vary, which may account for the differences in the occurrence, development, and prognosis of female patients with PTC. Objective. The aim of this study was to investigate the ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2017/5702716
更新日期:2017-01-01 00:00:00
abstract::The complementary role of hyperglycemia and p27(kip1) suppression on islet beta cell regeneration was investigated in a syngeneic mouse model. p27(kip1) gene silencing was performed by infecting islets of C57BL/6 with shRNA lentiviral particles. At 54 hours after viral infection, p27(kip1) protein content in cultured ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/417390
更新日期:2012-01-01 00:00:00
abstract:Objective:Neuroendocrine neoplasias (NENs) represent a rare and biologically heterogeneous group of malignancies. Treatment of NEN patients remains challenging due to lack of prospective evidence on the choice of ideal therapeutic sequence and therapeutic efficacy in specific individual scenarios. Methods:Clinical dat...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/1491475
更新日期:2020-01-31 00:00:00
abstract::The determination of B-type natriuretic peptides (BNP) may have a role in the diagnosis of heart failure (HF) or guiding HF therapy. This study investigated the role of BNP determination in a cohort of elderly patients admitted to hospital with acute decompensated HF and its correlation with main demographic, clinical...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/239136
更新日期:2015-01-01 00:00:00
abstract::Background. Management of thyroid nodules with benign aspirates following atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is not well established. We reviewed the risk of malignancy and the role of ultrasound (US) features among thyroid nodules with benign results followin...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/354612
更新日期:2014-01-01 00:00:00
abstract::The presence of brown adipose tissue (BAT) in humans is unclear. Pheochromocytomas (PHEO) are rare tumors of neuroectodermal origin which occur in 0.1-0.2% of patients with hypertension. We sought to evaluate the presence and activity of BAT surrounding adrenal PHEO in a well-studied sample of 11 patients who were dia...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/126751
更新日期:2013-01-01 00:00:00
abstract::There is inconsistency among published guidelines for the optimal diagnostic and management pathways for patients with typical (TC) or atypical (AC) pulmonary carcinoid tumours. We conducted a UK-wide clinician survey to assess current practice for the diagnosis, management, and follow-up of patients with TC/AC and de...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/9287536
更新日期:2020-02-28 00:00:00
abstract::Diabetes mellitus (DM) is one of the primary causes of premature death and disability worldwide. We performed a systematic review and meta-analysis of the published literature regarding the trends in prevalence, awareness, treatment, and control of diabetes mellitus in mainland China. PUBMED, EMBASE, Chinese Biomedica...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2013/753150
更新日期:2013-01-01 00:00:00
abstract:Objective:Cystic parathyroid adenoma is a rare cause of primary hyperparathyroidism, but its preoperative diagnosis and management remain inconclusive. Method:We retrospectively identified patients with cystic parathyroid adenomas who underwent surgery at Peking Union Medical College Hospital. Results:Patients with c...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/3745239
更新日期:2018-07-15 00:00:00
abstract::Objective. To analyze changes in vital signs (heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP)) during and after intravenous methylprednisolone (IVMP) and any other adverse effects. Methods. Retrospective review of charts of patients who received IVMP as treatment regime for thyroid eye disease. All...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/457123
更新日期:2015-01-01 00:00:00
abstract::Clinical evidences have highlighted the efficacy of myo-inositol and selenium in the treatment of autoimmune thyroiditis. Aim of this study was to further analyze the role of myo-inositol plus selenium (Myo-Ins-Se) in restoring a normal thyroid function of Hashimoto's patients with subclinical hypothyroidism. Eighty-s...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2017/2549491
更新日期:2017-01-01 00:00:00
abstract::Type 2 diabetes is characterized by frequent ectopic fat accumulation in several tissues and organs. In particular, a number of studies showed that these subjects frequently have hepatic fat accumulation, which may play a role in the metabolic abnormalities typical of diabetes and has been also linked to increased ris...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2013/309191
更新日期:2013-01-01 00:00:00
abstract::Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2017/2452853
更新日期:2017-01-01 00:00:00
abstract::Obesity is a growing problem in modern society and medicine. It closely associates with metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and cardiovascular diseases such as nonalcoholic fatty liver disease, atherosclerosis, myocarditis, and hypertension. Obesity is often associated with latent i...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2017/5076732
更新日期:2017-01-01 00:00:00
abstract::Few studies address alteration of sexual function in women with diabetes and chronic kidney disease (CKD). Quality of life surveys suggest that discussion of sexual function and other reproductive issues are of psychosocial assessment and that education on sexual function in the setting of chronic diseases such as dia...
journal_title:International journal of endocrinology
pub_type: 杂志文章,收录出版,评审
doi:10.1155/2014/346834
更新日期:2014-01-01 00:00:00