A new aurora in anaplastic thyroid cancer therapy.

abstract：Background:Genome-wide association studies have found an obesity-related single-nucleotide polymorphism rs10938397 near the glucosamine-6-phosphate deaminase 2 gene (GNPDA2) encoding, an enzyme that catalyzes the deamination of the glucosamine-6-phosphate involved in the hexosamine signaling pathway, but the molecular ...

journal_title：International journal of endocrinology

authors： Wu L,Ma F,Zhao X,Zhang MX,Wu J,Mi J

更新日期：2019-08-01 00:00:00

abstract：:Diabetes mellitus (DM) is one of the primary causes of premature death and disability worldwide. We performed a systematic review and meta-analysis of the published literature regarding the trends in prevalence, awareness, treatment, and control of diabetes mellitus in mainland China. PUBMED, EMBASE, Chinese Biomedica...

journal_title：International journal of endocrinology

authors： Li MZ,Su L,Liang BY,Tan JJ,Chen Q,Long JX,Xie JJ,Wu GL,Yan Y,Guo XJ,Gu L

更新日期：2013-01-01 00:00:00

abstract：Objective:Once-weekly PEGylated recombinant human growth hormone (rhGH) is the sole long-acting GH formulation available currently for pediatric patients with GH deficiency (GHD). The aim of this study was to evaluate the efficacy and safety of PEGylated rhGH therapy compared to daily rhGH therapy in GHD children treat...

journal_title：International journal of endocrinology

authors： Qiao Y,Wang Z,Han J,Li G

更新日期：2019-09-19 00:00:00

abstract：:Objective. To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis. Methods. This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy subjects (group HP...

journal_title：International journal of endocrinology

authors： Song W,Wang X,Tian Y,Zhang X,Lu R,Meng H

更新日期：2016-01-01 00:00:00

abstract：Background:Gynecomastia (GM) is a benign enlargement of male breast due to glandular tissue proliferation. GM is a symptom of systemic or local hormonal disturbances, which could be associated with functional changes or pathological conditions. However, the long-lasting steroid imbalance in men with GM might exert nega...

journal_title：International journal of endocrinology

authors： Robeva R,Elenkova A,Zacharieva S

更新日期：2019-10-03 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2014/690783.]. ...

journal_title：International journal of endocrinology

authors： Napoli N,Strollo R,Paladini A,Briganti SI,Pozzilli P,Epstein S

更新日期：2017-01-01 00:00:00

abstract：:With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through infl...

journal_title：International journal of endocrinology

authors： Xiong Q,Liu J,Xu Y

更新日期：2019-10-13 00:00:00

abstract：:The hypothalamus is an essential relay in the neural circuitry underlying energy metabolism that needs to continually adapt to changes in the energetic environment. The neuroendocrine control of food intake and energy expenditure is associated with, and likely dependent upon, hypothalamic plasticity. Severe disturbanc...

journal_title：International journal of endocrinology

authors： Stranahan AM,Martin B,Chadwick W,Park SS,Wang L,Becker KG,Woodiii WH,Zhang Y,Maudsley S

更新日期：2012-01-01 00:00:00

abstract：:Hypogonadotropic hypogonadism (HH) can be sustained by organic or functional alterations of the hypothalamic-pituitary-testicular axis. Functional HH is related to systemic alterations, such as obesity or chronic inflammatory diseases, but could contribute to a negative course of the illness. For such situation, accor...

journal_title：International journal of endocrinology

authors： Giagulli VA,Silvestrini A,Bruno C,Triggiani V,Mordente A,Mancini A

更新日期：2020-01-21 00:00:00

abstract：Introduction:Obesity has an unclear pathogenesis. MicroRNAs (miRNAs) may function as biologically active molecules for obesity through regulating adipocyte differentiation. This study aimed to identify how miR-129-5p (a specific miRNA) regulates adipogenesis in vitro and explore its possible role in the pathogenesis of...

journal_title：International journal of endocrinology

authors： Fu X,Jin L,Han L,Yuan Y,Mu Q,Wang H,Yang J,Ning G,Zhou D,Zhang Z

更新日期：2019-11-06 00:00:00

abstract：:To elucidate whether adrenergic overtone is involved in the pathophysiology of men with lifelong (LL) premature ejaculation (PE), we investigated differences in reactive hyperemia index (RHI) responses by using peripheral arterial tonometry (PAT). 20 men with LL-PE (18-40 years) were enrolled in an 8-week, double-blin...

journal_title：International journal of endocrinology

authors： Francomano D,Donini LM,Lenzi A,Aversa A

更新日期：2013-01-01 00:00:00

abstract：:Anovulatory cycles and endometriosis are the main causes of female infertility. The most frequently anovulatory cycles are related to polycystic ovary syndrome (PCOS) commonly associated with obesity and hormonal disturbances in the course of obesity. Recently published studies revealed that infertility affects about ...

journal_title：International journal of endocrinology

authors： Kocełak P,Chudek J,Naworska B,Bąk-Sosnowska M,Kotlarz B,Mazurek M,Madej P,Skrzypulec-Plinta V,Skałba P,Olszanecka-Glinianowicz M

更新日期：2012-01-01 00:00:00

abstract：Purpose:Primary hypertrophic osteoarthropathy (PHO) is a rare, autosomal, recessive genetic disease characterized by digital clubbing, periostosis, and pachydermia. The underlying cause for the pathogenesis of this disease is a defect in prostaglandin E2 (PGE2) degradation, caused by mutations in HPGD or SLCO2A1. In th...

journal_title：International journal of endocrinology

authors： Li N,Ma Y,Jiang Y,You L,Huang Y,Peng Y,Ding X,Zhao L

更新日期：2020-12-03 00:00:00

abstract：:The objective of this cross-sectional study was to assess differences in the control and treatment of modifiable cardiovascular risk factors (CVRF: HbA1c, blood pressure [BP], LDL-cholesterol, body mass index, and smoking habit) according to gender and the presence of cardiovascular disease (CVD) in patients with type...

journal_title：International journal of endocrinology

authors： Franch-Nadal J,Mata-Cases M,Vinagre I,Patitucci F,Hermosilla E,Casellas A,Bolivar B,Mauricio D

更新日期：2014-01-01 00:00:00

abstract：:X-linked Adrenal Hypoplasia Congenita (AHC) is caused by deletions or point mutations in the NR0B1 (DAX1) gene. We present a boy with AHC who came at the age of 25 days in a severe state due to prolonged vomiting and progressive dehydration. Laboratory studies showed prominent hyponatremia and hyperkaliemia but not hy...

journal_title：International journal of endocrinology

authors： Rojek A,Krawczynski MR,Jamsheer A,Sowinska-Seidler A,Iwaniszewska B,Malunowicz E,Niedziela M

更新日期：2016-01-01 00:00:00

abstract：Background:Little information is available on the association between parents' metabolic syndrome (MetS) and adolescent offspring's obesity in Korea. The aim of our study is to determine the association between parent's metabolic syndrome and offspring's obesity. Methods:The study data were obtained from the Korean Na...

journal_title：International journal of endocrinology

authors： Lee NY,Han K,Lee Y,Kim S,Lee S,Choi Y,Ahn MB,Kim SH,Cho WK,Cho KS,Jung MH,Park YG,Suh BK

更新日期：2020-10-30 00:00:00

abstract：Background:gp91phox, the catalytic core of NADPH oxidase (NOX) and biomarker of NOX activation, has been recently recognized as a parameter of systemic oxidative stress in several studies. Subclinical hypothyroidism (SH) is characteristic of elevated level of serum thyroid stimulating hormone (TSH) and is frequently ac...

journal_title：International journal of endocrinology

authors： Ma X,Wang F,Zhen X,Zhao L,Fang L,Dong Z,Chen W,Zhou X

更新日期：2020-05-06 00:00:00

abstract：:Parathyroid glands contain the vitamin D receptor (VDR) and 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24A1), which catalyze the production and degradation of 1,25-dihydroxyvitamin D [1,25(OH)2D], respectively. Previous studies have shown that the serum level of intact parathyroid hormone (iPT...

journal_title：International journal of endocrinology

authors： Jiang Y,Liao L,Li J,Wang L,Xie Z

更新日期：2020-04-09 00:00:00

abstract：:Objectives. The roles of PI3K/AKT/mTOR and MAPK/ERK pathways involved in the pathogenesis of pheochromocytoma and paraganglioma (PPGL) were demonstrated mostly by in vitro studies with rat or mouse cells and were mainly studied at transcriptional level. This study aimed to investigate the effect of these pathways on t...

journal_title：International journal of endocrinology

authors： Du J,Tong A,Wang F,Cui Y,Li C,Zhang Y,Yan Z

更新日期：2016-01-01 00:00:00

abstract：:Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been established. Howeve...

journal_title：International journal of endocrinology

authors： Gacci M,Baldi E,Tamburrino L,Detti B,Livi L,De Nunzio C,Tubaro A,Gravas S,Carini M,Serni S

更新日期：2014-01-01 00:00:00

abstract：:To investigate the correlation between gender and the clinical presentation of papillary thyroid cancer and the long-term followup results, 435 patients who underwent total or near-total thyroidectomy were enrolled in this study. Among these papillary thyroid cancer patients, 12.2% showed lymph node metastases and a h...

journal_title：International journal of endocrinology

authors： Hsieh SH,Chen ST,Hsueh C,Chao TC,Lin JD

更新日期：2012-01-01 00:00:00

abstract：Background:Insulin promotes glucose consumption as the main cardiac energy source, while increasing myocardial efficiency. The short-term effects of insulin on cardiac function and its potential curative role in an acute diabetological cardiology setting remain unknown. Our study evaluated the role of acute insulin adm...

journal_title：International journal of endocrinology

authors： Daoud Naccache D,Yalonetsky S,Bar-Yoseph R

更新日期：2020-03-17 00:00:00

abstract：Introduction:Gut microbiota is involved in the progression of metabolic diseases such as obesity and type 2 diabetes. The ob/ob and db/db mice are extensively used as models in studies on the pathogenesis of these diseases. The goal of this study is to characterize the composition and structure of gut microbiota in the...

journal_title：International journal of endocrinology

authors： Yang M,Liu Y,Xie H,Wen Z,Zhang Y,Wu C,Huang L,Wu J,Xie C,Wang T,Peng W,Liu S,Chen L,Liu X

更新日期：2019-03-11 00:00:00

abstract：:Thyroid nodules, with their high prevalence in the general population, represent a diagnostic challenge for clinicians. Ultrasound (US), although absolutely reliable in detecting thyroid nodules, is still not accurate enough to differentiate them into benign and malignant. A promising novel modality, US elastography, ...

journal_title：International journal of endocrinology

authors： Cantisani V,Grazhdani H,Drakonaki E,D'Andrea V,Di Segni M,Kaleshi E,Calliada F,Catalano C,Redler A,Brunese L,Drudi FM,Fumarola A,Carbotta G,Frattaroli F,Di Leo N,Ciccariello M,Caratozzolo M,D'Ambrosio F

更新日期：2015-01-01 00:00:00

abstract：:Background. Nonclassic congenital adrenal hyperplasia (NCAH), caused by mutations in the gene encoding 21-hydroxylase, is a common autosomal recessive disorder. In the present work, our aim was to determine the prevalence of NCAH presenting as premature pubarche (PP), hirsutism, or polycystic ovarian syndrome (PCOS) a...

journal_title：International journal of endocrinology

authors： Binay C,Simsek E,Cilingir O,Yuksel Z,Kutlay O,Artan S

更新日期：2014-01-01 00:00:00

abstract：Background:The aim was to investigate the amounts of saliva and serum asprosin in order to determine whether it is related to obesity and whether salivary glands synthesize asprosin or not. Methods:A total of 116 underweight, normal weight, overweight, and obese (class I, class II, and class III) volunteers participat...

journal_title：International journal of endocrinology

authors： Ugur K,Aydin S

更新日期：2019-03-27 00:00:00

abstract：:To investigate effects of long-term testosterone (T) therapy in obese men with T deficiency (TD) and type 2 diabetes mellitus (T2DM), data were collected from two observational, prospective, and cumulative registry studies of 561 men with TD receiving T therapy for up to 6 years. A subgroup of obese hypogonadal men wi...

journal_title：International journal of endocrinology

authors： Haider A,Yassin A,Doros G,Saad F

更新日期：2014-01-01 00:00:00

abstract：:Introduction. The mechanisms underlying the association between insulin resistance and intrahepatic lipid (IHL) accumulation are not completely understood. We sought to determine whether this association was explained by differences in fasting non-esterified fatty acid (NEFA) levels and/or NEFA suppression after oral ...

journal_title：International journal of endocrinology

authors： Finucane FM,Sharp SJ,Hatunic M,Sleigh A,De Lucia Rolfe E,Sayer AA,Cooper C,Griffin SJ,Savage DB,Wareham NJ

更新日期：2013-01-01 00:00:00

abstract：:The risk for cardiovascular diseases and type 2 diabetes mellitus significantly increases in the patient population with metabolic syndrome (MeS). The present study aimed to investigate the association between the epicardial adipose tissue thickness (EATT) and the oxidative stress parameters in MeS patients. The study...

journal_title：International journal of endocrinology

authors： Demir B,Demir E,Acıksarı G,Uygun T,Utku IK,Gedikbasi A,Caglar IM,Pirhan O,Tureli HO,Oflar E,Ungan İ,Ciftci S,Karakaya O

更新日期：2014-01-01 00:00:00

abstract：Background:Aromatase inhibitors in women with breast cancer have been associated with cancer treatment-induced bone loss (CTIBL), increased fracture risk, and impairment of glucose metabolism. Denosumab (Dmab), a monoclonal antibody against RANKL, which is a key regulator of the osteoclast activity, is effective as an ...

journal_title：International journal of endocrinology

authors： Rossini A,Frigerio S,Dozio E,Trevisan R,Perseghin G,Corbetta S

更新日期：2020-11-06 00:00:00