GNPDA2 Gene Affects Adipogenesis and Alters the Transcriptome Profile of Human Adipose-Derived Mesenchymal Stem Cells.

abstract：Background:Gonadal injury following chemotherapy is of increasing importance with the continuous improvement of survival rates. The protection of gonadotropin hormone antagonist (GnRHant) in long-term adult survivors of adolescent cancers and some autoimmune diseases has not yet been evaluated. Methods:The present stu...

journal_title：International journal of endocrinology

authors： Xie R,Chen L,Wu H,Chen T,Wang F,Chen X,Sun H,Li X

更新日期：2018-06-10 00:00:00

abstract：:Background. Liraglutide (a glucagon-like peptide 1 analog) was used for the treatment of type 2 diabetes (T2DM) which could produce glucose-dependent insulin secretion. Aim. The aim was to investigate whether liraglutide could improve myofibril and mitochondria injury in skeletal muscle and the mechanisms in diabetic ...

journal_title：International journal of endocrinology

authors： Ji W,Chen X,Lv J,Wang M,Ren S,Yuan B,Wang B,Chen L

更新日期：2014-01-01 00:00:00

abstract：:Anaplastic thyroid cancers (ATC) are among the most aggressive human neoplasms with a dire prognosis and a median survival time of few months from the diagnosis. The complete absence of effective therapies for ATC renders the identification of novel therapeutic approaches sorely needed. Chromosomal instability, a feat...

journal_title：International journal of endocrinology

authors： Baldini E,D'Armiento M,Ulisse S

更新日期：2014-01-01 00:00:00

abstract：:In the last 20 years, a pituitary-hypothalamus tissue culture system with intact neural and portal connections has been developed in our lab and used to understand the feedback mechanisms that regulate the secretions of adenohypophyseal hormones and fertility of male rats. In the last decade, several in vivo rat model...

journal_title：International journal of endocrinology

authors： Gill-Sharma MK

更新日期：2009-01-01 00:00:00

abstract：:Bariatric surgery is currently the most effective therapy to induce weight loss in morbidly obese patients. Objective. This controlled, clinical trial with a two-year intervention was aimed at comparing the efficacy of two nonsurgical approaches versus bariatric surgery, on body weight changes and metabolic parameters...

journal_title：International journal of endocrinology

authors： Burguera B,Jesús Tur J,Escudero AJ,Alos M,Pagán A,Cortés B,González XF,Soriano JB

更新日期：2015-01-01 00:00:00

abstract：:Puerarin, the main isoflavone glycoside extracted from Radix Puerariae, is an isoflavone traditional Chinese herb. Previous studies have demonstrated that puerarin could regulate osteoblast proliferation and differentiation to promote bone formation. However, the effect of puerarin on the process of human osteoblasts ...

journal_title：International journal of endocrinology

authors： Liu LJ,Liu LQ,Bo T,Li SJ,Zhu Z,Cui RR,Mao DA

更新日期：2013-01-01 00:00:00

abstract：Objective:Type 2 diabetes (T2DM) is a global epidemic and increases mortality due to its vascular complications. Chemerin has been found to exert a major role in glucose and lipid metabolism. The aim of this study was to explore the correlation between plasma chemerin levels and microangiopathy in patients with T2DM. ...

journal_title：International journal of endocrinology

authors： Gu P,Wang W,Yao Y,Xu Y,Wang L,Zang P,Ma J,Yang C,Liang J,Lu B,Shao J

更新日期：2019-07-16 00:00:00

abstract：:The 5-alpha-reductase type 2 deficiency (5ARD2) is an autosomal recessive condition associated with impairment in the conversion of testosterone to dihydrotestosterone. This condition leads to undervirilisation in 46,XY individuals. To date, there have been more than 100 variations identified in the gene responsible f...

journal_title：International journal of endocrinology

authors： Marzuki NS,Idris FP,Kartapradja HD,Harahap AR,Batubara JRL

更新日期：2019-12-01 00:00:00

abstract：:Insulin resistance increases the risk for cardiovascular disease (CVD) even in the absence of classic risk factors, such as hyperglycemia, hypertension, dyslipidemia, and obesity. Low-grade chronic inflammatory state is associated both with insulin resistance and atherosclerosis. An increased circulating level of proi...

journal_title：International journal of endocrinology

authors： Nikołajuk A,Matulewicz N,Stefanowicz M,Karczewska-Kupczewska M

更新日期：2018-09-13 00:00:00

abstract：:Atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) in thyroid fine needle aspiration (FNA) is a challenging category. The malignancy risk is different by multiple factors and subsequent management strategy is inconclusive. Therefore, we analyzed the malignancy risk of AUS/FLU...

journal_title：International journal of endocrinology

authors： Hong SH,Lee H,Cho MS,Lee JE,Sung YA,Hong YS

更新日期：2018-07-30 00:00:00

abstract：:The aim of this retrospective study was to evaluate the effects of a treatment with α-lipoic acid (ALA) associated with two different doses of myo-inositol (MI) on clinical and metabolic features of women with polycystic ovary syndrome (PCOS). Eighty-eight women received the treatment, and 71 among them had complete c...

journal_title：International journal of endocrinology

authors： Fruzzetti F,Benelli E,Fidecicchi T,Tonacchera M

更新日期：2020-03-19 00:00:00

abstract：Objectives:To compare the predictive ability of six anthropometric indices for identification of metabolic syndrome (MetS) and to determine their optimal cut-off points among Chinese adults. Methods:A total of 59,029 participants were enrolled. Body mass index (BMI), waist circumference (WC), waist-to-height ratio (WH...

journal_title：International journal of endocrinology

authors： Zhang J,Zhu W,Qiu L,Huang L,Fang L

更新日期：2018-09-17 00:00:00

abstract：:Type 2 diabetes mellitus (T2D) is a disorder of glucose metabolism. It is a complex process involving the regulation of insulin secretion, insulin sensitivity, gluconeogenesis, and glucose uptake at the cellular level. Diabetic peripheral neuropathy (DPN) is one of the debilitating complications that is present in app...

journal_title：International journal of endocrinology

authors： Prabodha LBL,Sirisena ND,Dissanayake VHW

更新日期：2018-03-15 00:00:00

abstract：:The aim of this study is to investigate the circulating OPG levels in postmenopausal women with diabetes and prediabetes and explore the relationships between serum OPG and insulin resistance. A total of 271 unrelated Chinese postmenopausal women were recruited in this study. The subjects were divided into type 2 diab...

journal_title：International journal of endocrinology

authors： Duan P,Yang M,Wei M,Liu J,Tu P

更新日期：2017-01-01 00:00:00

abstract：:Pancreatic beta-cells, which secrete the hormone insulin, are the key arbiters of glucose homeostasis. Defective beta-cell numbers and/or function underlie essentially all major forms of diabetes and must be restored if diabetes is to be cured. Thus, the identification of the molecular regulators of beta-cell mass and...

journal_title：International journal of endocrinology

authors： Tarabra E,Pelengaris S,Khan M

更新日期：2012-01-01 00:00:00

abstract：:Objectives. Vitamin D deficiency plays a role in insulin resistance and the pathogenesis of type 2 diabetes mellitus. Little information is available about the association between vitamin D status and insulin resistance in the Chinese population. Currently, vitamin D status is evaluated by the concentrations of serum ...

journal_title：International journal of endocrinology

authors： Zhang J,Ye J,Guo G,Lan Z,Li X,Pan Z,Rao X,Zheng Z,Luo F,Lin L,Lin Z,Xue Y

更新日期：2016-01-01 00:00:00

abstract：:The increased prevalence of obesity represents, currently, one of the major public health issues, due to its consequences on physical and psychological health status as well as on the psychosocial functioning. As defined by the World Health Organization, sexual health is "a state of physical, emotional, mental, and so...

journal_title：International journal of endocrinology

authors： Poggiogalle E,Di Lazzaro L,Pinto A,Migliaccio S,Lenzi A,Donini LM

更新日期：2014-01-01 00:00:00

abstract：:Clinical evidences have highlighted the efficacy of myo-inositol and selenium in the treatment of autoimmune thyroiditis. Aim of this study was to further analyze the role of myo-inositol plus selenium (Myo-Ins-Se) in restoring a normal thyroid function of Hashimoto's patients with subclinical hypothyroidism. Eighty-s...

journal_title：International journal of endocrinology

authors： Nordio M,Basciani S

更新日期：2017-01-01 00:00:00

abstract：:Background. Hyperinsulinaemic Hypoglycaemia (HH) is the most common cause of severe and persistent hypoglycemia in the neonatal period. It has been shown that the neonates with HH fail to generate adequate serum cortisol counterregulatory response to symptomatic hypoglycemia. However the role played by growth hormone ...

journal_title：International journal of endocrinology

authors： Senniappan S,Hussain K

更新日期：2013-01-01 00:00:00

abstract：:Estroprogestins (EPs) are combinations of estrogen and progestin with several actions on women's health. The different pharmacological composition of EPs is responsible for different clinical effects. One of the most used low-dose EP associations is ethinylestradiol 20 mcg plus levonorgestrel 100 mcg in monophasic reg...

journal_title：International journal of endocrinology

authors： Lello S,Cavani A

更新日期：2014-01-01 00:00:00

abstract：:Objectives. Growth hormone deficiency patients exhibited reduced bone mineral density compared with healthy controls, but previous researches demonstrated uncertainty about the effect of growth hormone replacement therapy on bone in growth hormone deficient adults. The aim of this study was to determine whether the gr...

journal_title：International journal of endocrinology

authors： Xue P,Wang Y,Yang J,Li Y

更新日期：2013-01-01 00:00:00

abstract：Introduction:Obesity has an unclear pathogenesis. MicroRNAs (miRNAs) may function as biologically active molecules for obesity through regulating adipocyte differentiation. This study aimed to identify how miR-129-5p (a specific miRNA) regulates adipogenesis in vitro and explore its possible role in the pathogenesis of...

journal_title：International journal of endocrinology

authors： Fu X,Jin L,Han L,Yuan Y,Mu Q,Wang H,Yang J,Ning G,Zhou D,Zhang Z

更新日期：2019-11-06 00:00:00

abstract：:A quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism. Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis. We conducted a randomiz...

journal_title：International journal of endocrinology

authors： Dhindsa S,Chemitiganti R,Ghanim H,Santiago E,Haider A,Chaar N,Mok M,McKee A,Dandona P

更新日期：2018-10-31 00:00:00

abstract：:Purpose. To evaluate whether inferior rectus muscle (IRM) thickness, the degree of adipose change in the IRM, smoking status, and the previous history of orbital radiotherapy can predict the dose-effect relationship regarding unilateral IRM recession in thyroid eye disease (TED). Methods. Twenty-five patients were ret...

journal_title：International journal of endocrinology

authors： Takahashi Y,Kakizaki H

更新日期：2015-01-01 00:00:00

abstract：:Objective. To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis. Methods. This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy subjects (group HP...

journal_title：International journal of endocrinology

authors： Song W,Wang X,Tian Y,Zhang X,Lu R,Meng H

更新日期：2016-01-01 00:00:00

abstract：Objective:We sought to evaluate the association between femoral neck (FN) and lumbar spine (LS) bone mineral densities (BMDs) with severity of chronic kidney disease (CKD) and prevalence of osteopenia or osteoporosis (OP) among the CKD group. Methods:Cross-sectional data from 11050 participants aged ≥20 years from the...

journal_title：International journal of endocrinology

authors： Huang JF,Zheng XQ,Sun XL,Zhou X,Liu J,Li YM,Wang XY,Zhang XL,Wu AM

更新日期：2020-10-26 00:00:00

abstract：Introduction:Gut microbiota is involved in the progression of metabolic diseases such as obesity and type 2 diabetes. The ob/ob and db/db mice are extensively used as models in studies on the pathogenesis of these diseases. The goal of this study is to characterize the composition and structure of gut microbiota in the...

journal_title：International journal of endocrinology

authors： Yang M,Liu Y,Xie H,Wen Z,Zhang Y,Wu C,Huang L,Wu J,Xie C,Wang T,Peng W,Liu S,Chen L,Liu X

更新日期：2019-03-11 00:00:00

abstract：Purpose:Primary hypertrophic osteoarthropathy (PHO) is a rare, autosomal, recessive genetic disease characterized by digital clubbing, periostosis, and pachydermia. The underlying cause for the pathogenesis of this disease is a defect in prostaglandin E2 (PGE2) degradation, caused by mutations in HPGD or SLCO2A1. In th...

journal_title：International journal of endocrinology

authors： Li N,Ma Y,Jiang Y,You L,Huang Y,Peng Y,Ding X,Zhao L

更新日期：2020-12-03 00:00:00

abstract：Objective:To identify the clinicopathological features correlated to lymph node metastasis (LNM) in patients with papillary thyroid microcarcinoma (PTMC). Methods:Clinical data of 785 PTMC patients who underwent surgical treatment at the Lishui Municipal Central Hospital from September 2008 to December 2017 were retro...

journal_title：International journal of endocrinology

authors： Cheng F,Chen Y,Zhu L,Zhou B,Xu Y,Chen Y,Wen L,Chen S

更新日期：2019-01-15 00:00:00

abstract：:Enucleation-induced adrenal regeneration is a highly controlled process; however, only some elements involved in this process have been recognized. Therefore, we performed studies on regenerating rat adrenals. Microarray RNA analysis and QPCR revealed that enucleation resulted in a rapid elevation of expression of gen...

journal_title：International journal of endocrinology

authors： Tyczewska M,Rucinski M,Ziolkowska A,Szyszka M,Trejter M,Hochol-Molenda A,Nowak KW,Malendowicz LK

更新日期：2014-01-01 00:00:00