Abstract:
:Background. Liraglutide (a glucagon-like peptide 1 analog) was used for the treatment of type 2 diabetes (T2DM) which could produce glucose-dependent insulin secretion. Aim. The aim was to investigate whether liraglutide could improve myofibril and mitochondria injury in skeletal muscle and the mechanisms in diabetic KKAy mice. Method. We divided the male KKAy mice into 2 groups: liraglutide group (250 μg/kg/day liraglutide subcutaneous injection) and model group; meanwhile, the male C57BL/6J mice were considered as the control. After 6 weeks, the ultrastructure of skeletal muscle was observed by electron microscope. The gene expressions of protein tyrosine phosphatase 1B (PTP1B), phosphatidylinositol 3-kinase (PI3K), and glucose transporter type 4 (GLUT4) were determined by real-time PCR. The protein levels of the above molecules and phospho-Akt2 (p-Akt2) were measured by Western blot. Results. Liraglutide significantly ameliorated the injury of mitochondria by increasing the number (+441%) and the area (+113%) of mitochondria and mitochondrial area/100 µm(2) (+396%) in skeletal muscle of KKAy mice. The results of real-time PCR and Western blot showed that liraglutide downregulated PTP1B while it upregulated PI3K and GLUT4 (P < 0.01). The protein level of p-Akt2/Akt2 was also increased (P < 0.01). Conclusion. These results revealed that liraglutide could improve myofibril and mitochondria injury in skeletal muscle against T2DM via PTP1B and PI3K/Akt2 signaling pathway.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Ji W,Chen X,Lv J,Wang M,Ren S,Yuan B,Wang B,Chen Ldoi
10.1155/2014/312452subject
Has Abstractpub_date
2014-01-01 00:00:00pages
312452eissn
1687-8337issn
1687-8345journal_volume
2014pub_type
杂志文章abstract:Objective:Selenium, as an antioxidant, has been implicated in the development of autoimmune thyroiditis (AIT). Many studies showed selenium supplementation could decrease thyroid autoantibodies in patients with AIT. However, the underlying mechanisms have not been well determined. Therefore, we performed a clinical stu...
journal_title:International journal of endocrinology
pub_type: 杂志文章
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更新日期:2020-06-30 00:00:00
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
pub_type: 杂志文章
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/516718
更新日期:2012-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
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journal_title:International journal of endocrinology
pub_type: 杂志文章
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journal_title:International journal of endocrinology
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/732636
更新日期:2012-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/608497
更新日期:2014-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/168047
更新日期:2015-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2018-03-07 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2017/8724869
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journal_title:International journal of endocrinology
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
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更新日期:2018-10-31 00:00:00
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journal_title:International journal of endocrinology
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更新日期:2015-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/957105
更新日期:2015-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type:
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更新日期:2010-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2017/8130796
更新日期:2017-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/8134548
更新日期:2020-03-17 00:00:00