The serum level of fibroblast growth factor-23 and calcium-phosphate homeostasis in obese perimenopausal women.

Abstract:

:Plasma FGF-23 concentrations and its relationship with calcium-phosphate homeostasis were evaluated in 48 perimenopausal obese women and in 29 nonobese controls. Serum parathyroid hormone, 25-hydroxyvitamin D(3), CTX1, osteocalcin, total calcium, phosphorus, creatinine, and plasma intact FGF-23 concentrations were assessed. DXA of lumbar spine and femoral neck was performed to determine bone mineral density (BMD). Plasma iFGF-23 concentration was significantly higher in obese patients (by 42%) and correlated with age and BMD of proximal femur (R = -0.346; R = 0.285, resp.) but not with markers of bone turnover. However, serum phosphorus level in obese subjects was significantly lower. iFGF-23 concentration correlated significantly with body mass index (R = 0.292) and fat content (R = 0.259) in all study subjects. Moreover, a significant correlation between iFGF-23 and iPTH (R = 0.254) was found. No correlation between serum phosphorus or eGFR and plasma iFGF-23 and between eGFR and serum phosphorus was found. Elevated serum iFGF-23 concentration may partially explain lower phosphorus levels in the obese and seems not to reflect bone turnover.

journal_name

Int J Endocrinol

authors

Holecki M,Chudek J,Więcek A,Titz-Bober M,Duława J

doi

10.1155/2011/707126

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

707126

eissn

1687-8337

issn

1687-8345

journal_volume

2011

pub_type

杂志文章
  • Differences in the Cardiometabolic Control in Type 2 Diabetes according to Gender and the Presence of Cardiovascular Disease: Results from the eControl Study.

    abstract::The objective of this cross-sectional study was to assess differences in the control and treatment of modifiable cardiovascular risk factors (CVRF: HbA1c, blood pressure [BP], LDL-cholesterol, body mass index, and smoking habit) according to gender and the presence of cardiovascular disease (CVD) in patients with type...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/131709

    authors: Franch-Nadal J,Mata-Cases M,Vinagre I,Patitucci F,Hermosilla E,Casellas A,Bolivar B,Mauricio D

    更新日期:2014-01-01 00:00:00

  • gp91phox, a Novel Biomarker Evaluating Oxidative Stress, Is Elevated in Subclinical Hypothyroidism.

    abstract:Background:gp91phox, the catalytic core of NADPH oxidase (NOX) and biomarker of NOX activation, has been recently recognized as a parameter of systemic oxidative stress in several studies. Subclinical hypothyroidism (SH) is characteristic of elevated level of serum thyroid stimulating hormone (TSH) and is frequently ac...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/3161730

    authors: Ma X,Wang F,Zhen X,Zhao L,Fang L,Dong Z,Chen W,Zhou X

    更新日期:2020-05-06 00:00:00

  • The Clinicopathological Features of BRAF Mutated Papillary Thyroid Cancers in Chinese Patients.

    abstract::The BRAF(V600E) mutation is commonly found in papillary thyroid cancers (PTCs) at different frequencies in different regions. However, the association between the BRAF(V600E) mutation and clinicopathological features in Chinese PTC patients is unknown. A total of 543 Chinese patients with histologically confirmed PTC ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/642046

    authors: Yang LB,Sun LY,Jiang Y,Tang Y,Li ZH,Zhang HY,Bu H,Ye F

    更新日期:2015-01-01 00:00:00

  • Propylthiouracil-induced acute liver failure: role of liver transplantation.

    abstract::Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the c...

    journal_title:International journal of endocrinology

    pub_type:

    doi:10.1155/2010/910636

    authors: Carrion AF,Czul F,Arosemena LR,Selvaggi G,Garcia MT,Tekin A,Tzakis AG,Martin P,Ghanta RK

    更新日期:2010-01-01 00:00:00

  • Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice.

    abstract::Fibroblast growth factor 21 (FGF21) modulates a diverse range of biological functions, including glucose and lipid metabolism, adaptive starvation response, and energy homeostasis, but with limited mechanistic insight. FGF21 treatment has been shown to inhibit hepatic growth hormone (GH) intracellular signaling. To ev...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/282375

    authors: Boparai RK,Arum O,Miquet JG,Masternak MM,Bartke A,Khardori RK

    更新日期:2015-01-01 00:00:00

  • Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis.

    abstract:Objective:Selenium, as an antioxidant, has been implicated in the development of autoimmune thyroiditis (AIT). Many studies showed selenium supplementation could decrease thyroid autoantibodies in patients with AIT. However, the underlying mechanisms have not been well determined. Therefore, we performed a clinical stu...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/9210572

    authors: Tian X,Li N,Su R,Dai C,Zhang R

    更新日期:2020-06-30 00:00:00

  • GNPDA2 Gene Affects Adipogenesis and Alters the Transcriptome Profile of Human Adipose-Derived Mesenchymal Stem Cells.

    abstract:Background:Genome-wide association studies have found an obesity-related single-nucleotide polymorphism rs10938397 near the glucosamine-6-phosphate deaminase 2 gene (GNPDA2) encoding, an enzyme that catalyzes the deamination of the glucosamine-6-phosphate involved in the hexosamine signaling pathway, but the molecular ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2019/9145452

    authors: Wu L,Ma F,Zhao X,Zhang MX,Wu J,Mi J

    更新日期:2019-08-01 00:00:00

  • Angiogenesis in pituitary adenomas: human studies and new mutant mouse models.

    abstract::The role of angiogenesis in pituitary tumor development has been questioned, as pituitary tumors have been usually found to be less vascularized than the normal pituitary tissue. Nevertheless, a significantly higher degree of vasculature has been shown in invasive or macropituitary prolactinomas when compared to nonin...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2014/608497

    authors: Cristina C,Luque GM,Demarchi G,Lopez Vicchi F,Zubeldia-Brenner L,Perez Millan MI,Perrone S,Ornstein AM,Lacau-Mengido IM,Berner SI,Becu-Villalobos D

    更新日期:2014-01-01 00:00:00

  • Validation of Point-of-Care Glucose Testing for Diagnosis of Type 2 Diabetes.

    abstract::Point-of-care (POC) glucose technology is currently considered to be insufficiently accurate for the diagnosis of diabetes. The objective of this study was to investigate the diagnostic accuracy of an innovative, interference-resistant POC glucose meter (StatStrip glucose hospital meter, Nova Biomedical, USA) in subje...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2013/206309

    authors: Vučić Lovrenčić M,Radišić Biljak V,Božičević S,Pape-Medvidović E,Ljubić S

    更新日期:2013-01-01 00:00:00

  • Corrigendum to "Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction".

    abstract::[This corrects the article DOI: 10.1155/2016/7838290.]. ...

    journal_title:International journal of endocrinology

    pub_type: 已发布勘误

    doi:10.1155/2018/1239718

    authors: Villagarcía HG,Sabugo V,Castro MC,Schinella G,Castrogiovanni D,Spinedi E,Massa ML,Francini F

    更新日期:2018-10-23 00:00:00

  • Prevalence of nonclassic congenital adrenal hyperplasia in Turkish children presenting with premature pubarche, hirsutism, or oligomenorrhoea.

    abstract::Background. Nonclassic congenital adrenal hyperplasia (NCAH), caused by mutations in the gene encoding 21-hydroxylase, is a common autosomal recessive disorder. In the present work, our aim was to determine the prevalence of NCAH presenting as premature pubarche (PP), hirsutism, or polycystic ovarian syndrome (PCOS) a...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/768506

    authors: Binay C,Simsek E,Cilingir O,Yuksel Z,Kutlay O,Artan S

    更新日期:2014-01-01 00:00:00

  • Trends in prevalence, awareness, treatment, and control of diabetes mellitus in mainland china from 1979 to 2012.

    abstract::Diabetes mellitus (DM) is one of the primary causes of premature death and disability worldwide. We performed a systematic review and meta-analysis of the published literature regarding the trends in prevalence, awareness, treatment, and control of diabetes mellitus in mainland China. PUBMED, EMBASE, Chinese Biomedica...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2013/753150

    authors: Li MZ,Su L,Liang BY,Tan JJ,Chen Q,Long JX,Xie JJ,Wu GL,Yan Y,Guo XJ,Gu L

    更新日期:2013-01-01 00:00:00

  • Latent Inflammation and Insulin Resistance in Adipose Tissue.

    abstract::Obesity is a growing problem in modern society and medicine. It closely associates with metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and cardiovascular diseases such as nonalcoholic fatty liver disease, atherosclerosis, myocarditis, and hypertension. Obesity is often associated with latent i...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5076732

    authors: Stafeev IS,Vorotnikov AV,Ratner EI,Menshikov MY,Parfyonova YV

    更新日期:2017-01-01 00:00:00

  • Comparison of Exenatide and Metformin Monotherapy in Overweight/Obese Patients with Newly Diagnosed Type 2 Diabetes.

    abstract:Aims:The present study assessed the therapeutic effect of exenatide and metformin as the initial therapy on overweight/obese patients with newly diagnosed type 2 diabetes (T2D). Methods:The prospective, nonrandomized, interventional study enrolled a total of 230 overweight or obese patients with newly diagnosed T2D wh...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2017/9401606

    authors: Liu J,Hu Y,Xu Y,Jia Y,Miao L,Wang G

    更新日期:2017-01-01 00:00:00

  • Inflammatory response in islet transplantation.

    abstract::Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes. Here we revie...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2014/451035

    authors: Kanak MA,Takita M,Kunnathodi F,Lawrence MC,Levy MF,Naziruddin B

    更新日期:2014-01-01 00:00:00

  • Aerobic Training Associated with Arginine Supplementation Reduces Collagen-Induced Platelet Hyperaggregability in Rats under High Risk to Develop Metabolic Syndrome.

    abstract:Background:Increased platelet response is seen in individuals with metabolic syndrome. Previous reports have shown that arginine supplementation and aerobic exercise training enhance vascular nitric oxide (NO) activity and inhibit platelet hyperaggregability; however, the effects of their association remain unknown. A...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2019/8919435

    authors: Motta NAV,Fumian MM,Medeiros RF,Lima GF,Scaramello CBV,Oliveira KJ,Nóbrega ACL,Brito FCF

    更新日期:2019-01-06 00:00:00

  • Serum Osteoprotegerin Is a Potential Biomarker of Insulin Resistance in Chinese Postmenopausal Women with Prediabetes and Type 2 Diabetes.

    abstract::The aim of this study is to investigate the circulating OPG levels in postmenopausal women with diabetes and prediabetes and explore the relationships between serum OPG and insulin resistance. A total of 271 unrelated Chinese postmenopausal women were recruited in this study. The subjects were divided into type 2 diab...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2017/8724869

    authors: Duan P,Yang M,Wei M,Liu J,Tu P

    更新日期:2017-01-01 00:00:00

  • Association between Bone Mineral Density and Severity of Chronic Kidney Disease.

    abstract:Objective:We sought to evaluate the association between femoral neck (FN) and lumbar spine (LS) bone mineral densities (BMDs) with severity of chronic kidney disease (CKD) and prevalence of osteopenia or osteoporosis (OP) among the CKD group. Methods:Cross-sectional data from 11050 participants aged ≥20 years from the...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/8852690

    authors: Huang JF,Zheng XQ,Sun XL,Zhou X,Liu J,Li YM,Wang XY,Zhang XL,Wu AM

    更新日期:2020-10-26 00:00:00

  • Free triiodothyronine concentrations are inversely associated with microalbuminuria.

    abstract::Thyroid function and microalbuminuria are both associated with vascular disease and endothelial damage. However, whether thyroid function is associated with microalbuminuria is not well established. The objective was to explore the relationship between thyroid hormones and microalbuminuria in Chinese population. A com...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/959781

    authors: Zhou Y,Ye L,Wang T,Hong J,Bi Y,Zhang J,Xu B,Sun J,Huang X,Xu M

    更新日期:2014-01-01 00:00:00

  • The Association between 25-Hydroxyvitamin D and Hemoglobin A1c Levels in Patients with Type 2 Diabetes and Stage 1-5 Chronic Kidney Disease.

    abstract::Aim. To examine the relationship between plasma 25-hydroxyvitamin D (25(OH)D) levels and blood hemoglobin A1c (HbA1c) levels in diabetic patients at various stages of chronic kidney disease (CKD). Methods. We screened for data collected between 2003 and 2012. The correlation between 25(OH)D and HbA1c levels was studie...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/142468

    authors: Kajbaf F,Mentaverri R,Diouf M,Fournier A,Kamel S,Lalau JD

    更新日期:2014-01-01 00:00:00

  • Rare Somatic MEN1 Gene Pathogenic Variant in a Patient Affected by Atypical Parathyroid Adenoma.

    abstract:Objective:Atypical parathyroid adenoma is a rare neoplasm, showing atypical histological features intermediate between classic benign adenoma and the rarest parathyroid carcinoma, whose the clinical behaviour and outcome is not yet understood or predictable. Up to date only two cases of atypical adenoma were found asso...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/2080797

    authors: Cinque L,Pugliese F,Clemente C,Castellana S,Leone MP,de Martino D,Balsamo T,Battista C,Biagini T,Graziano P,Castori M,Scillitani A,Guarnieri V

    更新日期:2020-04-27 00:00:00

  • Long Noncoding RNA LOC100129940-N Is Upregulated in Papillary Thyroid Cancer and Promotes the Invasion and Progression.

    abstract::Thyroid cancer is the most common endocrine malignancy, and its incidence has increased rapidly in recent decades worldwide. Papillary thyroid cancer (PTC) is the most common type of all thyroid cancers. The molecular mechanisms underlying the disease still need to be further investigated. Long noncoding RNAs (lncRNAs...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2019/7043509

    authors: Choy M,Guo Y,Li H,Wei G,Ye R,Liang W,Xiao H,Li Y,Guan H

    更新日期:2019-04-07 00:00:00

  • Regulation of the Human Ghrelin Promoter Activity by Transcription Factors, NF-κB and Nkx2.2.

    abstract::To examine the gene expression of ghrelin, a growth hormone releasing and appetite stimulating hormone from stomach, we constructed human ghrelin promoter-reporter vectors and analyzed the promoter activity. The ghrelin promoter activity was high when cultured cells that express ghrelin mRNA endogenously like TT or EC...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/580908

    authors: Shiimura Y,Ohgusu H,Sato T,Kojima M

    更新日期:2015-01-01 00:00:00

  • Corrigendum to "The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes".

    abstract::[This corrects the article DOI: 10.1155/2014/690783.]. ...

    journal_title:International journal of endocrinology

    pub_type: 已发布勘误

    doi:10.1155/2017/5924671

    authors: Napoli N,Strollo R,Paladini A,Briganti SI,Pozzilli P,Epstein S

    更新日期:2017-01-01 00:00:00

  • Clinicopathological Characteristics and Prognosis of Papillary Thyroid Carcinoma in Naturally Menopausal Women with Various Durations of Premenarche, Reproductive Periods, and Postmenopausal Stages.

    abstract::Background. Papillary thyroid cancer (PTC) exhibits a higher incidence in women. Due to various ages at menarche and menopause, estrogen levels vary, which may account for the differences in the occurrence, development, and prognosis of female patients with PTC. Objective. The aim of this study was to investigate the ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2017/5702716

    authors: Zhu X,Yu B,Huang YQ,Zhou JN,Ge MH

    更新日期:2017-01-01 00:00:00

  • Osteoarticular changes in acromegaly.

    abstract::Acromegaly is caused by hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor-I (IGF-1) due to pituitary tumor. Other causes, such as increased growth-hormone releasing hormone (GHRH) production, ectopic GHRH production, and ectopic GH secretion, are rare. Growth hormone and IGF-1 play a...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2012/839282

    authors: Killinger Z,Kužma M,Sterančáková L,Payer J

    更新日期:2012-01-01 00:00:00

  • Isolation of pancreatic progenitor cells with the surface marker of hematopoietic stem cells.

    abstract::To isolate pancreatic progenitor cells with the surface markers of hematopoietic stem cells, the expression of stem cell antigen (Sca-1) and c-Kit and the coexpression of them with pancreatic duodenal homeobox-1 (PDX-1), neurogenin 3 (Ngn3), and insulin were examined in murine embryonic pancreas. Then different pancre...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2012/948683

    authors: Ma F,Chen F,Chi Y,Yang S,Lu S,Han Z

    更新日期:2012-01-01 00:00:00

  • Peripheral arterial tonometry to measure the effects of vardenafil on sympathetic tone in men with lifelong premature ejaculation.

    abstract::To elucidate whether adrenergic overtone is involved in the pathophysiology of men with lifelong (LL) premature ejaculation (PE), we investigated differences in reactive hyperemia index (RHI) responses by using peripheral arterial tonometry (PAT). 20 men with LL-PE (18-40 years) were enrolled in an 8-week, double-blin...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2013/394934

    authors: Francomano D,Donini LM,Lenzi A,Aversa A

    更新日期:2013-01-01 00:00:00

  • Exercise for hepatic fat accumulation in type 2 diabetic subjects.

    abstract::Type 2 diabetes is characterized by frequent ectopic fat accumulation in several tissues and organs. In particular, a number of studies showed that these subjects frequently have hepatic fat accumulation, which may play a role in the metabolic abnormalities typical of diabetes and has been also linked to increased ris...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2013/309191

    authors: Bacchi E,Moghetti P

    更新日期:2013-01-01 00:00:00

  • Comparison of two creatinine-based equations for predicting decline in renal function in type 2 diabetic patients with nephropathy in a korean population.

    abstract::Aim. To compare two creatinine-based estimated glomerular filtration rate (eGFR) equations, the chronic kidney disease epidemiology collaboration (CKD-EPI) and the modification of diet in renal disease (MDRD), for predicting the risk of CKD progression in type 2 diabetic patients with nephropathy. Methods. A total of ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2013/848963

    authors: Lee EY,Lee YM,Choi KH,Lee HC,Lee BW,Kim BS

    更新日期:2013-01-01 00:00:00