Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis.

abstract：Background:Aromatase inhibitors in women with breast cancer have been associated with cancer treatment-induced bone loss (CTIBL), increased fracture risk, and impairment of glucose metabolism. Denosumab (Dmab), a monoclonal antibody against RANKL, which is a key regulator of the osteoclast activity, is effective as an ...

journal_title：International journal of endocrinology

authors： Rossini A,Frigerio S,Dozio E,Trevisan R,Perseghin G,Corbetta S

更新日期：2020-11-06 00:00:00

abstract：:The aim of this retrospective study was to evaluate the effects of a treatment with α-lipoic acid (ALA) associated with two different doses of myo-inositol (MI) on clinical and metabolic features of women with polycystic ovary syndrome (PCOS). Eighty-eight women received the treatment, and 71 among them had complete c...

journal_title：International journal of endocrinology

authors： Fruzzetti F,Benelli E,Fidecicchi T,Tonacchera M

更新日期：2020-03-19 00:00:00

abstract：:Insulin resistance increases the risk for cardiovascular disease (CVD) even in the absence of classic risk factors, such as hyperglycemia, hypertension, dyslipidemia, and obesity. Low-grade chronic inflammatory state is associated both with insulin resistance and atherosclerosis. An increased circulating level of proi...

journal_title：International journal of endocrinology

authors： Nikołajuk A,Matulewicz N,Stefanowicz M,Karczewska-Kupczewska M

更新日期：2018-09-13 00:00:00

abstract：:Aim of the study was to examine cardiorespiratory parameters at individual ventilatory threshold (IVT) and peak exercise capacity ([Formula: see text]) in outpatient diabetic and sarcopenic obese subjects. Seventeen obese subjects (BMI: 36.6 ± 4.1 kg·m(-1)) and sixteen SO subjects (BMI: 37.0 ± 7.3 kg·m(-1)) were compa...

journal_title：International journal of endocrinology

authors： Emerenziani GP,Gallotta MC,Migliaccio S,Greco EA,Marocco C,di Lazzaro L,Fornari R,Lenzi A,Baldari C,Guidetti L

更新日期：2016-01-01 00:00:00

abstract：Background:Total thyroidectomy (TT) is recommended in the treatment of malignant and benignant thyroid diseases, and, to date, transient hypocalcemia is the most frequent complication after the procedure. We prospectively evaluated the role of vitamin D deficiency as a predictor of postoperative hypocalcemia. Methods:...

journal_title：International journal of endocrinology

authors： Bove A,Dei Rocini C,Di Renzo RM,Farrukh M,Palone G,Chiarini S,Staniscia T

更新日期：2020-10-10 00:00:00

abstract：:The complementary role of hyperglycemia and p27(kip1) suppression on islet beta cell regeneration was investigated in a syngeneic mouse model. p27(kip1) gene silencing was performed by infecting islets of C57BL/6 with shRNA lentiviral particles. At 54 hours after viral infection, p27(kip1) protein content in cultured ...

journal_title：International journal of endocrinology

authors： Chen ST,Fu SH,Hsu S,Huang YY,Hsu BR

更新日期：2012-01-01 00:00:00

abstract：Background:Gonadal injury following chemotherapy is of increasing importance with the continuous improvement of survival rates. The protection of gonadotropin hormone antagonist (GnRHant) in long-term adult survivors of adolescent cancers and some autoimmune diseases has not yet been evaluated. Methods:The present stu...

journal_title：International journal of endocrinology

authors： Xie R,Chen L,Wu H,Chen T,Wang F,Chen X,Sun H,Li X

更新日期：2018-06-10 00:00:00

abstract：:This study investigated potential markers for predicting nonfunctioning pituitary adenoma (NFPA) invasion and recurrence by high-throughput tissue microarray analyses. We retrospectively studied two groups of patients: 60 nonrecurrent NFPA cases that included noninvasion and invasion subtypes and 43 recurrent cases th...

journal_title：International journal of endocrinology

authors： Yao X,Zhang Y,Wu L,Cheng R,Li C,Qu C,Ji H

更新日期：2019-05-16 00:00:00

abstract：Objective:Atypical parathyroid adenoma is a rare neoplasm, showing atypical histological features intermediate between classic benign adenoma and the rarest parathyroid carcinoma, whose the clinical behaviour and outcome is not yet understood or predictable. Up to date only two cases of atypical adenoma were found asso...

journal_title：International journal of endocrinology

authors： Cinque L,Pugliese F,Clemente C,Castellana S,Leone MP,de Martino D,Balsamo T,Battista C,Biagini T,Graziano P,Castori M,Scillitani A,Guarnieri V

更新日期：2020-04-27 00:00:00

abstract：:Anaplastic thyroid cancers (ATC) are among the most aggressive human neoplasms with a dire prognosis and a median survival time of few months from the diagnosis. The complete absence of effective therapies for ATC renders the identification of novel therapeutic approaches sorely needed. Chromosomal instability, a feat...

journal_title：International journal of endocrinology

authors： Baldini E,D'Armiento M,Ulisse S

更新日期：2014-01-01 00:00:00

abstract：:Acromegaly is caused by hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor-I (IGF-1) due to pituitary tumor. Other causes, such as increased growth-hormone releasing hormone (GHRH) production, ectopic GHRH production, and ectopic GH secretion, are rare. Growth hormone and IGF-1 play a...

journal_title：International journal of endocrinology

authors： Killinger Z,Kužma M,Sterančáková L,Payer J

更新日期：2012-01-01 00:00:00

abstract：:A retrospective review of 626 patients with multifocal papillary thyroid carcinoma (PTC) including 147 patients (23.5%) with multifocal papillary thyroid microcarcinoma (PTMC) from a total of 2,536 patients with PTC who visited the Chang Gung Medical Center in Linkou, Taiwan, was performed. A comparison of the clinica...

journal_title：International journal of endocrinology

authors： Ng SC,Kuo SF,Chen ST,Hsueh C,Huang BY,Lin JD

更新日期：2017-01-01 00:00:00

abstract：Aims:The present study assessed the therapeutic effect of exenatide and metformin as the initial therapy on overweight/obese patients with newly diagnosed type 2 diabetes (T2D). Methods:The prospective, nonrandomized, interventional study enrolled a total of 230 overweight or obese patients with newly diagnosed T2D wh...

journal_title：International journal of endocrinology

authors： Liu J,Hu Y,Xu Y,Jia Y,Miao L,Wang G

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Recent guidelines from the American Thyroid Association (ATA) indicate that, in many patients affected by differentiated thyroid cancer (DTC), the serum TSH should be maintained between 0.1 and 0.5 mU/L. The purpose of this study was to evaluate the TSH variability of patients affected by DTC treated with li...

journal_title：International journal of endocrinology

authors： Cappelli C,Pirola I,Gandossi E,Casella C,Lombardi D,Agosti B,Marini F,Delbarba A,Castellano M

更新日期：2017-01-01 00:00:00

abstract：:The hypothalamus is an essential relay in the neural circuitry underlying energy metabolism that needs to continually adapt to changes in the energetic environment. The neuroendocrine control of food intake and energy expenditure is associated with, and likely dependent upon, hypothalamic plasticity. Severe disturbanc...

journal_title：International journal of endocrinology

authors： Stranahan AM,Martin B,Chadwick W,Park SS,Wang L,Becker KG,Woodiii WH,Zhang Y,Maudsley S

更新日期：2012-01-01 00:00:00

abstract：:The aim of this work was to study the androgen receptors (AR) expression in pituitary pars distalis (PD) of male viscachas in relation to growth and reproductive cycle. AR were detected by immunocytochemistry and quantified by image analysis. Pituitary glands from fetus, immature, prepubertal, and adult viscachas duri...

journal_title：International journal of endocrinology

authors： Filippa VP,Rosales GJ,Cruceño AA,Mohamed FH

更新日期：2015-01-01 00:00:00

abstract：:Sex steroid hormones have neuroprotective properties which may be mediated by brain-derived neurotrophic factor (BDNF). This study sought to determine the interactive effects of preadolescent hormone manipulation and BDNF heterozygosity (+/-) on hippocampal NMDA-R expression. Wild-type and BDNF+/- mice were gonadectom...

journal_title：International journal of endocrinology

authors： McCarthny CR,Du X,Wu YC,Hill RA

更新日期：2018-01-31 00:00:00

abstract：:Aim. To examine the relationship between plasma 25-hydroxyvitamin D (25(OH)D) levels and blood hemoglobin A1c (HbA1c) levels in diabetic patients at various stages of chronic kidney disease (CKD). Methods. We screened for data collected between 2003 and 2012. The correlation between 25(OH)D and HbA1c levels was studie...

journal_title：International journal of endocrinology

authors： Kajbaf F,Mentaverri R,Diouf M,Fournier A,Kamel S,Lalau JD

更新日期：2014-01-01 00:00:00

abstract：:Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes. Here we revie...

journal_title：International journal of endocrinology

authors： Kanak MA,Takita M,Kunnathodi F,Lawrence MC,Levy MF,Naziruddin B

更新日期：2014-01-01 00:00:00

abstract：:Melatonin (N-acetyl-5-methoxytryptamine) is a hormone synthesized and secreted by the pineal gland mainly during the night, since light exposure suppresses its production. Initially, an implication of this indoleamine in malignant disease was described in endocrine-responsive breast cancer. Data from several clinical ...

journal_title：International journal of endocrinology

authors： Menéndez-Menéndez J,Martínez-Campa C

更新日期：2018-10-02 00:00:00

abstract：:Whether serum magnesium deficiency is independently associated with the prevalence of microalbuminuria is still unclear. The objective of the present study was to elucidate the association between serum magnesium and microalbuminuria in diabetic patients. A cross-sectional study was conducted in 1829 diabetic subjects...

journal_title：International journal of endocrinology

authors： Xu B,Sun J,Deng X,Huang X,Sun W,Xu Y,Xu M,Lu J,Bi Y

更新日期：2013-01-01 00:00:00

abstract：:We investigated the role of urokinase plasminogen activator (uPA) and its soluble receptors (suPAR) and plasminogen activator inhibitor-1 (PAI-1) in metabolic syndrome (MetS) components, insulin secretion, and resistance in schoolchildren. We enrolled 387 children, aged 10.3 ± 1.5 years, in Taipei. Anthropometry, fibr...

journal_title：International journal of endocrinology

authors： Chen JS,Wu CZ,Chu NF,Chang LC,Pei D,Lin YF

更新日期：2015-01-01 00:00:00

abstract：:Diabetes is a lifelong course disease, so insulin treatment has to be effective and safe, and patients should be satisfied with it. We aimed to compare efficacy, safety, and quality of treatment satisfaction of human and premixed analogue insulin among 3264 patients (53.58% women) with type 2 diabetes mellitus (T2DM) ...

journal_title：International journal of endocrinology

authors： Nabrdalik K,Kwiendacz H,Sawczyn T,Tomasik A,Kukla M,Masierek M,Gumprecht J

更新日期：2018-03-05 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) patients are more likely to have vitamin D deficiency when compared to the general population. This study aimed to determine the levels of 25-OH-vitamin D [25(OH)D] in individuals with NF1 and disease-unaffected controls and analyze FokI and BsmI VDR gene polymorphisms in a case and in a...

journal_title：International journal of endocrinology

authors： Souza Mario Bueno L,Rosset C,Aguiar E,Pereira Fde S,Izetti Ribeiro P,Scalco R,Matzenbacher Bittar C,Brinckmann Oliveira Netto C,Gischkow Rucatti G,Chies JA,Camey SA,Ashton-Prolla P

更新日期：2015-01-01 00:00:00

abstract：:In the last 20 years, a pituitary-hypothalamus tissue culture system with intact neural and portal connections has been developed in our lab and used to understand the feedback mechanisms that regulate the secretions of adenohypophyseal hormones and fertility of male rats. In the last decade, several in vivo rat model...

journal_title：International journal of endocrinology

authors： Gill-Sharma MK

更新日期：2009-01-01 00:00:00

abstract：Introduction:Gut microbiota is involved in the progression of metabolic diseases such as obesity and type 2 diabetes. The ob/ob and db/db mice are extensively used as models in studies on the pathogenesis of these diseases. The goal of this study is to characterize the composition and structure of gut microbiota in the...

journal_title：International journal of endocrinology

authors： Yang M,Liu Y,Xie H,Wen Z,Zhang Y,Wu C,Huang L,Wu J,Xie C,Wang T,Peng W,Liu S,Chen L,Liu X

更新日期：2019-03-11 00:00:00

abstract：:The aim of this study is to evaluate carotid atherosclerosis in patients of type 2 diabetes mellitus with microalbuminuria (MA) by high-frequency ultrasonography. Two hundred and fifty patients of type 2 diabetes mellitus were divided into two groups according to urinary albumin excretion rate (UAER): normoalbuminuria...

journal_title：International journal of endocrinology

authors： Zhang YH,Gao Y,Mao X,Shang J,Su BL

更新日期：2013-01-01 00:00:00

abstract：:Background. Abdominal obesity and its relative distribution are known to differ in association with metabolic characteristics and cardiorespiratory fitness. This study aimed to determine an association between fitness level and abdominal adiposity in overweight and obese adults. Methods. 228 overweight and obese indiv...

journal_title：International journal of endocrinology

authors： Kim S,Kim JY,Lee DC,Lee HS,Lee JW,Jeon JY

更新日期：2014-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2015/164087.]. ...

journal_title：International journal of endocrinology

authors： Zhao P,Hu W,Wang H,Yu S,Li C,Bai J,Gui S,Zhang Y

更新日期：2018-09-06 00:00:00

abstract：:Enucleation-induced adrenal regeneration is a highly controlled process; however, only some elements involved in this process have been recognized. Therefore, we performed studies on regenerating rat adrenals. Microarray RNA analysis and QPCR revealed that enucleation resulted in a rapid elevation of expression of gen...

journal_title：International journal of endocrinology

authors： Tyczewska M,Rucinski M,Ziolkowska A,Szyszka M,Trejter M,Hochol-Molenda A,Nowak KW,Malendowicz LK

更新日期：2014-01-01 00:00:00