Abstract:
:Vascular calcification and bone fragility are common and interrelated health problems that affect chronic kidney disease (CKD) patients. Bone fragility, which leads to higher risk of fracture and mortality, arises from the abnormal bone remodeling and mineralization that are seen in chronic kidney disease. Recently, sclerostin and Dickkopf-related protein 1 were suggested to play a significant role in CKD-related bone disease as they are known inhibitors of the Wnt pathway, thus preventing bone formation. This review focuses on new knowledge about the Wnt pathway in bone, how its function is affected by chronic kidney disease and how this affects bone structure. Expression of components and inhibitors of the Wnt pathway has been shown to be affected by the loss of kidney function, and a better understanding of the bone effects of Wnt pathway inhibitors could allow the development of new therapies to prevent bone fragility in this population.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Bisson SK,Ung RV,Mac-Way Fdoi
10.1155/2018/5893514subject
Has Abstractpub_date
2018-04-02 00:00:00pages
5893514eissn
1687-8337issn
1687-8345journal_volume
2018pub_type
杂志文章,评审abstract::Background. Reduced testicular volume (TV) (<12 cm(3)) is associated with lower testicular function. Several studies explored the conventional sperm parameters (concentration, motility, and morphology) and the endocrine function (gonadotropins and testosterone serum concentrations) in the patients with reduction of TV...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/145792
更新日期:2013-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2017/7053959
更新日期:2017-01-01 00:00:00
abstract::Diabetes is a lifelong course disease, so insulin treatment has to be effective and safe, and patients should be satisfied with it. We aimed to compare efficacy, safety, and quality of treatment satisfaction of human and premixed analogue insulin among 3264 patients (53.58% women) with type 2 diabetes mellitus (T2DM) ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/6536178
更新日期:2018-03-05 00:00:00
abstract:Purpose:Primary hypertrophic osteoarthropathy (PHO) is a rare, autosomal, recessive genetic disease characterized by digital clubbing, periostosis, and pachydermia. The underlying cause for the pathogenesis of this disease is a defect in prostaglandin E2 (PGE2) degradation, caused by mutations in HPGD or SLCO2A1. In th...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/6698878
更新日期:2020-12-03 00:00:00
abstract::Parathyroid carcinoma (PC) is a rare disease responsible for about 1% of primary hyperparathyroidism (PHPT) cases. PC usually has an indolent course, tough to differentiate from the benign causes of PHPT, and the only certain diagnosis is histologic. The gold standard surgical treatment is the en bloc resection associ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/7048185
更新日期:2020-03-06 00:00:00
abstract::HDL cholesterol is known to be inversely correlated with cardiovascular disease due to its diverse antiatherogenic functions. SR-BI mediates the selective uptake of HDL-C. SR-BI knockout diminishes but does not completely block the transport of HDL; other receptors may be involved. Ectopic ATP synthase β-chain in hepa...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/356432
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abstract:Background:Type 2 diabetes mellitus is a serious public health problem worldwide. Accumulating evidence has shown that β-cell dysfunction is an important mechanism underlying diabetes mellitus. The changes in the physiological state of islet stellate cells (ISCs) and the effects of these cells on β-cell dysfunction is ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/4708132
更新日期:2020-02-24 00:00:00
abstract::Purpose. To evaluate whether inferior rectus muscle (IRM) thickness, the degree of adipose change in the IRM, smoking status, and the previous history of orbital radiotherapy can predict the dose-effect relationship regarding unilateral IRM recession in thyroid eye disease (TED). Methods. Twenty-five patients were ret...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/703671
更新日期:2015-01-01 00:00:00
abstract::Iodine supplementation through salt iodization is a worldwide, effective strategy for preventing iodine deficiency-related problems. Its safety and efficacy profile has been extensively investigated, and benefits far outweigh the potential iodine-induced risks. Moreover, iodine supplementation during pregnancy in orde...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/312305
更新日期:2015-01-01 00:00:00
abstract::Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2017/2452853
更新日期:2017-01-01 00:00:00
abstract::Background. The Japan Thyroid Association recently published guidelines for clinical practice for the management of thyroid nodules, which include a diagnostic system for reporting thyroid fine needle aspiration cytology. It is characterized by the subclassification of follicular neoplasms, which is different from oth...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/938305
更新日期:2015-01-01 00:00:00
abstract::Preeclampsia is a serious medical problem affecting the mother and her child and influences their health not only during the pregnancy, but also many years after. Although preeclampsia is a subject of many research projects, the etiology of the condition remains unclear. One of the hypotheses related to the etiology o...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2016/5279462
更新日期:2016-01-01 00:00:00
abstract::Objective. In pediatric central diabetes insipidus (CDI), etiology diagnosis and pituitary function monitoring are usually delayed. This study aimed to illustrate the importance of regular follow-up and pituitary function monitoring in pediatric CDI. Methods. The clinical, hormonal, and neuroradiological characteristi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/6365830
更新日期:2016-01-01 00:00:00
abstract:Objectives:To compare the predictive ability of six anthropometric indices for identification of metabolic syndrome (MetS) and to determine their optimal cut-off points among Chinese adults. Methods:A total of 59,029 participants were enrolled. Body mass index (BMI), waist circumference (WC), waist-to-height ratio (WH...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/1067603
更新日期:2018-09-17 00:00:00
abstract::Thyroid nodules, with their high prevalence in the general population, represent a diagnostic challenge for clinicians. Ultrasound (US), although absolutely reliable in detecting thyroid nodules, is still not accurate enough to differentiate them into benign and malignant. A promising novel modality, US elastography, ...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/908575
更新日期:2015-01-01 00:00:00
abstract:Objective:To evaluate the effectiveness and safety of coenzyme Q10 for patients with type 2 diabetes mellitus (T2DM). Methods:Data from randomized controlled trials were obtained to assess the effects of coenzyme Q10 versus placebo or western medicine on patients with T2DM. The study's registration number is CRD420180...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/6484839
更新日期:2018-09-16 00:00:00
abstract:Objective:The aim of the present study was to investigate the association between dietary patterns and precocious puberty among Shanghai children. Methods:A cross-sectional study was conducted among Shanghai children by multistage stratified cluster random sampling in June 2014. Diet was assessed using a simplified fo...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/4528704
更新日期:2018-01-16 00:00:00
abstract:Introduction:Gut microbiota is involved in the progression of metabolic diseases such as obesity and type 2 diabetes. The ob/ob and db/db mice are extensively used as models in studies on the pathogenesis of these diseases. The goal of this study is to characterize the composition and structure of gut microbiota in the...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/1394097
更新日期:2019-03-11 00:00:00
abstract:Background:Little information is available on the association between parents' metabolic syndrome (MetS) and adolescent offspring's obesity in Korea. The aim of our study is to determine the association between parent's metabolic syndrome and offspring's obesity. Methods:The study data were obtained from the Korean Na...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/8737912
更新日期:2020-10-30 00:00:00
abstract:BACKGROUND:Evidence on the association between subclinical thyroid dysfunction and the risk of cardiovascular outcomes are conflicting. METHODS AND RESULTS:PubMed, EMbase, Web of Science, Cochrane Library, and China Biology Medicine (CBM) databases were searched from inception to July 10, 2016. A total of 16 studies w...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2017/8130796
更新日期:2017-01-01 00:00:00
abstract::Spermatozoa are highly specialized cells that can be easily obtained and purified. Mature spermatozoa are transcriptionally and translationally inactive and incapable of protein synthesis. In addition, spermatozoa contain relatively higher amounts of membrane proteins compared to other cells; therefore, they are very ...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2013/360986
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/9145452
更新日期:2019-08-01 00:00:00
abstract::Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is an autosomal dominant disorder characterized by parathyroid tumors in association with fibro-osseous jaw tumors and uterine and renal lesions. HPT-JT syndrome is caused by germline mutations of the cell division cycle 73 (CDC73) gene that encodes the parafibromin, a 5...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2019/1761030
更新日期:2019-12-18 00:00:00
abstract::The goal of this study was to determine the prevalence and associated risk factors of impaired glucose regulation (IGR) in the population of Tongzhou, China, and to provide scientific basis for preventive interventions. In the study, the overall age-standardized prevalence of IGR (16.0%) in Tongzhou residents was high...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/731583
更新日期:2015-01-01 00:00:00
abstract::Aim of the study was to examine cardiorespiratory parameters at individual ventilatory threshold (IVT) and peak exercise capacity ([Formula: see text]) in outpatient diabetic and sarcopenic obese subjects. Seventeen obese subjects (BMI: 36.6 ± 4.1 kg·m(-1)) and sixteen SO subjects (BMI: 37.0 ± 7.3 kg·m(-1)) were compa...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/6739150
更新日期:2016-01-01 00:00:00
abstract::Stevia rebaudiana (Bert.) Bertoni besides being a source of noncaloric sweeteners is also an important source of bioactive molecules. Many plant extracts, mostly obtained with ethyl acetate solvent, are rich in polyphenol compounds that present insulinotropic effects. To investigate whether the nonsweetener fraction, ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/3189879
更新日期:2018-04-29 00:00:00
abstract::Objective. To identify factors predicting the need for insulin therapy in pregnancies complicated by gestational diabetes mellitus (GDM). Methods. A total of 1352 patients with GDM diagnosed by the 75-g/2-h oral glucose tolerance test (OGTT) were enrolled in this study. Univariate and multivariate analysis were perfor...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/4858976
更新日期:2016-01-01 00:00:00
abstract:Background:Gonadal injury following chemotherapy is of increasing importance with the continuous improvement of survival rates. The protection of gonadotropin hormone antagonist (GnRHant) in long-term adult survivors of adolescent cancers and some autoimmune diseases has not yet been evaluated. Methods:The present stu...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/4272575
更新日期:2018-06-10 00:00:00
abstract:OBJECTIVE:We aimed to explore whether squamous cell carcinoma antigen (SCC), cytokeratin 19 fragment (Cyfra21-1), neuron-specific enolase (NSE), and carcinoembryonic antigen (CEA) are elevated in diabetic nephropathy (DN) and the association between urinary albumin-to-creatinine ratio (UACR) and tumor markers in diabet...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2017/5304391
更新日期:2017-01-01 00:00:00
abstract::Background. Nonclassic congenital adrenal hyperplasia (NCAH), caused by mutations in the gene encoding 21-hydroxylase, is a common autosomal recessive disorder. In the present work, our aim was to determine the prevalence of NCAH presenting as premature pubarche (PP), hirsutism, or polycystic ovarian syndrome (PCOS) a...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/768506
更新日期:2014-01-01 00:00:00