Role of the Wnt/β-Catenin Pathway in Renal Osteodystrophy.

Abstract:

:Vascular calcification and bone fragility are common and interrelated health problems that affect chronic kidney disease (CKD) patients. Bone fragility, which leads to higher risk of fracture and mortality, arises from the abnormal bone remodeling and mineralization that are seen in chronic kidney disease. Recently, sclerostin and Dickkopf-related protein 1 were suggested to play a significant role in CKD-related bone disease as they are known inhibitors of the Wnt pathway, thus preventing bone formation. This review focuses on new knowledge about the Wnt pathway in bone, how its function is affected by chronic kidney disease and how this affects bone structure. Expression of components and inhibitors of the Wnt pathway has been shown to be affected by the loss of kidney function, and a better understanding of the bone effects of Wnt pathway inhibitors could allow the development of new therapies to prevent bone fragility in this population.

journal_name

Int J Endocrinol

authors

Bisson SK,Ung RV,Mac-Way F

doi

10.1155/2018/5893514

subject

Has Abstract

pub_date

2018-04-02 00:00:00

pages

5893514

eissn

1687-8337

issn

1687-8345

journal_volume

2018

pub_type

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