Abstract:
OBJECTIVE:We aimed to explore whether squamous cell carcinoma antigen (SCC), cytokeratin 19 fragment (Cyfra21-1), neuron-specific enolase (NSE), and carcinoembryonic antigen (CEA) are elevated in diabetic nephropathy (DN) and the association between urinary albumin-to-creatinine ratio (UACR) and tumor markers in diabetic patients. METHODS:Nondialysis patients with diabetes (n = 261) and 90 healthy controls were enrolled. DN was defined as an UACR ≥ 30 mg/g in the absence of a urinary tract infection or other renal abnormalities. RESULTS:Patients with DN had significantly higher serum SCC, Cyfra21-1, and CEA levels than those with normoalbuminuria and healthy controls. The rates of positive SCC, Cyfra21-1, and CEA significantly increased with increasing urinary albumin excretion (all P for trend < 0.001). In contrast, NSE was not affected by DN. SCC, Cyfra21-1, and CEA were significantly and positively correlated with UACR. In logistic regression, after multivariable adjustment, increased UACR was associated with increased odds ratio of elevated tumor marker levels (all P for trend < 0.05). CONCLUSIONS:Serum levels of SCC, Cyfra21-1, and CEA are markedly increased with increasing urinary albumin excretion, which affects the specificity for diagnosis for lung cancer. Appropriate interpretation of tumor markers in diabetic patients is mandatory to avoid unnecessary and even hazardous biopsies.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Chen J,Tao F,Zhang B,Chen Q,Qiu Y,Luo Q,Gen Y,Meng J,Zhang J,Lu Hdoi
10.1155/2017/5304391subject
Has Abstractpub_date
2017-01-01 00:00:00pages
5304391eissn
1687-8337issn
1687-8345journal_volume
2017pub_type
杂志文章abstract::Atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) in thyroid fine needle aspiration (FNA) is a challenging category. The malignancy risk is different by multiple factors and subsequent management strategy is inconclusive. Therefore, we analyzed the malignancy risk of AUS/FLU...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/4521984
更新日期:2018-07-30 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/1794894
更新日期:2016-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2014/690783.]. ...
journal_title:International journal of endocrinology
pub_type: 已发布勘误
doi:10.1155/2017/5924671
更新日期:2017-01-01 00:00:00
abstract::Point-of-care (POC) glucose technology is currently considered to be insufficiently accurate for the diagnosis of diabetes. The objective of this study was to investigate the diagnostic accuracy of an innovative, interference-resistant POC glucose meter (StatStrip glucose hospital meter, Nova Biomedical, USA) in subje...
journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/1528437
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abstract::Bariatric surgery is currently the most effective therapy to induce weight loss in morbidly obese patients. Objective. This controlled, clinical trial with a two-year intervention was aimed at comparing the efficacy of two nonsurgical approaches versus bariatric surgery, on body weight changes and metabolic parameters...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/194696
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abstract::The complementary role of hyperglycemia and p27(kip1) suppression on islet beta cell regeneration was investigated in a syngeneic mouse model. p27(kip1) gene silencing was performed by infecting islets of C57BL/6 with shRNA lentiviral particles. At 54 hours after viral infection, p27(kip1) protein content in cultured ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/417390
更新日期:2012-01-01 00:00:00
abstract:Background:Little information is available on the association between parents' metabolic syndrome (MetS) and adolescent offspring's obesity in Korea. The aim of our study is to determine the association between parent's metabolic syndrome and offspring's obesity. Methods:The study data were obtained from the Korean Na...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/8737912
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abstract::Vascular calcification and bone fragility are common and interrelated health problems that affect chronic kidney disease (CKD) patients. Bone fragility, which leads to higher risk of fracture and mortality, arises from the abnormal bone remodeling and mineralization that are seen in chronic kidney disease. Recently, s...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2018/5893514
更新日期:2018-04-02 00:00:00
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journal_title:International journal of endocrinology
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doi:10.1155/2012/380902
更新日期:2012-01-01 00:00:00
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journal_title:International journal of endocrinology
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doi:10.1155/2016/4658469
更新日期:2016-01-01 00:00:00
abstract::Sestrin (SESN) is known as a cysteine sulfinic acid reductase. Recently, nonredox functions of SESN in metabolic regulation and antitumor property have been recognized. While mechanisms underlying the expression of SESN are not fully understood. Here we report that insulin markedly increased SESN2 level in HepG2 cells...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/505849
更新日期:2015-01-01 00:00:00
abstract::The presence of brown adipose tissue (BAT) in humans is unclear. Pheochromocytomas (PHEO) are rare tumors of neuroectodermal origin which occur in 0.1-0.2% of patients with hypertension. We sought to evaluate the presence and activity of BAT surrounding adrenal PHEO in a well-studied sample of 11 patients who were dia...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/126751
更新日期:2013-01-01 00:00:00
abstract::Background. Pediatric CAH patients have an increased risk of cardiovascular disease, and it remains unknown if genetic predisposition is a contributing factor. Glucocorticoid receptor gene (NR3C1) polymorphisms are associated with an adverse metabolic profile. Our aim was to analyze the association between the NR3C1 p...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/594710
更新日期:2014-01-01 00:00:00
abstract::Thyroid function and microalbuminuria are both associated with vascular disease and endothelial damage. However, whether thyroid function is associated with microalbuminuria is not well established. The objective was to explore the relationship between thyroid hormones and microalbuminuria in Chinese population. A com...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/959781
更新日期:2014-01-01 00:00:00
abstract::The study explored the utility of four-point preprandial glucose self-monitoring to calculate several indices of glycemic control and variability in a study adding the DPP-4 inhibitor vildagliptin to ongoing insulin therapy. This analysis utilized data from a double-blind, randomized, placebo-controlled crossover stud...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/484231
更新日期:2015-01-01 00:00:00
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journal_title:International journal of endocrinology
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doi:10.1155/2010/681647
更新日期:2010-01-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women of reproductive age. Although PCOS is diagnosed exclusively based on reproductive criteria, it is also a metabolic disorder. Insulin resistance, impaired glucose tolerance, type 2 diabetes mellitus, obesity, and dyslipidemia are more ...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/786362
更新日期:2015-01-01 00:00:00
abstract::A considerable increase in endocrine abnormalities has been reported over the last few decades worldwide. A growing exposure to endocrine-disrupting chemicals (EDCs) can be one of the causes of endocrine disorders in populations, and these disorders are not only restricted to the metabolic hormone system but can also ...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2019/7396716
更新日期:2019-04-17 00:00:00
abstract::To isolate pancreatic progenitor cells with the surface markers of hematopoietic stem cells, the expression of stem cell antigen (Sca-1) and c-Kit and the coexpression of them with pancreatic duodenal homeobox-1 (PDX-1), neurogenin 3 (Ngn3), and insulin were examined in murine embryonic pancreas. Then different pancre...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/948683
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2017/9401606
更新日期:2017-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/4528704
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journal_title:International journal of endocrinology
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journal_title:International journal of endocrinology
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doi:10.1155/2014/436725
更新日期:2014-01-01 00:00:00
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journal_title:International journal of endocrinology
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doi:10.1155/2013/361895
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2010/957174
更新日期:2010-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/683515
更新日期:2014-01-01 00:00:00
abstract::In the last 20 years, a pituitary-hypothalamus tissue culture system with intact neural and portal connections has been developed in our lab and used to understand the feedback mechanisms that regulate the secretions of adenohypophyseal hormones and fertility of male rats. In the last decade, several in vivo rat model...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2009/687259
更新日期:2009-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/4802720
更新日期:2016-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/371608
更新日期:2013-01-01 00:00:00