Abstract:
:A considerable increase in endocrine abnormalities has been reported over the last few decades worldwide. A growing exposure to endocrine-disrupting chemicals (EDCs) can be one of the causes of endocrine disorders in populations, and these disorders are not only restricted to the metabolic hormone system but can also cause abnormal functions. Thyroid hormone (TH) disruption is defined as an abnormal change in TH production, transport, function, or metabolism, which results in some degree of impairment in body homeostasis. Many EDCs, including organotin compounds (OTCs), are environmental contaminants that are commonly found in antifouling paints used on ships and in several other industrial procedures. OTCs are obesogenic and can disrupt TH metabolism; however, abnormalities in thyroid function resulting from OTC exposure are less well understood. OTCs, one of the most prevalent EDCs that are encountered on a daily basis, modulate the thyroid axis. In most toxicology studies, it has been reported that OTCs might contribute to hypothyroidism.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
de Oliveira M,Rodrigues BM,Olimpio RMC,Graceli JB,Gonçalves BM,Costa SMB,da Silva TM,De Sibio MT,Moretto FCF,Mathias LS,Cardoso DBM,Tilli HP,Freitas-Lima LC,Nogueira CRdoi
10.1155/2019/7396716subject
Has Abstractpub_date
2019-04-17 00:00:00pages
7396716eissn
1687-8337issn
1687-8345journal_volume
2019pub_type
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