The Association between Treatment for Metabolic Disorders and Breast Cancer Characteristics.

Abstract:

:Purpose. To evaluate the associations between metformin, insulin, statins, and levothyroxine and breast cancer characteristics and outcome. Methods. Retrospective chart review of patients treated in our institute for early estrogen receptor (ER) positive, human epidermal growth factor receptor 2 negative breast cancer, whose tumors were sent to Oncotype DX (ODX) analysis. Patients were grouped according to medications usage during the time of breast cancer diagnosis. Each group was compared to the rest of the study population. Results. The study cohort included 671 patients. Sixty (9.1%) patients were treated with metformin, 9 (1.4%) with insulin, 208 (31.7%) with statins, and 62 (9.4%) with levothyroxine. Patients treated with metformin had more intense ER stain (p = 0.032) and a lower ODX recurrence score (RS) (p = 0.035). Diagnosis of diabetes mellitus was also associated with lower ODX RS (p = 0.014). Insulin usage was associated with a higher rate of angiolymphatic invasion (p = 0.041), but lower Ki67% (p = 0.017). Levothyroxine usage was associated with different histological subtype distribution (p = 0.02). Extended levothyroxine usage was associated with lower ODX RS (p = 0.005). Statin usage had no impact on tumor characteristics. Outcome was comparable in the studied subgroups. Conclusions. Common medications for metabolic disorders might be associated with breast cancer characteristics.

journal_name

Int J Endocrinol

authors

Goldvaser H,Rizel S,Hendler D,Neiman V,Shepshelovich D,Shochat T,Sulkes A,Brenner B,Yerushalmi R

doi

10.1155/2016/4658469

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

4658469

eissn

1687-8337

issn

1687-8345

journal_volume

2016

pub_type

杂志文章
  • Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease.

    abstract::Objective. To analyze changes in vital signs (heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP)) during and after intravenous methylprednisolone (IVMP) and any other adverse effects. Methods. Retrospective review of charts of patients who received IVMP as treatment regime for thyroid eye disease. All...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/457123

    authors: Yong KL,Chng CL,Htoon HM,Lim LH,Seah LL

    更新日期:2015-01-01 00:00:00

  • Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin.

    abstract::Aims. To evaluate the predictive power of pretransplant HbA1c for new-onset diabetes after transplantation (NODAT) in kidney transplant candidates, who had several predispositions for fluctuated HbA1c levels. Methods. We performed a retrospective study of 119 patients without diabetes who received kidney transplantati...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/436725

    authors: Tokodai K,Amada N,Haga I,Nakamura A,Kashiwadate T,Kawagishi N,Ohuchi N

    更新日期:2014-01-01 00:00:00

  • Comparison of ox-LDL Levels in Diabetic Patients with Normo-, Micro-, and Macroalbuminuria with Their First Degree Relatives and the Healthy Control Group.

    abstract::Oxidized low density lipoprotein (ox-LDL) is a product of oxidative stress. In this cross-sectional study, we compared the ox-LDL concentrations in diabetic patients with normoalbuminuria (n = 28), microalbuminuria (n = 28), and macroalbuminuria (n = 28) with their first degree relatives (n = 28) and healthy control p...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2012/167154

    authors: Behzadi P,Torabi F,Amini M,Aminorroaya A

    更新日期:2012-01-01 00:00:00

  • Free triiodothyronine concentrations are inversely associated with microalbuminuria.

    abstract::Thyroid function and microalbuminuria are both associated with vascular disease and endothelial damage. However, whether thyroid function is associated with microalbuminuria is not well established. The objective was to explore the relationship between thyroid hormones and microalbuminuria in Chinese population. A com...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/959781

    authors: Zhou Y,Ye L,Wang T,Hong J,Bi Y,Zhang J,Xu B,Sun J,Huang X,Xu M

    更新日期:2014-01-01 00:00:00

  • Hyperoside Alleviates High Glucose-Induced Proliferation of Mesangial Cells through the Inhibition of the ERK/CREB/miRNA-34a Signaling Pathway.

    abstract:Purpose:Hyperoside, a flavonoid isolated from conventional medicinal herbs, has been demonstrated to exert a significant protective effect in diabetic nephropathy. This study aimed to determine the underlying mechanisms, by which hyperoside inhibits high glucose-(HG-) induced proliferation in mouse renal mesangial cell...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/1361924

    authors: Zhang L,Dai Q,Hu L,Yu H,Qiu J,Zhou J,Long M,Zhou S,Zhang K

    更新日期:2020-07-21 00:00:00

  • Benign Aspirates on Follow-Up FNA May Be Enough in Patients with Initial Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance.

    abstract::Background. Management of thyroid nodules with benign aspirates following atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is not well established. We reviewed the risk of malignancy and the role of ultrasound (US) features among thyroid nodules with benign results followin...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/354612

    authors: Kim GR,Yoon JH,Kim EK,Moon HJ,Kwak JY

    更新日期:2014-01-01 00:00:00

  • Age- and Gender-Related Differences in LDL-Cholesterol Management in Outpatients with Type 2 Diabetes Mellitus.

    abstract::Background. Dyslipidemia contribute to the excess of coronary heart disease (CHD) risk observed in women with type 2 diabetes (T2DM). Low density lipoprotein-cholesterol (LDL-C) is the major target for CHD prevention, and T2DM women seem to reach LDL-C targets less frequently than men. Aim. To explore age- and gender-...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/957105

    authors: Russo G,Pintaudi B,Giorda C,Lucisano G,Nicolucci A,Cristofaro MR,Suraci C,Mulas MF,Napoli A,Rossi MC,Manicardi V

    更新日期:2015-01-01 00:00:00

  • Psychological status and quality of life in relation to the metabolic syndrome: Isfahan Cohort Study.

    abstract:OBJECTIVE:Current study was designed to investigate the association of metabolic syndrome (MetS) with depression, anxiety, psychological distress, and quality of life (QoL). DESIGN:Two hundred and fifteen contributors with MetS and 253 participants without MetS were randomly selected from 2151 participants of Isfahan ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2012/380902

    authors: Roohafza H,Sadeghi M,Talaei M,Pourmoghaddas Z,Sarrafzadegan N

    更新日期:2012-01-01 00:00:00

  • The Age-Specific Association of Waist Circumference and Risk of Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus in Shandong, China.

    abstract::Objective. To examine the association of three most common obesity measures including body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) with chronic kidney disease (CKD) risk in patients with type 2 diabetes mellitus (T2D). Design. Cross-sectional evaluation of the effect of anthropometric ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/715871

    authors: Xu L,Yu W,Huang P,Li C,Li Y,Wang M,Xu Q,Wang J,Zheng C,Qu B,Zhao Y,Niu M,Wang O,Gong F

    更新日期:2015-01-01 00:00:00

  • Regulation of the Human Ghrelin Promoter Activity by Transcription Factors, NF-κB and Nkx2.2.

    abstract::To examine the gene expression of ghrelin, a growth hormone releasing and appetite stimulating hormone from stomach, we constructed human ghrelin promoter-reporter vectors and analyzed the promoter activity. The ghrelin promoter activity was high when cultured cells that express ghrelin mRNA endogenously like TT or EC...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/580908

    authors: Shiimura Y,Ohgusu H,Sato T,Kojima M

    更新日期:2015-01-01 00:00:00

  • Differences in the Cardiometabolic Control in Type 2 Diabetes according to Gender and the Presence of Cardiovascular Disease: Results from the eControl Study.

    abstract::The objective of this cross-sectional study was to assess differences in the control and treatment of modifiable cardiovascular risk factors (CVRF: HbA1c, blood pressure [BP], LDL-cholesterol, body mass index, and smoking habit) according to gender and the presence of cardiovascular disease (CVD) in patients with type...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/131709

    authors: Franch-Nadal J,Mata-Cases M,Vinagre I,Patitucci F,Hermosilla E,Casellas A,Bolivar B,Mauricio D

    更新日期:2014-01-01 00:00:00

  • Latent Inflammation and Insulin Resistance in Adipose Tissue.

    abstract::Obesity is a growing problem in modern society and medicine. It closely associates with metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and cardiovascular diseases such as nonalcoholic fatty liver disease, atherosclerosis, myocarditis, and hypertension. Obesity is often associated with latent i...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5076732

    authors: Stafeev IS,Vorotnikov AV,Ratner EI,Menshikov MY,Parfyonova YV

    更新日期:2017-01-01 00:00:00

  • Usefulness of an Image Fusion Model Using Three-Dimensional CT and MRI with Indocyanine Green Fluorescence Endoscopy as a Multimodal Assistant System in Endoscopic Transsphenoidal Surgery.

    abstract::Purpose. We investigate the usefulness of multimodal assistant systems using a fusion model of preoperative three-dimensional (3D) computed tomography (CT) and magnetic resonance imaging (MRI) along with endoscopy with indocyanine green (ICG) fluorescence in establishing endoscopic endonasal transsphenoidal surgery (E...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/694273

    authors: Inoue A,Ohnishi T,Kohno S,Nishida N,Nakamura Y,Ohtsuka Y,Matsumoto S,Ohue S

    更新日期:2015-01-01 00:00:00

  • Distribution of abdominal obesity and fitness level in overweight and obese korean adults.

    abstract::Background. Abdominal obesity and its relative distribution are known to differ in association with metabolic characteristics and cardiorespiratory fitness. This study aimed to determine an association between fitness level and abdominal adiposity in overweight and obese adults. Methods. 228 overweight and obese indiv...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/854392

    authors: Kim S,Kim JY,Lee DC,Lee HS,Lee JW,Jeon JY

    更新日期:2014-01-01 00:00:00

  • Synergistic Effect of Hyperglycemia and p27(kip1) Suppression on Adult Mouse Islet Beta Cell Replication.

    abstract::The complementary role of hyperglycemia and p27(kip1) suppression on islet beta cell regeneration was investigated in a syngeneic mouse model. p27(kip1) gene silencing was performed by infecting islets of C57BL/6 with shRNA lentiviral particles. At 54 hours after viral infection, p27(kip1) protein content in cultured ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2012/417390

    authors: Chen ST,Fu SH,Hsu S,Huang YY,Hsu BR

    更新日期:2012-01-01 00:00:00

  • Predictors of the Dose-Effect Relationship regarding Unilateral Inferior Rectus Muscle Recession in Patients with Thyroid Eye Disease.

    abstract::Purpose. To evaluate whether inferior rectus muscle (IRM) thickness, the degree of adipose change in the IRM, smoking status, and the previous history of orbital radiotherapy can predict the dose-effect relationship regarding unilateral IRM recession in thyroid eye disease (TED). Methods. Twenty-five patients were ret...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/703671

    authors: Takahashi Y,Kakizaki H

    更新日期:2015-01-01 00:00:00

  • Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications.

    abstract::With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through infl...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2019/9691345

    authors: Xiong Q,Liu J,Xu Y

    更新日期:2019-10-13 00:00:00

  • miR-129-5p Inhibits Adipogenesis through Autophagy and May Be a Potential Biomarker for Obesity.

    abstract:Introduction:Obesity has an unclear pathogenesis. MicroRNAs (miRNAs) may function as biologically active molecules for obesity through regulating adipocyte differentiation. This study aimed to identify how miR-129-5p (a specific miRNA) regulates adipogenesis in vitro and explore its possible role in the pathogenesis of...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2019/5069578

    authors: Fu X,Jin L,Han L,Yuan Y,Mu Q,Wang H,Yang J,Ning G,Zhou D,Zhang Z

    更新日期:2019-11-06 00:00:00

  • Potential role of sugar transporters in cancer and their relationship with anticancer therapy.

    abstract::Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. Cancer cells are well known to display an enhanced sugar uptake and consumption. In fact, sugar transporters ar...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2010/205357

    authors: Calvo MB,Figueroa A,Pulido EG,Campelo RG,Aparicio LA

    更新日期:2010-01-01 00:00:00

  • Association between Parent's Metabolic Syndrome and 12- to18-Year-Old Offspring's Overweight: Results from the Korea National Health and Nutrition Examination Survey (K-NHANES) 2009-2016.

    abstract:Background:Little information is available on the association between parents' metabolic syndrome (MetS) and adolescent offspring's obesity in Korea. The aim of our study is to determine the association between parent's metabolic syndrome and offspring's obesity. Methods:The study data were obtained from the Korean Na...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/8737912

    authors: Lee NY,Han K,Lee Y,Kim S,Lee S,Choi Y,Ahn MB,Kim SH,Cho WK,Cho KS,Jung MH,Park YG,Suh BK

    更新日期:2020-10-30 00:00:00

  • Evidence of Insulin Resistance and Other Metabolic Alterations in Boys with Duchenne or Becker Muscular Dystrophy.

    abstract::Aim. Our aim was (1) to determine the frequency of insulin resistance (IR) in patients with Duchenne/Becker muscular dystrophy (DMD/BMD), (2) to identify deleted exons of DMD gene associated with obesity and IR, and (3) to explore some likely molecular mechanisms leading to IR. Materials and Methods. In 66 patients wi...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/867273

    authors: Rodríguez-Cruz M,Sanchez R,Escobar RE,Cruz-Guzmán Odel R,López-Alarcón M,Bernabe García M,Coral-Vázquez R,Matute G,Velázquez Wong AC

    更新日期:2015-01-01 00:00:00

  • Quality of Life and Sexual Health in the Aging of PCa Survivors.

    abstract::Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been established. Howeve...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2014/470592

    authors: Gacci M,Baldi E,Tamburrino L,Detti B,Livi L,De Nunzio C,Tubaro A,Gravas S,Carini M,Serni S

    更新日期:2014-01-01 00:00:00

  • Simultaneous Quantification of 25-Hydroxyvitamin D3 and 24,25-Dihydroxyvitamin D3 in Rats Shows Strong Correlations between Serum and Brain Tissue Levels.

    abstract::While vitamin D3 is recognized as a neuroactive steroid affecting both brain development and function, efficient analytical method in determining vitamin D3 metabolites in the brain tissue is still lacking, and the relationship of vitamin D3 status between serum and brain remains elusive. Therefore, we developed a nov...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/296531

    authors: Xue Y,He X,Li HD,Deng Y,Yan M,Cai HL,Tang MM,Dang RL,Jiang P

    更新日期:2015-01-01 00:00:00

  • Contributions of Fasting and Postprandial Glucose Concentrations to Haemoglobin A1c in Drug-Naïve Mal-Glucose Metabolism in Chinese Population Using Continuous Glucose Monitoring System.

    abstract:Aim:To clarify the contributions of fasting glucose (FG) and postprandial glucose (PG) to HbA1c in drug-naïve patients with type 2 diabetes (T2D) and impaired glucose tolerate (IGT)/impaired fasting glucose (IFG). Methods:Continuous glucose monitoring (CGM) was performed in 305 drug-naïve Chinese patients with T2D or ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2019/1267475

    authors: Yan R,Hu Y,Li F,Jiang L,Xu X,Wang J,Zhang Y,Ye L,Lee KO,Su X,Ma J

    更新日期:2019-12-01 00:00:00

  • A new aurora in anaplastic thyroid cancer therapy.

    abstract::Anaplastic thyroid cancers (ATC) are among the most aggressive human neoplasms with a dire prognosis and a median survival time of few months from the diagnosis. The complete absence of effective therapies for ATC renders the identification of novel therapeutic approaches sorely needed. Chromosomal instability, a feat...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2014/816430

    authors: Baldini E,D'Armiento M,Ulisse S

    更新日期:2014-01-01 00:00:00

  • Influence of the A3669G Glucocorticoid Receptor Gene Polymorphism on the Metabolic Profile of Pediatric Patients with Congenital Adrenal Hyperplasia.

    abstract::Background. Pediatric CAH patients have an increased risk of cardiovascular disease, and it remains unknown if genetic predisposition is a contributing factor. Glucocorticoid receptor gene (NR3C1) polymorphisms are associated with an adverse metabolic profile. Our aim was to analyze the association between the NR3C1 p...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/594710

    authors: Moreira RP,Gomes LG,Madureira G,Mendonca BB,Bachega TA

    更新日期:2014-01-01 00:00:00

  • Corrigendum to "The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes".

    abstract::[This corrects the article DOI: 10.1155/2014/690783.]. ...

    journal_title:International journal of endocrinology

    pub_type: 已发布勘误

    doi:10.1155/2017/5924671

    authors: Napoli N,Strollo R,Paladini A,Briganti SI,Pozzilli P,Epstein S

    更新日期:2017-01-01 00:00:00

  • Gut Microbiota Composition and Structure of the Ob/Ob and Db/Db Mice.

    abstract:Introduction:Gut microbiota is involved in the progression of metabolic diseases such as obesity and type 2 diabetes. The ob/ob and db/db mice are extensively used as models in studies on the pathogenesis of these diseases. The goal of this study is to characterize the composition and structure of gut microbiota in the...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2019/1394097

    authors: Yang M,Liu Y,Xie H,Wen Z,Zhang Y,Wu C,Huang L,Wu J,Xie C,Wang T,Peng W,Liu S,Chen L,Liu X

    更新日期:2019-03-11 00:00:00

  • Association between Dietary Patterns and Precocious Puberty in Children: A Population-Based Study.

    abstract:Objective:The aim of the present study was to investigate the association between dietary patterns and precocious puberty among Shanghai children. Methods:A cross-sectional study was conducted among Shanghai children by multistage stratified cluster random sampling in June 2014. Diet was assessed using a simplified fo...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2018/4528704

    authors: Chen C,Chen Y,Zhang Y,Sun W,Jiang Y,Song Y,Zhu Q,Mei H,Wang X,Liu S,Jiang F

    更新日期:2018-01-16 00:00:00

  • Comorbidity between Type 2 Diabetes and Depression in the Adult Population: Directions of the Association and Its Possible Pathophysiological Mechanisms.

    abstract::Type 2 diabetes and depression are regarded as comorbid conditions, and three possible directions of the association between the diseases can underlie this observation of comorbidity. First, common etiology can increase a person's risk of both diseases; second, persons with type 2 diabetes have increased prevalence or...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2015/164760

    authors: Berge LI,Riise T

    更新日期:2015-01-01 00:00:00