Relationship between Testicular Volume and Conventional or Nonconventional Sperm Parameters.

Abstract:

:Background. Reduced testicular volume (TV) (<12 cm(3)) is associated with lower testicular function. Several studies explored the conventional sperm parameters (concentration, motility, and morphology) and the endocrine function (gonadotropins and testosterone serum concentrations) in the patients with reduction of TV. No other parameters have been examined. Aim. This study aims at evaluating some biofunctional sperm parameters by flow cytometry in the semen of men with reduced TV compared with that of subjects with normal TV. Methods. 78 patients without primary scrotal disease were submitted to ultrasound evaluation of the testis. They were divided into two groups according to testicular volume: A Group, including 40 patients with normal testicular volume (TV > 15 cm(3)) and B Group, including 38 patients with reduced testicular volume (TV ≤ 12 cm(3)). All patients underwent serum hormone concentration, conventional and biofunctional (flow cytometry) sperm parameters evaluation. Results. With regard to biofunctional sperm parameters, all values (mitochondrial membrane potential, phosphatidylserine externalization, chromatin compactness, and DNA fragmentation) were strongly negatively correlated with testicular volume (P < 0.0001). Conclusions. This study for the first time in the literature states that the biofunctional sperm parameters worsen and with near linear correlation, with decreasing testicular volume.

journal_name

Int J Endocrinol

authors

Condorelli R,Calogero AE,La Vignera S

doi

10.1155/2013/145792

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

145792

eissn

1687-8337

issn

1687-8345

journal_volume

2013

pub_type

杂志文章
  • Sex- and Age-Specific Optimal Anthropometric Indices as Screening Tools for Metabolic Syndrome in Chinese Adults.

    abstract:Objectives:To compare the predictive ability of six anthropometric indices for identification of metabolic syndrome (MetS) and to determine their optimal cut-off points among Chinese adults. Methods:A total of 59,029 participants were enrolled. Body mass index (BMI), waist circumference (WC), waist-to-height ratio (WH...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2018/1067603

    authors: Zhang J,Zhu W,Qiu L,Huang L,Fang L

    更新日期:2018-09-17 00:00:00

  • Diagnostic and Management Pathways for Pulmonary Carcinoid Tumours in the United Kingdom: Results from the National Lung Neuroendocrine Tumour Pathway Project.

    abstract::There is inconsistency among published guidelines for the optimal diagnostic and management pathways for patients with typical (TC) or atypical (AC) pulmonary carcinoid tumours. We conducted a UK-wide clinician survey to assess current practice for the diagnosis, management, and follow-up of patients with TC/AC and de...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/9287536

    authors: Mansoor W,Ferguson S,Ross V,Talbot D

    更新日期:2020-02-28 00:00:00

  • Fatty Acid modulation of the endocannabinoid system and the effect on food intake and metabolism.

    abstract::Endocannabinoids and their G-protein coupled receptors (GPCR) are a current research focus in the area of obesity due to the system's role in food intake and glucose and lipid metabolism. Importantly, overweight and obese individuals often have higher circulating levels of the arachidonic acid-derived endocannabinoids...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2013/361895

    authors: Naughton SS,Mathai ML,Hryciw DH,McAinch AJ

    更新日期:2013-01-01 00:00:00

  • Gut Microbiota Composition and Structure of the Ob/Ob and Db/Db Mice.

    abstract:Introduction:Gut microbiota is involved in the progression of metabolic diseases such as obesity and type 2 diabetes. The ob/ob and db/db mice are extensively used as models in studies on the pathogenesis of these diseases. The goal of this study is to characterize the composition and structure of gut microbiota in the...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2019/1394097

    authors: Yang M,Liu Y,Xie H,Wen Z,Zhang Y,Wu C,Huang L,Wu J,Xie C,Wang T,Peng W,Liu S,Chen L,Liu X

    更新日期:2019-03-11 00:00:00

  • Regulation of the Human Ghrelin Promoter Activity by Transcription Factors, NF-κB and Nkx2.2.

    abstract::To examine the gene expression of ghrelin, a growth hormone releasing and appetite stimulating hormone from stomach, we constructed human ghrelin promoter-reporter vectors and analyzed the promoter activity. The ghrelin promoter activity was high when cultured cells that express ghrelin mRNA endogenously like TT or EC...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/580908

    authors: Shiimura Y,Ohgusu H,Sato T,Kojima M

    更新日期:2015-01-01 00:00:00

  • Free triiodothyronine concentrations are inversely associated with microalbuminuria.

    abstract::Thyroid function and microalbuminuria are both associated with vascular disease and endothelial damage. However, whether thyroid function is associated with microalbuminuria is not well established. The objective was to explore the relationship between thyroid hormones and microalbuminuria in Chinese population. A com...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/959781

    authors: Zhou Y,Ye L,Wang T,Hong J,Bi Y,Zhang J,Xu B,Sun J,Huang X,Xu M

    更新日期:2014-01-01 00:00:00

  • The Association between 25-Hydroxyvitamin D and Hemoglobin A1c Levels in Patients with Type 2 Diabetes and Stage 1-5 Chronic Kidney Disease.

    abstract::Aim. To examine the relationship between plasma 25-hydroxyvitamin D (25(OH)D) levels and blood hemoglobin A1c (HbA1c) levels in diabetic patients at various stages of chronic kidney disease (CKD). Methods. We screened for data collected between 2003 and 2012. The correlation between 25(OH)D and HbA1c levels was studie...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/142468

    authors: Kajbaf F,Mentaverri R,Diouf M,Fournier A,Kamel S,Lalau JD

    更新日期:2014-01-01 00:00:00

  • Comparison of Exenatide and Metformin Monotherapy in Overweight/Obese Patients with Newly Diagnosed Type 2 Diabetes.

    abstract:Aims:The present study assessed the therapeutic effect of exenatide and metformin as the initial therapy on overweight/obese patients with newly diagnosed type 2 diabetes (T2D). Methods:The prospective, nonrandomized, interventional study enrolled a total of 230 overweight or obese patients with newly diagnosed T2D wh...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2017/9401606

    authors: Liu J,Hu Y,Xu Y,Jia Y,Miao L,Wang G

    更新日期:2017-01-01 00:00:00

  • Puerarin Suppress Apoptosis of Human Osteoblasts via ERK Signaling Pathway.

    abstract::Puerarin, the main isoflavone glycoside extracted from Radix Puerariae, is an isoflavone traditional Chinese herb. Previous studies have demonstrated that puerarin could regulate osteoblast proliferation and differentiation to promote bone formation. However, the effect of puerarin on the process of human osteoblasts ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2013/786574

    authors: Liu LJ,Liu LQ,Bo T,Li SJ,Zhu Z,Cui RR,Mao DA

    更新日期:2013-01-01 00:00:00

  • Parathyroid Carcinoma: An Up-to-Date Retrospective Multicentric Analysis.

    abstract::Parathyroid carcinoma (PC) is a rare disease responsible for about 1% of primary hyperparathyroidism (PHPT) cases. PC usually has an indolent course, tough to differentiate from the benign causes of PHPT, and the only certain diagnosis is histologic. The gold standard surgical treatment is the en bloc resection associ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2020/7048185

    authors: Quaglino F,Manfrino L,Cestino L,Giusti M,Mazza E,Piovesan A,Palestini N,Lauro C,Castellano E

    更新日期:2020-03-06 00:00:00

  • Propylthiouracil-induced acute liver failure: role of liver transplantation.

    abstract::Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the c...

    journal_title:International journal of endocrinology

    pub_type:

    doi:10.1155/2010/910636

    authors: Carrion AF,Czul F,Arosemena LR,Selvaggi G,Garcia MT,Tekin A,Tzakis AG,Martin P,Ghanta RK

    更新日期:2010-01-01 00:00:00

  • Assessment of carotid atherosclerosis in type 2 diabetes mellitus patients with microalbuminuria by high-frequency ultrasonography.

    abstract::The aim of this study is to evaluate carotid atherosclerosis in patients of type 2 diabetes mellitus with microalbuminuria (MA) by high-frequency ultrasonography. Two hundred and fifty patients of type 2 diabetes mellitus were divided into two groups according to urinary albumin excretion rate (UAER): normoalbuminuria...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2013/819584

    authors: Zhang YH,Gao Y,Mao X,Shang J,Su BL

    更新日期:2013-01-01 00:00:00

  • Seeking out high risk population: the prevalence characteristics and outcome of diabetic patients of arab ethnicity hospitalized in internal medical and acute coronary units in Israel.

    abstract::Aims. To seek high risk population for diabetes and to improve their health care by investigating the characteristics and outcome of hospitalization in hospitals with predominant Arab patients in Northern Israel. Methods. Retrospective analysis of the prevalence of diabetes and the outcome of diabetic in comparison to...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2013/371608

    authors: Nseir W,Haj S,Beshara B,Mograbi J,Cohen O

    更新日期:2013-01-01 00:00:00

  • Effects of Vitamin D Supplementation on Glucose and Insulin Homeostasis and Incident Diabetes among Nondiabetic Adults: A Meta-Analysis of Randomized Controlled Trials.

    abstract:Aims:Emerging evidence has suggested a mechanistic link from vitamin D metabolism to glucose and insulin homeostasis. This study is aimed at specifically quantifying the direct effects of vitamin D supplementation on indexes of glucose and insulin homeostasis as well as incidence of type 2 diabetes (T2D) among nondiabe...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2018/7908764

    authors: Tang H,Li D,Li Y,Zhang X,Song Y,Li X

    更新日期:2018-12-03 00:00:00

  • Usefulness of an Image Fusion Model Using Three-Dimensional CT and MRI with Indocyanine Green Fluorescence Endoscopy as a Multimodal Assistant System in Endoscopic Transsphenoidal Surgery.

    abstract::Purpose. We investigate the usefulness of multimodal assistant systems using a fusion model of preoperative three-dimensional (3D) computed tomography (CT) and magnetic resonance imaging (MRI) along with endoscopy with indocyanine green (ICG) fluorescence in establishing endoscopic endonasal transsphenoidal surgery (E...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/694273

    authors: Inoue A,Ohnishi T,Kohno S,Nishida N,Nakamura Y,Ohtsuka Y,Matsumoto S,Ohue S

    更新日期:2015-01-01 00:00:00

  • Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes.

    abstract::A quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism. Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis. We conducted a randomiz...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2018/6170154

    authors: Dhindsa S,Chemitiganti R,Ghanim H,Santiago E,Haider A,Chaar N,Mok M,McKee A,Dandona P

    更新日期:2018-10-31 00:00:00

  • Effect of gelam honey on the oxidative stress-induced signaling pathways in pancreatic hamster cells.

    abstract::Background. Oxidative stress induced by reactive oxygen and nitrogen species is critically involved in the impairment of β -cell function during the development of diabetes. Methods. HIT-T15 cells were cultured in 5% CO2 and then preincubated with Gelam honey extracts (20, 40, 60, and 80 µg/mL) as well as quercetin (2...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2013/367312

    authors: Batumalaie K,Zaman Safi S,Mohd Yusof K,Shah Ismail I,Devi Sekaran S,Qvist R

    更新日期:2013-01-01 00:00:00

  • Treatment with Myo-Inositol and Selenium Ensures Euthyroidism in Patients with Autoimmune Thyroiditis.

    abstract::Clinical evidences have highlighted the efficacy of myo-inositol and selenium in the treatment of autoimmune thyroiditis. Aim of this study was to further analyze the role of myo-inositol plus selenium (Myo-Ins-Se) in restoring a normal thyroid function of Hashimoto's patients with subclinical hypothyroidism. Eighty-s...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2017/2549491

    authors: Nordio M,Basciani S

    更新日期:2017-01-01 00:00:00

  • Liraglutide Exerts Antidiabetic Effect via PTP1B and PI3K/Akt2 Signaling Pathway in Skeletal Muscle of KKAy Mice.

    abstract::Background. Liraglutide (a glucagon-like peptide 1 analog) was used for the treatment of type 2 diabetes (T2DM) which could produce glucose-dependent insulin secretion. Aim. The aim was to investigate whether liraglutide could improve myofibril and mitochondria injury in skeletal muscle and the mechanisms in diabetic ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/312452

    authors: Ji W,Chen X,Lv J,Wang M,Ren S,Yuan B,Wang B,Chen L

    更新日期:2014-01-01 00:00:00

  • The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach.

    abstract::The risk for cardiovascular diseases and type 2 diabetes mellitus significantly increases in the patient population with metabolic syndrome (MeS). The present study aimed to investigate the association between the epicardial adipose tissue thickness (EATT) and the oxidative stress parameters in MeS patients. The study...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2014/954045

    authors: Demir B,Demir E,Acıksarı G,Uygun T,Utku IK,Gedikbasi A,Caglar IM,Pirhan O,Tureli HO,Oflar E,Ungan İ,Ciftci S,Karakaya O

    更新日期:2014-01-01 00:00:00

  • Differential Role of Leptin and Adiponectin in Cardiovascular System.

    abstract::Leptin and adiponectin are differentially expressed adipokines in obesity and cardiovascular diseases. Leptin levels are directly associated with adipose tissue mass, while adiponectin levels are downregulated in obesity. Although significantly produced by adipocytes, leptin is also produced by vascular smooth muscle ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1155/2015/534320

    authors: Ghantous CM,Azrak Z,Hanache S,Abou-Kheir W,Zeidan A

    更新日期:2015-01-01 00:00:00

  • Predictors of the Dose-Effect Relationship regarding Unilateral Inferior Rectus Muscle Recession in Patients with Thyroid Eye Disease.

    abstract::Purpose. To evaluate whether inferior rectus muscle (IRM) thickness, the degree of adipose change in the IRM, smoking status, and the previous history of orbital radiotherapy can predict the dose-effect relationship regarding unilateral IRM recession in thyroid eye disease (TED). Methods. Twenty-five patients were ret...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/703671

    authors: Takahashi Y,Kakizaki H

    更新日期:2015-01-01 00:00:00

  • Four-Point Preprandial Self-Monitoring of Blood Glucose for the Assessment of Glycemic Control and Variability in Patients with Type 2 Diabetes Treated with Insulin and Vildagliptin.

    abstract::The study explored the utility of four-point preprandial glucose self-monitoring to calculate several indices of glycemic control and variability in a study adding the DPP-4 inhibitor vildagliptin to ongoing insulin therapy. This analysis utilized data from a double-blind, randomized, placebo-controlled crossover stud...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/484231

    authors: Tura A,Farngren J,Schweizer A,Foley JE,Pacini G,Ahrén B

    更新日期:2015-01-01 00:00:00

  • Prolactin and male fertility: the long and short feedback regulation.

    abstract::In the last 20 years, a pituitary-hypothalamus tissue culture system with intact neural and portal connections has been developed in our lab and used to understand the feedback mechanisms that regulate the secretions of adenohypophyseal hormones and fertility of male rats. In the last decade, several in vivo rat model...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2009/687259

    authors: Gill-Sharma MK

    更新日期:2009-01-01 00:00:00

  • Causes and Metabolic Consequences of Gynecomastia in Adult Patients.

    abstract:Background:Gynecomastia (GM) is a benign enlargement of male breast due to glandular tissue proliferation. GM is a symptom of systemic or local hormonal disturbances, which could be associated with functional changes or pathological conditions. However, the long-lasting steroid imbalance in men with GM might exert nega...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2019/6718761

    authors: Robeva R,Elenkova A,Zacharieva S

    更新日期:2019-10-03 00:00:00

  • Fasting-Evoked En Route Hypoglycemia in Diabetes (FEEHD): An Overlooked Form of Hypoglycemia in Clinical Practice.

    abstract:Objective:Many patients with diabetes opt to fast for lab tests, especially for lipid profiles, thus missing breakfast. In parallel, recent studies and international guidelines have indicated that routine fasting for lipid panels may not be necessary. Missing breakfast while fasting for lab tests may invoke hypoglycemi...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2018/1528437

    authors: Aldasouqi S,Mora S,Bhalla G,Kakumanu N,Corser W,Abela G,Dlewati M,Estrada K,Almounajed A,Tabbaa T,Hammoud J,Newkirk C

    更新日期:2018-10-24 00:00:00

  • Vitamin D Status and VDR Genotype in NF1 Patients: A Case-Control Study from Southern Brazil.

    abstract::Neurofibromatosis type 1 (NF1) patients are more likely to have vitamin D deficiency when compared to the general population. This study aimed to determine the levels of 25-OH-vitamin D [25(OH)D] in individuals with NF1 and disease-unaffected controls and analyze FokI and BsmI VDR gene polymorphisms in a case and in a...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2015/402838

    authors: Souza Mario Bueno L,Rosset C,Aguiar E,Pereira Fde S,Izetti Ribeiro P,Scalco R,Matzenbacher Bittar C,Brinckmann Oliveira Netto C,Gischkow Rucatti G,Chies JA,Camey SA,Ashton-Prolla P

    更新日期:2015-01-01 00:00:00

  • The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas.

    abstract::Objectives. The roles of PI3K/AKT/mTOR and MAPK/ERK pathways involved in the pathogenesis of pheochromocytoma and paraganglioma (PPGL) were demonstrated mostly by in vitro studies with rat or mouse cells and were mainly studied at transcriptional level. This study aimed to investigate the effect of these pathways on t...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2016/5286972

    authors: Du J,Tong A,Wang F,Cui Y,Li C,Zhang Y,Yan Z

    更新日期:2016-01-01 00:00:00

  • Psychological status and quality of life in relation to the metabolic syndrome: Isfahan Cohort Study.

    abstract:OBJECTIVE:Current study was designed to investigate the association of metabolic syndrome (MetS) with depression, anxiety, psychological distress, and quality of life (QoL). DESIGN:Two hundred and fifteen contributors with MetS and 253 participants without MetS were randomly selected from 2151 participants of Isfahan ...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2012/380902

    authors: Roohafza H,Sadeghi M,Talaei M,Pourmoghaddas Z,Sarrafzadegan N

    更新日期:2012-01-01 00:00:00

  • Low serum magnesium level is associated with microalbuminuria in chinese diabetic patients.

    abstract::Whether serum magnesium deficiency is independently associated with the prevalence of microalbuminuria is still unclear. The objective of the present study was to elucidate the association between serum magnesium and microalbuminuria in diabetic patients. A cross-sectional study was conducted in 1829 diabetic subjects...

    journal_title:International journal of endocrinology

    pub_type: 杂志文章

    doi:10.1155/2013/580685

    authors: Xu B,Sun J,Deng X,Huang X,Sun W,Xu Y,Xu M,Lu J,Bi Y

    更新日期:2013-01-01 00:00:00