Abstract:
:In the present study we evaluated in vivo and in vitro effects of 4-tert-octylphenol (OP) on the expression and distribution of adherens and gap junction proteins, N-cadherin, β -catenin, and connexin 43 (Cx43), in testes of seasonally breeding rodents, bank voles. We found that in bank vole testes expression and distribution of N-cadherin, β -catenin, and Cx43 were photoperiod dependent. Long-term treatment with OP (200 mg/kg b.w.) resulted in the reduction of junction proteins expressions (P < 0.05, P < 0.01) and their delocalization in the testes of males kept in long photoperiod, whereas in short-day animals slight increase of Cx43 (P < 0.05), N-cadherin, and β -catenin (statistically nonsignificant) levels was observed. Effects of OP appeared to be independent of FSH and were maintained during in vitro organ culture, indicating that OP acts directly on adherens and gap junction proteins in the testes. An experiment performed using an antiestrogen ICI 182,780 demonstrated that the biological effects of OP on β -catenin and Cx43 involve an estrogen receptor-mediated response. Taken together, in bank vole organization of adherens and gap junctions and their susceptibility to OP are related to the length of photoperiod. Alterations in cadherin/catenin and Cx43-based junction may partially result from activation of estrogen receptor α and/or β signaling pathway.
journal_name
Int J Endocrinoljournal_title
International journal of endocrinologyauthors
Hejmej A,Kotula-Balak M,Chojnacka K,Kuras P,Lydka-Zarzycka M,Bilinska Bdoi
10.1155/2013/134589subject
Has Abstractpub_date
2013-01-01 00:00:00pages
134589eissn
1687-8337issn
1687-8345journal_volume
2013pub_type
杂志文章abstract::Background. Management of thyroid nodules with benign aspirates following atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is not well established. We reviewed the risk of malignancy and the role of ultrasound (US) features among thyroid nodules with benign results followin...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/354612
更新日期:2014-01-01 00:00:00
abstract::Background. Separate lines of research have shown that menstrual cycling and contextual factors such as the gender of research personnel influence experimental pain reporting. Objectives. This study examines how brief, procedural interactions with female and male experimenters can affect experimentally reported pain (...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/520719
更新日期:2015-01-01 00:00:00
abstract::With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through infl...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2019/9691345
更新日期:2019-10-13 00:00:00
abstract:Background:Gynecomastia (GM) is a benign enlargement of male breast due to glandular tissue proliferation. GM is a symptom of systemic or local hormonal disturbances, which could be associated with functional changes or pathological conditions. However, the long-lasting steroid imbalance in men with GM might exert nega...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/6718761
更新日期:2019-10-03 00:00:00
abstract::Objective. To determine the role of imaging-cytology correlation in reducing false negative results of fine-needle aspiration (FNA) at thyroid nodules. Methods. This retrospective study included 667 nodules 1 cm or larger in 649 patients diagnosed as benign at initial cytologic evaluation and that underwent follow-up ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/491508
更新日期:2014-01-01 00:00:00
abstract::Purpose. To evaluate alteration in serum TSH in hypertensives with OSA and its relation with cardiometabolic risk factors. Methods. 517 hypertensives were cross-sectionally studied. OSA was determined by polysomnography and thyroid function by standard methods. Results. OSA was diagnosed in 373 hypertensives (72.15%)....
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/4802720
更新日期:2016-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/4708132
更新日期:2020-02-24 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/715871
更新日期:2015-01-01 00:00:00
abstract:Objective:Once-weekly PEGylated recombinant human growth hormone (rhGH) is the sole long-acting GH formulation available currently for pediatric patients with GH deficiency (GHD). The aim of this study was to evaluate the efficacy and safety of PEGylated rhGH therapy compared to daily rhGH therapy in GHD children treat...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/1438723
更新日期:2019-09-19 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/436725
更新日期:2014-01-01 00:00:00
abstract::Anaplastic thyroid cancers (ATC) are among the most aggressive human neoplasms with a dire prognosis and a median survival time of few months from the diagnosis. The complete absence of effective therapies for ATC renders the identification of novel therapeutic approaches sorely needed. Chromosomal instability, a feat...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/816430
更新日期:2014-01-01 00:00:00
abstract::Fibroblast growth factor 21 (FGF21) modulates a diverse range of biological functions, including glucose and lipid metabolism, adaptive starvation response, and energy homeostasis, but with limited mechanistic insight. FGF21 treatment has been shown to inhibit hepatic growth hormone (GH) intracellular signaling. To ev...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/282375
更新日期:2015-01-01 00:00:00
abstract:Objective:Cystic parathyroid adenoma is a rare cause of primary hyperparathyroidism, but its preoperative diagnosis and management remain inconclusive. Method:We retrospectively identified patients with cystic parathyroid adenomas who underwent surgery at Peking Union Medical College Hospital. Results:Patients with c...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2018/3745239
更新日期:2018-07-15 00:00:00
abstract::Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer. It shows a wide spectrum of morphological presentations and the diagnosis could be challenging due to its high degree of dedifferentiation. Molecular and genetic features of ATC are widely heterogeneous as well and many efforts have been...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/790834
更新日期:2014-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type:
doi:10.1155/2010/681647
更新日期:2010-01-01 00:00:00
abstract::The main purpose of our retrospective study was to evaluate the medical care of the patients with subclinical hypothyroidism (sHT) and to investigate the rationale for administering L-thyroxine (LT-4) to young sHT patients. Patients and Methods. Based on a retrospective review of the charts of 261 patients referred to...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/1671820
更新日期:2016-01-01 00:00:00
abstract:Background:Total thyroidectomy (TT) is recommended in the treatment of malignant and benignant thyroid diseases, and, to date, transient hypocalcemia is the most frequent complication after the procedure. We prospectively evaluated the role of vitamin D deficiency as a predictor of postoperative hypocalcemia. Methods:...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/8875257
更新日期:2020-10-10 00:00:00
abstract::Background. Oxidative stress induced by reactive oxygen and nitrogen species is critically involved in the impairment of β -cell function during the development of diabetes. Methods. HIT-T15 cells were cultured in 5% CO2 and then preincubated with Gelam honey extracts (20, 40, 60, and 80 µg/mL) as well as quercetin (2...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2013/367312
更新日期:2013-01-01 00:00:00
abstract::Iodine supplementation through salt iodization is a worldwide, effective strategy for preventing iodine deficiency-related problems. Its safety and efficacy profile has been extensively investigated, and benefits far outweigh the potential iodine-induced risks. Moreover, iodine supplementation during pregnancy in orde...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/312305
更新日期:2015-01-01 00:00:00
abstract::Leptin and adiponectin are differentially expressed adipokines in obesity and cardiovascular diseases. Leptin levels are directly associated with adipose tissue mass, while adiponectin levels are downregulated in obesity. Although significantly produced by adipocytes, leptin is also produced by vascular smooth muscle ...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2015/534320
更新日期:2015-01-01 00:00:00
abstract:Aims:The present study assessed the therapeutic effect of exenatide and metformin as the initial therapy on overweight/obese patients with newly diagnosed type 2 diabetes (T2D). Methods:The prospective, nonrandomized, interventional study enrolled a total of 230 overweight or obese patients with newly diagnosed T2D wh...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2017/9401606
更新日期:2017-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/642046
更新日期:2015-01-01 00:00:00
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journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2014/470592
更新日期:2014-01-01 00:00:00
abstract::Background. The purpose of the present study was to assess the feasibility of using miR-126 in the urine as a biomarker for diabetic nephropathy. Methods. miRNAs were extracted from the urine samples of T2DM patients with diabetic nephropathy (DN; n = 92), T2DM without DN (n = 86), and 85 healthy volunteers using quan...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2014/393109
更新日期:2014-01-01 00:00:00
abstract::The aim of this review was to summarize current knowledge on the correlation between depressive symptoms with a syndrome called partial androgen deficiency of the aging male (PADAM) and on the potential benefits of testosterone (T) treatment on mood. Despite, the causative nature of the relationship between low T leve...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2012/280724
更新日期:2012-01-01 00:00:00
abstract::Aim. Our aim was (1) to determine the frequency of insulin resistance (IR) in patients with Duchenne/Becker muscular dystrophy (DMD/BMD), (2) to identify deleted exons of DMD gene associated with obesity and IR, and (3) to explore some likely molecular mechanisms leading to IR. Materials and Methods. In 66 patients wi...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2015/867273
更新日期:2015-01-01 00:00:00
abstract::Objectives. The roles of PI3K/AKT/mTOR and MAPK/ERK pathways involved in the pathogenesis of pheochromocytoma and paraganglioma (PPGL) were demonstrated mostly by in vitro studies with rat or mouse cells and were mainly studied at transcriptional level. This study aimed to investigate the effect of these pathways on t...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2016/5286972
更新日期:2016-01-01 00:00:00
abstract::Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of...
journal_title:International journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1155/2017/2452853
更新日期:2017-01-01 00:00:00
abstract:Aim:To clarify the contributions of fasting glucose (FG) and postprandial glucose (PG) to HbA1c in drug-naïve patients with type 2 diabetes (T2D) and impaired glucose tolerate (IGT)/impaired fasting glucose (IFG). Methods:Continuous glucose monitoring (CGM) was performed in 305 drug-naïve Chinese patients with T2D or ...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2019/1267475
更新日期:2019-12-01 00:00:00
abstract::There is inconsistency among published guidelines for the optimal diagnostic and management pathways for patients with typical (TC) or atypical (AC) pulmonary carcinoid tumours. We conducted a UK-wide clinician survey to assess current practice for the diagnosis, management, and follow-up of patients with TC/AC and de...
journal_title:International journal of endocrinology
pub_type: 杂志文章
doi:10.1155/2020/9287536
更新日期:2020-02-28 00:00:00